Predictive factors for success of awake proning in hypoxemic respiratory failure secondary to COVID-19: A retrospective cohort studyCOVID-19에 이차적인 저산소성 호흡 부전에서 각성 복식의 성공을 위한 예측 요인: 후향적 코호트 연구Article Published on 2021-05-012022-09-11 Journal: Respiratory medicine [Category] MERS, 바이오마커, [키워드] ARDS Awake prone positioning Awake proning benefit candidate conducted COVID-19 COVID-19 pandemic Endotracheal intubation Factor FiO2 hypoxemic Hypoxemic respiratory failure improvement increase in Inflammatory marker inflammatory markers institution Mechanical mechanical ventilation Mild mild to moderate moderate mortality rates Oxygenation Patient performed Pneumonia predicted prone positioning proning Rate remains uncertain respiratory Respiratory failure respiratory parameter respiratory parameters respiratory rate retrospective retrospective cohort study ROX secondary to serum SpO2 therapy variable Ventilation [DOI] 10.1016/j.rmed.2021.106379 PMC 바로가기 [Article Type] Article
Fatal outcome of anti-MDA5 juvenile dermatomyositis in a paediatric COVID-19 patient: a case report소아 코로나19 환자에서 발생한 항MDA5 소아 피부근염의 치명적 결과: 증례 보고Case Reports Published on 2021-01-012022-09-11 Journal: Modern rheumatology case reports [Category] 진단, 치료제, [키워드] addition Admission Anti-MDA5 BAL BAS Bronchoalveolar lavage Case report children COVID-19 Cyclophosphamide dermatomyositis diagnosed died disease drug emphysema health condition hemophagocytic lymphohistiocytosis high mortality rate high risk hospital hypoxemic Hypoxemic respiratory failure Immunoglobulin immunosuppressive immunosuppressive therapy Infection initiated Intensive Interstitial lung disease interstitial lung disease (ILD) intravenous Intravenous immunoglobulin juvenile dermatomyositis Lung disease MDA5 Methylprednisolone outcome Patient performed Pneumomediastinum Pneumothorax poor prognosis positive Real-time PCR real-time RT-PCR referred to Respiratory failure risk risk for disease SARS-CoV-2 SARS-COV-2 infection secondary hemophagocytic lymphohistiocytosis Septic shock severe complications subcutaneous emphysema sulfamethoxazole therapy Tofacitinib Treatment worsening [DOI] 10.1080/24725625.2020.1832755 PMC 바로가기 [Article Type] Case Reports
Inflammatory Biomarker Trends Predict Respiratory Decline in COVID-19 Patients염증성 바이오마커 트렌드, COVID-19 환자의 호흡 감소 예측Article Published on 2020-11-172022-09-11 Journal: Cell Reports Medicine [Category] Coronavirus, MERS, SARS, 바이오마커, [키워드] acute respiratory distress acute respiratory distress syndrome Analysis C-reactive protein C-reactive protein (CRP coronavirus disease Coronavirus disease 2019 correlated COVID-19 CRP CRP level CRP levels cytokine Cytokine storm D-dimer Decline Deterioration disease examination ferritin Hospitalization Hospitalized hypoxemic Hypoxemic respiratory failure IL-6 Increasing Inflammation inflammatory biomarker level inflammatory biomarker levels initial intensive care intensive care unit interleukin-6 intubation measure Patient patients physiological plateau predict Proinflammatory cytokine respiratory respiratory distress Respiratory failure Respiratory function respiratory function) retrospective cohort reveal rising ROX sensitivity single-center subsequent subset trend [DOI] 10.1016/j.xcrm.2020.100144 PMC 바로가기 [Article Type] Article
Prone Positioning in Awake, Nonintubated Patients With COVID-19 Hypoxemic Respiratory Failure깨어 있고 삽관되지 않은 COVID-19 저산소성 호흡부전 환자의 엎드린 자세Research Published on 2020-11-172022-09-12 Journal: JAMA Internal Medicine [Category] Fulltext, SARS, 진단, [키워드] cohort study COVID-19 failure hypoxemic Hypoxemic respiratory failure intubation Oxygenation Patient positioning prone Prone position respiratory Respiratory failure risk severe COVID-19 [DOI] 10.1001/jamainternmed.2020.3030 PMC 바로가기 [Article Type] Research
High dose dexamethasone treatment for Acute Respiratory Distress Syndrome secondary to COVID-19: a structured summary of a study protocol for a randomised controlled trialCOVID-19에 따른 급성 호흡곤란 증후군에 대한 고용량 덱사메타손 치료: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2020-08-262022-08-13 Journal: Trials [Category] MERS, 임상, [키워드] 1:1 active cancer acute respiratory distress acute respiratory distress syndrome Adult patients advance directives Advanced cancer age alpha error anticipated approved ARDS assessment assigned bilateral pulmonary infiltrates Blinding block breast-feeding Buenos Aires capture cardiac disease CEMIC clinical clinical trial code Complete concealed Confirmed COVID-19 COVID-19, Dexamethasone, Acute Respiratory Distress Syndrome, Randomised controlled trial, protocol, Steroids delirium develop Dexamethasone diagnosis of SARS-CoV-2 directive discharge disease dissemination do not resuscitate dose Effectiveness element End-Expiratory Pressure evaluate exclusion criteria Expiratory Pressure explained failure followed by Frequency glucocorticoid Glucocorticoids group hemodynamic High dose HIV infection hypoxemic Hypoxemic respiratory failure ICU Immunosuppression Immunosuppressive agents include inclusion criteria Infection Informed consent intensive care unit International legal guardian Length less Life expectancy local Ethics Committee mechanical ventilation Mortality multicenter muscle weakness Nosocomial infection Nosocomial infections number objective open open label open trial other disease other diseases outcome Palliative care PaO parallel group participant Participation Patient Patient care platform Pneumonia Positive end-expiratory pressure power power of 80% Prednisone pressure Prone position protocol R language random randomised randomised controlled trial randomization Randomized randomized clinical trial receive recruitment Registered renal renal disease respiratory respiratory distress Respiratory distress syndrome Respiratory failure resuscitate order RT-PCR Sample size SARS-COV-2 infection SARS-CoV-2 pneumonia secondary Secondary outcomes secondary to sequence Sequential Organ Failure Assessment severe immunosuppression SOFA Standard deviation status Stratified randomization Study protocol subject Support syndrome table terminal Terminal disease title Treatment treatment groups Trial Trial registration two-tailed alpha error Variation ventilator ventilator-free day Ventilator-free days ventilatory Version viral shedding weakness website women [DOI] 10.1186/s13063-020-04646-y PMC 바로가기 [Article Type] Letter
A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in patients with COVID-19 admitted to the intensive care unit (MelCOVID study): a structured summary of a study protocol for a randomized controlled trial중환자실에 입원한 COVID-19 환자의 정맥 주사 멜라토닌의 효능과 안전성을 조사하기 위한 2상, 단일 센터, 이중 맹검, 무작위 위약 대조 시험(MelCOVID 연구): 연구 프로토콜의 구조화된 요약 무작위 대조 시험을 위해Letter Published on 2020-08-052022-08-13 Journal: Trials [Category] MERS, 임상, [키워드] 6 hours Acute hypoxemic respiratory failure addition Admission Adult patients adverse effect adverse event adverse events age allocation anticipated Autoimmune disease Biochemical parameters blinded Blinding blood gas blood gas analysis body weight C-reactive protein Caregivers carried chronic Chronic kidney disease clinical condition clinical development commercialization comparator compatible symptom compatible symptoms Complete completion computer conducted Confirmed Consent Control control arm control group COVID-19 COVID-19-associated thromboembolic phenomena Critically ill D-dimer daily dose Date determined by disease dissemination double-blind Efficacy and safety element enzyme EU Clinical Trial evaluate evaluate the effect exclusion criteria expected experimental arm experimental group failing organ failing organs family member ferritin Frequency gas analysis GFR greater hematologic Hemodialysis hypoxemic Hypoxemic respiratory failure ICU ICU admission impairment Inclusion inclusion criteria increase in inflammatory state Informed institutional protocols intensive care intensive care unit interleukin interleukin-6 intravenous Kidney disease legal guardian less liver enzymes maximum mechanical ventilation medical illness melatonin Mortality multi-organ failure normal range number objective Organ failure outcome parameters participant Patient patient condition patients with COVID-19 per day performed phase physician Placebo placebo-controlled randomized trial plasma Plasma levels positive RT-PCR Pregnancy pregnancy test Prevent procalcitonin Program protocol provided randomization randomization sequence Randomized Randomized controlled trial randomized placebo-controlled trial receive recruited recruitment reduced reduction Respiratory failure Sample size SARS-COV-2 infection SAS version 9.4 SAS version 9.4 statistical software secondary Secondary objectives Sequential Organ Failure Assessment severity single center single-center SOFA Spain Stage Standard-of-care statistical status study drug study group study groups study period Study protocol systemic inflammatory response Terminal surgical thromboembolic Treatment Trial Trial registration two-arm parallel Ventilator-free days website with COVID-19 worsening written Informed Consent [DOI] 10.1186/s13063-020-04632-4 PMC 바로가기 [Article Type] Letter
Ventilation Techniques and Risk for Transmission of Coronavirus Disease, Including COVID-19: A Living Systematic Review of Multiple Streams of Evidence환기 기술 및 COVID-19를 포함한 코로나바이러스 질병 전파 위험: 여러 증거 흐름에 대한 살아있는 체계적 검토Article Published on 2020-08-042022-09-11 Journal: Annals of internal medicine [Category] SARS, 비임상, [키워드] acute respiratory syndrome adjusted aerosol-generating procedure aerosol-generating procedures AGPs animal approach benefit breath certainty certainty of evidence confounders coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus infections COVID-19 Direct eligible Evidence GRADE Health care Health care worker health care workers Health Organization hospitalized patient hospitalized patients hypoxemic Hypoxemic respiratory failure IMV Including independent Invasive mechanical ventilation Laboratory language Mechanical mechanical ventilation MERS Middle East Middle East respiratory syndrome Mortality Multiple NIV Noninvasive ventilation Other oxygen Oxygen therapy Oxygenation Patient patients with SARS PROSPERO reduce reduction in mortality reported respiratory Respiratory failure review risk Severe acute respiratory syndrome stream syndrome systematic review systematic reviews technique Transmission treat Ventilation virus transmission with COVID-19 World Health Organization [DOI] 10.7326/M20-2306 PMC 바로가기 [Article Type] Article
The Role of Interleukin-6 Inhibitors in the Treatment of COVID-19 Infections: A Case SeriesInternal Medicine Published on 2020-06-152022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory distress Administered China Clinical course clinical trial coronavirus coronavirus disease COVID 19 COVID-19 COVID-19 patient cytokine D-dimer levels effective ferritin level health emergency Healthcare systems Hydroxychloroquine hypoxemic Hypoxemic respiratory failure IMPROVE increase in Infection Inflammation Inflammatory marker inflammatory mediator inhibitors interleukin (il)-6 lactate dehydrogenase medication moderate morbidity and mortality Novel coronavirus outbreak oxygen saturation Pathogenesis pathophysiology Pneumonia Research Respiratory failure role SARS-CoV-2 Sery severe symptoms syndrome targeting the disease Tocilizumab Treatment World Health Organization worsened [DOI] 10.7759/cureus.8631 PMC 바로가기 [Article Type] Internal Medicine
Flowchart for non-invasive ventilation support in COVID-19 patients from a northern Italy Emergency DepartmentArticle Published on 2020-05-202023-06-16 Journal: Internal and Emergency Medicine [Category] MERS, SARS, [키워드] continuous positive airways pressure COVID-19 Hypoxemic respiratory failure non-invasive ventilation [DOI] 10.1007/s11739-020-02370-8 PMC 바로가기