Prominent coagulation disorder is closely related to inflammatory response and could be as a prognostic indicator for ICU patients with COVID-19Article Published on 2020-08-062022-10-30 Journal: Journal of Thrombosis and Thrombolysis [Category] COVID-19, SARS, [키워드] abnormality AKI analyzed anticoagulation APACHE II ARDS baseline Blood coagulation Characteristics classical Coagulation coagulation disorder consecutive patient correlated COVID-19 Cytokines disorder Factors ferritin global public health had more ICU ICU patient IL6 IL8 in-hospital mortality Inflammation Inflammatory response LDH lymphocyte Neutrophils outbreak parameter Patient positively correlated prognostic indicator Prominent qSOFA SARS-CoV-2 significantly SOFA supplementary material the patient total bilirubin with COVID-19 Wuhan [DOI] 10.1007/s11239-020-02174-9 PMC 바로가기 [Article Type] Article
Tiotropium Is Predicted to Be a Promising Drug for COVID-19 Through Transcriptome-Based Comprehensive Molecular Pathway AnalysisArticle Published on 2020-07-202022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] activate acute respiratory syndrome addition Affect Airway inflammation Antiviral approaches bioinformatics caused Cell chronic obstructive complex Comprehensive COPD coronavirus coronavirus disease COVID-19 COVID-19 patients deregulated drug effective enrichment analyses epithelial expression Genes IL1B IL6 IL8 IMPROVE in vitro in vivo indicated Infection inhibit Interaction Lung fibrosis molecular molecular pathways negative regulation NFkB1 NFKB2 NHBE Ontology outbreak pathologic feature pathway Pathways Patient patients predicted pulmonary disease Pulmonary function Rapamycin reduced RELA RelB Remdesivir Replication rheumatoid arthritis RNA-Seq RNA-seq data SARS-CoV-2 shown significantly the SARS-CoV-2 therapeutic intervention tiotropium TNF upregulated upregulation [DOI] 10.3390/v12070776 PMC 바로가기 [Article Type] Article
COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis Research Published on 2020-06-262022-10-05 Journal: Nature biotechnology [Category] 유전자 메커니즘, 치료법, [키워드] ACE2 activated acute respiratory syndrome airway Analysis average CCL2 CCL20 CCL3 CCR1 CCR5 cell interaction clinical observation clinically contribute coronavirus correlated COVID-19 COVID-19 severity Critical Critical case Critical disease CXCL1 CXCL10 CXCL3 entry receptor epithelial epithelial cell epithelial cell type exhibited expressing expression expression profiles FIVE healthy controls Hyperactivation IL1B IL8 immune immune cells immune response increase in indicated Infection Inflammatory inflammatory macrophage Interaction interferon Lung injury mechanism moderate nasopharyngeal pathway patients with COVID-19 patients with moderate performed Respiratory failure SARS-CoV-2 severe coronavirus disease single-cell Single-cell RNA sequencing suppress the SARS-CoV-2 tissue damage TNF transcriptional difference [DOI] 10.1038/s41587-020-0602-4 [Article Type] Research
Leucocyte Subsets Effectively Predict the Clinical Outcome of Patients With COVID-19 Pneumonia: A Retrospective Case-Control Study백혈구 하위 집합이 COVID-19 폐렴 환자의 임상 결과를 효과적으로 예측합니다: 후향적 사례 대조 연구Public Health Published on 2020-06-182022-09-12 Journal: Frontiers in Public Health [Category] MERS, SARS, 진단, [키워드] age albumin Aspartate aminotransferase AUC Binary logistic regression Blood urea nitrogen C-reactive protein cells characteristic clinical Clinical characteristics Clinical outcome coronavirus disease correlated correlation COVID-19 COVID-19 pneumonia patient cured cytokine D-dimer diagnostic died effective Efficiency elevated eosinophil Factor helper T cells IL10 IL6 IL8 independent indicated Inflammatory response investigated involved leucocyte lymphocyte Lymphocyte count Lymphocytes mechanism Mortality Natural killer cells neutrophil neutrophil count Neutrophil-to-lymphocyte ratio NLR outcome parameter Patient patients with COVID-19 Pneumonia positively correlated predict predicted predictor Prognosis Prognostic factor Prothrombin time Research SARS-CoV-2 serum cytokine serum lactate subject subset T cells T lymphocyte TNF-α total bilirubin [DOI] 10.3389/fpubh.2020.00299 PMC 바로가기 [Article Type] Public Health
Overexpression of the nucleocapsid protein of Middle East respiratory syndrome coronavirus up-regulates CXCL10Research Articles Published on 2018-09-212022-10-28 Journal: Bioscience Reports [Category] Coronavirus, [키워드] A549 cells addition airway epithelial cell antiviral genes antiviral response cause cells cellular processe CXCL10 dendritic cells determine Factor fibroblast cells Genes high mortality rate Host Human IL6 IL8 independent infected cell Infection interactions knowledge lung MERS-CoV Middle East Middle East respiratory syndrome Coronavirus monoclonal antibody monocyte-derived macrophage motif murine N-terminal domain nucleocapsid nucleocapsid protein overexpressed overexpression Patient PCR Protein regulate regulated reported residue Respiratory disease respiratory syndrome coronavirus secretion selected Severity of disease TNF transcriptional transcriptionally transiently transfected translational up-regulate up-regulated was used [DOI] 10.1042/BSR20181059 PMC 바로가기 [Article Type] Research Articles
Expression profiles of immune mediators in feline Coronavirus-infected cells and clinical samples of feline Coronavirus-positive catsResearch Article Published on 2017-04-072022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] addition cause CCL8 Cell clinical sample clinically coronavirus CrFK CXCL10 cytokine definitive diagnosis examined expected expression expression profile fatal disease Feline coronavirus GM-CSF IFNγ IL1β IL6 IL8 immune Immune-mediators immunoassay increase in kidney MCP1 multiplex MX1 PBMC performed plasma pro-inflammatory cytokine profile provide RANTES Real-time PCR responsible Result secretion serum supernatant TNFα Viral load virus [DOI] 10.1186/s12917-017-1019-2 PMC 바로가기 [Article Type] Research Article
Pandemic influenza A/H1N1 virus infection and TNF , LTA , IL1B , IL6 , IL8 , and CCL polymorphisms in Mexican population: a case–control studyResearch Article Published on 2012-11-132023-05-24 Journal: BMC Infectious Diseases [Category] Fulltext, 신종인플루엔자, [키워드] CCL1 IL1B IL6 IL8 Influenza AH1N1 LTA TNF [DOI] 10.1186/1471-2334-12-299 PMC 바로가기 [Article Type] Research Article
A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infectionResearch Article Published on 2004-09-092022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, [키워드] 24 hours activated acute respiratory syndrome Analysis Antibody binding array assay Blood cell activation change chemokine clinical feature Coagulation coronavirus CoV cytokine production described disease pathology distress donors examined Gene Expression healthy donor high-density host response IL17 IL8 immune response in vitro indicated infecting Infection infiltration inhibited inoculated interstitial interstitial inflammation lung trafficking lymphopenia mechanism molecular basis monocyte-macrophage mononuclear cell Pathogenesis pathology pathway PBMC PBMCs Peripheral blood provide Quantitative assays Result SARS Coronavirus SARS patient SARS-CoV Signaling specific antibody the disease TLR9 upregulation viral replication viral replication kinetics [DOI] 10.1186/1471-2334-4-34 PMC 바로가기 [Article Type] Research Article