Short-chain fatty acid acetate triggers antiviral response mediated by RIG-I in cells from infants with respiratory syncytial virus bronchiolitis짧은 사슬 지방산 아세테이트는 호흡기 세포융합 바이러스 세기관지염이 있는 유아의 세포에서 RIG-I에 의해 매개되는 항바이러스 반응을 유발합니다Article Published on 2022-03-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 치료제, [키워드] A549 A549 cell A549 cells Acetate Admission animal animals antiviral response Bronchiolitis Cell clinical clinical isolates code COVID-19 demonstrated disease severity duration of fever Effect epithelial cell epithelial cells examined expression faster fatty fecal gut microbiota Hospitalized IFNB1 Impact in vitro Increased increased expression Infant Infants Infection interferon interferon-stimulated gene interferon-stimulated genes intranasally ISG ISG15 ISGs isolate isolates lung MAVS mice microbial modulation mouse model OAS1 oxygen oxygen saturation Patient PROTECT receptor reduce reduced reduction in respiratory respiratory cell respiratory epithelial cell respiratory epithelial cells respiratory syncytial virus RIG-I RSV SARS-CoV-2 infected patient SARS-CoV-2 infected patients severity significantly Stool strain Strains treated Treatment Trigger Viral load virus virus recognition [DOI] 10.1016/j.ebiom.2022.103891 PMC 바로가기 [Article Type] Article
Targeting the Ubiquitylation and ISGylation Machinery for the Treatment of COVID-19Covid-19의 처리를위한 유비 퀴 틸화 및 이슬 화 기계를 표적으로Review Published on 2022-02-122022-09-10 Journal: Biomolecules [Category] COVID19(2023년), Fulltext, MERS, SARS, 변종, [키워드] A20 Activation avoidance COVID-19 CYLD effective enzyme Enzymes event highlight host defense host defense response host immune system host–pathogen interactions involved ISG15 ISGylation pathway Pattern recognition pattern recognition receptor PLPro post-translational modification protease Protein PRRs PTMs SARS-CoV-2 targeting the disease therapeutic intervention Treatment TRIM25 ubiquitin ubiquitin proteasome system ubiquitomics USP18 vaccine-resistant variant Viral viral replication virus viruses [DOI] 10.3390/biom12020300 PMC 바로가기 [Article Type] Review
N7-Methylation of the Coronavirus RNA Cap Is Required for Maximal Virulence by Preventing Innate Immune RecognitionResearch Article Published on 2022-01-252022-10-29 Journal: mBio [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] ACE2 acute respiratory syndrome Brain CAP caused comparable Complete contribute coronavirus coronavirus disease CoV COVID-19 disease effective vaccine exhibited expression guanine IFN-I immune response immunological in vitro Infection Innate interferons ISG15 liver MDA5 MHV mice morbidity and mortality mouse hepatitis virus mutant mutant virus Mutation myeloid cell N7-methylation nonstructural protein 14 nonstructural protein 14 (nsp14) nsp14 pandemic Pathogenesis phenotype Prevent Preventing previous study Recognition reduced replicated required restored RNA RNA cap structure RNA methylation SARS-CoV-2 SARS-COV-2 infection Signaling significantly subsequent the vaccine therapy transgenic mice type I interferon understanding upregulated viral replication Viral RNA virulence wild-type [DOI] 10.1128/mbio.03662-21 PMC 바로가기 [Article Type] Research Article
Streptococcus pneumoniae autolysin LytA inhibits ISG15 and ISGylation through decreasing bacterial DNA abnormally accumulated in the cytoplasm of macrophagesarticle Published on 2021-12-312024-09-01 Journal: Molecular Immunology [Category] 폐렴구균 감염증, [키워드] Autolysin bacterial DNA ISG15 macrophages Streptococcus pneumoniae [Article Type] article
Identification of Differentially Expressed Genes in COVID-19 and Integrated Bioinformatics Analysis of Signaling PathwaysCOVID-19에서 차별적으로 발현되는 유전자의 식별 및 신호 전달 경로의 통합 생물정보학 분석Research Article Published on 2021-12-242022-09-10 Journal: Genetics Research [Category] MERS, SARS, 유전자 메커니즘, [키워드] Analysis analyzed annotation bioinformatics cause CD69 cellular response chromosome complications coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cutoff CXCR4 cytokine cytokine production DAVID DEGs Diabetic diabetic complications Diagnosis Differentially expressed genes downregulated enrichment FN1 FoxO FOXP3 gene expression profile Gene ontology GO terms group GSEA help HLA-G hub genes identification IL-17 immune response involved ISG15 KEGG Kyoto leukocyte lung tissue mechanism MMP9 myeloid leukocyte necrotic necrotic cell death nuclear other disease pathway Pathways Pneumonia positive potential mechanisms potential molecular PPI protein-protein interaction RAGE Regulation Research screened selected signaling pathway target Treatment type I interferon upregulated Visualization [DOI] 10.1155/2021/2728757 PMC 바로가기 [Article Type] Research Article
An integrative bioinformatics analysis for identifying hub genes associated with infection of lung samples in patients infected with SARS-CoV-2SARS-CoV-2에 감염된 환자의 폐 샘플 감염과 관련된 허브 유전자 식별을 위한 통합 생물정보학 분석Research Published on 2021-12-172022-09-11 Journal: European Journal of Medical Research [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis approach approaches Bioinformatics analysis biological processe biological processes BPS coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 data set DDX58 DEGs differentially expressed gene Differentially expressed genes EGR1 function functions Gene ontology Genes genomes GO analysis GSE147507 Guidance Health Organization hub genes human body identify IFIH1 IFITM1 immune responses infected with SARS-CoV-2 Infection International Intersection ISG15 KEGG Kyoto lung OASL online tool pathophysiological mechanism Patient performed PHEIC PPI PPI network processed programming Protein–protein interaction Protein–protein interactions network public health emergency respiratory Result SAMD9 SAMD9L SARS-CoV-2 SARS-COV-2 infection screened selected severe acute respiratory syndrome Coronavirus severity STRING supplementary material TNFSF10 turn Viral viral infection WHO World Health Organization XAF1 [DOI] 10.1186/s40001-021-00609-4 PMC 바로가기 [Article Type] Research
ISGylation in Innate Antiviral Immunity and Pathogen Defense Responses: A ReviewArticle Published on 2021-11-252023-08-30 Journal: Frontiers in Cell and Developmental Biology [Category] E형 간염, [키워드] immune response innate antiviral immunity ISG15 ISGylation SARS PLpro [DOI] 10.3389/fcell.2021.788410 PMC 바로가기
Transcriptional Profiling and Machine Learning Unveil a Concordant Biosignature of Type I Interferon-Inducible Host Response Across Nasal Swab and Pulmonary Tissue for COVID-19 Diagnosis전사 프로파일링 및 기계 학습, COVID-19 진단을 위한 비강 면봉 및 폐 조직 전반에 걸쳐 I형 인터페론 유도성 숙주 반응의 일치하는 생체특징 공개Immunology Published on 2021-11-222022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] adjusted adopted Analysis approach biosignature BST2 caused complementary computational analysis concordant conserved COVID-19 COVID-19 diagnosis data interpretation dataset Diagnosis Diagnostic method embedding Factor false-negative Genes geometric global pandemic GSE147507 heterogeneous high mortality homological Host host response IFIT1 IFIT2 IFIT3 IFITM1 IFN-I IFN-I signaling infection control Interferome interferon involved ISG15 Limited lung tissue machine learning morbidity MX1 MX2 nasal swab NCBI-GEO network OAS1 OAS2 OAS3 OASL objective other respiratory infections outcome Profiling pulmonary respiratory respiratory infections response Result retrieved RNA-seq data RNA-sequencing RSAD2 RT-PCR SARS-CoV-2 SARS-CoV-2 virus sequencing data severity of COVID-19 similarity Stat1 stochastic stratified transcriptional transcriptional level transcriptomics Type type I interferon virus was used WGCNA [DOI] 10.3389/fimmu.2021.733171 PMC 바로가기 [Article Type] Immunology
The Effect of Allicin on the Proteome of SARS-CoV-2 Infected Calu-3 CellsMicrobiology Published on 2021-10-282022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] Allicin Allium Antiviral ARHGAP17 Bacteria Calu-3 Calu-3 cell calu-3 cells caused cell cultures changes in CLTCL1 compounds decrease derivative dose Effect effector effectors exposure expression fungi Future greater GSH Host human cell IFI16 Ifi44 IFN signaling pathway immunomodulatory activity interferon-stimulated gene investigated ISG ISG15 low molecular weight metabolism Modification OAS ORF3 OSBPL2 pathway plant produced Protein proteome proteomics Quantitative reduced Research SARS-CoV-2 SARS-COV-2 infection stability tight junction tissue damage Tolerance Toxicity Transcription translation Treatment uninfected cells Vero E6 VERO E6 cells Vesicular Transport Viral particles Viral protein Viral RNA was used [DOI] 10.3389/fmicb.2021.746795 PMC 바로가기 [Article Type] Microbiology
Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection Research Published on 2021-10-192022-10-05 Journal: Nature Immunology [Category] SARS, 변종, 치료제, [키워드] activity Altered Analysis Antigen presentation contribute Defense driven by enzyme Enzymes expression generate Host immune response implicated induce Infection inflammatory gene Influenza Influenza virus interferon-stimulated gene involved ISG15 Macrophage macrophage polarization Macrophage response mechanisms mutant Papain-like protease phenotype PLPro pro-inflammatory pro-inflammatory cytokines Protein proteomic purified SARS-CoV-2 SARS-COV-2 infection Secretome substrate the cytokine storm Trigger triggered virus while wild-type Zika Zika virus [DOI] 10.1038/s41590-021-01035-8 [Article Type] Research