Secretory phospholipase A2 in SARS-CoV-2 infection and multisystem inflammatory syndrome in children (MIS-C)SARS-CoV-2 감염 및 소아의 다기관 염증 증후군(MIS-C)에서 분비성 포스포리파제 A2Observational Study Published on 2021-07-132022-09-11 Journal: Experimental Biology and Medicine [Category] 바이오마커, 임상, [키워드] acute COVID-19 acute illness Admission Asymptomatic Biomarker cellular damage children children with COVID-19 Compound contribute controls convalescent correlated COVID-19 COVID-19 infection COVID-19 severity disease disease pathogenesis distal elevated event Hospitalized IgG antibodies inflammasome activation Inflammatory inflammatory cascade intensive care management mediator Mild MIS-C multisystem inflammatory syndrome in children Patient Patient management pediatric Phospholipase A2 plasma proximal risk SARS-CoV-2 IgG antibodies SARS-CoV-2 IgG antibody SARS-COV-2 infection SARS-CoVC-2 secretory secretory phospholipase A2 seronegative severe COVID-19 severe disease severity significantly significantly higher syndrome with COVID-19 [DOI] 10.1177/15353702211028560 PMC 바로가기 [Article Type] Observational Study
Inhibition of SARS CoV Envelope Protein by Flavonoids and Classical Viroporin InhibitorsMicrobiology Published on 2021-07-082022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome blocked buffer Cell cell viability assay classical conserved contribute coronavirus E protein Effect effective envelope envelope protein epigallocatechin expressed expression Extracellular family Coronaviridae flavonoid genus Betacoronavirus HEK293 cell inflammasome activation inhibited inhibition inhibitor inhibitors inhibitory activity introduced involved ion channel inhibitors kDa membrane protein novel antiviral drug patch-clamp electrophysiology plasma membrane proliferation Protein quercetin RNA virus SARS CoV SARS CoV-1 SARS-CoV SARS-CoV E SARS-CoV-2 sequence signal peptide single-stranded positive-sense suppress tested transfer transmembrane viability viroporins virus Virus life cycle [DOI] 10.3389/fmicb.2021.692423 PMC 바로가기 [Article Type] Microbiology
NLRP3 and Infections: β-Amyloid in Inflammasome beyond NeurodegenerationReview Published on 2021-06-292022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] activated Alzheimer’s disease Alzheimer’s disease amyloid beta arise Central nervous system CNS component contribute COVID-19 COVID-19 infection Critical Defense disease Diseases Host impairment Infection infections Inflammasome inflammasome activation inflammasomes Inflammatory diseases Injury innate immune system low-grade systemic inflammation memory neurodegeneration neurodegenerative Neuroinflammation NLRP3 NLRP3 inflammasome pathogen Pathogenesis pathology progression Research SARS-CoV-2 systemic inflammation tissue damage [DOI] 10.3390/ijms22136984 PMC 바로가기 [Article Type] Review
Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19Article Published on 2021-06-162022-11-01 Journal: EMBO Molecular Medicine [Category] COVID-19, MERS, SARS, [키워드] adaptive cause convalescent COVID‐19 COVID‐19 patient COVID‐19 patients Epigenetic gene expression signature healthy hyperinflammation Hyperinflammatory syndrome Immunity immunology in vivo Inflammasome inflammasome activation Innate innate immune innate immune memory Innate immunity longitudinal analysis Macrophage Microbiology, Virology & Host Pathogen Interaction Modification monocyte naïve individuals NLRP3 patients responsible resulting robust SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 secretion Signaling Spike protein subset Surface glycoprotein transcriptional Trigger vaccine antigen viral control [DOI] 10.15252/emmm.202114150 PMC 바로가기 [Article Type] Article
Migraine and neuroinflammation: the inflammasome perspectiveReview Article Published on 2021-06-102022-10-29 Journal: The Journal of Headache and Pain [Category] COVID-19, MERS, SARS, [키워드] Activation addition Biomarkers Brain candidate cause characterized Comorbidity complex component conditions connection cortical Cortical spreading depolarization disease disorder domain epilepsy Evidence Factor Genetic highlight Infection Inflammasome inflammasome activation Inflammatory cytokine inflammatory pain innate immune system migraine mitochondrial DNA multiprotein complex Neuroinflammation Neuron NLRP3 Pain pathophysiology Pathways Perspective Proteins receptor Signaling stimulate stroke targets Treatment variety with COVID-19 [DOI] 10.1186/s10194-021-01271-1 PMC 바로가기 [Article Type] Review Article
Inflammasome Activation-Induced Hypercoagulopathy: Impact on Cardiovascular Dysfunction Triggered in COVID-19 PatientsReview Published on 2021-04-162022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] Activation activation of inflammasome addressed angiotensin-converting enzyme 2 Arrhythmias cardiovascular cardiovascular complications cardiovascular condition cardiovascular disorder cellular response contribute Coronavirus disease 2019 COVID-19 COVID-19 complications COVID-19 patient COVID-19 patients Cytokine storm Defense dendritic cells described downstream endothelial cells Host Hypercoagulopathy hyperinflammation Impact Infectious disease Inflammasome inflammasome activation Inflammation Inflammatory response Interaction less macrophages mechanism modulation myocardial injury myocarditis NLRP3 NLRP3 inflammasome Pathogenesis Perturbation Pneumocytes poor prognosis positive reduction SARS-CoV-2 SARS-COV-2 infection shown signaling pathways significantly suppress target cell tissue triggered Venous Thromboembolism viral infections [DOI] 10.3390/cells10040916 PMC 바로가기 [Article Type] Review
Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patientsInflammasomes는 SARS-CoV-2 감염에 반응하여 활성화되며 환자의 COVID-19 중증도와 관련이 있습니다.Article Published on 2021-03-012022-09-12 Journal: The Journal of Experimental Medicine [Category] SARS, 진단, [키워드] activated Activation Autopsy caspase-1 characterized cleavage Clinical outcome correlated COVID-19 COVID-19 patients COVID-19 severity disease severity IL-18 IL-1β IL-6 Inflammasome inflammasome activation Inflammation Inflammatory inflammatory process LDH marker moderate molecular NLRP3 inflammasome Organ failure outcome pathophysiology Patient patient death PBMC platform potential therapeutic target promote SARS-COV-2 infection sera severe COVID-19 patients severity the disease tissue with COVID-19 [DOI] 10.1084/jem.20201707 PMC 바로가기 [Article Type] Article
Glucose-6-phosphate dehydrogenase deficiency and hydroxychloroquine in the COVID-19 era: a mini reviewCOVID-19 시대의 포도당-6-인산 탈수소효소 결핍과 하이드록시클로로퀸: 미니 리뷰Review Published on 2021-03-012022-09-11 Journal: Molecular biology reports [Category] MERS, 신약개발, 진단, 치료제, [키워드] activities addition antiviral agent Antiviral agents association caused Cellular immune response Chloroquine coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID-19 patients cytokine deficiency effective effective drug effective drugs effort Final G6PD G6PD deficiency glucose-6-phosphate dehydrogenase deficiency HCQ health emergency hemoglobin Hemolysis hemolytic hemolytic anemia Hemolytic crisis Hydroxychloroquine immune responses in vitro inflammasome activation Innocent Intensive involved limelight modulating occur oxygen Patient patients performed Prevent pro-inflammatory cytokine question raised reactive oxygen species reactive oxygen specy Safe searched shown today treat [DOI] 10.1007/s11033-021-06234-y PMC 바로가기 [Article Type] Review
SARS-CoV-2 Nonstructural Proteins 1 and 13 Suppress Caspase-1 and the NLRP3 Inflammasome ActivationArticle Published on 2021-02-262022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] activate Activation activation of inflammasome amino acid residue antagonist antiviral immune response caspase-1 cDNA cells complementary complexes coronavirus disease Coronaviruses detrimental effect DNA domain dysregulated Effect Effector mechanism evade Helicase Host IL-1β implicated induce Inflammasome inflammasome activation inhibit inhibited involved MERS-CoV NLRP3 NLRP3 inflammasome nonstructural protein nsp1 Open reading frame ORFs Pathogenesis positive promote reduced Replication responsible SARS-CoV SARS-CoV-2 SARS-CoV-2 NSP1 Screening secretion severe acute respiratory syndrome coronavirus 2 severity significantly THP-1 translation viral clearance viral replication virus [DOI] 10.3390/microorganisms9030494 PMC 바로가기 [Article Type] Article
Cannabinoids as Key Regulators of Inflammasome Signaling: A Current PerspectiveInflammasome 신호 전달의 주요 조절자로서의 칸나비노이드: 현재의 관점Review Published on 2021-01-282022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료기술, 치료제, [키워드] activated Anti-inflammatory cannabidiol cannabinoid cannabinoids cannabis caspase caspase-1 chronic inflammatory diseases chronic inflammatory disorder chronic inflammatory disorders concerning coronavirus coronavirus disease COVID-19 current Cytokines cytoplasmic Delta-9 tetrahydrocannabinol detect drug elements etiology Evidence human disease human diseases human disorder IL-18 indicate Inflammasome inflammasome activation inflammasome signaling inflammasomes Inflammatory Inflammatory diseases inflammatory disorders inflammatory signaling ingredient Innate immunity interleukin marijuana maturation mechanism Medical conditions microbial milieu modulating pandemic pathophysiology plant pro-inflammatory cytokines promote protein complex protein complexes pyroptosis referred to Regulation regulator Research secretion Support tetrahydrocannabinol Treatment variety [DOI] 10.3389/fimmu.2020.613613 PMC 바로가기 [Article Type] Review