Personalized health and the coronavirus vaccines—Do individual genetics matter?Review Published on 2021-07-262023-07-02 Journal: Bioessays [Category] SARS, [키워드] COVID‐19 HLA human polymorphism Immunogenetics reactogenicity Vaccines [DOI] 10.1002/bies.202100087 PMC 바로가기 [Article Type] Review
Individual HLA-A, -B, -C , and -DRB1 Genotypes Are No Major Factors Which Determine COVID-19 SeverityImmunology Published on 2021-07-262022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] in silico prediction Antigen benefit courses COVID-19 COVID-19 severity determine effective element Factor functional Genotype heterozygote HLA HLA molecule HLA-A Immunogenetics in silico individual infected individuals investigated Major observé physicochemical predict predicted robust SARS-CoV-2 SARS-CoV-2 infections severity similarity spike glycoprotein T-cell epitope T-cell epitopes T-cell Response [DOI] 10.3389/fimmu.2021.698193 PMC 바로가기 [Article Type] Immunology
Germline variants in UNC13D and AP3B1 are enriched in COVID-19 patients experiencing severe cytokine stormsUNC13D 및 AP3B1의 생식선 변이체는 심각한 사이토카인 폭풍을 경험하는 COVID-19 환자에서 풍부합니다Brief Communication Published on 2021-04-192022-09-10 Journal: European Journal of Human Genetics [Category] MERS, 변종, 유전자 메커니즘, [키워드] analyzed AP3B1 association characterized conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cytokine Cytokine storm Cytokine storms DHX58 Factor Genes germline help hemophagocytic lymphohistiocytosis HLH hospitalized COVID-19 patient host inflammatory response host inflammatory responses Hyperinflammatory Immunogenetics individual Infection management outcome outcomes PID Primary Immunodeficiency RNF168 significantly susceptibility UNC13D variant variants viral infection whole-exome sequencing [DOI] 10.1038/s41431-021-00886-x PMC 바로가기 [Article Type] Brief Communication
HLA Alleles B * 53:01 and C * 06:02 Are Associated With Higher Risk of P. falciparum Parasitemia in a Cohort in UgandaHLA 대립유전자 B * 53:01 및 C * 06:02는 우간다의 한 집단에서 P. falciparum 기생충 혈증의 높은 위험과 관련이 있습니다.Original Research Published on 2021-03-192024-08-08 Journal: Frontiers in immunology [Category] 말라리아, [키워드] HLA Immunogenetics malaria MHC Plasmodium falciparum [DOI] 10.3389/fimmu.2021.650028 PMC 바로가기 [Article Type] Original Research
HLA-DRB1 Alleles Associated with Lower Leishmaniasis Susceptibility Share Common Amino Acid Polymorphisms and Epitope Binding RepertoiresArticle Published on 2021-03-172024-09-02 Journal: Vaccines [Category] 대상포진, [키워드] Antigen presentation HLA association human leukocyte antigen Immunogenetics immunoinformatics Leishmania Leishmaniasis vaccine candidates [DOI] 10.3390/vaccines9030270 PMC 바로가기 [Article Type] Article
The Role of Immunogenetics in COVID-19COVID-19에서 면역유전학의 역할Review Published on 2021-03-052022-09-10 Journal: International Journal of Molecular Sciences [Category] 변종, 신약개발, 유전자 메커니즘, [키워드] AB0 Asymptomatic available data clinical manifestations coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients cytokine Cytokine storm disease Drug repurposing Evolution experimental evidence genetic variability Genetic variant genetic variants help HLA Host immune response immune system Immunogenetics immunosenescence Impact IMPROVE KIR knowledge life-threatening maintenance molecular mechanism Multiorgan outcome reactivity Research Respiratory failure role SARS-CoV-2 SARS-COV-2 infection susceptibility the disease Therapeutic strategies Treatment Variability variety Viral viral infection viral infections [DOI] 10.3390/ijms22052636 PMC 바로가기 [Article Type] Review
The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2SARS-CoV-2와 관련된 인간 폐의 노화 전사체 및 세포 경관Article Published on 2021-01-042022-09-10 Journal: Nature Communications [Category] MERS, 유전자 메커니즘, 진단, [키워드] age airway smooth muscle alveolar Analysis basal cells Cell cells cellular change characterized contribute coronavirus coronavirus disease COVID-19 Data integration deconvolution analysis decrease dendritic cell dendritic cells dysregulated Endothelial cell endothelial cells Factor feature fibroblasts goblet cells human lung identify IGSF21 Immunogenetics in vitro lung Mitochondria Older Patient pericytes populations proportion proportions proteome reduced Replication responses reveal risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro SARS-CoV-2 proteome severe coronavirus disease severe COVID-19 severity of COVID-19 smooth muscle Stress stress responses the SARS-CoV-2 the strongest transcriptional transcriptionally Transcriptome transcriptomes viral infection [DOI] 10.1038/s41467-020-20323-9 PMC 바로가기 [Article Type] Article
Dynamic data-driven meta-analysis for prioritisation of host genes implicated in COVID-19COVID-19와 관련된 숙주 유전자의 우선 순위를 지정하기 위한 동적 데이터 기반 메타 분석Meta-Analysis Published on 2020-12-182022-09-10 Journal: Scientific Reports [Category] MERS, 바이오마커, 유전자 메커니즘, 임상, 치료제, [키워드] Algorithm Betacoronavirus CD3E CD4 chromosome chromosome 3 conducted content COVID-19 COVID-19 pathogenesis CXCL10 cyclosporine data-driven datasets described disease-associated dynamic evaluate Evidence experiment Factor Factors FYCO1 GWAS Host host gene host genes human betacoronavirus IL1A Immunogenetics immunology implicated Infection Infectious diseases Interpretation list list of gene locus MERS MERS-CoV Meta-analysis Other PPIA Prognostic factor Prognostic factors resource robust SARS-CoV SARS-CoV-2 seasonal coronaviruses systematic review therapeutic target Therapies viral infection Weighting [DOI] 10.1038/s41598-020-79033-3 PMC 바로가기 [Article Type] Meta-Analysis
No impact of cancer and plague-relevant FPR1 polymorphisms on COVID-19COVID-19에 대한 암 및 전염병 관련 FPR1 다형성의 영향 없음Multicenter Study Published on 2020-12-082022-09-11 Journal: Oncoimmunology [Category] MERS, SARS, 진단, 치료기술, [키워드] accelerate Affect allelic anticancer Antigen presentation Bacterial Cancer coding coronavirus coronavirus disease Coronavirus disease-19 COVID-19 danger-associated molecular pattern defect dendritic cells detect Effect fibrosis formyl FPR1 Frequency hospital Hypothesis immune responses Immunogenetics innate immune response innate immune responses investigated involved Lung inflammation manifestation myeloid cells nucleotide Paris pathogen pathogen-associated molecular pathogen-associated molecular patterns Patient peptide plague polymorphism receptor reduced reported SARS-CoV-2 secondary to severity severity of COVID-19 single nucleotide Single nucleotide polymorphism Trigger Yersinia Yersinia pestis [DOI] 10.1080/2162402X.2020.1857112 PMC 바로가기 [Article Type] Multicenter Study
Host genetics and infectious disease: new tools, insights and translational opportunitiesReview Article Published on 2020-12-042023-06-15 Journal: Nature reviews. Genetics [Category] MERS, SARS, [키워드] Disease genetics Evolutionary genetics Genome-wide association studies Immunogenetics Pathogens [DOI] 10.1038/s41576-020-00297-6 PMC 바로가기 [Article Type] Review Article