Why Do Immunosuppressed Patients with Inflammatory Bowel Disease Not Seem to Be at a Higher Risk of COVID-19?Review Published on 2021-09-012023-07-06 Journal: Digestive diseases and sciences [Category] SARS, [키워드] adherence containment measures COVID-19 immunotherapies Inflammatory bowel disease SARS-CoV-2 [DOI] 10.1007/s10620-020-06624-5 PMC 바로가기 [Article Type] Review
Rationale for Polyclonal Intravenous Immunoglobulin Adjunctive Therapy in COVID-19 Patients: Report of a Structured Multidisciplinary ConsensusArticle Published on 2021-08-082022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] available data bacterial superinfection clinical phenotype Consensus COVID-19 COVID-19 patient COVID-19 patients defined dysregulated early phase Effectiveness Evidence Hyperinflammatory immune Immunocompromised patients immunotherapies Infection intravenous intravenous immunoglobulin therapy IVIG late phase literature review management manuscript mechanism ongoing trial paralysis pathobiology of COVID-19 Patient phenotype polyclonal rationale report Respiratory failure Sepsis severe COVID-19 severe respiratory failure Shock the SARS-CoV-2 therapy was used [DOI] 10.3390/jcm10163500 PMC 바로가기 [Article Type] Article
Immune cell profiling in atherosclerosis: role in research and precision medicine Reviews Published on 2021-07-152022-10-05 Journal: Nature reviews. Cardiology [Category] 신약개발, [키워드] alteration Atherosclerosis atherosclerotic atherosclerotic plaque cardiovascular disease cardiovascular event cardiovascular risk Cell cellular cellular and molecular clinical trial CRISPR Cytometry data-driven early phase epitope experimental models group Human identify immune immunotherapies Immunotherapy Inflammation involved mouse model Myocardial infarction Patient patient population patients Precision randomized clinical trial reduce Research review Sequencing single-cell Single-cell RNA sequencing Stage These data Transcriptome translation treat treated patients [DOI] 10.1038/s41569-021-00589-2 [Article Type] Reviews
Lipopeptides for Vaccine DevelopmentReview Published on 2021-07-062022-10-04 Journal: Bioconjugate chemistry [Category] 비임상, [키워드] adjuvants Antigen antigens Cancer clinical development COVID-19 CSK derivative described development example Hepatitis highlight immunogenic Immunological response immunotherapies Immunotherapy include Infectious disease Influenza linear lipopeptide malaria peptides Research sequence shown Structure Toll-like receptor agonist treat Vaccine Vaccine development [DOI] 10.1021/acs.bioconjchem.1c00258 PMC 바로가기 [Article Type] Review
Vectored Immunotherapeutics for Infectious Diseases: Can rAAVs Be The Game Changers for Fighting Transmissible Pathogens?Immunology Published on 2021-05-112022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] adeno-associated virus antibody antigens Can Clinical efficacy Clinical studies Conventional de novo synthesis Diseases Efficacy Efficiency expression Fighting foreign protein game Gene therapy genomic variation HIV Host Immunity immunomodulatory immunotherapies Immunotherapy in vivo Infection Infectious disease Influenza inherent lentivirus malaria mechanism neutralizing antibody offer passive transfer Pathogens pre-existing immunity profiles Prophylactic reduce repeated Severity of disease single dose tested therapeutic strategy Topology transgene Treatment vaccination Vaccines vectors viral vectors virus [DOI] 10.3389/fimmu.2021.673699 PMC 바로가기 [Article Type] Immunology
Lipid-Based Nanoparticles in the Clinic and Clinical Trials: From Cancer Nanomedicine to COVID-19 VaccinesReview Published on 2021-04-082022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] approval Cancer carriers clinic clinical clinical trials COVID-19 COVID-19 vaccine COVID-19 vaccines Doxil highlight immunotherapies Immunotherapy Lipid nanoparticle Lipid nanoparticles liposomes nanomedicine nanomedicines nanoparticle physicochemical property Regulatory required Research therapeutic Vaccine Vaccines [DOI] 10.3390/vaccines9040359 PMC 바로가기 [Article Type] Review
The great escape? SARS-CoV-2 variants evading neutralizing responses대단한 탈출? 중화 반응을 회피하는 SARS-CoV-2 변종Article Published on 2021-03-102022-09-11 Journal: Cell Host & Microbe [Category] Fulltext, SARS, 변종, 진단, [키워드] article Efficacy highlight immunotherapies microbe Mutation neutralizing response neutralizing responses Receptor binding domain Reinfection SARS-CoV-2 evolution SARS-CoV-2 variant spike Spike receptor binding domain Surveillance the SARS-CoV-2 Vaccine vaccine efficacy variant [DOI] 10.1016/j.chom.2021.02.010 PMC 바로가기 [Article Type] Article
Evaluation of the safety and efficacy of XAV-19 in patients with COVID-19-induced moderate pneumonia: study protocol for a randomized, double-blinded, placebo-controlled phase 2 (2a and 2b) trialCOVID-19 유발 중등도 폐렴 환자에서 XAV-19의 안전성 및 효능 평가: 무작위 배정, 이중 맹검, 위약 대조 2상(2a 및 2b) 시험을 위한 연구 프로토콜Study Protocol Published on 2021-03-092022-09-01 Journal: Trials [Category] SARS, 비임상, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered administration anti-SARS-CoV-2 antibodies Anti-viral antibody Antibody Response blunting breath cells clinical benefit clinical benefits Combination convalescent plasma coronavirus COVID-19 COVID-19 patients determine dose double-blinded Drug-drug interactions effective Efficacy EudraCT evaluate Heterologous human cell humanized humans Immunity immunotherapies Immunotherapy indicated infected patient infected patients Infection inhibiting intravenous kidney lack long term moderate Moderate pneumonia neutralizing antibody New not adapted offer pathogenic Patient patients with SARS-CoV-2 performed pharmacodynamic studies pharmacodynamic study Phase 2 Placebo placebo-controlled placebo-controlled study plasma Pneumonia polyclonal polyclonal antibody populations primates pro-inflammatory Prophylaxis raised Randomized Randomized controlled trial recipient recipients Registered Replication respiratory SARS-CoV-2 selected severe acute respiratory syndrome Coronavirus Spike protein spike protein of SARS-CoV-2 Study protocol supplementary material the spike protein Therapeutic approach therapeutic option to define treat Treatment treatment for COVID-19 Trial Trial registration [DOI] 10.1186/s13063-021-05132-9 PMC 바로가기 [Article Type] Study Protocol
Reassessing IVIg therapy in chronic inflammatory demyelinating polyradiculoneuropathy during COVID-19: a chance to verify the need for chronic maintenance therapyCOVID-19 기간 동안 만성 염증성 탈수초성 다발성 신경근신경병증에서 IVIg 요법 재평가: 만성 유지 요법의 필요성을 확인할 기회Article Published on 2021-03-012022-09-12 Journal: Neurological Sciences [Category] SARS, 진단, [키워드] acute respiratory syndrome administration analyzed caused CIDP Clinical deterioration COVID-19 demonstrated Follow-up Health health facilities immunotherapies increased risk Inflammatory IVIG Novel coronavirus outbreak pandemic Patient protective role raised repeated reported risk SARS-CoV-2 SCIg. selected the patient therapy treated Treatment [DOI] 10.1007/s10072-020-04983-5 PMC 바로가기 [Article Type] Article
Oncologic immunomodulatory agents in patients with cancer and COVID-19Article Published on 2021-03-012022-10-04 Journal: Scientific Reports [Category] SARS, 유전자 메커니즘, 치료법, [키워드] absence administration Affect anti-CD20 anti-CD20 therapy association benefit Cancer cancer patient center Characteristics Chemotherapy cohorts Corticosteroid Course COVID-19 death diagnosed hematologic Immunomodulatory agent immunotherapies Immunotherapy infected with SARS-CoV-2 investigated Medical research medication Memorial neutropenia outcome outcomes Patient Patients with cancer patients with COVID-19 Prevalence previous study Prospective Study receive relative Respiratory failure Respiratory Support risk SARS-CoV-2 statistically significant difference Thoracic Treatment [DOI] 10.1038/s41598-021-84137-5 PMC 바로가기 [Article Type] Article