Potential Roles of Muscle-Derived Extracellular Vesicles in Remodeling Cellular Microenvironment: Proposed Implications of the Exercise-Induced Myokine, IrisinReview Published on 2021-02-052023-08-30 Journal: Frontiers in Cell and Developmental Biology [Category] E형 간염, [키워드] Extracellular vesicles homing niche Integrins irisin muscle myokines tissue microenvironment tumor metastasis [DOI] 10.3389/fcell.2021.634853 PMC 바로가기 [Article Type] Review
Biological and Clinical Consequences of Integrin Binding via a Rogue RGD Motif in the SARS CoV-2 Spike ProteinReview Published on 2021-01-202022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] ACE2 activate Activation aggregation Alternative pathway alveolar cell Amino acid amplify Angiogenesis B.1.1.7 binding Biological Blood Cell cell entry clinical Coagulation consequence Consequences contribute COVID-19 developmental domain dysregulation endothelial Endothelial cell ENhance enzyme Factor Factors high variability Host Hypothesis Impact impacts in viral include independent integrin integrin-mediated integrin-mediated signaling Integrins Interaction microthrombi modulated motif Mutation N501Y Numerous pathway Pathways Platelet Platelets Pneumocytes procoagulant receptor Receptor-binding domain resulting RGD motif SARS CoV-2 sequence Signaling signaling pathway spike Spike protein strain stroke suggested susceptibility the receptor-binding domain the SARS-CoV-2 virus the spike protein thrombosis thrombotic tissue tissue damage tissue microenvironment variant viral entry virion virion binding virus widespread [DOI] 10.3390/v13020146 PMC 바로가기 [Article Type] Review
Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implicationsReview Published on 2021-01-122022-10-04 Journal: Science Signaling [Category] 유전자 메커니즘, [키워드] ACE2 affinity binding Amino acid sequences amino acids angiotensin-converting enzyme 2 assays autophagic autophagy autophagy machinery binding bioinformatics candidate cause Cell cell entry complex component components conserved COVID-19 cytoplasmic tail cytosolic develop Disease progression endocytic engage examined host cell host cell surface host-directed therapy hypothese identify implication integrin integrin signaling Integrins Interaction interactions linear mechanism membrane molecular motif overlap peptide Phosphorylation predict predicted Prevent Protein protein domain Proteins PTB receptor recruit regulated Regulatory Replication reported resource SARS-CoV-2 SARS-CoV-2 entry sequence Signaling subunit surface receptor therapeutic tyrosine Vertebrate viral infection viral spike protein virus [DOI] 10.1126/scisignal.abd0334 PMC 바로가기 [Article Type] Review
Transcriptome of nasopharyngeal samples from COVID-19 patients and a comparative analysis with other SARS-CoV-2 infection models reveal disparate host responses against SARS-CoV-2COVID-19 환자의 비인두 샘플 전사체 및 다른 SARS-CoV-2 감염 모델과의 비교 분석은 SARS-CoV-2에 대한 이질적인 숙주 반응을 보여줍니다Comparative Study Published on 2021-01-072022-09-10 Journal: Journal of Translational Medicine [Category] 변종, 유전자 메커니즘, [키워드] ACE2 Analysis Antigen presentation Apoptosis Atf3 CCL2 CCL4 CCR1 COVID-19 COVID-19 patient CXCL2 cytokine cytokine signaling disparate DPP4 effective enrichment analysis exhibited expressed expression feature Functional enrichment analyses GATA6 Genome variations genomic HDAC2 Host host response Host transcriptional response host transcriptome hypoxia IFN IL1A IL6 immune immune response immune system incorporation induction of apoptosis Innate immunity integrin Integrins interferon Invasion isolates ITGA2B ITGA4 ITGA5 ITGA6 ITGA8 ITGA9 ITGAE ITGAV ITGB3 ITGB7 lung Lung injury Lungs Missense mutation nasopharyngeal cells nasopharyngeal sample Nasopharyngeal samples NFAT non-structural protein overexpression Pathogenesis patients progression protease reported response Result SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection TCF12 transcription factor transcription factors Transcriptome upregulation Viral viral pathogenesis Viral protein Viral proteins virus [DOI] 10.1186/s12967-020-02695-0 PMC 바로가기 [Article Type] Comparative Study
α v β 6 -Targeted Molecular PET/CT Imaging of the Lungs After SARS-CoV-2 Infectionα v β 6 - SARS-CoV-2 감염 후 폐의 표적 분자 PET/CT 영상Case Reports Published on 2020-12-012022-09-12 Journal: Journal of Nuclear Medicine [Category] MERS, 진단, [키워드] acute phase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach cell surface receptor coronavirus Critical elevated epithelium-specific cell fibrosis healthy identify imaging Infection integrin Integrins lung lung damage lung parenchyma Lungs molecular molecular target MONITOR noninvasive organ organs Patient peptide peptides persistence PET/CT Positron emission tomography progression SARS-CoV-2 severe acute respiratory syndrome Coronavirus surface receptor systemic damage tissues undetectable upregulated Visualization [DOI] 10.2967/jnumed.120.255364 PMC 바로가기 [Article Type] Case Reports
Risk of postoperative infectious complications from medical therapies in inflammatory bowel diseasearticle Published on 2020-10-242024-09-04 Journal: The Cochrane database of systematic reviews [Category] 대상포진, [키워드] Adrenal cortex hormones Adrenal Cortex Hormones/adverse effects Adult Aminosalicylic Acids Aminosalicylic Acids/adverse effects bias Colitis, ulcerative Colitis, Ulcerative/drug therapy Confidence intervals Crohn disease Crohn Disease/drug therapy female humans Immunologic factors Immunologic Factors/adverse effects infections Infections/chemically induced Infections/epidemiology inflammatory bowel diseases Inflammatory Bowel Diseases/drug therapy Integrins male Observational Studies as Topic Odds ratio Postoperative Complications Postoperative Complications/chemically induced Postoperative Complications/epidemiology Surgical Wound Dehiscence Surgical Wound Dehiscence/chemically induced Surgical Wound Dehiscence/epidemiology Surgical Wound Infection Surgical Wound Infection/chemically induced Surgical Wound Infection/epidemiology Time factors tumor necrosis factor-alpha [DOI] 10.1002/14651858.CD013256.pub2 PMC 바로가기 [Article Type] article
Covid-19 in a patient with multiple sclerosis treated with natalizumab: May the blockade of integrins have a protective role?나탈리주맙으로 치료받은 다발성 경화증 환자의 Covid-19: 인테그린의 차단이 보호 역할을 할 수 있습니까?Case Reports Published on 2020-09-012022-09-12 Journal: Multiple sclerosis and related disorders [Category] 진단, [키워드] approved blockade caused COVID-19 develop disease human cells Infection integrin Integrins Multiple multiple sclerosis Natalizumab new coronavirus SARS-CoV-2 Patient Protective recent repeated SARS-CoV-2 sclerosis Spread Support therapy treated Treatment [DOI] 10.1016/j.msard.2020.102250 PMC 바로가기 [Article Type] Case Reports
Autotaxin Implication in Cancer Metastasis and Autoimunne Disorders: Functional Implication of Binding Autotaxin to the Cell SurfaceReview Published on 2019-12-312023-08-30 Journal: Cancers [Category] E형 간염, [키워드] Autotaxin heparan sulfate Inflammation Integrins lysophosphatidic acid Metastasis osteoclast Platelets T cells [DOI] 10.3390/cancers12010105 PMC 바로가기 [Article Type] Review
Bacterial adhesion and host cell factors leading to effector protein injection by type III secretion systemarticle Published on 2019-07-312024-09-01 Journal: International Journal of Medical Microbiology [Category] 세균성이질, [키워드] Bacteria-host cell interaction Host cell targets immune system Integrins T3SS virulence [Article Type] article
The role of integrins in the pathogenesis of inflammatory bowel disease: Approved and investigational anti‐integrin therapiesReview Article Published on 2019-06-192023-08-30 Journal: Medicinal research reviews [Category] E형 간염, [키워드] anti‐integrin therapy Crohn's disease, ulcerative colitis Inflammatory bowel disease Integrins [DOI] 10.1002/med.21601 PMC 바로가기 [Article Type] Review Article