inflammatory signaling – Page 3 – Communicable Diseases Research

Cannabinoids as Key Regulators of Inflammasome Signaling: A Current Perspective

Inflammasome 신호 전달의 주요 조절자로서의 칸나비노이드: 현재의 관점

Review

Published on 2021-01-282022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 치료기술, 치료제,

[키워드] activated Anti-inflammatory cannabidiol cannabinoid cannabinoids cannabis caspase caspase-1 chronic inflammatory diseases chronic inflammatory disorder chronic inflammatory disorders concerning coronavirus coronavirus disease COVID-19 current Cytokines cytoplasmic Delta-9 tetrahydrocannabinol detect drug elements etiology Evidence human disease human diseases human disorder IL-18 indicate Inflammasome inflammasome activation inflammasome signaling inflammasomes Inflammatory Inflammatory diseases inflammatory disorders inflammatory signaling ingredient Innate immunity interleukin marijuana maturation mechanism Medical conditions microbial milieu modulating pandemic pathophysiology plant pro-inflammatory cytokines promote protein complex protein complexes pyroptosis referred to Regulation regulator Research secretion Support tetrahydrocannabinol Treatment variety
[DOI] 10.3389/fimmu.2020.613613 PMC 바로가기 [Article Type] Review

Transcriptomic Analysis of Respiratory Tissue and Cell Line Models to Examine Glycosylation Machinery during SARS-CoV-2 Infection

SARS-CoV-2 감염 중 당화 기계를 검사하기 위한 호흡기 조직 및 세포주 모델의 전사체 분석

Article

Published on 2021-01-082022-09-10
Journal: Viruses [Category] MERS, 바이오마커,

[키워드] addition affecting Analysis approach biological significance Biomarker correlation COVID-19 immunity cytokine Cytokine storm database differentially expressed downstream epitope Epitopes expression functional functional enrichment Functional genomics glycan glycans glycosylation glycosylation pathway glycosylation pathways Host immune response host inflammatory response hypothetical immune function immune response immunomodulatory implicated in silico Infection infectious agents inflammatory signaling LINE Localization macromolecule macromolecules marker Model modulated modulating negative and positive pathogen Pathways performed post-translational modification Protein Proteoglycan proteoglycans receptor Repository respiratory SARS-CoV-2 SARS-COV-2 infection Stratification susceptibility therapeutic Transcription transcriptomic analysis Treatment Viral
[DOI] 10.3390/v13010082 PMC 바로가기 [Article Type] Article

Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19

Multi-Omics는 경증과 중등도의 COVID-19 사이의 급격한 질병 상태 변화를 해결합니다

Clinical Trial

Published on 2020-12-102022-09-11
Journal: Cell [Category] SARS, 유전자 메커니즘, 임상,

Consensus transcriptional regulatory networks of coronavirus-infected human cells

Analysis

Published on 2020-09-222022-10-29
Journal: Scientific Data [Category] COVID-19, SARS,

Cellular and Molecular Pathways of COVID-19 and Potential Points of Therapeutic Intervention

Pharmacology

Published on 2020-07-292022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] ACE2 Alpha alveolar cell antagonists Apoptosis AT1 biological marker blockade blockers capillary leakage CDK9 Cell cellular and molecular chemotactic clinical feature clinical marker contribute COVID-19 COVID-19 immune response CRP cytokine release Cytokine storm Cytokines cytoplasmic Defense Degradation Dexamethasone differentiation Diffuse alveolar damage downstream signaling pathway doxycycline element elevated elevated lactate dehydrogenase entry of SARS-CoV-2 epithelial estrogen receptor expression IL-17 IL-6 immune immune response Immunity include infiltration Inflammatory Inflammatory cytokine inflammatory cytokine production inflammatory signaling inhibitor initial Injury interferon response Intervention Ivermectin Jak kinase inhibitors LDH lung tissue MAPK mechanism melatonin membrane fusion membrane-bound molecular monocyte monocyte-derived macrophage NETosis NETs neutrophil Neutrophil extracellular trap Neutrophil-to-lymphocyte ratio NF-κB NLR p65 pathogenic pathophysiology pathway Platelet Pneumocytes Point Potential pro-inflammatory promote Prophylaxis provoke receptor reduce Remdesivir Research respiratory epithelia respiratory epithelial cells SARS-CoV-2 coronavirus selective Signal transduction skewed subtype T-cell therapeutic interventions therapeutic response Therapeutics thrombosis TNF-α type I interferons type III Vascular Viral load virus
[DOI] 10.3389/fphar.2020.01169 PMC 바로가기 [Article Type] Pharmacology

Targeting GM-CSF in COVID-19 Pneumonia: Rationale and Strategies

Immunology

Published on 2020-07-032022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] administration alveolar macrophage animal model binding blockade blunting cells circulating Clinical improvement clinical trial compassionate use COVID-19 Cytokine release syndrome death described driven by FDA approval GM-CSF healthy controls help Hospitalization hyperinflammation IL-6 Increased Inflammatory cytokine Inflammatory response inflammatory signaling interferon-γ intranasal intravenous dose involved lung damage Macrophage macrophages mavrilimumab mechanical ventilation Mild symptom monoclonal antibodies monoclonal antibody MOST outcomes Oxygenation patients with COVID-19 placebo-controlled trial produced proliferation Prospective provided Randomized rationale receptor Respiratory failure respiratory infections SARS-CoV-2 Severe case severe pneumonia Signaling Strategy syndrome T-cells targeting tested treated Trial while
[DOI] 10.3389/fimmu.2020.01625 PMC 바로가기 [Article Type] Immunology

Immune and Metabolic Signatures of COVID-19 Revealed by Transcriptomics Data Reuse

Immunology

Published on 2020-06-262022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] absence Activation addition affected approach BALF Bronchoalveolar lavage fluid caused cells characterized chemokines complex coronavirus disease COVID-19 COVID-19 patient Critical death Deceased demonstrated dysregulated expression expression of gene feature functional Humoral immunity IAV immunopathological individual Inflammation inflammatory signaling Influenza innate immune response interferon involved leukocyte leukocytes lung tissue Meta-analysis metabolic metabolic pathway metabolism mitochondrial molecular mechanism neutrophil overcome oxidative phosphorylation pandemic pathophysiology Perspective progression promote reported respiratory virus response Revealed robust SARS-CoV SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection signature significant enrichment target the disease These data tissue transcriptional transcriptome datasets transcriptomic profile transcriptomics type I viruses
[DOI] 10.3389/fimmu.2020.01636 PMC 바로가기 [Article Type] Immunology