inflammasome activation

[키워드] Absent in melanoma 2 ACE2angiotensin-converting enzyme 2 addition Affect AIM2Absent in melanoma 2 angiotensin-converting enzyme 2 ccf-mtDNAcirculating cell-free mitochondrial DNA CFcystic fibrosis cGASCyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) (cGAMP) synthase chronic obstructive pulmonary disease circulating circulating cell-free mitochondrial DNA COPDchronic obstructive pulmonary disease Coronavirus disease 2019 COVID-19 COVID-19coronavirus disease 2019 Critical Cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) (cGAMP) synthase cystic fibrosis damage-associated molecular pattern DAMPdamage-associated molecular pattern Diseases DNA Endoplasmic reticulum ERendoplasmic reticulum gasdermin D GSDMDgasdermin D HIVhuman immunodeficiency virus host cells HPVhuman papillomavirus Human immunodeficiency virus human papillomavirus ICUIntensive Care Unit Idiopathic pulmonary fibrosis immune function immune response Infection inflammasome activation Inflammatory response intensive care unit interferon stimulatory gene IPFidiopathic pulmonary fibrosis ISGinterferon stimulatory gene leucine rich repeat lncRNAlong non-coding RNA long non-coding RNA LRRleucine rich repeat MAVSmitochondrial antiviral signaling mesenchymal stem cell Mitochondria mitochondrial mitochondrial antiviral signaling mitochondrial DNA mitochondrial reactive oxygen species mitochondrial- damage-associated molecular pattern MSCMesenchymal stem cell Mt-DAMPmitochondrial- damage-associated molecular pattern MtDNAmitochondrial DNA mtROSmitochondrial reactive oxygen species MyD88myeloid differentiation factor 88 myeloid differentiation factor 88 NBDnucleotide binding domain NLRnucleotide binding domain and leucine rich repeat nucleotide binding domain nucleotide binding domain and leucine rich repeat Open reading frame ORFopen reading frame pathogen-recognition receptors Pathogens pathway Prognosis provide PRRpathogen-recognition receptors reactive oxidative stress Regulation role ROSreactive oxidative stress SARS-CoV-2 SARS-CoV-2severe acute respiratory coronavirus 2 severe acute respiratory coronavirus 2 severity signaling pathways stimulator of interferon genes STINGstimulator of interferon genes targeting therapeutic strategy TLRToll-like receptor TMPRSS2transmembrane serine protease 2 Toll-like receptor transmembrane serine protease 2
[DOI] 10.1016/j.gene.2022.146681 [Article Type] Review article