Iota-carrageenan neutralizes SARS-CoV-2 and inhibits viral replication in vitroIota-carrageenan은 SARS-CoV-2를 중화하고 시험관 내에서 바이러스 복제를 억제합니다Research Article Published on 2021-02-172022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, 진단, 치료제, [키워드] absence acute respiratory syndrome administration attachment caused cell entry clinical effectiveness common cold competent coronavirus demonstrated dose duration of symptom effective Endemic in vitro in vitro data inhibit iota-carrageenan lentivirus nasal Nasal spray neutralize neutralized Particle Patient Prophylactic Prophylaxis pseudotyped public health threat reduction Replication respiratory respiratory viruses Safe SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 spike SARS-CoV-2 spike pseudotyped lentivirus SARS-CoV-2 virus Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus severity spike glycoprotein the cell the SARS-CoV-2 therapeutic translated Treatment Vaccine viral replication wild type [DOI] 10.1371/journal.pone.0237480 PMC 바로가기 [Article Type] Research Article
Protective Effects of Lactoferrin against SARS-CoV-2 Infection In Vitro시험관 내 SARS-CoV-2 감염에 대한 락토페린의 보호 효과Article Published on 2021-01-232022-09-10 Journal: Nutrients [Category] MERS, 진단, 치료제, [키워드] analyzed anti-inflammatory cytokine Anti-inflammatory effects Antiviral antiviral immune response antiviral immunity Caco-2 Caco-2 cell Caco-2 cells COVID-19 curative cytokine determined by Effect epithelial cells expression Gene Expression Genes glycoprotein IFNA1 IFNB1 immune immune response immune response gene immunomodulatory immunostaining in vitro in vitro data Infection inhibited intestinal epithelial cell intestinal epithelial cells IRF3 IRF7 lack lactoferrin MAVS moderate non-toxic Plaque assay qRT-PCR Replication SARS-CoV-2 SARS-COV-2 infection significantly Support TLR3 TLR7 treated uninfected virus was determined was performed [DOI] 10.3390/nu13020328 PMC 바로가기 [Article Type] Article
Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infectionTMPRSS2와 카텝신 B/L을 함께 표적으로 삼는 것은 SARS-CoV-2 감염에 대해 상승적일 수 있습니다Research Article Published on 2020-12-082022-08-13 Journal: PLoS Computational Biology [Category] Biochemistry, COVID-19, SARS, [키워드] ‘repurposing’ drugs achievement activate Activation blockade blocking blocking virus entry cathepsin Cathepsin B/L Cell cell lines cell population levels cell types cells clinical trials combination therapies combination therapy corresponding protease expression level COVID-19 COVID-19 pandemic cysteine cysteine protease cysteine proteases deployability dose-dependent manner drug drug combination drug combinations drugs targeting Effect Efficacy Efficiency effort entry of SARS-CoV-2 Evidence expression level facilitate help highlighting host protease host proteases host serine protease IMPROVE in vitro in vitro data in vivo independent independent entry pathway inhibitor inhibitors involved mathematical mathematical model minimal toxicities pathway Pathways potential treatment option predict predicted Prevent protease Proteases required SARS-CoV entry SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection Serine Single Cell Spike protein synergistic Synergistic drug combination Synergistic drug combinations synergy target cell target cells targeting the cell tissue tropism TMPRSS2 toxicities Treatment triggered virus entry [DOI] 10.1371/journal.pcbi.1008461 PMC 바로가기 [Article Type] Research Article
Hydroxychloroquine as Prophylaxis for COVID-19: A ReviewPharmacology Published on 2020-12-032022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] approach approved available data Clinical data clinical setting clinical trial clinical trials conducted COVID-19 COVID-19 pandemic disease drug effective effective drug effort examined expired HCQ HCW healthcare worker highlighting Hydroxychloroquine identify in vitro data include indicate lack Loading dose majority methodological Phase 3 Placebo preclinical data promote Prophylactic Prophylaxis Randomized randomized studies recruit Repository resource review Scientific community Standard of care subject Toxicity translational Treatment Trial Vaccines [DOI] 10.3389/fphar.2020.605185 PMC 바로가기 [Article Type] Pharmacology
Chloroquine, the Coronavirus Crisis, and Neurodegeneration: A PerspectiveNeurology Published on 2020-11-132022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] accumulate acidic organelle cellular cellular pathways Chloroquine clinical trial clinical trials coronavirus COVID-19 crisis demonstrated Diseases downstream drug Effect Efficacy Evidence feature folded protein Hydroxychloroquine Hypothesis in vitro data lack neurodegeneration neurodegenerative Neuroinflammation pandemic pathogenic Perspective raise SARS-COV-2 infection suggested Support therapy these compound widespread [DOI] 10.3389/fneur.2020.596528 PMC 바로가기 [Article Type] Neurology
IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome530 Published on 2020-09-082022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS, [키워드] accompanied Activation acute respiratory distress ARDS Bacteria Bacterial Bacterial infection Bacterial sepsis blockade Burn causes chimeric antigen receptor Clinical efficacy clinical manifestation coagulation cascade COVID-19 COVID-19 patient Critical CRS cytokine cytokine production Cytokine release syndrome diagnosed dysfunction elevated endothelial Endothelial cell Endothelial dysfunction endotheliopathy exhibited highlight Human monoclonal antibody Hyperinflammatory hyperinflammatory responses IL-10 IL-6 IL-6 signaling IL-8 Immunotherapy in vitro data indicate induce infections Inflammation involved life-threatening MCP-1 molecular mechanism monocyte chemotactic protein-1 Pathogenesis Patient Proinflammatory cytokine promoted robust Sepsis severe COVID-19 patient severe COVID-19 patients Signaling Significance syndrome systemic inflammatory response T cell therapy Tocilizumab trans-signaling Treatment vascular endothelial cell [DOI] 10.1073/pnas.2010229117 PMC 바로가기 [Article Type] 530
Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains UnclearArticle Published on 2020-07-032022-10-05 Journal: Cell [Category] SARS, 변종, [키워드] change COVID-19 D614G disease dominant in vitro data Making Mutation phenotype SARS-CoV-2 variant sense the spike protein therapeutic Transmission Vaccine virus [DOI] 10.1016/j.cell.2020.06.040 [Article Type] Article
In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 치료를 위한 하이드록시클로로퀸의 시험관 내 항바이러스 활성 및 최적화된 투여 설계의 예측Major Article Published on 2020-03-092022-09-10 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 비임상, [키워드] activity acute respiratory syndrome coronavirus advance autoimmune conditions breath China Chloroquine Chloroquine phosphate Concentration coronavirus coronavirus 2 Critically ill cytokine Cytokine storm Dosing dosing regimen drug effective Evidence followed by Hydroxychloroquine hydroxychloroquine sulfate immunomodulatory effect in vitro in vitro data inhibit SARS-CoV-2 Loading dose lung maintenance dose malaria mechanism of action occur pharmacokinetic pharmacological phosphate projection reached regimen respiratory Result safety profile SARS-CoV-2 SARS-CoV-2 infected patients SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread sulfate Support the cytokine storm tolerable treat treating SARS-CoV-2 infection use of hydroxychloroquine Vero cells was tested Wuhan [DOI] 10.1093/cid/ciaa237 PMC 바로가기 [Article Type] Major Article