SARS‐CoV‐2‐related IFITM3 in immune dysfunction and tumor microenvironment: An integrative analysis in pan‐cancersLetter to Editor Published on 2021-02-232022-10-31 Journal: Clinical and Translational Medicine [Category] COVID-19, MERS, [키워드] IFITM3 immune dysfunction Integrative analysis [DOI] 10.1002/ctm2.345 PMC 바로가기 [Article Type] Letter to Editor
The Polybasic Cleavage Site in SARS-CoV-2 Spike Modulates Viral Sensitivity to Type I Interferon and IFITM2Cellular Response to Infection Published on 2021-02-092022-10-30 Journal: Journal of Virology [Category] COVID-19, SARS, [키워드] Activation Antiviral antiviral activity cathepsin Cell cellular entry cleavage cleavage site consequence coronavirus COVID-19 entry of SARS-CoV-2 exacerbated expression furin cleavage furin cleavage site furin-like protease glycoprotein IFITM IFITM2 IFITM3 individuals inhibit inhibited innate immune Innate immunity interferons (IFNs late endosomes maturation membrane protein mitigate polybasic potential therapeutic target precursor producer cell promote protease Protein reduce reduce viral replication Replication restrict S1/S2 boundary SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 replication SARS-CoV-2 spike sensitivity Site spike suggested the spike protein therapeutic strategy transmembrane Transmissibility transmissibility of SARS-CoV-2 Transmission Treatment Type type 1 interferon type I type I IFNs type I interferon type II IFN viral entry viral spike viruses [DOI] 10.1128/JVI.02422-20 PMC 바로가기 [Article Type] Cellular Response to Infection
Strong Correlation between the Case Fatality Rate of COVID-19 and the rs6598045 Single Nucleotide Polymorphism (SNP) of the Interferon-Induced Transmembrane Protein 3 ( IFITM3 ) Gene at the Population-Level인구 수준에서 코로나19의 치사율과 인터페론 유도 막관통 단백질 3(IFITM3) 유전자의 rs6598045 단일 뉴클레오티드 다형성(SNP) 사이의 강한 상관관계Brief Report Published on 2020-12-302022-09-10 Journal: Genes [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] 1000 Genomes Project ABO ABO gene ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition allele allele frequency angiotensin angiotensin I best Biomarker calculated Case fatality rate case fatality rates caused coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 case COVID-19 cases death distribution enzyme ethnic group Ethnic groups evaluated Fatality rate Genes Genetic Genetic polymorphism genetic polymorphisms Health Organization identify IFITM3 IL6 Infection interferon Interferon-induced transmembrane protein 3 interleukin 6 knowledge leucine LZTFL1 mechanism nucleotide pandemic disease Pathogenesis pathogenesis of COVID-19 performed polymorphism Polymorphisms protease Protein protein 3 Rate regression analysis reported respiratory risk SARS-CoV-2 SAS version 9.4 Serine serine 2 severe acute respiratory syndrome Coronavirus single nucleotide Single nucleotide polymorphism SNP Strong TMPRSS2 Transcription transmembrane transmembrane protein WHO World Health Organization [DOI] 10.3390/genes12010042 PMC 바로가기 [Article Type] Brief Report
Opposing activities of IFITM proteins in SARS‐CoV‐2 infectionArticle Published on 2020-12-212023-06-15 Journal: The EMBO Journal [Category] MERS, SARS, [키워드] COVID‐19 IFITM IFITM3 interferon Microbiology, Virology & Host Pathogen Interaction SARS‐CoV‐2 [DOI] 10.15252/embj.2020106501 PMC 바로가기 [Article Type] Article
Syncytia formation by SARS-CoV-2-infected cellsSARS-CoV-2에 감염된 세포에 의한 융합체 형성Article Published on 2020-12-012022-09-11 Journal: The EMBO Journal [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, [키워드] ACE2 Antiviral effect cellular cellular mechanism contrary COVID-19 Effect ENhance Express extensive lung damage facilitate family FUSE fusion IFITM1 IFITM2 IFITM3 IFITMs increase infected cells inhibit interferon lung damage modulated neighboring cells Pneumocytes Protein restriction factor SARS-CoV-2 SARS-CoV-2-infected cell SARS-CoV-2-infected cells Serine serine protease severe cases Spike protein Syncytia syncytia formation the Spike TMPRSS2 transmembrane protein Trigger triggers Viral Viral protein Viral proteins virions viruses [DOI] 10.15252/embj.2020106267 PMC 바로가기 [Article Type] Article
The frequency of combined IFITM3 haplotype involving the reference alleles of both rs12252 and rs34481144 is in line with COVID-19 standardized mortality ratio of ethnic groups in Englandrs12252 및 rs34481144의 참조 대립유전자를 포함하는 결합된 IFITM3 일배체형의 빈도는 영국의 인종 그룹의 COVID-19 표준화된 사망률과 일치합니다Computational Biology Published on 2020-11-122022-08-13 Journal: PeerJ [Category] 유전자 메커니즘, [키워드] 1000 Genomes Project allele allele frequency alleles Analysis Asian association Bame black cellular Chinese Cohort collected Combination contribute correlation COVID-19 COVID-19 patient COVID-19 severity cytokine cytokine production Dengue Ebola England ethnic group Ethnic groups explain focus Frequency Genetic Haplotype HIV IFITM3 immune effector protein implicated implication Implications Influenza Invasion Latino mechanism Mortality mortality risk outcome past polymorphism Population protein 3 reference allele Regulation reported restriction rs12252 rs34481144 SARS-CoV-2 SARS-CoV-2 pandemic severity SNP Socioeconomic factor Socioeconomic Factors standardized mortality ratio Standardized Mortality Ratios subgroup subgroups suggested the disease transmembrane protein USA vaccination efficacy variant Viral viral replication viruses while White people with COVID-19 [DOI] 10.7717/peerj.10402 PMC 바로가기 [Article Type] Computational Biology
Ethnic variation in risk genotypes based on single nucleotide polymorphisms (SNPs) of the interferon-inducible transmembrane 3 ( IFITM3 ) gene, a susceptibility factor for pandemic 2009 H1N1 influenza A virusOriginal Article Published on 2020-11-102023-06-23 Journal: Immunogenetics [Category] 신종인플루엔자, [키워드] IFITM3 interferon Promoter region, pandemic influenza A 2009 rs12252 rs34481144 rs6598045 SNP [DOI] 10.1007/s00251-020-01188-0 PMC 바로가기 [Article Type] Original Article
Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19Article Published on 2020-10-292022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] activated Algorithm Analysis APOC1 ApoE BAL BCL2A1 Bronchoalveolar lavage Bronchoalveolar lavage (BAL) C1QB canonical category CCL2 CCL3 CCL5 CCL8 CCR1 Cell cellular chemotactic chemotaxis circulation Clustering Cohort complex coronavirus disease correlation COVID-19 CXCL8 Cytokine storm dataset diagnostic disease severity downregulated EPSTI1 FABP4 FIVE FPR1 functional gene signature gene signatures hallmark healthy subject healthy subjects ICGS2 identify IFI27 IFI30 Ifi44 IFI44L IFI6 IFIT1 IFIT3 IFITM1 IFITM2 IFITM3 IFNg IL17 IL1A IL1B IL1RN immune Immune cell Inflammatory inflammatory macrophages Inflammatory response interstitial iterative KLF6 Macrophage MALAT1 Mild mononuclear cell MX1 myeloid cells NEAT1 neutrophil Neutrophils NFkB OAS1 OAS2 OAS3 OASL pathway Patient patients PBMCs Peripheral blood phagocytes phagocytosis PLSCR1 PRL reduction reflected role S100A8 SARS-CoV-2 SAT1 several gene severe COVID-19 severity Signaling Single Cell SPP1 STAT3 subset suppressed systemically TGM2 therapeutic interventions TLR7 TLR9 TNF TYMP UMAP upstream with COVID-19 [DOI] 10.3390/cells9112374 PMC 바로가기 [Article Type] Article
Comprehensive analysis of two potential novel SARS-CoV-2 entries, TMPRSS2 and IFITM3, in healthy individuals and cancer patientsResearch Paper Published on 2020-09-302022-10-29 Journal: International Journal of Biological Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE2 addition Analysis Breast carcinoma Cancer cancer patient caused Cell Comprehensive Coronavirus disease 2019 corpus COVID-19 COVID-19 patients CRS Cytokine release syndrome digestive distribution enzyme expressed expression expression patterns expressions functional Genes global pandemic Hepatocellular carcinoma human tissue human tissues IFITM3 Immune cell Immunity in healthy individual induce involved low expression lung lung adenocarcinoma lymphocyte much lower novel molecule organs other tissues Pneumonia preventing infection profile Prognosis Prostate Protein receptor renal reproductive Respiratory failure SARS-CoV-2 SARS-COV-2 infection suggested susceptibility susceptible Symptom symptoms of COVID-19 TMPRSS2 transmembrane protein transmembrane serine protease Tumor uterine virus [DOI] 10.7150/ijbs.51234 PMC 바로가기 [Article Type] Research Paper
SAMHD1 as the Potential Link Between SARS-CoV-2 Infection and Neurological ComplicationsNeurology Published on 2020-09-252022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome ADAR angiotensin-converting enzyme 2 bioinformatics BST2 caused cells chemokines clinical symptom Complication complications of COVID-19 coronavirus correlation CoV COVID-19 COVID19 CoVs Cytokines death Dipeptidyl peptidase 4 dissemination DPP4 event expression globe IFITM3 Infection influenza A virus IRF3 ISG15 mechanism MERS-CoV Middle East morbidity MX1 MX2 neurodegeneration neuroinvasion neurologic neurological Neurological complication Neurological symptoms NF-κB pathway other molecule pandemic Pathogenesis peripheral nerve system Pneumonia Potential produced Prognosis receptor respiratory syncytial virus RNASEL robust RSAD2 SAMHD1 SAR-CoV2 SARS-CoV-1 SARS-CoV-2 Spread STRING syndrome text mining triggered Type type III interferon with COVID-19 [DOI] 10.3389/fneur.2020.562913 PMC 바로가기 [Article Type] Neurology