Neonatal Multisystem Inflammatory Syndrome (MIS-N) Associated with Prenatal Maternal SARS-CoV-2: A Case SeriesArticle Published on 2021-07-022022-10-31 Journal: Children [Category] COVID-19, [키워드] anti SARS-CoV-2 antibodies anti-SARS-CoV-2 IgG antibodies antibody Asymptomatic children Clinical features COVID-19 COVID-19 disease died elevated feature Fever FIVE Hyperinflammatory syndrome IgG and IgM IgM antibodies Immune-mediated immunomodulation India Infant Inflammatory Inflammatory biomarker Maternal melena MIS-C mother multisystem inflammatory syndrome in children (MIS-C) Neonate Neonates Other outcome positive Pregnancy QTc renal Respiratory failure SARS-CoV-2 Sery Shock steroid syndrome tested transfer [DOI] 10.3390/children8070572 PMC 바로가기 [Article Type] Article
Role of testosterone in SARS-CoV-2 infection: A key pathogenic factor and a biomarker for severe pneumoniaSARS-CoV-2 감염에서 테스토스테론의 역할: 중증 폐렴의 주요 병원성 인자이자 바이오마커Article Published on 2021-07-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 바이오마커, [키워드] 1:1 age androgen Androgen sensitivity association Biomarker calculated case-control study Clinical severity Control controls coronavirus disease Coronavirus disease 2019 correlated COVID-19 evaluated free testosterone Gender imbalance hospital Hospital admission Hospital stay Hospitalization Hyperinflammatory syndrome Italian low-flow oxygen supplementation male marker median Mild mmHg mortality rate oxygen PaO pathogenic Patient patients with COVID-19 required role SARS-CoV-2 selected severe COVID-19 severe pneumonia severity Severity markers Sex sex hormone Sex hormones significantly lower systemic inflammation Testosterone ventilatory support Viral viral shedding [DOI] 10.1016/j.ijid.2021.05.042 PMC 바로가기 [Article Type] Article
Coronavirus Disease 2019 and the Thyroid – Progress and PerspectivesEndocrinology Published on 2021-06-242022-10-31 Journal: Frontiers in Endocrinology [Category] COVID-19, MERS, [키워드] accumulated Autoimmunity cause clinical evidence complication of COVID-19 coronavirus COVID-19 Cytokine storm disease Diseases Evidence Hashimoto’s thyroiditis Health Hyperinflammatory syndrome implicated Infection organ outbreak problem proceed Progress reported Respiratory system SARS-CoV SARS-CoV-2 SARS-COV-2 infection Thyroid thyroid gland Thyroiditis virus with COVID-19 [DOI] 10.3389/fendo.2021.708333 PMC 바로가기 [Article Type] Endocrinology
Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19Article Published on 2021-06-162022-11-01 Journal: EMBO Molecular Medicine [Category] COVID-19, MERS, SARS, [키워드] adaptive cause convalescent COVID‐19 COVID‐19 patient COVID‐19 patients Epigenetic gene expression signature healthy hyperinflammation Hyperinflammatory syndrome Immunity immunology in vivo Inflammasome inflammasome activation Innate innate immune innate immune memory Innate immunity longitudinal analysis Macrophage Microbiology, Virology & Host Pathogen Interaction Modification monocyte naïve individuals NLRP3 patients responsible resulting robust SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 secretion Signaling Spike protein subset Surface glycoprotein transcriptional Trigger vaccine antigen viral control [DOI] 10.15252/emmm.202114150 PMC 바로가기 [Article Type] Article
Hemophagocytic lymphohistiocytosis after COVID-19 vaccinationLetter to the Editor Published on 2021-06-042022-10-29 Journal: Journal of Hematology & Oncology [Category] COVID-19, MERS, SARS, [키워드] Acetate activated macrophage Bone marrow caused Chinese Coagulopathy coronavirus disease COVID-19 COVID-19 vaccination Critical Cytotoxic T cells cytotoxicity Dexamethasone discharged disorder DNA EBV elevated Epstein–Barr virus Epstein–Barr virus Fever fibrinogen first dose healthy hemoglobin hemophagocytic lymphohistiocytosis HLH Hyperinflammatory syndrome inactivated indicate Infection initial laboratory result life-threatening malaise multiple organ failure neutrophil count NK cell Platelet Positive test receiving reported resolved SARS-CoV-2 vaccine serum ferritin level SIGN the patient thrombotic Triglyceride Vaccine virus vomiting [DOI] 10.1186/s13045-021-01100-7 PMC 바로가기 [Article Type] Letter to the Editor
HLA class I-associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children어린이의 다기관 염증 증후군에서 TRBV11-2 T 세포의 HLA 클래스 I 관련 확장Article Published on 2021-05-172022-09-11 Journal: The Journal of Clinical Investigation [Category] SARS, 유전자 메커니즘, [키워드] Activation allele Antigen Bacterial CDR3 characterized children clinical feature Clinical features clone complementarity-determining region correlated COVID-19 distribution HLA HLA class I HLA class I alleles Hyperinflammatory syndrome immunology indicated Inflammatory Interaction mechanism MIS-C motif Patient residue SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein serum cytokine levels severity Shock specificity spike glycoprotein superantigen syndrome T cell T cell receptor T cells TCR Toxic shock Toxic shock syndrome TRBV11-2 triggered [DOI] 10.1172/JCI146614 PMC 바로가기 [Article Type] Article
Prognostic Factors in Hospitalized COVID-19 Patients at the Start of the Pandemic in Colombia: A Retrospective Cohort StudyInternal Medicine Published on 2021-05-062022-10-31 Journal: Cureus [Category] COVID-19, [키워드] age Analysis Comorbidities covid prognosis COVID-19 COVID-19 mortality Critical defined determine died disease mortality evaluate explain Factor greater Hospital admission hospitalized COVID-19 patient hospitalized patient hyperinflammation Hyperinflammatory syndrome in-hospital mortality independent information Latin LDH material Mortality multivariate logistic regression NEWS2 objective Older age PaO2/FiO2 ratio Patient patients performed populations Prognostic factor required Result retrospective cohort study SARS CoV-2 score serum Seven severe disease severity Severity of disease Tocilizumab type 2 diabete was performed [DOI] 10.7759/cureus.14865 PMC 바로가기 [Article Type] Internal Medicine
SARS-CoV-2 Triggering Severe Acute Respiratory Distress Syndrome and Secondary Hemophagocytic Lymphohistiocytosis in a 3-Year-Old Child With Down SyndromeSARS-CoV-2는 다운 증후군이 있는 3세 아동의 중증 급성 호흡곤란 증후군 및 이차성 혈구탐식성 림프조직구증을 유발합니다Case Reports Published on 2021-04-302022-09-11 Journal: Journal of the Pediatric Infectious Diseases Socie [Category] MERS, SARS, 진단, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Admission Child Complication coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 Down syndrome genetic susceptibility hemophagocytic lymphohistiocytosis hyperinflammation Hyperinflammatory syndrome Immunoglobulin intensive care Intravenous immunoglobulin investigation Patient pediatric pediatrics Remdesivir respiratory respiratory distress SARS-CoV-2 secondary secondary hemophagocytic lymphohistiocytosis secondary to severe acute respiratory distress syndrome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sHLH sHLH. Steroids syndrome Treatment triggers [DOI] 10.1093/jpids/piaa148 PMC 바로가기 [Article Type] Case Reports
The Challenging Diagnosis of Pediatric Multisystem Inflammatory Syndrome Associated with Sars-Cov-2 Infection-Two Case Reports and Literature ReviewArticle Published on 2021-04-192022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] affected cardiovascular complications caused children coronavirus disease COVID19 Cytokines described diagnosed Diagnosis died form high risk Hyperinflammatory syndrome incidence Inflammatory Kawasaki disease less literature MIS-C multisystem inflammatory syndrome in children Novel coronavirus pandemic pediatric COVID19—Kawasaki Pediatric patient raise reduced report Respiratory Coronavirus review SARS-CoV-2 SARS-COV-2 infection syndrome the disease were infected [DOI] 10.3390/jpm11040318 PMC 바로가기 [Article Type] Article
Tocilizumab improves survival in severe COVID-19 pneumonia with persistent hypoxia: a retrospective cohort study with follow-up from Mumbai, IndiaTocilizumab, 지속적인 저산소증이 있는 중증 COVID-19 폐렴의 생존율 향상: 인도 뭄바이에서 추적 관찰한 후향적 코호트 연구Observational Study Published on 2021-03-052022-09-01 Journal: BMC Infectious Diseases [Category] SARS, 신약개발, 임상, 진단, [키워드] 95% CI addition analysed Analysis Care China CO-RADS control group Controlled trial controlled trials controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 admission COVID-19 cytokine storm COVID-19 patient COVID-19 pneumonia Cox regression analysis CT-severity score cytokine Cytokine storm death defined FiO2 Follow-up high mortality hospital hyperinflammatory state Hyperinflammatory syndrome hypoxia IBM IL-6 IL-6 receptor IMPROVE independent predictor independent predictors India Interlukin-6 intravenously less log rank median minute monoclonal antibody Mortality multivariate multivariate Cox regression multivariate Cox regression analysis Mumbai non-rebreathing mask observational study oxygen oxygen saturation paO2/fiO2 PaO2/FiO2 ratio Patient predictor reported Result retrospective retrospective cohort study saturation severe coronavirus disease Severe COVID-19 pneumonia significantly SPSS standard care statistical analysis supplemental oxygen survival therapy Tocilizumab Treatment triggered was performed [DOI] 10.1186/s12879-021-05912-3 PMC 바로가기 [Article Type] Observational Study