Essential contribution of the JAK/STAT pathway to carcinogenesis, lytic infection of herpesviruses and pathogenesis of COVID‑19 (Review)Review Published on 2024-03-152024-09-05 Journal: Molecular medicine reports [Category] update2024, [키워드] carcinoma EBV herpesviruses JAK/STAT KSHV SARS-CoV-2 [DOI] 10.3892/mmr.2024.13163 PMC 바로가기 [Article Type] Review
Preclinical and clinical evaluation of the Janus Kinase inhibitor ruxolitinib in multiple myelomaResearch Perspective Published on 2024-02-052024-09-05 Journal: Oncotarget [Category] update2024, [키워드] clinical trial cytokine JAK/STAT Multiple myeloma ruxolitinib [DOI] 10.18632/oncotarget.28547 PMC 바로가기 [Article Type] Research Perspective
A multi-center, open-label, randomized study to explore efficacy and safety of baricitinib in active primary Sjogren’s syndrome patientsarticle Published on 2023-02-152024-09-02 Journal: Trials [Category] 대상포진, [키워드] Baricitinib ESSDAI Hydroxychloroquine JAK/STAT Primary Sjogren’s syndrome [DOI] 10.1186/s13063-023-07087-5 PMC 바로가기 [Article Type] article
Recent clinical findings on the role of kinase inhibitors in COVID-19 managementCOVID-19 관리에서 키나제 억제제의 역할에 대한 최근 임상 결과Review Published on 2022-10-012022-09-11 Journal: Life sciences [Category] 변종, 신약개발, 임상, 치료제, [키워드] activator affected alleviate Anti-inflammatory anti-viral effects antiviral agent Antiviral agents BTK clinical evidence Clinical finding Clinical practice clinical trial Complication complications Consequences coronavirus disease COVID-19 COVID-19 patient COVID-19 patients CRS cytokine release storm drug Efficacy glycogen synthase GSK-3 highly pathogenic inhibitor inhibitors JAK/STAT janus Janus kinase kinase Kinase inhibitor kinase inhibitors kinases management MAPK Novel coronavirus novel coronavirus disease outbreak p38 MAPK pandemic paradigm shift performed pharmacological pharmacological intervention protein kinase recent Signaling STAT therapy Transcription trials Viral load [DOI] 10.1016/j.lfs.2022.120809 PMC 바로가기 [Article Type] Review
JAK inhibition as a new treatment strategy for patients with COVID-19Review article Published on 2022-08-012022-10-05 Journal: Biochemical pharmacology [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료법, [키워드] AAK1 ACE-2 acute respiratory syndrome adverse outcomes angiotensin-converting enzyme 2 Bacterial infection blockers caused clinical trial clinical trials Combination coronavirus coronavirus disease Corticosteroids Course COVID-19 Critical cytokine Cytokine storm Cytokines Cytokines storm develop discharge Disease progression dysregulated effective Epidemic Future GAK greater herpes zoster Host ICU admission IL-2 IL-6 IL-6 receptor immune improve clinical outcome increased risk Infection Inflammation inhibit inhibiting involved Jak JAK inhibition JAK inhibitor Jak-STAT JAK/STAT JAK/STAT signaling janus medication medications Mortality MOST new treatment strategy offer pathway Patient patients with COVID-19 pro-inflammatory cytokine raised regulate released SARS-CoV-2 severe pneumonia significantly Spread Thromboembolic events TNF-α Transcription transmembrane protein Treatment upregulated viral endocytosis virus virus infection WHO guideline [DOI] 10.1016/j.bcp.2022.115162 [Article Type] Review article
Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19통합 혈장 단백질체 및 단일 세포 면역 신호 네트워크 시그니처는 경증, 중등도 및 중증 COVID-19를 구분합니다.Article Published on 2022-07-192022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 임상, 진단, 치료기술, [키워드] addition approach AUC Cell clinical manifestation clinical manifestations coronavirus Coronavirus 2019 COVID-19 COVID-19 progression COVID-19 severity CyTOF determinant dysregulation examination feature hallmark identify immune Immunophenotyping Inflammatory JAK/STAT Ligand MAPK mass cytometry Mild moderate mTOR NF-κB nuclear Olink Patient patients PBMC Peripheral blood phenotype phosphosignaling response plasma plasma protein plasma proteins proteomic proteomics response reveal SARS-CoV-2 severe COVID-19 Signaling single-cell stacked generalization. STAT therapeutic target therapeutic targets Treatment uninfected [DOI] 10.1016/j.xcrm.2022.100680 PMC 바로가기 [Article Type] Article
JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoidsJAK 억제제는 사구체 세포에서 COVID-19 사이토카인 유도 JAK/STAT/APOL1 신호전달 및 인간 신장 오르가노이드에서 족세포병증을 차단합니다Article Published on 2022-06-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] abundantly expressed alleles APOL1 Baricitinib best block blocked capillary carried carrier cause Cell Cell Biology cells collapse controls COVID-19 COVID-19 infection cytokine Cytokines demonstrated Endothelial cell endothelial cells expression glomerular glomerular capillaries human kidney Infection inhibitor iPS cells. JAK inhibitor jak inhibitors JAK/STAT JAK/STAT pathway JAK/STAT signaling JAK1 kidney Kidney disease knowledge majority mechanism Nephrology nephropathy Organoid organoids pathogenic Patient phenotype podocyte Podocytes Protein reduced rescued resulting risk SARS-CoV-2 Signaling STAT Support Therapeutic benefit therapeutic benefits Trigger viability [DOI] 10.1172/jci.insight.157432 PMC 바로가기 [Article Type] Article
The JAK/STAT signaling pathway: from bench to clinicReview Article Published on 2021-11-262022-10-04 Journal: Signal Transduction and Targeted Therapy [Category] 바이오마커, 변종, 치료제, [키워드] Activation Autoimmune diseases Cancer cellular processes Critical Diseases dysregulation Evidence expression highlight Immunopathogenesis induce Inflammation inhibitor JAK/STAT JAK/STAT pathway JAK/STAT signaling janus knowledge Molecular biology Molecular medicine Regulation Signaling signaling pathway Transcription [DOI] 10.1038/s41392-021-00791-1 PMC 바로가기 [Article Type] Review Article
Takinib Inhibits Inflammation in Human Rheumatoid Arthritis Synovial Fibroblasts by Targeting the Janus Kinase-Signal Transducer and Activator of Transcription 3 (JAK/STAT3) PathwayArticle Published on 2021-11-222024-09-02 Journal: International Journal of Molecular Sciences [Category] 대상포진, [키워드] JAK/STAT MAPK NF-kB RASFs rheumatoid arthritis TAK1 takinib THP-1 [DOI] 10.3390/ijms222212580 PMC 바로가기 [Article Type] Article
Altered increase in STAT1 expression and phosphorylation in severe COVID‐19Clinical Trial Published on 2021-11-172022-10-04 Journal: European Journal of Immunology [Category] MERS, SARS, 임상, [키워드] abnormality absence Altered antiviral defense mechanism baseline Biomarker CD14+ monocyte CD169 component correlated COVID‐19 COVID‐19 Cytokine storm downstream element expression flow cytometry IFN IFN signaling IFN‐γ Immune cell increase in induce interferon interferon pathway interferon signaling investigated IRF1 IRF9 ISRE JAK/STAT JAK/STAT signaling limit lower expression Mild mild cases monocyte Monocytes Patient PBMC Phosphorylation plasmablast Predictive pSTAT1 SARS‐CoV‐2 infection Severe case Severe infection severely infected patient Signaling STAT Stat1 STAT2 stimulated Stratification T cell target therapeutic target Transcription Transcriptional upregulation type I interferon upregulation [DOI] 10.1002/eji.202149575 PMC 바로가기 [Article Type] Clinical Trial