IL-1ra – Page 3 – Communicable Diseases Research

Clinical and Immunological Factors That Distinguish COVID-19 From Pandemic Influenza A(H1N1)

유행성 인플루엔자 A(H1N1)와 COVID-19를 구별하는 임상 및 면역학적 요인

Clinical Trial

Published on 2021-04-212022-09-12
Journal: Frontiers in Immunology [Category] MERS, 신종인플루엔자, 임상, 진단,

Proteomic blood profiling in mild, severe and critical COVID-19 patients

경증, 중증 및 중증 COVID-19 환자의 단백질체 혈액 프로파일링

Comparative Study

Published on 2021-03-182022-08-31
Journal: Scientific Reports [Category] 바이오마커, 진단,

[키워드] acute respiratory distress acute respiratory distress syndrome analyses ARDS Autoimmune Biomarker Blood blood protein blood proteins changes in CKAP4 Control COVID-19 COVID-19 cases COVID-19 disease COVID-19 positive patient Critical critical COVID-19 patient death Differential expression analysis disease Disease progression disease severity generate group identify IL-1ra IL6 in some individual individuals infected individuals Infection Inflammation LILRB4 Mild mild respiratory mild respiratory tract infection MONITOR multi-organ failure nine Olink PD-L1 potential therapeutic targets progression Protein proteomic proteomics respiratory respiratory distress respiratory tract infection SARS-CoV-2 pandemic severe pneumonia significantly syndrome the disease viral infection Visualization was performed
[DOI] 10.1038/s41598-021-85877-0 PMC 바로가기 [Article Type] Comparative Study

Similarities and differences between the immunopathogenesis of COVID-19-related pediatric multisystem inflammatory syndrome and Kawasaki disease

COVID-19 관련 소아 다기관 염증 증후군의 면역 병인과 가와사키병의 유사점 및 차이점

Comparative Study

Published on 2021-03-152022-09-11
Journal: The Journal of Clinical Investigation [Category] SARS, 진단, 치료기술,

[키워드] Activation chemokines children circulating circulating cytokine circulating cytokines COVID COVID-19 cytokine cytokine profile Cytokines described discriminant analysis elevated evaluated explain GM-CSF group HCs healthy control IFN-γ IL-18 IL-1ra IL-1α immune complex Immune complexes immunology Immunopathogenesis immunopathology Inflammation Inflammatory inflammatory monocyte IP-10 Kawasaki disease Linear Discriminant Analysis Macrophage macrophage activation syndrome management marker MCP-1 MIS-C monocyte overlapping pandemic Pathogenesis Patient patients PCR pediatric plasma sample plasma samples positive profile quantified RANTES SARS-CoV-2 SARS-CoV-2 pandemic SDF-1 serum significantly syndrome the SARS-CoV-2 therapeutic Trigger triggers unique Vasculitis
[DOI] 10.1172/JCI144554 PMC 바로가기 [Article Type] Comparative Study

Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients

중환자 코로나19 환자의 혈장 사이토카인 수치 증가 및 장기 부전 및 30일 사망률과의 상관관계

Article

Published on 2021-02-012022-09-11
Journal: Cytokine [Category] SARS, 바이오마커,

[키워드] 30-Day mortality abdominal surgery Acute kidney injury Admission Biomarkers Care caused Cohort controls Corona virus correlated correlation COVID-19 Critically ill critically ill COVID-19 patients cytokine cytokine expression cytokine response Cytokine storm Cytokine storm syndrome Cytokines death demonstrated expression IL-17A IL-1ra IL-4 IL-6 IL-8 increase increase in Increased induce Infection Inflammation inflammatory markers inflammatory mediator Inflammatory mediators Inflammatory response Informed consent initial symptoms intensive care IP-10 kidney Kidney injury MCP-1 median mediators moderate Mortality organ damage Organ failure Patient patients PCR-confirmed PCR-confirmed COVID-19 plasma Plasma cytokine plasma sample quantified Respiratory failure SARS CoV SARS CoV-2 SOFA score the strongest was obtained
[DOI] 10.1016/j.cyto.2020.155389 PMC 바로가기 [Article Type] Article

Case Report: Case Series of Children With Multisystem Inflammatory Syndrome Following SARS-CoV-2 Infection in Switzerland

Pediatrics

Published on 2021-01-052022-10-31
Journal: Frontiers in Pediatrics [Category] COVID-19,

Compartmental immunophenotyping in COVID-19 ARDS: A case series

Clinical Trial

Published on 2021-01-012022-10-05
Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 임상,

[키워드] Activation acute respiratory distress acute respiratory distress syndrome ARDS Blood bronchoalveolar Bronchoalveolar lavage Bronchoalveolar lavage fluid case sery CD4 CD8 T cell CD8 T-cell Cell coronavirus disease COVID-19 Critically ill patient cytokine Cytokines Deleterious distress evaluated exhibit expressed flow cytometry fraction hyperinflammation Hyperinflammatory IL-1ra IL-6 IL-8 immunopathology intubation IP-10 less leukocyte lung Lungs lymphopenia Macrophage manifestation marker mechanically ventilated patient moderate-to-severe COVID-19 monocyte multiplex neutrophil Patient phenotype Regulatory T cell Stage subpopulation syndrome upregulation were assessed were expressed with COVID-19
[DOI] 10.1016/j.jaci.2020.09.009 PMC 바로가기 [Article Type] Clinical Trial

Characterization of the cytokine storm reflects hyperinflammatory endothelial dysfunction in COVID-19

사이토카인 폭풍의 특성은 COVID-19의 과염증성 내피 기능 장애를 반영합니다

Article

Published on 2021-01-012022-09-11
Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADP-ribose Adult patients age Analysis analyzed assays association attenuate Baricitinib Biomarker Biomarkers blood sample Blood samples cardiovascular cardiovascular disease characterization characterized circulating circulation coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CXCL10 CXCL5 CXCL9 cytokine Cytokine storm Cytokine storms disease severity dominant dysregulation endothelial damage Endothelial dysfunction healthy control healthy controls help host inflammatory response host response Hyperinflammatory identify IFN-γ IL-10 IL-1ra IL-6 immune response immune responses increasingly Infection Inflammation Intervention marker MCP-3 mechanism Mild moderate monocyte observé Ordinal Scale Pathogenesis Patient patients hospitalized patients with COVID-19 physician platform polymerase Protein proteomic pursuit reduce reflect Regulation reliability reproducibility respiratory Result scale severe acute respiratory syndrome Coronavirus Spectrum statistically significant stratified the cytokine storm therapeutic options Vascular with COVID-19
[DOI] 10.1016/j.jaci.2020.08.031 PMC 바로가기 [Article Type] Article

The Systematic Effect of Mesenchymal Stem Cell Therapy in Critical COVID-19 Patients: A Prospective Double Controlled Trial

중증 코로나19 환자에서 중간엽 줄기세포 치료의 체계적인 효과: 전향적 이중 대조 시험

Controlled Clinical Trial

Published on 2021-01-012022-09-11
Journal: Cell transplantation [Category] 유전자 메커니즘, 임상,

[키워드] Analysis anti-inflammatory cytokine anti-inflammatory cytokines Apoptosis Biochemical parameters CD16 CD19 CD3 CD4 CD45 CD56 CD8 Cell cellular chemokines clinical manifestation clinical manifestations clinical trial Controlled COVID-19 COVID-19 patient COVID-19 patients Critical critical cases Critically ill critically ill COVID-19 patients critically ill patients CRP level CRP levels cytokine Cytokine storm Cytokines demonstrated died dose Effect evaluate evaluated fibrinogen group groups growth growth factor Growth factors HLA-DR IFNγ IL-10 IL-12 IL-13 IL-17A IL-1ra IL-2 IL-6 immunomodulatory effect immunomodulatory effects intravenously investigated KGF lymphocyte Lymphocyte subsets marker matrix metalloproteinases mechanism of action mesenchymal stem cell Mesenchymal stem cells moderate MSC MSCs Neutrophils NGF overall mortality Patient positive proinflammatory proinflammatory cytokines Prospective reducing mortality separated Serum ferritin significantly statistical STEM stem cell TGF-β the cytokine storm therapy tissue regeneration treated Treatment VEGF
[DOI] 10.1177/09636897211024942 PMC 바로가기 [Article Type] Controlled Clinical Trial

Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19

증가된 인터루킨-6 및 대식세포 chemoattractant protein-1은 COVID-19의 호흡 부전과 관련이 있습니다

Clinical Trial

Published on 2020-12-102022-08-13
Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 임상, 진단,

[키워드] analyzed association AUC benefit best Biomarker Biomarkers blood sample Blood samples clinical Clinical data collected Combination combinations correlated COVID-19 COVID-19 patient COVID-19 patients cytokine Cytokines defined FiO2 G-CSF Hospitalization hospitalized patients Human ICU identify IL-1ra IL-6 IL-8 Inclusion Increased Infectious diseases intensive care unit interleukin-6 investigated IP-10 Macrophage MCP-1 MIP-1α P/F PaO2 PaO2/FiO2 ratio Patient Plasma cytokine pro-inflammatory cytokine pro-inflammatory cytokines prospective cohort study recruited Respiratory failure risk ROC analyses ROC analysis SARS-COV-2 infection severe COVID-19 systemic cytokine target targets treated Treatment Treatment strategies
[DOI] 10.1038/s41598-020-78710-7 PMC 바로가기 [Article Type] Clinical Trial

Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm

Observational Study

Published on 2020-12-092022-10-04
Journal: Science Advances [Category] MERS, 임상,