COVID-19 in Smokeless Tobacco Habitués: Increased Susceptibility and TransmissionInfectious Disease Published on 2020-06-252022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome adverse effect angiotensin-converting enzyme 2 Asia assist Community Comorbidities Contact coronavirus coronavirus disease country COVID-19 decrease dissemination droplet effective expression facilitate form furin globe immune response Immunity Increased Infection lethal disease oral mucosa pandemic Patient receptor Regulation restrict Saliva SARS-CoV-2 smokeless tobacco social distancing measures South Spread spread of COVID-19 susceptibility Tobacco with COVID-19 [DOI] 10.7759/cureus.8824 PMC 바로가기 [Article Type] Infectious Disease
Predictors of severe or lethal COVID-19, including Angiotensin Converting Enzyme inhibitors and Angiotensin II Receptor Blockers, in a sample of infected Italian citizens감염된 이탈리아 시민의 표본에서 안지오텐신 전환 효소 억제제 및 안지오텐신 II 수용체 차단제를 포함한 심각하거나 치명적인 COVID-19의 예측자Research Article Published on 2020-06-242022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] ACEi age Analysis angiotensin Angiotensin II angiotensin-converting enzyme inhibitors AOR ARB ARBs association blocker Cancer cardiovascular disease cardiovascular diseases case-control study clinical charts COPD COVID-19 COVID-19 severity CVD Deceased diabete diabetes disease disease severity Electronic health records Enzyme inhibitor Gender hypertension hypertensive independent predictor Infection Italian lethal disease male median medication Mild Multivariate analysis Older age Patient Physicians predicted predictor proportion Receptor Blockers renal retrospective SARS-COV-2 infection severe disease severe symptoms Significant subject therapy treated Treatment [DOI] 10.1371/journal.pone.0235248 PMC 바로가기 [Article Type] Research Article
Rapid detection of African swine fever virus using Cas12a-based portable paper diagnosticsArticle Published on 2020-04-072022-10-04 Journal: Cell Discovery [Category] 진단, [키워드] affecting African applied Biological techniques comparable conserved contagious cross-reactivity detect diagnostics Disease surveillance dsDNA economic loss effective Fever Genes lethal disease Molecular biology mutations Pathogens qPCR Rapid responsible robust sensitivity Taking therapy Tolerance Vaccine virus [DOI] 10.1038/s41421-020-0151-5 PMC 바로가기 [Article Type] Article
Traditional Chinese Medicine in the Treatment of Patients Infected with 2019-New Coronavirus (SARS-CoV-2): A Review and PerspectiveReview Published on 2020-03-152022-10-29 Journal: International Journal of Biological Sciences [Category] COVID-19, MERS, SARS, [키워드] 2019-nCoV analyzed causative pathogen China Chinese clinical evidence Compound Coronaviral coronavirus 2 Coronavirus pneumonia COVID-19 patient current drug Epidemiology experiment greater homology Infection introduced lethal disease mechanism Medicine non-specific outbreak Pathogenesis patients with SARS Pneumonia receiving respiratory review SARS-CoV SARS-CoV-2 SARS-CoV-2 infected patient Spread supportive care Symptom TCM the patient the SARS-CoV-2 therapeutic effect Therapies Traditional traditional Chinese medicine (TCM) Treatment Vaccine [DOI] 10.7150/ijbs.45538 PMC 바로가기 [Article Type] Review
The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus InfectionResearch Article Published on 2016-12-132022-10-29 Journal: mBio [Category] Coronavirus, MERS, [키워드] abrogate acute respiratory syndrome ADP-ribose ADP-ribosylation antiviral property Cell culture changes in conserved coronavirus Coronavirus infection CoVs disease domain elicited enzyme epithelial cell line help highly pathogenic human CoV IFN Impact in viral in vitro Inclusion Infection Innate innate immune response Innate immunity interferon interferon-stimulated gene ISG lethal disease macrodomain mechanism mice Modification mutant virus Mutation mutations nonstructural protein 3 Nsp3 Pathogenesis positive-sense Proinflammatory cytokine promote PROTECT Protein protein targets Proteins reduced reducing reduction regulate Regulation Replication respiratory response RNA viruses SARS-CoV SARS-CoV infection strain suppressed target therapy understanding Viral load virulence virus virus attenuation [DOI] 10.1128/mBio.01721-16 PMC 바로가기 [Article Type] Research Article
Polymorphisms in the feline TNFA and CD209 genes are associated with the outcome of feline coronavirus infectionResearch Published on 2014-12-162022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] A allele allele Alpha association Birman caused CD209 coronavirus Coronavirus infection DC-SIGN Denmark disease domain ECD effective therapy Extracellular facilitate Feline infectious peritonitis FIVE genetic trait Genetic variant Genotype groups Host host gene immune-mediated disease Infection intron lethal disease multifactorial Necrosis Occurrence outcome populations promoter reduce significant difference Single nucleotide polymorphism SNP SNPs statistical suggested supplementary material susceptibility TNF-α USA variant [DOI] 10.1186/s13567-014-0123-6 PMC 바로가기 [Article Type] Research
Identification and genotyping of feline infectious peritonitis-associated single nucleotide polymorphisms in the feline interferon-γ geneResearch Published on 2014-05-212022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] allele amplification analyzed Asymptomatic caused cellular immunity coronavirus correlation Critical decrease effective Factor Feline infectious peritonitis Genotype genotyping heterozygous genotype identification IFN-γ Immune-mediated Infection interferon-γ intron 1 investigated isolates lethal disease morbidity Mutation outcome PCR plasma polymorphism Protective resistant allele Sequencing shown significant decrease Single nucleotide polymorphism SNP the disease thought Treatment Vaccine virulent [DOI] 10.1186/1297-9716-45-57 PMC 바로가기 [Article Type] Research
SREBP Coordinates Iron and Ergosterol Homeostasis to Mediate Triazole Drug and Hypoxia Responses in the Human Fungal Pathogen Aspergillus fumigatusSREBP는 인간 곰팡이 병원체 Aspergillus fumigatus에서 트리아졸 약물 및 저산소증 반응을 중재하기 위해 철과 에르고스테롤 항상성을 조정합니다Research Article Published on 2011-12-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] A. fumigatus acquisition activated adaptation Adding addition advance Aspergillus fumigatus Author binding Candida albican Candida albicans caused cellular response class clinically condition conditions Coordinate Critical Cryptococcus neoforman Cryptococcus neoformans decrease dependent on drug drug susceptibility drugs ergosterol eukaryotes found foundation fungal fungal infections fungal pathogen Gene Genetic growth growth defect Health Human hypoxia hypoxic identify immunocompromised condition infections initial involved iron iron homeostasis Iron metabolism led to lethal disease majority mechanism metabolism microenvironment Most patients mRNA mutant mutants pathogenic Pathogens Patient phenotype Protein regulate Regulation regulatory element required response restoration Sterol Support susceptibility susceptible These data transcription factor transcription factors triazole virulence [DOI] 10.1371/journal.pgen.1002374 PMC 바로가기 [Article Type] Research Article
Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion ChannelResearch Article Published on 2009-07-102022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome affecting alteration Anti-viral drugs antiviral strategy Author binding site C-terminal Cell channel characterized common cold coronavirus coronavirus protein described determined distribution drug design E protein embryonic kidney envelope envelope protein event expressed expressing feature form found full length HEK-293 Human humans in vitro inactivation infect inhibited inhibition Ion lethal disease mammalian cell mammals membrane Mild morphology N-terminal NMR pandemic Pathogenesis pharmacological target platform produced Protein Proteins provide reduced reported responsible SARS-CoV SARS-CoV E shown significantly Structure supported transmembrane domain Validity variety viral envelope viral pathogen viral replication virion virus viruses [DOI] 10.1371/journal.ppat.1000511 PMC 바로가기 [Article Type] Research Article