Omicron Binding Mode: Contact Analysis and Dynamics of the Omicron Receptor-Binding Domain in Complex with ACE2오미크론 결합 모드: ACE2와 복합된 오미크론 수용체 결합 도메인의 접촉 분석 및 역학Article Published on 2022-08-222022-09-11 Journal: Journal of Chemical Information and Modeling [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 affected angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies B.1.1.529 binding complex complexes Contact COVID-19 Department distribution domain Dynamics edge Effect electrostatic form H-bond host receptor human ACE2 IMPROVE Interaction Lineage molecular molecular dynamics Mutation mutations N501Y omicron Omicron variant Open Science Framework Protein Proteins Receptor-binding domain resistance S-RBD Salt Bridge salt bridges SARS-CoV-2 virus spike Spike protein Spike proteins Stanford the receptor-binding domain the SARS-CoV-2 virus the Spike the WHO unique variant VoC [DOI] 10.1021/acs.jcim.2c00397 PMC 바로가기 [Article Type] Article
Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1현재 순환 중인 Omicron SARS-CoV-2 하위 변이체 BA.2 및 BA.1.1에 대한 인간 ACE2의 더 높은 결합 친화도의 구조적 기초Article Published on 2022-08-042022-09-11 Journal: Cell [Category] COVID19(2023년), SARS, 변종, [키워드] absence Affect alteration angiotensin binding affinity binding pattern circulating complex structure complex structures contribute hACE2 highest human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 Interaction Mutation mutations omicron RBD RBDs receptor-binding domains SARS-CoV-2 SARS-CoV-2 strains strain the receptor-binding domain the SARS-CoV-2 variants [DOI] 10.1016/j.cell.2022.06.023 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection impairs the insulin/IGF signaling pathway in the lung, liver, adipose tissue, and pancreatic cells via IRF1SARS-CoV-2 감염은 IRF1을 통해 폐, 간, 지방 조직 및 췌장 세포의 인슐린/IGF 신호 전달 경로를 손상시킵니다Article Published on 2022-08-012022-09-11 Journal: Metabolism: clinical and experimental [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Activation adeno-associated virus adipose Adipose tissue AKT ameliorated analyzed association Autopsy Calu3 Calu3 cell CaLu3 cells Cell cell survival cells condition contribute COVID-19 COVID-19 pathology COVID-19 patient COVID-19 patients COVID-19 severity Critical critical patient critical patients cytokine determine Dexamethasone diabetes Diabetic diabetic patients Dihydrotestosterone Endocrine energy metabolism European population evaluate Evidence exacerbated exhibited Gain Gene Expression Genes GFP HEK293T Hospitalized Host human ACE2 human cells hyperglycemia impair impairment infected with SARS-CoV-2 insulin insulin resistance Insulin signaling Insulin/IGF signaling pathway interferon regulatory factor Interferone intron IRF1 liver lung Lungs male Male sex MAPK metabolic metabolic abnormalities Metabolic abnormality metabolism mouse model mTOR Multiorgan dysfunction Multiple organ damage Non-COVID-19 Non-COVID-19 patients obese obesity Older Older age Organoid overexpressing pancreatic Pancreatic cell pancreatic islets pathology patients patients with COVID-19 PI3K potential mechanism Prevalence provide Regulation reported Repository risk factor Risk factors SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-COV-2 infection serotype severe COVID-19 severity Signaling signaling pathway significantly stem cell survival tissue tissue damage Tissue damage. tissues Transcriptome transcriptome dataset transcriptome datasets Transgenic mouse variant Whole blood whole blood transcriptome with COVID-19 [DOI] 10.1016/j.metabol.2022.155236 PMC 바로가기 [Article Type] Article
Molecular and computational analysis of spike protein of newly emerged omicron variant in comparison to the delta variant of SARS-CoV-2 in Iraq이라크에서 SARS-CoV-2의 델타 변이체와 비교하여 새로 출현한 오미크론 변이체의 스파이크 단백질의 분자 및 컴퓨터 분석Article Published on 2022-08-012022-09-11 Journal: Molecular biology reports [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome coronavirus Affect amino acids angiotensin angiotensin converting enzyme binding affinity bioinformatics computational analysis computational tool computational tools concerning contagious contributing to COVID-19 Delta delta variant Delta variants disorder Docking studies docking study engage enzyme greater Health higher affinity human ACE2 human angiotensin converting enzyme 2 hydrophobic amino acid identify Interaction Iraq less molecular molecular docking omicron Omicron variant Omicron variants pathogenicity PCR Phylogenetic analysis physical physical and chemical properties predicted qPCR RBD RBD region Receptor binding domain respiratory SARS-CoV-2 SARS-CoV-2 variants Sequencing severe acute respiratory syndrome Coronavirus Spike protein stability the spike protein Transmissibility Transmission Vaccine variant variant of SARS-CoV-2 variants variants of concern virus were used WHO [DOI] 10.1007/s11033-022-07545-4 PMC 바로가기 [Article Type] Article
In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding시험관 내 진화는 ACE2 및 종간 결합에 대한 높은 친화도로 새로운 SARS-CoV-2 돌연변이를 예측합니다Article Published on 2022-07-182022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 affinity being binding binding affinity binding domain boost complex Containment COVID-19 pandemic creating Cross-species transmission Cryo-electron microscopy determine determined by driven by electron microscopy Evolution high affinity human ACE2 immune evasion in vitro increase inhibit mechanism Mutation N501Y mutation predict Q498 Q498H RBD RBD variant RBD variants S477N SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 RBD SARS-CoV-2 receptor SARS-CoV-2 variant SARS-CoV-2 variants Transmissibility Vaccines variant variants [DOI] 10.1371/journal.ppat.1010733 PMC 바로가기 [Article Type] Article
Impact of the temperature on the interactions between common variants of the SARS-CoV-2 receptor binding domain and the human ACE2SARS-CoV-2 수용체 결합 도메인의 일반적인 변이체와 인간 ACE2 간의 상호작용에 대한 온도의 영향Article Published on 2022-07-072022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] 1:1 ACE2 ACE2 binding acquisition Alpha angiotensin approach B.1.1.529 B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 Beta binding Delta dissimilarity experiment high accuracy human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 Impact Interaction kinetic L452R mutant Mutation offer omicron parameter parameters powerful tool Protein RBD RBD mutation RBD variants Receptor binding domain reproducibility Spike protein Spike protein receptor binding domain surface plasmon surface plasmon resonance temperature the RBD the SARS-CoV-2 the Spike variant wild type Wuhan [DOI] 10.1038/s41598-022-15215-5 PMC 바로가기 [Article Type] Article
Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strainsSARS-CoV-2 Omicron 계통 균주에 의한 감염에 대한 S309 및 AZD7442 단일클론 항체 치료의 회복력Article Published on 2022-07-022022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acting Antibody neutralization AstraZeneca Cell culture changes in Combination correlation analyses Correlation analysis Effect Efficacy Express FcγR hACE2 human ACE2 humans in vitro In vitro studies in vitro study in vivo Infection Interaction K18-hACE2 Lineage Lung infection mAb mechanism mice monoclonal antibody monoclonal antibody therapies monoclonal antibody treatment monotherapy neutralization neutralization potency Neutralizing activity omicron Omicron variant Omicron variants Prevent Prophylactic Protective reduced reductions reductions in Resilience retained S309 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 isolates SARS-CoV-2 variant Spike protein strain suggested susceptible the spike protein therapeutic therapy transgenic mice treat Treatment variant variants Viral viral burden [DOI] 10.1038/s41467-022-31615-7 PMC 바로가기 [Article Type] Article
Receptor binding domain of SARS-CoV-2 from Wuhan strain to Omicron B.1.1.529 attributes increased affinity to variable structures of human ACE2우한 균주에서 Omicron B.1.1.529까지의 SARS-CoV-2 수용체 결합 도메인은 인간 ACE2의 가변 구조에 대한 증가된 친화성을 특성으로 합니다.Article Published on 2022-07-012022-09-11 Journal: Journal of infection and public health [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] ACE2 ACE2 receptor ACE2 receptors ACE2 variant ACE2 variants ACE2-RBD affinity analysed Analysis angiotensin Angiotensin-converting enzyme attribute B.1.1.529 binding binding domain binding efficiency binding energy Care caused changes in coding region complexes contributing to COVID-19 detect determine docking dynamic Dynamic simulation enzyme Genetic variant genetic variants global pandemic help highlight homology model Homology models Human human ACE2 human host Infectious disease Interaction isolates lead management molecular molecular dynamics nucleotide omicron pathogenic polymorphism Protein docking RBD RBD complex RBDs receptor Receptor binding domain Repository retrieved risk RMSD RMSF Safe SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 virus SARS‐CoV‐2 selected severity single nucleotide stability Structural variant structural variants Structure the RBD Total variant Variation was performed wildtype Wuhan Wuhan strain [DOI] 10.1016/j.jiph.2022.06.004 PMC 바로가기 [Article Type] Article
Virtual and biochemical screening to identify the inhibitors of binding between SARS-CoV-2 spike protein and human angiotensin-converting enzyme 2SARS-CoV-2 스파이크 단백질과 인간 안지오텐신 전환 효소 2 간의 결합 억제제를 식별하기 위한 가상 및 생화학적 스크리닝Article Published on 2022-07-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus addressed Analysis angiotensin antiviral activity Antiviral agents antiviral medicine assays binding biochemical caused Chemotherapy coronavirus COVID-19 COVID-19 pandemic Critical drug candidate effective glycosylated host cell human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 identify in vitro inhibitor Interaction interaction pattern interaction patterns low molecular weight moderate physicochemical property Protein S-protein SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus spike Spike protein therapeutic target Treatment treatment of COVID-19 viral pathogen Virtual screening [DOI] 10.1016/j.jmgm.2022.108206 PMC 바로가기 [Article Type] Article
Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse originsBA.1 및 가능한 마우스 기원과 비교하여 Omicron BA.2 변이체의 증가된 감염성 및 면역 회피를 위한 구조적 및 생화학적 메커니즘Article Published on 2022-07-012022-09-11 Journal: Cell Research [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 binding addition antibody bind binding biochemical combating dominant effective Evolution exhibit high affinity high potency human ACE2 immune evasion implication infections infective inhibit interactions mechanism neutralization activity omicron open pathway RBDs Receptor-binding domain receptor-binding domains reveal SARS-CoV-2 viral shown spike trimer Strains Structure structures therapeutic trimer variant Viral viral infections wildtype WT spike [DOI] 10.1038/s41422-022-00672-4 PMC 바로가기 [Article Type] Article