Immunogenicity of SARS-CoV-2 vaccination in rituximab-treated patients: Effect of timing and immunologic parameters리툭시맙 치료 환자에서 SARS-CoV-2 백신 접종의 면역원성: 시기 및 면역학적 매개변수의 영향Article Published on 2022-01-012022-09-12 Journal: Clinical immunology (Orlando, Fla.) [Category] MERS, SARS, 진단, [키워드] anti-SARS-CoV-2 anti-Spike IgG antibody asked Autoimmune diseases B cell B cells Characteristics correlated COVID-19 Effect Hypogammaglobulinemia IgG IgM immune immune response immune system immunogenicity impair median time medications parameter Patient pre-vaccination recruited reduce reduced respond responses Rheumatic diseases rituximab RTX SARS-CoV-2 vaccination shown significantly therapeutic option therapy titers of IgG treated patient vaccination Vaccines [DOI] 10.1016/j.clim.2021.108897 PMC 바로가기 [Article Type] Article
Case Series: Convalescent Plasma Therapy for Patients with COVID-19 and Primary Antibody Deficiency사례 시리즈: COVID-19 및 1차 항체 결핍 환자를 위한 회복기 혈장 요법Original Article Published on 2021-12-102022-09-12 Journal: Journal of Clinical Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] antibody appear applied benefit Clinical symptoms Cohort common variable immunodeficiency convalescent plasma convalescent plasma treatment country Course COVID-19 COVID19 patient deficiency demonstrated Effectiveness Evidence Fever Follow-up Hypogammaglobulinemia immunocompromised individual immunocompromised individuals inborn errors of immunity Infection longitudinal many case many cases monoclonal antibody Mutation one patient option Patient PCR plasma primary antibody Primary immunodeficiencies reduction in resolved risk Safe SARS-CoV-2 Sequencing Side effect supplementary material Therapeutic benefit Therapies treated Treatment viral genome Viral load Viral RNA shedding viral shedding while with COVID-19 [DOI] 10.1007/s10875-021-01193-2 PMC 바로가기 [Article Type] Original Article
Impact of rituximab on COVID-19 outcomesCOVID-19 결과에 대한 리툭시맙의 영향Article Published on 2021-11-012022-09-12 Journal: Annals of Hematology [Category] MERS, SARS, 진단, [키워드] administration Admission Analysis Anti-spike antibodies antibody B-cell B-lymphocytes baseline characteristics checked Clinical outcome clinical outcomes conducted COVID-19 COVID-19 antibody COVID-19 diagnosis death diagnosed with COVID-19 died disease severity examined Hospitalization humoral Humoral immunity Hypogammaglobulinemia ICU admission Impact Infectious complications intensive care unit marker median time Mount Sinai Neutralizing neutralizing antibody not affect not significantly different outcome over Patient Protein required Retrospective study rituximab SARS-CoV-2 SARS-COV-2 infection survived System T-cell immunity therapy [DOI] 10.1007/s00277-021-04662-1 PMC 바로가기 [Article Type] Article
Efficacy of convalescent plasma therapy in immunocompromised patients with COVID-19: A case reportCase report Published on 2021-11-012022-10-05 Journal: Clinical Infection in Practice [Category] 변종, 임상, [키워드] absence Acquired antibody B-cell lymphoma Case report CCP CCP administration characteristic clinical clinical evaluation cohorts of patient Complete component convalescent plasma Convalescent plasma therapy Course COVID-19 COVID-19 patient Cytopathic effect effective Effectiveness Evidence female finding help hospital discharge Hospitalization Host host response Hypogammaglobulinemia immune immune deficiency immune response Immunocompromised Immunocompromised patient individuals infused inhibiting interstitial pneumonia mechanism Neutralizing antibodies nucleotide Patient performed plasma radiological finding reduce Remdesivir required Research Result rituximab SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selected severe COVID-19 sustained Symptom T-cell specific tested treated Treatment viral clearance viral culture Viral load virus [DOI] 10.1016/j.clinpr.2021.100096 [Article Type] Case report
COVID-19 in multiple-myeloma patients: cellular and humoral immunity against SARS-CoV-2 in a short- and long-term view다발성 골수종 환자의 코로나19: 단기 및 장기 관점에서 SARS-CoV-2에 대한 세포 및 체액 면역Case Reports Published on 2021-10-182022-09-10 Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] MERS, SARS, 진단, 치료기술, [키워드] Affect affecting anti-SARS-CoV-2 antibody antibody levels Antibody titer Antibody titers CD4+ T-cell cell activation cellular Cellular immune response Clinical management Combination Continuous Course COVID-19 Decision-making deficiency detectable diagnosed with COVID-19 Disease progression help humoral Humoral immunity Hypogammaglobulinemia IgA IgG antibodies IgM IgM and IgG immune response Immunity immunodeficiency immunological immunomodulatory drugs Immunosuppression infections information inhibitors Innate immunity Isolation lenalidomide Measures memory monoclonal antibodies monoclonal antibody Multiple Multiple myeloma Myeloma neutralizing antibody titers neutropenia Patient performed positive proteasome receiving recommendation remained robust SARS-CoV-2 supplementary material supportive therapy T cell T cell activation T-cell tested the patient therapy treated Treatment underlying disease virus-neutralizing virus-neutralizing antibody [DOI] 10.1007/s00109-021-02114-x PMC 바로가기 [Article Type] Case Reports
Convalescent Plasma in a Patient with Protracted COVID-19 and Secondary Hypogammaglobulinemia Due to Chronic Lymphocytic Leukemia: Buying Time to Develop Immunity?Case Report Published on 2021-09-272022-10-30 Journal: Infectious Disease Reports [Category] COVID-19, [키워드] Analysis antibody CCP Cellular immune response cellular immunity chronic chronic lymphocytic leukemia clinical recovery convalescent plasma coronavirus disease COVID-19 develop dosage Follow-up humoral Hypogammaglobulinemia immune response Immunological response in vitro T cell assay leukemia neutralizing antibody oxygen Patient performed provided repeated secondary serological test suffered time Treatment viral clearance with COVID-19 [DOI] 10.3390/idr13040077 PMC 바로가기 [Article Type] Case Report
MM-219: Outcome of COVID-19 Among Patients with Multiple Myeloma at the Armenian Hematology CenterConference abstract Published on 2021-09-012022-10-05 Journal: Clinical lymphoma, myeloma & leukemia [Category] 유전자 메커니즘, [키워드] addition administration age Analysis Antibiotics association cardiovascular risk center Characteristics Chronic kidney disease clinical Cohort Comorbidities cough country COVID-19 COVID-19 infection Critical demonstrated Diabetes Mellitus diagnosed diagnosed with COVID-19 died Dyspnea elevated epidemiological Fever Hematological malignancy hematology high mortality Hospitalization Hospitalized hospitalized patients Hydroxychloroquine hyperlipidemia Hypogammaglobulinemia Hypoxemia Immunosuppression incidence Inflammatory marker inflammatory markers initial symptom Laboratory laboratory characteristics Lung disease lung infiltrate male Male sex mandatory mechanical ventilation median median age Mild MM Mortality Most patient Multiple Multiple myeloma multiple organ failure Myeloma obesity Patient patients performed Preliminary data reported required Result Retrospective study serological response severity significantly the disease viral infection [DOI] 10.1016/S2152-2650(21)01959-5 [Article Type] Conference abstract
Combined intravenous immunoglobulin and baricitinib treatment for severe COVID-19 with rhabdomyolysis: A case report횡문근 융해증을 동반한 중증 COVID-19에 대한 정맥 면역글로불린 및 바리시티닙 병용 치료: 증례 보고Case Reports Published on 2021-09-012022-09-12 Journal: Journal of the Formosan Medical Association = Taiw [Category] SARS, 바이오마커, 진단, 치료법, [키워드] acute respiratory distress ARDS Asymptomatic carrier Baricitinib biochemical Biomarker Case report Clinical course Clinical improvement clinical recovery Combined combined use coronavirus disease correlated correlation COVID-19 creatine creatine kinase Cytokines disease severity Effects elevated Evidence female High dose Hydroxychloroquine Hypogammaglobulinemia Inflammatory biomarker inflammatory biomarkers Injury Intensive Intravenous immunoglobulin intubation IVIG IVIg. Laboratory laboratory biomarker lactate dehydrogenase Lymphocytes lymphopenia mechanical ventilation multiple organ complication neurological deficits Numerous outbreak outcome Patient patients with COVID-19 Platelets Potential treatment prognostic progressed Radiographic reflected serum severe COVID-19 severity of COVID-19 shown Spread syndrome therapy Treatment Treatment response [DOI] 10.1016/j.jfma.2021.03.014 PMC 바로가기 [Article Type] Case Reports
Follow‐up of renal transplant recipients after acute COVID‐19—A prospective cohort single‐center studyOriginal Article Published on 2021-08-202022-10-30 Journal: Immunity, Inflammation and Disease [Category] COVID-19, MERS, SARS, [키워드] activated assessments BK virus clinical complication clinical complications Clinical symptoms Cognitive impairment cohort study Complication complications conducted COVID‐19 D‐dimer develop Diabetes Mellitus discharge dry cough elevated eligible Epstein–Barr virus fibrinogen hospital Hospitalized Hypogammaglobulinemia increased mortality Injury Laboratory laboratory abnormalities laboratory abnormality Laboratory parameters long‐COVID‐19 majority morbidity Mortality MOST Multivariate analysis nonspecific organ outpatient clinic Patient patients patients died post‐COVID‐19 predictor Primary outcome problem problems prospective cohort recipient renal Renal transplantation reported Result risk RT‐PCR SARS‐CoV‐2 SARS‐CoV‐2 Sepsis Shortness of breath survived the median tiredness Treatment undergo university [DOI] 10.1002/iid3.509 PMC 바로가기 [Article Type] Original Article
Multiple Sclerosis, Disease-Modifying Therapies and COVID-19: A Systematic Review on Immune Response and Vaccination RecommendationsReview Published on 2021-07-112022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Administered advanced age anti-CD20 clinical clinical evidence Comorbidities conducted Course COVID-19 COVID-19 in patient COVID-19 incidence dose Evidence General population higher risk Hospitalization Hypogammaglobulinemia immune reaction immune response Immunosuppression Implications increased risk item lymphopenia MOST Multiple multiple sclerosis multiple sclerosis/therapy outcome outcomes Patient protocols Re-infection receiving recommendations reported Reporting response review risk SARS-CoV-2 vaccine sclerosis severe COVID-19 significantly Support Surveillance systematic review Therapies therapy treatment strategy understanding vaccination vaccine response Vaccines was used [DOI] 10.3390/vaccines9070773 PMC 바로가기 [Article Type] Review