Severe Adaptive Immune Suppression May Be Why Patients With Severe COVID-19 Cannot Be Discharged From the ICU Even After Negative Viral Tests심각한 적응 면역 억제가 심각한 COVID-19 환자가 음성 바이러스 검사 후에도 ICU에서 퇴원할 수 없는 이유일 수 있음Observational Study Published on 2021-11-192022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 임상, [키워드] adaptive adaptive immune suppression Adaptive immunity addition analyzed Arm blood sample Blood samples caused Cell changes in classic collected COVID-19 COVID-19 pandemic Critically ill CTLA-4 decreased expression discharged enrolled exhibited expression gene expression profile Gene expression profiles Genes HLA molecules Host ICU immune cells Immune suppression Immunosuppression Inflammatory responses mechanism negative Patient patients PD-1 PD-L1 phenomenon SARS-CoV-2 secondary infections Sepsis severe disease Severe infection severely infected patient suppression Symptom Test transcriptome sequencing Viral [DOI] 10.3389/fimmu.2021.755579 PMC 바로가기 [Article Type] Observational Study
Drug delivery systems as immunomodulators for therapy of infectious disease: Relevance to COVID-19감염성 질환 치료를 위한 면역조절제로서의 약물 전달 시스템: COVID-19와 관련성Review Published on 2021-11-012022-09-11 Journal: Advanced drug delivery reviews [Category] MERS, 신약개발, 진단, 치료제, [키워드] Activation adaptive approach approaches blocking agents cellular Coagulation complement complex complex interplay COVID-19 damage drug delivery system drug delivery systems endothelial Endothelium global pandemic identify immune Immune cell immune cells Immune suppression immunomodulator immunomodulatory IMPROVE improvement Inflammasome inflammasomes Inflammation Interaction involved limit moderate to severe molecular nanomedicine not limited outcome pathogen clearance pathology pathophysiology Patient patients with moderate Prognosis Relevance SARS-CoV-2 severe COVID-19 survival rates Therapeutic approach therapeutic approaches therapeutic option therapy tissue damage [DOI] 10.1016/j.addr.2021.113848 PMC 바로가기 [Article Type] Review
Coronavirus Nsp1: Immune Response Suppression and Protein Expression InhibitionMicrobiology Published on 2021-09-282022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] beta-coronavirus coronavirus Coronaviruses COVID-19 pandemic deaths expression gene expression level Host host cells Host immune response host protein immune response Immune suppression inhibition live-attenuated vaccine mechanisms Mutation nonstructural protein 1 pathogenicity Protein protein synthesis public health reduce response SARS-CoV-2 suppresse suppression translation translation inhibition unique Vaccine Viral proteins Viral RNA virus [DOI] 10.3389/fmicb.2021.752214 PMC 바로가기 [Article Type] Microbiology
Sargramostim (rhu GM-CSF) as Cancer Therapy (Systematic Review) and An Immunomodulator. A Drug Before Its Time?Immunology Published on 2021-08-172022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS, [키워드] accelerate accelerated acute respiratory distress Adaptive immune response adaptive immune system anti-cancer response approved ARDS Autoimmune biological activity Bone marrow bone marrow failure Cancer Clinical data clinical setting clinical settings COVID-19 database Diseases drug Efficacy ENhance Essential example FDA GM-CSF granulocyte-macrophage colony-stimulating factor hematologic host immunity humans immune Immune checkpoint inhibitor immune modulation Immune suppression immune therapy Immunotherapy Infection infections innate immune response less modulating monoclonal antibodies objective Other Pulmonary alveolar proteinosis reported Result resulting review safety profile sargramostim Sepsis significantly solid cancer survival syndrome Therapies therapy tissue repair Toxicity trauma US FDA Vaccine variety [DOI] 10.3389/fimmu.2021.706186 PMC 바로가기 [Article Type] Immunology
Downregulation of CD45 Signaling in COVID-19 Patients Is Reversed by C24D, a Novel CD45 Targeting PeptideMedicine Published on 2021-08-032022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Activation acute respiratory syndrome bind Breast cancer CD45 Cell Coronavirus-2 COVID-19 COVID-19 patient demonstrated function healthy volunteers Hypothesis immune Immune suppression immune system Immunosuppression in viral inhibited interfere intracellular signaling leukocytes modulating mononuclear cell novel Patient patients PBMC PBMCs peptide Peripheral blood Phosphorylation potential therapeutic target predominant Protein reported required rescued SARS-CoV-2 Signaling signaling pathway similarity Src family of tyrosine kinases T cell receptor targeting tested therapeutic transmembrane tyrosine tyrosine phosphatase virus [DOI] 10.3389/fmed.2021.675963 PMC 바로가기 [Article Type] Medicine
Clinical and Pathophysiologic Spectrum of Neuro-COVIDNeuro-COVID의 임상 및 병태생리학적 스펙트럼Review Published on 2021-08-012022-09-11 Journal: Molecular neurobiology [Category] SARS, 치료제, [키워드] affected anticipated Brain Central and peripheral nervous system Central nervous system clinical COVID-19 COVID-19 patient determine disease Effects explain immune immune modulation Immune suppression Infection investigated less lung Lungs majority manifestation nervous system Neurological involvement neurologist occur outcome pathophysiology patients with COVID-19 peripheral nerve Peripheral nervous system recent finding respond SARS-CoV-2 SARS-CoV-2-infected patients side Side effects Skeletal muscle Spectrum structures virus [DOI] 10.1007/s12035-021-02383-0 PMC 바로가기 [Article Type] Review
SARS-CoV-2 and Cytomegalovirus Co-Infections—A Case Series of Critically Ill PatientsArticle Published on 2021-06-252022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] case sery causes Clinical course CMV Co-infection Co-infections confounding factor contributing to COVID-19 COVID-19 patient Critical care Critically ill cytomegalovirus FIVE health care systems ICU Ill Immune suppression intensive care Patient Research Respiratory failure SARS-CoV-2 SARS-CoV-2 pandemic Sery severe COVID-19 turn [DOI] 10.3390/jcm10132792 PMC 바로가기 [Article Type] Article
Clinical and molecular characteristics of COVID-19 patients with persistent SARS-CoV-2 infection지속적인 SARS-CoV-2 감염이 있는 COVID-19 환자의 임상 및 분자 특성Article Published on 2021-06-092022-09-12 Journal: Nature Communications [Category] MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] activated Antimicrobial responses CD14 Cell Characteristics chemokines clinical correlation COVID-19 patient COVID-19 patients cytokine Cytokines described expression Genes healthy donor healthy donors immune characteristics Immune suppression Immunosuppression independent Infection interleukin LDs less lymphotoxin molecular molecular feature monocyte Monocytes natural killer Necrosis NK cell Pathways Patient patients patients with COVID-19 persistence persistent infection reduced Regulatory T cell regulatory T cells ribosomal protein RNA sequencing SARS-COV-2 infection short duration Single-cell RNA sequencing Systems analysis T cells TNF Tumor tumor necrosis tumor necrosis factor viral infection viral shedding [DOI] 10.1038/s41467-021-23621-y PMC 바로가기 [Article Type] Article
Tacrolimus exposure windows responsible for Listeria monocytogenes infection susceptibilityArticle Published on 2021-06-022024-09-04 Journal: Transplant infectious disease : an official journa [Category] 대상포진, [키워드] Adaptive immunity Immune suppression Intracelluar bacteria opportunistic infection T cell [DOI] 10.1111/tid.13655 PMC 바로가기 [Article Type] Article
SARS-CoV-2 genomic surveillance identifies naturally occurring truncation of ORF7a that limits immune suppressionSARS-CoV-2 게놈 감시는 면역 억제를 제한하는 ORF7a의 자연 발생 절단을 식별합니다Article Published on 2021-06-012022-09-11 Journal: Cell Reports [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect C-terminal change coronavirus Critical elevated Evolution of SARS-CoV-2 experiment growth growth defect identify IFN IFN response immune modulation immune response Immune suppression implicated indicate limit mechanism mutant virus Mutation occur ORF7a over Patient Protein responsible SARS-CoV-2 SARS-CoV-2 genomic surveillance sequence severe acute respiratory syndrome Coronavirus Spread type I interferon viral challenge viral infection virus Whole-genome sequence [DOI] 10.1016/j.celrep.2021.109197 PMC 바로가기 [Article Type] Article