immune dysregulation
[대역어] 면역 조절 장애
[용어속성] Disease
[용어속성] Disease
Characterisation of the blood RNA host response underpinning severity in COVID-19 patients
COVID-19 환자의 중증도를 뒷받침하는 혈액 RNA 숙주 반응의 특성화
Article
[키워드] abundance
addition
Administered
Alter
Analysis
asymptomatic infection
biological processe
biological processes
Blood
blood transcriptome
clinical manifestations
COVID-19 patient
COVID-19 severity
differential expression
Differential expression analysis
disease
dysregulation
Genes
groups
highlight
host response
immune dysregulation
Immunoglobulin
immunomodulatory
Increasing
individual
Infection
inflammatory immune response
life-threatening
macrophages
Mild
moderate
neutrophil
Neutrophils
offer
Pairwise comparison
pairwise comparisons
Pathway enrichment analysis
Pathways
performed
progression
Research
RNA
SARS-CoV-2
severe COVID-19
severe disease
severity
Transcriptome
Treatment
unique
upregulation
Whole blood
Whole blood transcriptomics
[DOI] 10.1038/s41598-022-15547-2 PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41598-022-15547-2 PMC 바로가기 [Article Type] Article
Impaired humoral immunity is associated with prolonged COVID-19 despite robust CD8 T cell responses
강력한 CD8 T 세포 반응에도 불구하고 손상된 체액성 면역은 장기간의 COVID-19와 관련이 있습니다
Article
[키워드] Affect
Analysis
analyzed
antibody
B cell
B cells
Cancer
CD20
CD4
CD8
CD8 T cell
cellular
clearance
convalescent
COVID-19
COVID-19 infection
Delayed
demonstrated
disease
disease control
dominant
dysregulation
effective
exhibited
functional
highlight
humoral immune response
Humoral immunity
immune dysregulation
immune responses
Impaired
incidence
increase in
nucleocapsid
Patient
Patients with cancer
Peripheral blood
peripheral blood samples
prolonged disease
response
rituximab
robust
SARS-CoV-2
SARS-CoV-2 clearance
Spike protein
Spike proteins
T cell
T cell memory
T cell receptor
T cell responses
T cells
TCR
viral clearance
[DOI] 10.1016/j.ccell.2022.05.013 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.ccell.2022.05.013 PMC 바로가기 [Article Type] Article
Pathogenic Mechanism and Multi-omics Analysis of Oral Manifestations in COVID-19
COVID-19의 구강 증상의 병원성 메커니즘 및 다중 오믹스 분석
Review
[키워드] acute respiratory distress
acute respiratory distress syndrome
acute respiratory syndrome
acute respiratory syndrome coronavirus
Analysis
bind
caused
clinical manifestation
clinical manifestations
coronavirus
coronavirus disease
Coronavirus disease 2019
COVID-19
COVID-19 patients
cytokine
Cytokines
decrease
droplets
dysfunction
dysregulation
Factors
Gustatory
Host
host cell
host cells
human ACE2 receptor
immune
immune cells
immune dysregulation
immune response
Immunological analyses
immunological analysis
include
infect
Inflammation
manifestation
mount
multi
Multi-omics
multiple organ failure
Numerous
oral
oral cavity
pathogen
pathogenic
phenotype
reported
respiratory distress
respiratory infectious disease
S protein
Saliva
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 particle
SARS-CoV-2 particles
severe acute respiratory syndrome Coronavirus
severe acute respiratory syndrome coronavirus 2
severe COVID-19
Spread
structural protein
structural proteins
syndrome
the S protein
Trigger
virus
Xerostomia
[DOI] 10.3389/fimmu.2022.879792 PMC 바로가기 [Article Type] Review
[DOI] 10.3389/fimmu.2022.879792 PMC 바로가기 [Article Type] Review
Antibody and cellular immune responses following dual COVID-19 vaccination within infection-naive residents of long-term care facilities: an observational cohort study
Observational Study
[키워드] age
antibody
Antibody Response
binding
blood sample
booster vaccination
Care
CD4 T-cell
Cellular immune response
cellular response
Clinical outcome
Comorbidity
COVID-19
COVID-19 vaccination
COVID-19 vaccine
CXCL10 production
Department
EDTA
eligible
exclusion criteria
Factors
for inclusion
frailty
functional
groups
humoral
IFN-γ
IL-2
immune dysregulation
immune protection
immune response
Impaired
individual
Infection
IQR
median
median age
neutralisation
Observational cohort study
Older
participant
Post-vaccine
quantified
response
risk factor
Sample
SARS-CoV-2
SARS-COV-2 infection
second vaccination
SFU
significantly
staff
stratified
T-cell Response
TNFα
vaccination
vaccine doses
variant spike
was reduced
were assessed
[DOI] 10.1016/S2666-7568(22)00118-0 PMC 바로가기 [Article Type] Observational Study
[DOI] 10.1016/S2666-7568(22)00118-0 PMC 바로가기 [Article Type] Observational Study
Clinical progress in MSC-based therapies for the management of severe COVID-19
Mini review
[키워드] MB-MSCs
Menstrual blood-derived Mesenchymal Stromal Cells
3-dioxygenase
ACE2angiotensin converting enzyme 2
acute graft-versus-host disease
acute respiratory distress syndrome
Adipose Tissue derived Mesenchymal Stromal Cells
admadministration
administration
alanine aminotransferase
Allo-MSCsAllogeneic Mesenchymal Stromal Cells
Alloallogeneic
Allogeneic
Allogeneic Mesenchymal Stromal Cells
ALTalanine aminotransferase
angiotensin converting enzyme 2
anti-inflammatory property
ARDS
ARDSacute respiratory distress syndrome
Aspartate aminotransferase
ASTaspartate aminotransferase
AT-MSCsAdipose Tissue derived Mesenchymal Stromal Cells
AT2type 2 alveolar cells of the lungs
BALFbronchoalveolar lavage fluid
BM-MSCsbone marrow derived MSCs
body weight
bone marrow derived MSCs
Bronchoalveolar lavage fluid
bwBody weight
C-reactive protein
cAMPcyclic adenosine monophosphate
candidate
CDcluster of differentiation
Cell
clinical
clinical trial
cluster of differentiation
complex
conducted
Coronavirus disease 2019
coronavirus disease of 2019
COVID-19
COVID-19Coronavirus disease of 2019
CRPC-reactive protein
cyclic adenosine monophosphate
cytokine
Daewoong Pharmaceutical’s Mesenchymal Stromal Cells
DCsdendritic cells
dendritic cells
driven by
DSCsPlacenta-derived decidua stromal cells
DW-MSCsDaewoong Pharmaceutical’s Mesenchymal Stromal Cells
EVsextracellular vesicles
Extracellular vesicles
Fas ligands
Fas-LFas ligands
FDAFood and Drug Administration
FGFfibroblast growth factor
fibroblast growth factor
Food and Drug Administration
forkhead box P3 +
FOXP3 +forkhead box P3 +
G-CSFgranulocyte colony-stimulating factor
Gal-1galectin-1
Gal-3galectin-3
Gal-9galectin-9
galectin-1
galectin-3
Galectin-9
GM-CSFgranulocyte macrophage-colony stimulating factor
granulocyte colony-stimulating factor
granulocyte macrophage-colony stimulating factor
growth factor
GvHDacute graft-versus-host disease
HB-AT-MSCsHope Biosciences autologous adipose-derived mesenchymal stromal cells
HdHigh dose
hepatocyte growth factor
HGFhepatocyte growth factor
High dose
HLAHuman leukocyte antigen
Hope Biosciences autologous adipose-derived mesenchymal stromal cells
human leukocyte antigen
ICUIntensive Care Unit
IDOIndoleamine 2
IFN-γinterferon-γ
IL-10interleukin-10
IL-1interleukin-1
IL-1βinterleukin-1β
IL-2 receptor
IL-2interleukin-2
IL-2RIL-2 receptor
IL-4interleukin-4
IL-6interleukin-6
IL-7Interleukin 7
IL-7interleukin-7
IL-8interleukin 8
IL-9interleukin
IL1-αinterleukin 1-α
IL1-βinterleukin 1-β
IL1RaInterleukin-1 receptor antagonist
immune dysregulation
immunological
immunomodulatory
IMVInvasive mechanical ventilation
Indoleamine 2
inducible protein 10
inflammatory process
inhalation
INHinhalation
intensive care unit
interferon-γ
interleukin
interleukin 1-α
interleukin 1-β
Interleukin 7
interleukin 8
interleukin-1
Interleukin-1 receptor antagonist
interleukin-10
interleukin-1β
interleukin-2
Interleukin-4
interleukin-6
interleukin-7
intravenous
Invasive mechanical ventilation
IP-10inducible protein 10
IVintravenous
keratinocyte growth factor
KGFkeratinocyte growth factor
lactate dehydrogenase
LDHlactate dehydrogenase
LdLow dose
lipopolysaccharide
low dose
LPSlipopolysaccharide
major histocompatibility complex
management
MAPKmitogen-activated protein kinase
MCP-1monocyte chemoattractant protein-1
Mesenchymal stromal cell
Mesenchymal stromal cells
MHCMajor Histocompatibility Complex
microRNA
miRNAmicroRNA
MIS-Cmultisystem inflammatory syndrome in children
mitogen-activated protein kinase
monocyte chemoattractant protein-1
MSCs
MSCsmesenchymal stromal cells
multisystem inflammatory syndrome in children
nanovesicles
National Institutes of Health
natural
NETsNeutrophil Extracellular Traps
Neutrophil extracellular traps
NF-κBnuclear factor-kappa B
NIHNational Institutes of Health
nitric oxide
NKnatural
NONitric Oxide
nuclear factor-kappa B
NVsnanovesicles
occur
PD-1programmed cell death protein 1
PD-L1programmed death ligand-1
PGE2prostaglandin E2
pharmacological management
PL-MSCsPlacental-derived Mesenchymal Stromal Cells
Placenta-derived decidua stromal cells
placental expanded
Placental-derived Mesenchymal Stromal Cells
PLX-PADplacental expanded
programmed cell death protein 1
programmed death ligand-1
prostaglandin E2
protein spike
public health
reactive oxygen species
Regulatory T cell
Respiratory failure
RFrespiratory failure
ROSreactive oxygen species
SARS-CoV-2severe acute respiratory syndrome coronavirus 2
Secretome
severe acute respiratory syndrome coronavirus 2
severe COVID-19
Severe respiratory distress
signal transducer activators of transcription-3
Sprotein spike
STAT3signal transducer activators of transcription-3
syndrome
TGF-β1transforming growth factor-β1
TGFtransforming growth factor
the cytokine storm
the disease
therapeutic
therapy
TLRtoll-like receptors
TNF-α-stimulating gene 6
TNF-αtumor necrosis factor-α
TNFTumor Necrosis Factor
Toll-like receptors
transforming growth factor
transforming growth factor-β1
treat
Tregregulatory T cell
TSG-6TNF-α-stimulating gene 6
tumor necrosis factor
tumor necrosis factor-α
type 2 alveolar cells of the lungs
UC-MSCsumbilical cord derived MSCs
umbilical cord derived MSCs
vascular endothelial growth factor
VEGFvascular endothelial growth factor
Wharton’s Jelly–derived Mesenchymal Stromal Cells
WJ-MSCsWharton’s Jelly–derived Mesenchymal Stromal Cells
[DOI] 10.1016/j.cytogfr.2022.07.002 [Article Type] Mini review
[DOI] 10.1016/j.cytogfr.2022.07.002 [Article Type] Mini review
Programmed Cell Death-1/Programmed Cell Death-1 Ligand as Prognostic Markers of Coronavirus Disease 2019 Severity
코로나바이러스 질병 2019 심각도의 예후 마커로서의 프로그램된 세포 사멸-1/프로그램된 세포 사멸-1 리간드
Article
[키워드] acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
analysed
association
B cells
B lymphocyte
baseline
Biomarker
CD19
Cell
Control
controls
coronavirus
coronavirus disease
Coronavirus disease 2019
COVID-19
COVID-19 infection
COVID-19 severity
current
disease
disease mortality
disease severity
dysregulation
evaluated
expression
groups
hospitalized patient
hospitalized patients
immune
immune dysregulation
immunophenotype
In-hospital
increase
Increased
Infection
intensive care
Laboratory
Ligand
lymphocyte
Lymphocytes
marker
mechanical ventilation
moderate
moderate to severe
Mortality
notable
oxygen
oxygen support
parameter
patients with COVID-19
patients with moderate
patients without COVID-19
PD-1
PD-L1
profile
programmed cell death
programmed cell death protein
programmed cell death protein 1
Protein
Research
respiratory
severe acute respiratory syndrome Coronavirus
severe acute respiratory syndrome coronavirus 2
severe COVID-19
severity
survival
T cell
T cells
Treatment
were used
[DOI] 10.3390/cells11121978 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/cells11121978 PMC 바로가기 [Article Type] Article
A phase I trial of cyclosporine for hospitalized patients with COVID-19
Clinical Trial
[키워드] administration
adverse events
antiviral property
application
Care
center
characterized
chemokine
chemokines
clinical response
conducted
Course
COVID-19
CsA
CXCL10
cyclosporine A
cytokine production
Cytokine storm
Cytokines
discharged
disease
dose
drug
evaluated
exacerbated
feasible
gene expression signature
gene-expression
Health
health emergency
healthcare
Hospitalized
hospitalized patient
hyperinflammation
ill patient
immune dysregulation
inhibitor
intensive care
modulate
New
oxygen
participant
Patient
patients with COVID-19
peripheral blood cell
Phase I
reduction in
reductions in
Registered
required
resource
Safe
serum cytokine
transaminitis
transcriptional profile
treated
Treatment
Trial
Type I IFN
Vaccine
with COVID-19
[DOI] 10.1172/jci.insight.155682 PMC 바로가기 [Article Type] Clinical Trial
[DOI] 10.1172/jci.insight.155682 PMC 바로가기 [Article Type] Clinical Trial
Mechanism of COVID-19-Related Proteins in Spinal Tuberculosis: Immune Dysregulation
척수결핵에서 COVID-19 관련 단백질의 메커니즘: 면역 조절 장애
Article
[키워드] Accuracy
Analysis
AUC
B cell
B cells
bioinformatics
C-index
calculated
calibration curve
Cell
clinical
Clinical data
collected
coronavirus disease
COVID-19
degree
Diagnosis
differentially expressed
dysregulation
enrichment analysis
expression
external validation
Factor
Gene ontology
immune
Immune cell
immune cells
immune dysregulation
immune genes
immune mechanism
indicated
Intersection
intervertebral
intervertebral disc
involved
KEGG
KEGG pathway
low expression
Lymphocytes
MCC
mechanism
mechanisms
negative correlation
nine
nomogram
PPI
predicted
Predictive
Protein
protein-protein interaction
Proteins
risk
ROC Curve
RPL19
significantly lower
spinal
spinal tuberculosis.
suppress
tissue
tissues
training set
Tuberculosis
was used
were used
[DOI] 10.3389/fimmu.2022.882651 PMC 바로가기 [Article Type] Article
[DOI] 10.3389/fimmu.2022.882651 PMC 바로가기 [Article Type] Article