Upper airway gene expression shows a more robust adaptive immune response to SARS-CoV-2 in children상기도 유전자 발현은 소아에서 SARS-CoV-2에 대한 보다 강력한 적응 면역 반응을 보여줍니다Article Published on 2022-07-082022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] activated Adaptive immune response airway B cell B cells cause cell type children ciliated cells contribute decrease disease elicit Gene Expression greater groups IFNγ IL-2 IL-4 immune response Infection interferon-stimulated gene interferon-stimulated genes macrophages nasopharyngeal Older Other respiratory viruses pathway Pathways Proinflammatory cytokine proinflammatory cytokine signaling proportion proportions recruitment respiratory viruses robust SARS-CoV-2 SARS-COV-2 infection severe disease T cell T cell activation target TNF upper airway upregulation virus [DOI] 10.1038/s41467-022-31600-0 PMC 바로가기 [Article Type] Article
Evidence of previous SARS-CoV-2 infection in seronegative patients with long COVID장기간 코로나바이러스에 감염된 혈청 음성 환자의 이전 SARS-CoV-2 감염의 증거Article Published on 2022-07-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute illness antibody assay Cambridge Cohort Consensus COVID COVID-19 illness Definition detectable Diagnosis diagnostic Evidence evidence of IFN-γ IL-2 Immunity infected with SARS-CoV-2 Innovation Long Long COVID Medical Research Council MRC NHSBT NIHR non-hospitalised Patient patients peptides positive PCR test Research reveal SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 peptide SARS-CoV-2 peptides seronegative patient seronegative patients supported Symptoms T cell T cell response T cell responses T cells tested Trust United Kingdom Wellcome Trust [DOI] 10.1016/j.ebiom.2022.104129 PMC 바로가기 [Article Type] Article
Antibody and cellular immune responses following dual COVID-19 vaccination within infection-naive residents of long-term care facilities: an observational cohort studyObservational Study Published on 2022-07-012022-10-05 Journal: The Lancet. Healthy longevity [Category] COVID19(2023년), SARS, 변종, 임상, 진단, [키워드] age antibody Antibody Response binding blood sample booster vaccination Care CD4 T-cell Cellular immune response cellular response Clinical outcome Comorbidity COVID-19 COVID-19 vaccination COVID-19 vaccine CXCL10 production Department EDTA eligible exclusion criteria Factors for inclusion frailty functional groups humoral IFN-γ IL-2 immune dysregulation immune protection immune response Impaired individual Infection IQR median median age neutralisation Observational cohort study Older participant Post-vaccine quantified response risk factor Sample SARS-CoV-2 SARS-COV-2 infection second vaccination SFU significantly staff stratified T-cell Response TNFα vaccination vaccine doses variant spike was reduced were assessed [DOI] 10.1016/S2666-7568(22)00118-0 PMC 바로가기 [Article Type] Observational Study
In Vitro Exposure of Primary Human T Cells and Monocytes to Polyclonal Stimuli Reveals a Basal Susceptibility to Display an Impaired Cellular Immune Response and Develop Severe COVID-19다클론 자극에 대한 1차 인간 T 세포 및 단핵구의 체외 노출은 손상된 세포 면역 반응을 표시하고 심각한 COVID-19를 발생시키는 기초 감수성을 나타냅니다Article Published on 2022-07-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] (PD-1 acute respiratory syndrome acute respiratory syndrome coronavirus Alpha analyzed Anosmia anti-CD3 Antibody titer Antibody titers basal baseline characteristics biochemical blood sample Blood samples CD14 CD16 CD4+ CD8+ T cell CD8+ T cells Cellular immune response cellular immunity classical classical monocytes clinical recovery conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression disease display distress drug Evidence exposure expression Fever Follow-up headache healthy volunteer Human Humoral immunity hypoxia IFN-alpha IFN-gamma IL-2 immune function immune response Immunoglobulin Immunoglobulin G Impaired in vitro interferon interleukin interleukin-2 Invasive mechanical ventilation lipopolysaccharide Mild mild cases monocyte monocyte subsets Monocytes Neutralizing no difference no differences non-classical monocyte Non-classical monocytes not differ participant Patient PD-1 Pneumonia polyclonal predisposition programmed cell death programmed cell death protein prospective cohort study Protein receiving Registered required respiratory respiratory distress response S1 protein SARS-CoV-2 SARS-COV-2 infection serum titer Severe case severe cases severe COVID-19 severity significantly subset Symptom T cell T cells virus worsening [DOI] 10.3389/fimmu.2022.897995 PMC 바로가기 [Article Type] Article
Beneficial ex vivo immunomodulatory and clinical effects of clarithromycin in COVID-19Research article Published on 2022-07-012022-10-05 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), SARS, 임상, [키워드] addition amoxicillin Anti-bacterial agents Antibiotics benefit CD4+ CD8+ clarithromycin Clinical effect Co-incubation confounder COVID COVID-19 COVID-19 patients Critical care Critically ill patient Cytokines decrease Effect Ex vivo had no healthy hospital ICU patient IFN-alpha IL-10 IL-2 IL-6 immunomodulation immunomodulatory immunomodulatory properties immunomodulatory property in viral increase in infections intensive care intracellular cytokine investigated lymphocyte Macrolide monocyte no effect PBMC phagocytosis reduction in mortality Result retrospective cohort study SARS-CoV-2 Spike protein stimulated synergistic T cell response TNF-alpha Univariate analysis was performed with COVID-19 [DOI] 10.1016/j.jiac.2022.04.001 [Article Type] Research article
Neutralizing Potency of Prototype and Omicron RBD mRNA Vaccines Against Omicron Variant오미크론 변이체에 대한 프로토타입 및 오미크론 RBD mRNA 백신의 중화 효능Article Published on 2022-06-302022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against Antisera booster CD4 coronavirus Delta domain dose effective effective vaccine Effective vaccines Efficacy ENCODE expressing feasibility Heterologous heterologous immunization highlighting IFN-γ IL-2 immunization immunization program increase in induce information mice mRNA mRNA vaccine Mutation neutralization neutralization titer neutralization titers Neutralizing Neutralizing antibodies neutralizing antibody omicron Omicron variant opposite potency prototype RBD Receptor binding domain Receptor-binding domain respiratory SARS-CoV-2 SARS-CoV-2 vaccine severe acute respiratory syndrome Coronavirus significantly Spike protein Strains T cell T cell response T cell responses the RBD the spike protein urgency Vaccine Vaccines variant wildtype [DOI] 10.3389/fimmu.2022.908478 PMC 바로가기 [Article Type] Article
Cytokine Profiles Associated With Acute COVID-19 and Long COVID-19 Syndrome급성 COVID-19 및 장기 COVID-19 증후군과 관련된 사이토카인 프로필Article Published on 2022-06-302022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] acute COVID-19 advanced age age clinical conditions clinical presentation Clinical presentations clinical status Cohort Comorbidities Comorbidity COVID COVID-19 COVID-19 treatment cytokine cytokine level cytokine levels cytokine profile Cytokines diagnosed with COVID-19 elevated evaluated Factor group IL-10 IL-17 IL-2 IL-4 IL-6 IL-6 level Long Long COVID-19 marker Mild mild cases moderate no significant difference Patient patients prevention strategies profile risk factor sample collection SARS-CoV-2 serum Serum level severe COVID-19 severity of COVID-19 subject syndrome target TNF-α Treatment younger patient younger patients [DOI] 10.3389/fcimb.2022.922422 PMC 바로가기 [Article Type] Article
Status of Humoral and Cellular Immune Responses within 12 Months following CoronaVac Vaccination against COVID-19COVID-19에 대한 CoronaVac 백신 접종 후 12개월 이내에 체액 및 세포 면역 반응의 상태Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] 12 months addition antibody approved baseline binding binding and neutralizing antibodies binding antibodies binding antibody CD4 CD8 Cell Cellular immune response cellular response Cellular responses central memory CoronaVac country COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines Critical declined detectable dose effector memory Emergency use Endpoint enrolled Evidence functional gamma interferon granzyme B GzmB humoral Humoral and cellular immune responses IFN-γ IL-2 IL-5 immune memory immune persistence immune responses Inactivated vaccine interleukin interleukin 2 memory T cell memory T cells Month Neutralizing antibodies neutralizing antibody neutralizing antibody responses participant persistence produced provide RBD Receptor-binding domain reported response SARS-CoV-2 SARS-CoV-2 RBD second dose secretion seroconversion rate seropositive significantly higher status Stimulation T cells the cells the receptor-binding domain understanding vaccination vaccination schedule Vaccination strategy Vaccine [DOI] 10.1128/mbio.00181-22 PMC 바로가기 [Article Type] Article
Phase 1/2 clinical trial of COVID-19 vaccine in Japanese participants: A report of interim findings일본 참가자를 대상으로 한 코로나19 백신 임상 1/2상: 중간 결과 보고Clinical Trial Published on 2022-06-152022-09-12 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] Adults Antigen CD4+ T-cell cellular immunity clinical clinical trial comparable convalescent serum COVID-19 COVID-19 vaccine evaluate evaluated healthy IFN-γ IgG IL-2 IL-4 immune reaction immunogenicity initiated interim analysis Intramuscular injection Japanese Mild neutralizing antibody Participants patients peptide phase Placebo placebo-controlled predominant Protein Randomized reactogenicity recombinant Recombinant protein regimen regimens response robust Safe Safety Serious Adverse Event Spike protein the vaccine Trial vaccination Vaccine [DOI] 10.1016/j.vaccine.2022.04.054 PMC 바로가기 [Article Type] Clinical Trial
Cellular and Humoral Immunity to SARS-CoV-2 Infection in Multiple Sclerosis Patients on Ocrelizumab and Other Disease-Modifying Therapies: A Multi-Ethnic Observational StudyOcrelizumab 및 기타 질병 수정 요법을 사용하는 다발성 경화증 환자의 SARS-CoV-2 감염에 대한 세포 및 체액 면역: 다민족 관찰 연구Observational Study Published on 2022-06-012022-09-11 Journal: Annals of neurology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료법, [키워드] age ANN antibody Antibody Response Antibody responses assays association Asymptomatic cellular Cellular and humoral immunity Cellular and humoral responses Cellular immune response chemiluminescence immunoassay Clinical course Clinical severity coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 determine domain Effect ELISA ELISPOT ELISpot assays enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated Evidence evidence of group Hospitalized humoral Humoral and cellular immune responses Humoral immunity Humoral response humoral responses IFNγ IL-2 immune responses immunoassay immunologic response immunologic responses Infection Laboratory Live virus microneutralization MOST Multiple multiple sclerosis multivariate analyses Multivariate analysis N-terminal domain Natalizumab not differ Ocrelizumab Other Patient performed Protein RBD receptor recruited respiratory response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike sclerosis Severe acute respiratory syndrome severity Spearman sphingosine spike Spike protein symptomatic infection T-cell Response T-cell responses therapy with COVID-19 [DOI] 10.1002/ana.26346 PMC 바로가기 [Article Type] Observational Study