Could Lower Testosterone in Older Men Explain Higher COVID-19 Morbidity and Mortalities?Review Published on 2022-01-152022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] age aging Anti-inflammatory benefit calcium regulation Cell cellular Concentration concentrations COVID-19 COVID-19 pandemic death decrease demonstrated diminishes diverse protein Epidemics facilitate Health healthy homeostasis immunological inflammaging involved lack Lower males mechanism men Middle East modulate modulation observation Older outcome Protein regulate Replication SARS-CoV SARS-CoV-2 syndrome Testosterone the SARS-CoV-2 virus tissue viral replication viruses [DOI] 10.3390/ijms23020935 PMC 바로가기 [Article Type] Review
Gut microbiome, Vitamin D, ACE2 interactions are critical factors in immune-senescence and inflammaging: key for vaccine response and severity of COVID-19 infection장내 미생물군유전체, 비타민 D, ACE2 상호작용은 면역노화 및 염증의 중요한 요소입니다: 백신 반응 및 COVID-19 감염의 중증도에 대한 핵심Review Published on 2022-01-012022-09-11 Journal: Inflammation research : official journal of the Eu [Category] SARS, 유전자 메커니즘, [키워드] ACE-2 ACE2 Adaptive immune response addition affected article assist association Blood Clinical outcome clinical outcomes Combination complex correlation COVID-19 COVID-19 infections COVID-19 sepsis COVID-19 severity Critical cross-talk determine Diseases Evidence expression Factor function growth Gut gut microbiome gut microbiota host response host responses immune responses immune system immune-senescence immunomodulatory include indicate Infection inflammaging Inflammation Inflammatory marker inflammatory markers interact Interaction microbial Microbiome molecular Mortality outcome Predictive promote Regulation Renin Research SARS-COV-2 infection SARS-CoV-2 pandemic Sepsis severity severity of COVID-19 Signaling Spread state status strain Systems biology vaccination Vaccine vaccine response vaccine responses viral infection Vitamin D with COVID-19 [DOI] 10.1007/s00011-021-01510-w PMC 바로가기 [Article Type] Review
Innate Receptors Expression by Lung Nociceptors: Impact on COVID-19 and Aging폐 통각 수용체에 의한 타고난 수용체 발현: COVID-19 및 노화에 미치는 영향Review Published on 2021-12-162022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료기술, 치료제, [키워드] Activation aging aging process airway airways competent contribute COVID-19 COVID-19 pandemic described disorder disorders disturbance dysfunction Evidence expression functional Immunity immunological Immunological response immunological responses Impact individual inflammaging Innate innate receptors local immune response lung Lung function Lungs mechanism neuroimmune crosstalk neurological New nociceptors organ outcomes Particle Particles pathogen pathogen invasion Pathogens physiological Prevent receptor receptors reservoir reservoirs respiratory respiratory tract responsible SARS-CoV-2 SARS-COV-2 infection sensory nerve sensory neuron sensory neurons shown Spread target threat Threats tissue injury Trigger Viral [DOI] 10.3389/fimmu.2021.785355 PMC 바로가기 [Article Type] Review
Age Related Differences in Monocyte Subsets and Cytokine Pattern during Acute COVID-19—A Prospective Observational Longitudinal Study급성 COVID-19 동안 단핵구 하위 집합 및 사이토카인 패턴의 연령 관련 차이 - 전향적 관찰 종단 연구Clinical Trial Published on 2021-11-302022-09-11 Journal: Cells [Category] MERS, SARS, 바이오마커, 임상, [키워드] accompanied Activation adverse outcome adverse outcomes age aging analyzed change circulating complex confounding factor confounding factors COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 patients cytokine Cytokines difference Disease progression dysregulated immune response dysregulated immune responses Hospitalization IL-6 IL-8 immune response immune responses immunoparalysis individual infection with SARS-CoV-2 inflammaging Inflammatory cytokine Inflammatory cytokines innate immune response interleukin interleukin 6 longitudinal marker mechanism monocyte Monocyte activation Monocytes Necrosis Non-survivors older patient older patients outcome Pathogenesis patients pattern Phenotypes progression Prospective risk SARS-COV-2 infection subset survivor symptom onset Threats TNF Tumor tumor necrosis tumor necrosis factor Viral vulnerability [DOI] 10.3390/cells10123373 PMC 바로가기 [Article Type] Clinical Trial
Transcriptome-Wide Analysis of Human Liver Reveals Age-Related Differences in the Expression of Select Functional Gene Clusters and Evidence for a PPP1R10-Governed ‘Aging Cascade’Article Published on 2021-11-252023-08-29 Journal: Pharmaceutics [Category] E형 간염, [키워드] aging EFS Hepatocellular carcinoma inflammaging liver regeneration liver transcriptome Non-alcoholic fatty liver disease non-alcoholic steatohepatitis pharmacogenes regulome [DOI] 10.3390/pharmaceutics13122009 PMC 바로가기 [Article Type] Article
How Immunosenescence and Inflammaging May Contribute to Hyperinflammatory Syndrome in COVID-19Review Published on 2021-11-212022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] accumulation aging alteration B-cell characterized CMV contribute coronavirus disease COVID-19 Cytokine storm Factor Hematopoiesis Hyperinflammatory syndrome Immune cell immune cells immune responses immune stimulation immune system immunosenescence Infection inflammaging Inflammatory mediators innate immune system low-grade inflammation Lymphocytes memory memory T modulate naïve occur peripheral circulation Phenotypes Population pro-inflammatory cytokines proportion reduced secrete secreting senescence-associated secretory phenotype (SASP) senescent severity stressors T-cell thymic [DOI] 10.3390/ijms222212539 PMC 바로가기 [Article Type] Review
Manifesto on the Value of Adult Immunization: “We Know, We Intend, We Advocate”Opinion Published on 2021-10-222022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Adults affected aging available data benefit caused children Comorbidities COVID-19 pandemic disease Diseases Europe Evidence favor General population Health health authorities Healthcare provider immunization immunosenescence Impact individual Infectious disease inflammaging introduced Italian Italy Manifesto Mortality Older plan PROTECT public health Quality of life recommendation recommendations vaccination Vaccines value [DOI] 10.3390/vaccines9111232 PMC 바로가기 [Article Type] Opinion
Immunology of Aging: the Birth of InflammagingArticle Published on 2021-09-182024-09-04 Journal: Clinical reviews in allergy & immunology [Category] 대상포진, [키워드] Cytokines Free radicals Immunobiography immunosenescence inflammaging macrophages Microbiome Mitochondria SASP Signaling trained immunity [DOI] 10.1007/s12016-021-08899-6 PMC 바로가기 [Article Type] Article
Post-COVID-19 acute sarcopenia: physiopathology and managementReview Published on 2021-07-302022-10-28 Journal: Aging Clinical and Experimental Research [Category] COVID-19, MERS, SARS, [키워드] Acute sarcopenia Adults Ageusia Anosmia appear approach autophagy build catabolic changes in characterized cognitive training complex COVID-19 COVID-19 patient Degradation Deleterious Deterioration disease endothelial damage ENhance exacerbate exacerbated Factors functional Hospitalization immunological In-hospital induce Infectious disease inflammaging Inflammatory information management mechanism microbiota mitochondrial dysfunction muscle mass Older Older adults outcome pathophysiologic physical Physical inactivity Prognosis psychological support quarantine rehabilitation sarcopenia SARS-COV-2 infection Skeletal muscle Support syndrome the SARS-CoV-2 [DOI] 10.1007/s40520-021-01942-8 PMC 바로가기 [Article Type] Review
Impact of age to ferritin and neutrophil‐lymphocyte ratio as biomarkers for intensive care requirement and mortality risk in COVID‐19 patients in Makassar, Indonesia인도네시아 마카사르의 COVID-19 환자에서 집중 치료 요구 사항 및 사망 위험에 대한 바이오마커로서의 연령 대 페리틴 및 호중구-림프구 비율의 영향Original Article Published on 2021-05-272022-09-10 Journal: Physiological Reports [Category] 바이오마커, [키워드] 95% confidence interval Admission Affect affected age aging AUC AUC value Biomarker change clinical endpoint Clinical outcome clinical outcomes Combination Comorbidities Comorbidity Complete COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 Deceased Disease progression Endpoint endpoints Factor ferritin group groups immune system immunosenescence Impact Indonesia inflammaging inflammatory parameter intensive care Makassar Mortality mortality risk Multivariate analysis neutrophil‐lymphocyte ratio NLR outcome pathophysiology Patient patients Predictive Predictive value prognostic biomarker Prognostic biomarkers retrospective cohort study risk significantly South survived was performed [DOI] 10.14814/phy2.14876 PMC 바로가기 [Article Type] Original Article