Suppression and Activation of Intracellular Immune Response in Initial Severe Acute Respiratory Syndrome Coronavirus 2 InfectionMicrobiology Published on 2021-11-262022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] activated acute respiratory syndrome Antiviral strategies candidate CD38 coronavirus coronavirus 2 correlation disease dysregulation early infection expression profile Factor highlighting Host Host immune response host restriction factors Immunity in viral in vitro experiments increase Infection inhibitory activity innate immune response Interaction interferon interferon response Intracellular Ion ion homeostasis log pathogen Ptx3 respiratory response SARS-CoV-2 suppressed suppression survival TCN1 therapeutic therapy transcriptional transcriptional dynamics Viral load virus Virus-host interactions [DOI] 10.3389/fmicb.2021.768740 PMC 바로가기 [Article Type] Microbiology
Transparent Polymeric Formulations Effective against SARS-CoV-2 InfectionSARS-CoV-2 감염에 효과적인 투명한 고분자 제제Article Published on 2021-11-242022-09-11 Journal: ACS applied materials & interfaces [Category] SARS, 치료제, [키워드] 229E alternative Antibacterial antibacterial activity antimicrobial agent antimicrobial agents Antiviral antiviral activity antiviral property approaches backbone Bacteria benzalkonium Candida albican Candida albicans candidate Cell CFU class Compound compounds Contact contaminated surface contaminated surfaces coronavirus decrease droplet droplets EMA European Medicines Agency evaluated Formulation fungal gram Gram-negative bacteria Gram-positive bacteria growth increasingly inhibit Ion Particle Polymer polymers polystyrene sulfonate Postinfection product reduction SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection SARS-CoV-2 virus silver Spread sulfonate target cell tested the SARS-CoV-2 virus Transmission transmitted variety virucidal virus [DOI] 10.1021/acsami.1c10404 PMC 바로가기 [Article Type] Article
Whole-Genome Sequencing of SARS-CoV-2: Assessment of the Ion Torrent AmpliSeq Panel and Comparison with the Illumina MiSeq ARTIC ProtocolSARS-CoV-2의 전체 게놈 시퀀싱: Ion Torrent AmpliSeq 패널 평가 및 Illumina MiSeq ARTIC 프로토콜과의 비교Article Published on 2021-11-182022-09-11 Journal: Journal of Clinical Microbiology [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification AmpliSeq Analysis approach ARTIC assessment automated average Chef Complete Concordance consensus sequences coronavirus Coverage cultured isolate effective genetic mutation genetic mutations Genome identify Illumina Illumina Miseq Ion ion torrent less lowest Metrics MiSeq Next-generation sequencing pandemic Panel Patient produced Research SARS-CoV-2 sequence sequenced Sequencing severe acute respiratory syndrome Coronavirus single-nucleotide SNV specimen specimens tested the SARS-CoV-2 threshold variant viral genome Viral load viral loads whole-genome sequencing [DOI] 10.1128/JCM.00649-21 PMC 바로가기 [Article Type] Article
Zn‐Induced Interactions Between SARS‐CoV‐2 orf7a and BST2/TetherinFull Paper Published on 2021-11-172022-10-31 Journal: ChemistryOpen [Category] COVID-19, SARS, [키워드] Absorption Analysis antiviral activity bind BST2 complex complexes Contact destabilize Dynamics Evidence experiments host protein immune response impairing information Interaction Ion Ligand orf7a protein Protein Proteins resulting SARS-CoV-2 SARS‐CoV‐2 SARS‐CoV‐2 virus Sequence analysis Spectroscopy Tetherin/BST2 Viral protein XANES Zn speciation [DOI] 10.1002/open.202100217 PMC 바로가기 [Article Type] Full Paper
Unravelling the Immunomodulatory Effects of Viral Ion Channels, towards the Treatment of DiseaseReview Published on 2021-10-272022-10-28 Journal: Viruses [Category] COVID-19, [키워드] Anti-viral antiviral therapy cellular membranes Community conserved contribute COVID-19 pandemic creating develop domain domains Effect Endoplasmic reticulum Express facilitate feature HCV hepatitis C highlight highlighting HIV Host host membrane HPV Human hydrophilic hydrophobic IAV immune evasion immune modulation immunomodulatory effect Infection Influenza Ion ion channels ion homeostasis knowledge mechanisms papillomavirus Polyomavirus Protein Proteins reading regulate replicative Research respiratory SARS-CoV Structure target Transport Treatment Vaccine Viral immune evasion viral infection virion assembly viroporins virus viruses [DOI] 10.3390/v13112165 PMC 바로가기 [Article Type] Review
SARS-CoV-2 variants in severely symptomatic and deceased persons who had been vaccinated against COVID-19 in São Paulo, BrazilShort Communication Published on 2021-10-252022-10-28 Journal: Revista Panamericana de Salud Pública [Category] COVID-19, [키워드] Analysis Betacoronavirus Brasil Brazil causas de morte causas de muerte cause of death ChAdOx1 city CoronaVac Coronavirus infections COVID-19 COVID-19 vaccination death deaths Deceased Department died dissemination Effectiveness Efficacy group grupos de riesgo grupos de risco HCWs healthcare worker highlighting Hospitalization IAL individuals Infecções por Coronavirus infecciones por coronavirus information Ion Laboratory lack manuscript measure platform public health receive Regional risk groups SARS-CoV-2 SARS-CoV-2 genomic surveillance SARS-CoV-2 variant Secretary Sequencing Severe case shown symptomatic the SARS-CoV-2 vaccinated against COVID-19 vaccinated individual vaccination Vaccine Vaccines Vacinas vacunas variant virus VoC VOCs was performed [DOI] 10.26633/RPSP.2021.126 PMC 바로가기 [Article Type] Short Communication
Structural dynamics of single SARS-CoV-2 pseudoknot molecules reveal topologically distinct conformersArticle Published on 2021-08-062022-10-29 Journal: Nature Communications [Category] COVID-19, MERS, SARS, [키워드] applied conformational cryo-EM drug target favor form frameshift heterogeneity highlight implication Ion mechanism Molecular conformation optical probe promote required respond ribosomes rigidity RNA SARS-CoV-2 Single-molecule biophysics stability stimulate Structure structures tension the SARS-CoV-2 thought topologies translation [DOI] 10.1038/s41467-021-25085-6 PMC 바로가기 [Article Type] Article
Determination of Ligand Binding Modes in Hydrated Viral Ion Channels to Foster Drug Design and Repositioning약물 디자인 및 재배치 촉진을 위한 수화된 바이러스 이온 채널의 리간드 결합 모드 결정Article Published on 2021-07-272022-09-10 Journal: Journal of Chemical Information and Modeling [Category] MERS, SARS, 신약개발, 치료제, [키워드] amantadine antiviral drug atomic resolution binding bridging interaction build candidate capture channel complex complex structure complexes COVID-19 pandemic derivative Determination determined by Diversity drug drug candidate drug design Drug discovery envelope protein experiment foster help hydrocarbon hydrophobic IMPROVE Influenza influenza A investigated Ion ion channel ion channels Ligand mechanism of action mode Numerous positioned protocol Region reliability repositioning resulting SARS-CoV-2 scratch Structure structures the SARS-CoV-2 transmembrane Undetermined water water molecules waters while [DOI] 10.1021/acs.jcim.1c00488 PMC 바로가기 [Article Type] Article
Role of bacterial motility in differential resistance mechanisms of silver nanoparticles and silver ions Research Published on 2021-06-212022-10-05 Journal: Nature nanotechnology [Category] 변종, 유전자 메커니즘, [키워드] aggregation AgNP AgNPs Antimicrobials Bacterial Combination Concentration driven by eight Escherichia coli Factors Genome sequencing Inconclusive increase in indicated infancy inhibitory concentration Ion ions K-12 mechanism MG1655 Mutation passage question released repeated resistance mechanism role silver nanoparticle specific resistance statistically significant [DOI] 10.1038/s41565-021-00929-w [Article Type] Research
Lactoferrin Against SARS-CoV-2: In Vitro and In Silico EvidencesPharmacology Published on 2021-06-172022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Against anionic anti-inflammatory activity antiviral activity Bacterial bovine lactoferrin cationic Cell cells components Concentration COVID-19 COVID-19 patients demonstrated disorder DNA down-regulate exocrine gland feature Genes glycoprotein Host host cells Hypothesis IL-6 in silico in vitro in vitro assays Infection inflammation sites inhibiting involved Ion iron homeostasis lactoferrin management multiplicity of infection neutrophil nucleus observation performed Proinflammatory cytokine RNA S glycoprotein SARS-CoV-2 SARS-COV-2 infection secreted spike supported Vero viral entry viral replication virus [DOI] 10.3389/fphar.2021.666600 PMC 바로가기 [Article Type] Pharmacology