DeepImmuno: deep learning-empowered prediction and generation of immunogenic peptides for T-cell immunityDeepimmuno : T- 세포 면역을위한 면역 원성 펩티드의 딥 러닝에 대한 예측 및 생성Problem Solving Protocol Published on 2021-11-032022-09-10 Journal: Briefings in Bioinformatics [Category] MERS, SARS, 변종, [키워드] AdaBoost adaptive immune system addition Algorithms alleles Antigen antigen recognition antigens approach best binding Cancer Cancer immunotherapy Cell chose CNN computational method Computational methods conducted Convolutional neural network COVID-19 dataset datasets deep learning Dengue dengue virus distribution elicit FIVE foreign antigen foreign antigens forest GAN generative adversarial network human leukocyte antigen immunogenic peptide immunogenic potential immunogenicity Impact independent killing lack leukocyte life-threatening neoantigen Pathogens peptide peptides Physicochemical properties physicochemical property predict Random forest residual residue SARS-CoV-2 SARS-CoV-2 variants seeking sequence source code Support support vector machine T-cell T-cell immunity T-cell Response T-cells targeted therapy Vaccine [DOI] 10.1093/bib/bbab160 PMC 바로가기 [Article Type] Problem Solving Protocol
Mass spectrometric identification of immunogenic SARS-CoV-2 epitopes and cognate TCRs면역원성 SARS-CoV-2 에피토프 및 동족 TCR의 질량 분석 식별420 Published on 2021-11-012022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis approach best binding affinities caused cell lines cells cellular immune responses conserved coronavirus COVID-19 COVID-19 infection Critical defined effective elicit epitope Epitopes Evidence expressing glycoprotein histocompatibility complex humoral Humoral response humoral responses immune immune protection immune responses immunogenic immunogenicity In silico method in vitro increasingly Infection infectious kill killing major histocompatibility complex malignant disease malignant diseases mass spectrometric mass spectrometry membrane membrane glycoprotein MGP MHC MHC peptide nsp13 peptide peptides predict processed Protein recognize recognizing Region reported respiratory robust SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 epitope SARS-CoV-2 epitopes SARS-CoV-2 peptide SARS-CoV-2 strains severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Significance specificity T cell T cell epitope T cell epitopes T cell response T cell responses T cells tandem Tandem mass spectrometry target cells TCR TCR-T the disease the SARS-CoV-2 therapy to define Treatment variants [DOI] 10.1073/pnas.2111815118 PMC 바로가기 [Article Type] 420
The impact of viral mutations on recognition by SARS-CoV-2 specific T cellsArticle Published on 2021-10-282022-10-30 Journal: iScience [Category] COVID-19, [키워드] Abstract Amino acid assays CD8+ clone dominant epitope highlight Humoral immunity identify IFN-γ immune response immunology killing Lineage Molecular biology nucleocapsid ORF3a phylogenetics receptor recognize resulting SARS-CoV-2 SARS-CoV-2 variant sequence Surveillance variant viral mutation Virology [DOI] 10.1016/j.isci.2021.103353 PMC 바로가기 [Article Type] Article
A 10-Year Social Media Analysis Exploring Hospital Online Support of Black Lives Matter and the Black CommunityResearch Published on 2021-10-152022-10-29 Journal: JAMA Network Open [Category] Coronavirus, MERS, SARS, [키워드] analyzed black Black patient BLM Care categories category clinician cohort study collected Community COVID-19 death equity expressed expression finding Health hospital imperative Importance investigated killing longitudinal cohort study matter measure media objective participant Point raised ranged Relevance remained Result retrospective returned Safe serious complication setting Support the United State Treatment unique with COVID-19 [DOI] 10.1001/jamanetworkopen.2021.26714 PMC 바로가기 [Article Type] Research
mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection statusmRNA 백신 유도 T 세포는 우려되는 SARS-CoV-2 변이체에 동일하게 반응하지만 이전 감염 상태에 따라 수명과 귀환 특성이 다릅니다.Research Article Published on 2021-10-122022-09-10 Journal: eLife [Category] MERS, SARS, 변종, [키워드] activate activated Analysis antibodies antibody Antigen-specific T cells B.1.1.7 B.1.351 B.1.351 variant best boost immunity booster dose both groups caused Cell changed Characteristics conducted convalescent coronavirus coronavirus SARS-CoV-2 COVID-19 COVID-19 convalescent donor COVID-19 convalescent donors CyTOF Cytometry determine dose doses elicit Epitopes Examining flight Focusing generate highlight homing Human identity Immune cell immune cells immune defense immune response immune system IMPROVE individuals Infection investigated killing longitudinal study Lungs Lymphocyte subsets mimicking MOST mRNA mRNA vaccine mRNA vaccines naïve vaccinees nasopharynx natural infection nose not need offer persistence phenotype Phenotypes phenotypic phenotypic feature phenotypic features Prevent PROTECT Protein Proteins quantity reassurance recognizing Research researcher respiratory tract respond SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells second dose severe COVID-19 spike epitope spike epitopes spike-specific T cell Stimulation Strains surface protein surface proteins T cell T cell response T cells the cells the vaccine These cells two group two groups unique vaccination Vaccine vaccine dose vaccine doses vaccine-elicited T cell vaccinee vaccinees variant variants Viral Viral variants virus viruses while [DOI] 10.7554/eLife.72619 PMC 바로가기 [Article Type] Research Article
Consequences of the COVID-19 Lockdown in Germany: Effects of Changes in Daily Life on Musical Engagement and Functions of MusicArticle Published on 2021-10-052022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] affected asked attribute change connection consequence coronavirus COVID-19 COVID-19 pandemic Daily Effect Engagement Factor function Germany handling investigated killing killing time life lockdown logistic regression model loneliness music music listening pandemic participant reactivity reduced reflect Social distance spring Stress synchronization worries [DOI] 10.3390/ijerph181910463 PMC 바로가기 [Article Type] Article
TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cellsArticle Published on 2021-09-232022-10-04 Journal: Cell Death & Disease [Category] 신약개발, [키워드] Activation anti-TNF Apoptosis autoinflammatory disease biochemical biopsy canonical CASP8 caspase caspase-8 cell death Cell death and immune response contribute Critical Crohn's disease Crohn’s disease cytokine death dependence driven by driver epithelial Ex vivo feature Genetic Gut Host IBD IEC IFN-γ immunopathology independent induce Inflammatory bowel disease inhibitor interferons intestinal epithelial cell Intestinal Organoids involved JAK inhibitor kill killing kinase loss-of-function mechanisms MLKL mucosal necroptosis Organoid pathway required retained sustained synergistic T cells therapeutic efficacy TNF-α TNFR1 Tumour-necrosis factors ZBP1 [DOI] 10.1038/s41419-021-04151-3 PMC 바로가기 [Article Type] Article
Pattern Recognition Proteins: First Line of Defense Against CoronavirusesImmunology Published on 2021-09-232022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress syndrome adaptive Adaptive immune response Affect affecting Against apoptotic cell ATH - atherosclerosis atherosclerotic lesions C-reactive protein C1q cardiovascular complication cardiovascular system caused clearance combination treatment complement Complication composed coronavirus Coronaviruses COVID- 19 COVID-19 COVID-19 disease death development Direct Effect enhancement global healthcare host’s immune system IgM antibodies immune Immunity Innate innate and adaptive IgM antibodies Innate immunity involved killing LINE lung novel coronavirus SARS-CoV-2 outbreak pandemic patients with SARS-CoV-2 pattern pattern recognition proteins Prevent Prophylactic Protein Recognition recognition protein reduce RNA virus RNA viruses SARS-CoV-2 SARS-CoV-2 virus severe disease severe respiratory syndrome surfactant surfactant proteins A and D (SP-A and SP-D) the SARS-CoV-2 Therapeutic approach therapy Vaccine viral particle virus worldwide pandemic Wuhan, China [DOI] 10.3389/fimmu.2021.652252 PMC 바로가기 [Article Type] Immunology
Persistent High Percentage of HLA-DR + CD38 high CD8 + T Cells Associated With Immune Disorder and Disease Severity of COVID-19COVID-19의 면역 장애 및 질병 중증도와 관련된 HLA-DR + CD38 높은 CD8 + T 세포의 지속적인 높은 비율Immunology Published on 2021-09-092022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, [키워드] apoptotic Beijing blood sample Blood samples Care caused CD38 CD8 chemokines Clinical and laboratory data collected coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patients critical cases Cytokines died disease severity disease severity of COVID-19 dysregulation Ebola evaluated examined expression Factor flow cytometric Growth factors Health crisis heterogeneous HLA-DR Hospital admission Hospitalization immune disorder immune disorders indicated infected with SARS-CoV-2 Influenza influenza infection inhibitory killing laboratory data lymphopenia manifested Mild moderate Multiplex assay outbreak overactivation Patient percentage persistent Progressive public health crisis recruited reported Result Retrospective study SARS-COV-2 infection sensitivity Serum level serum levels severe cases severe COVID-19 severe COVID-19 patients Severe patient severe patients severity stimulatory subset supported systemic inflammation T cell T cells tissue injury transcriptional regulation [DOI] 10.3389/fimmu.2021.735125 PMC 바로가기 [Article Type] Immunology
Mitigating Impacts of the COVID-19 Pandemic on Gorilla Conservation: Lessons From Bwindi Impenetrable Forest, UgandaPublic Health Published on 2021-08-122022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] absence affecting Alliance authority Biodiversity coffee Community conservation COVID-19 COVID-19 pandemic deaths Donor example Face masks forest Gorilla gorillas Health hygiene Impact impacts IMPROVE killing lesson livelihoods lockdowns mitigate one health park Prevent promote Protective provided Public reduce responsible Support team Transmission Uganda Village wildlife [DOI] 10.3389/fpubh.2021.655175 PMC 바로가기 [Article Type] Public Health