Global Diversification and Distribution of Coronaviruses With Furin Cleavage SitesMicrobiology Published on 2021-10-072022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] addition Animal host bovine Cell cleavage sites coronavirus Coronaviruses country CoV COVID-19 COVID-19 pandemic CoVs diversification Epidemiology event examined explain FIVE furin furin cleavage site Germany glycoprotein HCoV-HKU1 HCoV-OC43 Human humans hydrolysis infect MERS-CoV outbreak plasma membrane required SARS-CoV-2 Site [DOI] 10.3389/fmicb.2021.649314 PMC 바로가기 [Article Type] Microbiology
The nucleoside antiviral prodrug remdesivir in treating COVID-19 and beyond with interspecies significanceReview Published on 2021-09-072022-10-28 Journal: Animal Diseases [Category] COVID-19, [키워드] accelerated acute respiratory syndrome animal model Antiviral approved Black Death Carboxylesterases caused cellular Clinical sign Concentration coronavirus Coronavirus disease 2019 COVID-19 COVID-19 pandemic Critical cross deaths demonstrated drug Drug-drug interactions, interspecies difference Ebola Efficacy Efficacy and safety example food hydrolysis IMPROVE in vitro increase intravenously Mortality notable pandemic Pandemics parameter preclinical studies Randomized controlled trial Remdesivir SARS-CoV-2 Seven Spanish spike the United State therapeutic therapeutic option Toxicity treating COVID-19 Treatment Vaccines viral disease virus viruses [DOI] 10.1186/s44149-021-00017-5 PMC 바로가기 [Article Type] Review
Elimination of SARS-CoV-2 along wastewater and sludge treatment processes폐수 및 슬러지 처리 공정에 따른 SARS-CoV-2 제거Article Published on 2021-09-012022-09-11 Journal: Water research [Category] SARS, 치료기술, [키워드] acute respiratory syndrome coronavirus affinity applied bacteriophage Chain Reaction characterized chlorination comparability coronavirus 2 COVID-19 COVID-19 incidence demonstrated digestion Effectiveness eliminated Elimination evaluate feces genetic material genomic RNA hydrolysis Laboratory Occurrence participated plant polymerase chain polymerase chain reaction positive result processed Quantitative question raised reduced reducing reduction Region reliability removal respiratory reverse transcriptase RNA RNA copy RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA secondary Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly Sludge transcriptase treated Treatment Viral RNA virus virus particle virus particles virus RNA was done wastewater water Water treatment WWTP [DOI] 10.1016/j.watres.2021.117435 PMC 바로가기 [Article Type] Article
Real-time optical analysis of a colorimetric LAMP assay for SARS-CoV-2 in saliva with a handheld instrument improves accuracy compared with endpoint assessment휴대용 기기를 사용하여 타액에서 SARS-CoV-2에 대한 비색 LAMP 분석의 실시간 광학 분석으로 종말점 평가와 비교하여 정확도 향상Article Published on 2021-09-012022-09-11 Journal: Journal of biomolecular techniques : JBT [Category] SARS, 진단, 치료기술, [키워드] Accuracy acute respiratory syndrome coronavirus Analysis approach approved bypassed change clinical sample clinical samples collected color controlling coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Course COVID-19 current detect detection system diagnostic diagnostic testing diagnostics drop drug Drug administration Endpoint FDA approval food hydrolysis IMPROVE inactivated invasive isothermal LAMP less limit of detection MONITOR Nasopharyngeal swab nasopharyngeal swabs near patient. negative sample nucleic acid nucleic acid amplification nucleotide observation optical pandemic Patient pH indicator positive processed protocol Quantitative reaction respiratory RNA RNA detection RNA extraction RT-LAMP Saliva SARS-CoV-2 SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specimen this system Viral Viral load virus widespread [DOI] 10.7171/jbt.21-3203-011 PMC 바로가기 [Article Type] Article
Mexican Oregano ( Lippia graveolens Kunth) as Source of Bioactive Compounds: A ReviewReview Published on 2021-08-252022-10-30 Journal: Molecules [Category] Coronavirus, SARS, [키워드] Lippia graveolens Anti-inflammatory antioxidant bioactive compounds can be used Compound conditions COVID-19 cytotoxicity Defense extraction techniques fraction functional Health hydrolysis inhibitor Lippia graveolen nutraceuticals oregano Phenolic compounds quercetin Research review selective Source [DOI] 10.3390/molecules26175156 PMC 바로가기 [Article Type] Review
Drug Design Strategies for the Treatment of Viral Disease. Plant Phenolic Compounds and Their DerivativesPharmacology Published on 2021-07-302022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Affect affecting Antiviral antiviral activity antiviral drugs antiviral property benefit biochemical cause cellular complexes Compound contribute coronavirus derivative drug drug design element Host host cells hydrolysis increase in infected cells inhibit Interaction M pro maturation mechanism of action membrane metal complexes pandemic penetration Phenolic compounds plant protease Protein RdRP receptors Replication Research RNA-dependent RNA polymerase SARS CoV-2 secretion selected shown significantly Spike protein Stage Strategy transfer Treatment Triglyceride turn viral disease viral life cycle virus [DOI] 10.3389/fphar.2021.709104 PMC 바로가기 [Article Type] Pharmacology
Potential In Vitro Inhibition of Selected Plant Extracts against SARS-CoV-2 Chymotripsin-Like Protease (3CL Pro ) ActivityCommunication Published on 2021-06-292022-11-01 Journal: Foods [Category] COVID-19, [키워드] 3CL acting activity acute respiratory syndrome allyl isothiocyanate approach Brassica nigra calculated clinical trials complementary component concentrations contribute coronavirus coronavirus disease 19 COVID-19 Curcuma Curcumin energy transfer evaluated Extract FRET assay hydrolysis identify in vitro in vivo inhibited inhibiting inhibition inhibitors of SARS-CoV-2 inhibitory inhibitory effect main role molecule mustard mustard seeds natural compounds pandemic plant plant extracts Potential Pro protease Protease activity reducing Replication resulting SARS-CoV-2 SARS-CoV-2 3CLPro SARS-CoV-2 replication Sinigrin the SARS-CoV-2 Treatment turmeric vaccination wall rocket [DOI] 10.3390/foods10071503 PMC 바로가기 [Article Type] Communication
Complementary methods for SARS-CoV-2 diagnosis in times of material shortage재료 부족시 SARS-COV-2 진단을위한 보완 적 방법Article Published on 2021-06-072022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] caused classical Diagnosis diagnostic diagnostic tests dramatic increase gold gold standard guanidine hydrolysis Infectious diseases Infectious-disease diagnostics Molecular biology pandemic phenol protocol Quantitative reagent reagents Real-time PCR Region resources reverse transcription RNA extraction RT-qPCR sampling SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2 infections Swab swabbing tested [DOI] 10.1038/s41598-021-91457-z PMC 바로가기 [Article Type] Article
Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivativesArticle Published on 2021-05-242022-10-04 Journal: Nature Communications [Category] SARS, 치료제, [키워드] Analysis antiviral activity binding mode catalytic dyad Critical crystal structures crystallographic structure cysteine demonstrated derivative derivatives develop Drug discovery and development Ebselen enzyme examined global effort hydrolysis infected cell inhibit inhibition investigated M pro mechanism pandemic protease reactivity SARS-CoV-2 SARS-CoV-2 main protease the SARS-CoV-2 therapeutic these compound triggered viral replication viruses X-ray crystallography zoonotic [DOI] 10.1038/s41467-021-23313-7 PMC 바로가기 [Article Type] Article
Strategies for the Production of Soluble Interferon-Alpha Consensus and Potential Application in Arboviruses and SARS-CoV-2Article Published on 2021-05-212022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] Alpha Amino acid analyzed Antiviral Antiviral effect application approach arbovirus Arboviruses Bacteria biological activity biopharmaceutical cells Clinical use Consensus COVID-19 Culture culture media E. coli Fh8 growth Healthcare system hydrolysis IFN-α IMPROVE in vitro model Inclusion inhibit medium Potential prevalent produced Production protein sequence purified Research SARS-CoV-2 SARS-CoV-2 virus infection solubility tag Strategy susceptible temperature treat virus multiplication viruses was tested Zika [DOI] 10.3390/life11060460 PMC 바로가기 [Article Type] Article