killing – Communicable Diseases Research

The TLR-NF-kB axis contributes to the monocytic inflammatory response against a virulent strain of Lichtheimia corymbifera, a causative agent of invasive mucormycosis

Article

Published on 2022-10-132022-11-15
Journal: Frontiers in Immunology [Category] 진단,

Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregates

Article

Published on 2022-10-052022-11-15
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료제,

[키워드] absence activated Activation aggregate aggregates analysed antiviral immunity Blood blood cell CD107a CD62P Cell cells changes in chemokines Cohort correlated COVID-19 COVID-19 disease COVID-19 patient cytokine Cytokines Cytometry cytotoxicity discharged disease pathology early stage Ex vivo Features flow cytometry form Frequency gene signature hospital hospitalised hospitalised COVID-19 patient ICU ICU patient IFN-γ IL-15 in vitro increased expression Infection innate immune response intensive care unit killing majority natural Neutrophils NK cell NK cells Patient patients phenotype phenotyped plasma Platelet platelet aggregates. Platelets Post-COVID-19 patients quantified SARS-CoV-2 scRNA-seq severe COVID-19 disease severe symptoms Single-cell RNA-sequencing Stage subset Symptom Symptoms target cells the timing TNF-α viral infections were measured while
[DOI] 10.3389/fimmu.2022.861251 PMC 바로가기

Molecular dynamics simulation on surface modification of quantum scaled CuO nano-clusters to support their experimental studies

Article

Published on 2022-10-052022-11-16
Journal: Scientific Reports [Category] 치료기술,

FACT subunit SUPT16H associates with BRD4 and contributes to silencing of interferon signaling

FACT 소단위 SUPT16H는 BRD4와 연관되어 인터페론 신호 전달 억제에 기여합니다

Article

Published on 2022-08-262022-09-11
Journal: Nucleic Acids Research [Category] SARS, 유전자 메커니즘,

[키워드] acetylated acetylation Activation Affect association BRD4 cause CBL0137 cells chromatin co-culture complex composed contribute demonstrated Depletion domain enzyme epithelial EZH2 gene transcription Genetic HDAC1 heterodimeric protein histone chaperone IFN IFN signaling IFNs infected cells Infection Influenza inhibit inhibitor interferon interferon signaling interferon-stimulated gene interferon-stimulated genes ISGs killing knockdown lysine mechanism Modification natural killer NK cells pharmacological promote promoter Protein protein stability regulate regulated reported RNAi SARS-CoV-2 shown Signaling SSRP1 subunit suppression SUPT16H Transcription treat viral infections virus-infected cell virus-infected cells viruses Zika
[DOI] 10.1093/nar/gkac645 PMC 바로가기 [Article Type] Article

Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational study

Research article

Published on 2022-08-242022-10-05
Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 진단,

[키워드] admitted to ICU Affect affecting Analysis Antwerp Aspergillus autophagy Belgium Bronchoalveolar lavage fluid bronchoalveolar lavage sample bronchoalveolar lavage samples calculate Cell chemokines collected Concentration conidia COVID-19 Critically ill patient Cytokines development diagnose differentially expressed disrupting downregulated downregulation elevated Eligible patients encoding protein enrichment analysis epithelial European expression expression data finding foundation fraction France function funding Gene expression analysis growth factor Horizon hospital hyphae ICU IFNγ IL-1β Immunity in vivo increased mortality Influenza Influenza virus Innate immunity intensive care invasive invasive ventilation investigated kill killing lung epithelial Max Planck Society network neutrophil Neutrophils Non-invasive pathophysiology pathway Pathway analysis Pathways Patient patients patients with COVID-19 patients with influenza performed phagocytosis Protein recruited Regional retrieved SARS-COV-2 infection SARS-CoV-2 RNA several gene significantly significantly lower spores TNF-α tracheobronchial transcriptomics Treatment Type I IFN type II IFN university University Hospitals Leuven were used
[DOI] 10.1016/S2213-2600(22)00259-4 [Article Type] Research article

Natural killer cell-mediated ADCC in SARS-CoV-2-infected individuals and vaccine recipients

SARS-CoV-2에 감염된 개인 및 백신 수혜자의 자연 살해 세포 매개 ADCC

Article

Published on 2022-08-012022-09-11
Journal: European Journal of Immunology [Category] COVID19(2023년), SARS, 진단, 치료법,

[키워드] adaptive immune system ADCC ADCC activity anti-SARS-CoV-2 vaccine anti-SARS-CoV-2 vaccines antibodies antibody antibody-dependent cellular cytotoxicity BNT162b2 BNT162b2 vaccine caused CD107a cells characterized collected correlated COVID-19 COVID-19 pandemic cross-reactive cross-reactive antibodies cross-reactive antibody degranulation Endemic expected expression focus global pandemic identify immune response immune responses individual infected individuals Innate Innate immunity killing less natural NK cell NK cells nucleocapsid Protein recipient Research response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S1 SARS-CoV-2-infected individual second vaccination serum sample serum samples significantly significantly higher These data Trigger Vaccine while
[DOI] 10.1002/eji.202149470 PMC 바로가기 [Article Type] Article

Single-cell sorting based on secreted products for functionally defined cell therapies

Reviews

Published on 2022-07-222022-10-05
Journal: Microsystems & Nanoengineering [Category] 바이오마커,

The Robustness of Cellular Immunity Determines the Fate of SARS-CoV-2 Infection

세포 면역의 견고함이 SARS-CoV-2 감염의 운명을 결정합니다

Review

Published on 2022-06-272022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제,

[키워드] addition Administered Analysis antibody secreting cells antiviral cytokine antiviral cytokines antiviral immunity antiviral response appearance approach autosomal recessive axis B cell booster dose breadth CD4+ CD4+ T cell CD8+ Cell cellular Cellular immune response cellular immunity component contribute coordinating correlated COVID-19 COVID-19 patient Critical cross-protection Cytokines cytotoxic lymphocytes cytotoxic T lymphocytes described disease Disease progression disease severity dysregulated evasion Evolution follicular functional Germinal center global pandemic greater helper T cells humoral IFN-γ immune protection immune system Immunity in some infected cells Infection infection control inflammatory cascade innate immune system killing knowledge long-lasting lymphocyte Lymphocytes magnitude memory modulating neutralizing antibody pathogenic inflammation phenotypic pro-inflammatory cytokine pro-inflammatory cytokines protective immunity reported responsible robustness SARS-CoV-2 SARS-CoV-2 virus secreting severe COVID-19 severity Stage stages T cell T cell response T cell responses T cells T helper cell T helper cells Tfh Tfh cells the SARS-CoV-2 virus thought TNF-α vaccination Vaccine viral replication X-linked
[DOI] 10.3389/fimmu.2022.904686 PMC 바로가기 [Article Type] Review

Identification of a promiscuous conserved CTL epitope within the SARS-CoV-2 spike protein

SARS-CoV-2 스파이크 단백질 내 무차별 보존 CTL 에피토프 식별

Coronaviruses

Published on 2022-03-012022-09-10
Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종,

Role of toll-like receptors in modulation of cytokine storm signaling in SARS-CoV-2-induced COVID-19

SARS-CoV-2로 유발된 COVID-19에서 사이토카인 폭풍 신호전달의 조절에서 톨 유사 수용체의 역할

Review

Published on 2022-03-012022-09-11
Journal: Journal of medical virology [Category] SARS, 치료법,

[키워드] Balanced Blood circulation COVID-19 cytokine Cytokine storm Cytokine storms Cytokines death driving dsRNA Elimination endosomal Factor help IL-1β IL-4 IL-6 IL-8 Imbalance immune regulation individual Inflammatory inflammatory signaling innate immune system interferon interleukin killing MAPK membrane-bound modulation multiple organ failure multiple organ failures multiple-organ multiple-organ failure Necrosis NF-κB nonself other organs pathogen Pro-inflammatory genes pro-inflammatory mediator pro-inflammatory mediators recognize recognizing replicate role SARS-CoV-2 Signaling ssRNA ssRNA. systemic circulation the cytokine storm TLR TLR3 TLR4 TLR7 TLR7/8 TLR8 TLRs Toll-like receptor Toll-like receptors Transcription translation TRIF Tumor tumor necrosis tumor necrosis factor
[DOI] 10.1002/jmv.27405 PMC 바로가기 [Article Type] Review