Attenuated Subcomponent Vaccine Design Targeting the SARS-CoV-2 Nucleocapsid Phosphoprotein RNA Binding Domain: In Silico AnalysisResearch Article Published on 2020-09-172022-10-29 Journal: Journal of Immunology Research [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome analyzed Antigen antigenic antigenic peptide antigenicity B cell binding domain C-terminal caused CD4 CD8 chimeric coronavirus COVID-19 creating effective Efficiency expression humans hypersensitivity reaction immunogenic In silico cloning in viral linear epitope MHC-I MHC-II alleles molecular docking molecular interaction N-terminal novel coronavirus disease nucleocapsid protein pandemic peptide Phosphoprotein predicted provide public health Replication Research RNA Safe SARS-CoV-2 selected Selected epitopes T cell epitope targeting the SARS-CoV-2 the vaccine TLR5 Toxicity translation triggered Vaccine was performed [DOI] 10.1155/2020/2837670 PMC 바로가기 [Article Type] Research Article
ChemoPROphyLaxIs with hydroxychloroquine For covId-19 infeCtious disease (PROLIFIC) to prevent covid-19 infection in frontline healthcare workers: A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-07-022022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] active treatment phase Amiodarone anticipated Arm ARMS assessment baseline blinded Block randomisation block size Blood Group Breastfeeding Cambridge Care Chemoprophylaxis Chloroquine Chronic kidney disease ciprofloxacin clarithromycin clinical clinical testing Compliance Contact coronavirus disease COVID-19 COVID-19 case COVID-19 disease COVID-19 disease severity COVID-19 infection COVID-19 patients criteria current cyclosporin Daily Daily-dosing Date Day deficiency defined described determine diagnosed with COVID-19 Diagnosis digoxin disease dissemination dose dosed element enrolled enrolment epilepsy EU Clinical Trial EudraCT evaluated Factor File fluconazole Follow-up foundation frontline healthcare workers G6PD Genetic Glucose-6-phosphate halofantrine HCQ healthcare Healthcare workers heart failure hospital Hydroxychloroquine hypersensitivity reaction increase Infection Intervention investigator Laboratory Liver disease maintenance Matched mefloquine moxifloxacin National Health Service NHS number objective oral outcome participant Participants Patient patients with COVID-19 pharmacokinetic phase Placebo placebo tablet placebo-controlled trial porphyria positive COVID-19 positive individual Positive test Praziquantel predicted Prevent problem prochlorperazine protocol randomised randomised controlled trial recruited recruitment regimen Registered reported Research Retinal disease Sample size Secondary objective serology serum biomarker Standard statistical analysis status Stratification stratified Study protocol susceptibility symptoms onset syndrome table Tablet tablets time Treatment treatment period Trial Trust university Variation website Weekly Weekly-dosing work [DOI] 10.1186/s13063-020-04543-4 PMC 바로가기 [Article Type] Letter
Wolf’s post-herpetic isotopic response to tocilizumab for rheumatoid arthritis류마티스 관절염에 대한 토실리주맙의 울프의 포진 후 동위 반응Case Reports Published on 2018-05-012023-06-01 Journal: The Australasian journal of dermatology [Category] 대상포진, 두창, 수두, 홍역, [키워드] hypersensitivity reaction Rash rheumatoid arthritis TNF-α inhibitor Tocilizumab Wolf's isotopic response [DOI] 10.1111/ajd.12698 [Article Type] Case Reports
Fever, rash, and systemic symptoms: understanding the role of virus and HLA in severe cutaneous drug allergyReview Published on 2014-01-012023-06-02 Journal: The journal of allergy and clinical immunology. In [Category] 두창, [키워드] abacavir ABC Acute generalized exanthematous pustulosis ADR Adverse drug reaction AGEP bid Carbamazepine CBZ CMV CTL cytomegalovirus Cytotoxic lymphocyte DIHS DRESS DRESS-DIHS-HSS Drug reaction with eosinophilia and systemic symptoms Drug-induced hypersensitivity syndrome EBV Epstein-Barr virus HHV HLA HSR HSS human herpesvirus human leukocyte antigen hypersensitivity reaction Hypersensitivity syndrome INF-γ interferon gamma nonsteroidal anti-inflammatory drug NSAID Orally PBMC Peripheral blood mononuclear cell po. scar Severe cutaneous adverse drug reaction SJS SJS-TEN Steven-Johnson syndrome T-cell receptor TCR TEN Toxic epidermal necrolysis twice a day viral reactivation [DOI] 10.1016/j.jaip.2013.11.005 PMC 바로가기 [Article Type] Review