Type I Interferon (IFN)-Regulated Activation of Canonical and Non-Canonical Signaling PathwaysImmunology Published on 2020-11-232022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] accumulating approach biological activity canonical cells clinical implication consequence COVID-19 Critical cytoplasm element event Evidence group of disease IFN-stimulated gene IFNs immune response interferon ISG ISGs JAK/STAT mammalian target of rapamycin MAP kinase signaling mRNA translation nucleus outcomes Pathways positive Protein SARS-CoV-2 Signal transducer and activator of transcription Signaling signaling cascade signaling pathways Transcription transcriptional activation treat Type Type I IFN type I interferon [DOI] 10.3389/fimmu.2020.606456 PMC 바로가기 [Article Type] Immunology
Targeting pivotal inflammatory pathways in COVID-19: A mechanistic reviewArticle Published on 2020-10-072023-06-15 Journal: European journal of pharmacology [Category] MERS, SARS, [키워드] COVID-19 Cytokines inflammatory pathways interleukin JAK/STAT TLR [DOI] 10.1016/j.ejphar.2020.173620 PMC 바로가기
Combined IL-6 and JAK/STAT inhibition therapy in COVID-19-related sHLH, potential game changerCOVID-19 관련 sHLH에서 IL-6 및 JAK/STAT 억제 요법 결합, 잠재적 게임 체인저Case Reports Published on 2020-08-012022-09-12 Journal: British Journal of Haematology [Category] MERS, SARS, 진단, [키워드] Abstract Combined COVID cytokine Cytokine storm IL-6 JAK/STAT ruxolitinib secondary haemophagocytic lymphohistiocytosis Severe COVID sHLH therapy Tocilizumab [DOI] 10.1111/bjh.16966 PMC 바로가기 [Article Type] Case Reports
Protective Effect of Epigallocatechin-3-Gallate (EGCG) in Diseases with Uncontrolled Immune Activation: Could Such a Scenario Be Helpful to Counteract COVID-19?Review Published on 2020-07-212022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] activated activity anti-inflammatory drug antioxidant Antiviral antiviral activity Autoimmune diseases B cell benefit clinical trials coronavirus coronavirus disease COVID-19 COVID-19 patients cytokine Cytokine storm syndrome Cytokines develop downregulate downstream Effect effective Efficacy EGCG expression green tea extract homeostasis hyper-inflammation immunological Infection inflammatory bowel diseases Inflammatory mediators ingredient inhibit JAK/STAT management multiple sclerosis NF-κB NF-κB nuclear Pathways Patient Pneumonia pro-inflammatory signaling Registered respiratory rheumatoid arthritis Safe SARS-CoV-2 scenario severe COVID-19 Signaling therapy Transcription transcription factors uncontrolled [DOI] 10.3390/ijms21145171 PMC 바로가기 [Article Type] Review
The Nucleoprotein and Phosphoprotein of Peste des Petits Ruminants Virus Inhibit Interferons Signaling by Blocking the JAK-STAT PathwayArticle Published on 2019-07-082023-08-29 Journal: Viruses [Category] E형 간염, [키워드] interferon JAK/STAT nucleoprotein peste des petits ruminants virus Phosphoprotein [DOI] 10.3390/v11070629 PMC 바로가기 [Article Type] Article
Interleukin-21 receptor gene polymorphism is associated with hepatitis B virus-related hepatocellular carcinoma in Chinese patientsArticle Published on 2019-06-012023-06-19 Journal: Journal of Clinical Laboratory Analysis [Category] B형 간염, [키워드] Hepatitis B virus Hepatocellular carcinoma IL-21 IL-21R JAK/STAT Single nucleotide polymorphism [DOI] 10.1002/jcla.22860 PMC 바로가기
Interleukin 15: A key cytokine for immunotherapyarticle Published on 2016-10-312024-09-01 Journal: Cytokine & Growth Factor Reviews [Category] 말라리아, [키워드] Autoimmune diseases Interleukin-15 JAK/STAT mTOR [Article Type] article
Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila초파리의 혈구에 의한 장 줄기 세포 활동의 원격 제어Research Article Published on 2016-05-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate activated Activation activity Bacterial infection blood cell Blood cells canonical cell proliferation circulating contribute Control Coordinate Critical Defense Drosomycin Drosophila Express expression fat Gut haemocyte haemocytes Host receptors Immunity indicate induce Inflammation Injury Innate Interaction intestinal epithelium intestinal stem cell intestine involved JAK/STAT JAK/STAT pathway JNK pathway lipopolysaccharide liver mammals mode multiple tissues Mutation oral bacterial infection organ Organisms overcome pathway peptidoglycan Previous studies previous study proliferation promote recognize Regulation released remote required reveal secreted molecule secreted protein secreted proteins septic injury signaling pathway STAT STEM stem cell stimulate suggested survival systemic immune response tissue damage tissue repair turn Upd Upd1 Upd2 Upd3 Upds while wound [DOI] 10.1371/journal.pgen.1006089 PMC 바로가기 [Article Type] Research Article