Evidence of Long-Lasting Humoral and Cellular Immunity against SARS-CoV-2 Even in Elderly COVID-19 Convalescents Showing a Mild to Moderate Disease ProgressionArticle Published on 2021-08-092022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] age anti-SARS-CoV-2 antibody Cellular and humoral immunity Cellular immune response Cohort concerning convalescent COVID-19 detectable domain Donor donors elderly elevated ELISA assay Epitopes equipment evaluate evidence of flow cytometry healthy controls humoral Humoral immunity IFN-γ Immune cell Immunity individuals interferon-γ knowledge Laboratory leucocyte long-lasting membrane Mild Moderate COVID-19 Multiplex assay natural killer cell NK-cells no difference nucleocapsid protein performed persistence post infection previous study provide SARS-CoV-2 SARS-CoV-2-specific peptides significantly specimen subpopulations viral spike while [DOI] 10.3390/life11080805 PMC 바로가기 [Article Type] Article
Ruling Out Coronavirus Disease 2019 in Patients with Pneumonia: The Role of Blood Cell Count and Lung UltrasoundArticle Published on 2021-08-062022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95%CI Accuracy basophil basophils Blood blood cell count characterized cohorts Combination Community community acquired pneumonia consecutive patient Coronavirus disease 2019 count COVID-19 COVID-19 diagnosis COVID-19 in patient Cutoff cutoff value diagnosed enrolled eosinophil eosinophils evaluate help Hospital admission leucocyte likelihood likelihood ratio lung Lung ultrasound marker moderate NAAT nucleic acid amplification patient triage patients Pneumonia positive Predictive role sensitivity subjects syndrome Ultrasound [DOI] 10.3390/jcm10163481 PMC 바로가기 [Article Type] Article
Correlation of Viral Load With the Clinical and Biochemical Profiles of COVID-19 PatientsInfectious Disease Published on 2021-07-272022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome Alanine albumin ALP ALT analyzed Aspartate aminotransferase AST Bilirubin biochemical biochemical parameter Biochemical parameters calculated caused chi-square test clinical clinical parameter Clinical severity coronavirus correlated correlation COVID 19 COVID-19 COVID-19 patients cross-sectional CRP cycle threshold D-dimer disease Disease progression disease severity ferritin group IBM Infectious disease lactate dehydrogenase LDH leucocyte load lymphocyte Mild moderate Patient PCT profile Protein Result retrospective RT-PCR SARS-CoV-2 severity shown single-center study SPSS statistically statistically significant the disease three group variations Viral load was done was used with COVID-19 [DOI] 10.7759/cureus.16655 PMC 바로가기 [Article Type] Infectious Disease
The Role of P-Selectin in COVID-19 Coagulopathy: An Updated ReviewReview Published on 2021-07-262022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] activated Activation aggregate Blood blood clot cardiovascular complication characterized circulating Coagulopathy complex interplay contribute contributing to COVID-19 COVID-19 pathogenesis disrupting endothelial Endothelial cell Endothelium expressed Frame incidence inflammatory storm knowledge leucocyte leukocytes marker Migration neutrophil-platelet P-selectin Platelets recruitment reported review role SARS-CoV-2 severe COVID-19 Severe infection severity therapeutic intervention thrombotic event tissue tissues venous [DOI] 10.3390/ijms22157942 PMC 바로가기 [Article Type] Review
Shorter leukocyte telomere length is associated with adverse COVID-19 outcomes: A cohort study in UK Biobank더 짧은 백혈구 텔로미어 길이는 부정적인 COVID-19 결과와 관련이 있습니다: UK Biobank의 코호트 연구Research Paper Published on 2021-07-232022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] 95% CI adjusted age Analysis association Biological Biotechnology Causality cohort study collider bias Community Composite conducted coronavirus coronavirus disease Coronavirus disease-19 Council COVID-19 Critical care defined determine Ethnicity evaluate exploratory finding foundation funding genetic variants heart higher risk Hospital admission independent independent of infection with SARS-CoV-2 information leucocyte leukocyte marker Medical Research Council Mortality MR analyses Odds ratio outcome outcomes participant positive randomisation recorded recruited reduced reflect respiratory Respiratory Support risk risk factor Science Sex tested UK biobank UKB with COVID-19 [DOI] 10.1016/j.ebiom.2021.103485 PMC 바로가기 [Article Type] Research Paper
Coronary artery calcification on low-dose chest CT is an early predictor of severe progression of COVID-19—A multi-center, multi-vendor study저선량 흉부 CT의 관상동맥 석회화는 COVID-19의 심각한 진행을 조기에 예측할 수 있는 지표입니다.Multicenter Study Published on 2021-07-212022-09-12 Journal: PLoS ONE [Category] Coronavirus, MERS, 진단, [키워드] active smoking Admission age Analysis C-reactive protein calcium cardiovascular Chest computed tomography Chest CT Comorbidity Computed tomography consecutive patient Coronary artery COVID-19 COVID-19 case COVID-19 cases creatinine D-dimer death diabetes diagnostic follow-up period help hospital hyperlipidemia hypertension ICU independent independent variable independent variables initial intensive care treatment interquartile range intubation laboratory parameter Laboratory parameters Lactate lactate dehydrogenase leucocyte Logistic regression low-dose lung involvement lymphocyte Lymphocyte count multicollinearity multivariate Multivariate analysis multivariate logistic regression Patient positive RT-PCR predict predictor primary endpoint progression Result SARS-CoV-2 severe COVID-19 Sex significantly higher smoking the primary endpoint three centers thrombocyte tracheal tracheal intubation [DOI] 10.1371/journal.pone.0255045 PMC 바로가기 [Article Type] Multicenter Study
Cell Analysis from Dried Blood Spots: New Opportunities in Immunology, Hematology, and Infectious DiseasesResearch Article Published on 2021-07-182022-10-28 Journal: Advanced Science [Category] COVID-19, SARS, [키워드] analyses Analysis Biomarker Biomedical research Blood blood cell buffer CD169 Cell cells cellular compartments cellular molecule common coronavirus 2 Cytometry degrade described Dried blood spots elution buffer facilitate Flow healthcare hematology implication Infection Infectious disease Laboratory leucocyte majority management mRNA mRNA expression New opportunity Patient performed permeabilized preserved Rapid red blood cell resource respiratory SARS‐CoV‐2 shaking staining Support temperature variety while [DOI] 10.1002/advs.202100323 PMC 바로가기 [Article Type] Research Article
Biomarkers of cytokine storm as red flags for severe and fatal COVID-19 cases: A living systematic review and meta-analysis심각하고 치명적인 코비드 -19 사례에 대한 적기로서의 사이토 카인 폭풍의 바이오 마커 : 살아있는 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-06-292022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 바이오마커, [키워드] abstracts Analysis aspartate Aspartate aminotransferase Biomarker Biomarkers C-reactive protein C-Reactive-Protein conducted Confidence intervals Controlled controlled trials COVID-19 creatinine cytokine Cytokine storm Cytokine storm syndrome D-dimer database elevated eligible fatal COVID-19 ferritin Final final analysis for inclusion Grey literature hematology Hyperferritinemia IBECS identify interleukin interleukin-6 Laboratory laboratory biomarker laboratory biomarkers laboratory data laboratory parameter Laboratory parameters Lactate lactate dehydrogenase leucocyte leucocytes leukocytes LILACS Lymphocytes lymphopenia mean difference mean differences meta-analyses Meta-analysis Mild moderate neutrophil Neutrophils Newcastle-Ottawa Scale objective parameters patients Platelets poor prognosis predictor procalcitonin retrieved risk of bia screened selected serum serum interleukin-6 levels severe and fatal COVID-19 cases severe COVID-19 syndrome synonym systematic review systemic inflammation the cytokine storm the MEDLINE the Newcastle-Ottawa Scale thrombocytopenia was performed [DOI] 10.1371/journal.pone.0253894 PMC 바로가기 [Article Type] Meta-Analysis
Patients’ treatment limitations as predictive factor for mortality in COVID-19: results from hospitalized patients of a hotspot region for SARS-CoV-2 infectionsResearch Published on 2021-06-042022-10-28 Journal: Respiratory Research [Category] COVID-19, MERS, [키워드] addition Admission age analyses C-reactive protein cardiac disease Cardiopulmonary CCI characterized clinical Comorbidity COVID-19 COVID-19 mortality CRP death Dementia diabetes discharge female glomerular filtration rate hemoglobin hospital hospitalized patient hotspot incidence independent independent risk factor intubation Laboratory LDH leucocyte Life supporting care limitation limitation malignant disease median Mortality multivariate analyses neutrophil outcome Patient patient treatment PCR-confirmed Predictive Prognostic factors pulse oximetry Region Registered renal Respiratory Support Result SARS-CoV-2 SARS-COV-2 infection Sex supplementary material Symptoms transfer Treatment Trial registration Variation variations vital signs with COVID-19 [DOI] 10.1186/s12931-021-01756-2 PMC 바로가기 [Article Type] Research
Outcomes After Vascular Surgery Procedures in Patients with COVID-19 Infection: A National Multicenter Cohort Study (COVID-VAS)Observational Study Published on 2021-05-012022-10-05 Journal: Annals of vascular surgery [Category] 임상, [키워드] 30-Day mortality acute renal failure acute respiratory distress age analyzed ARDS assessment bilateral lung infiltrate clinical Coma complications Computed tomography failure hospital increased the risk independent variable Infection invasive ventilation lactate dehydrogenase LDH leucocyte lymphocyte Lymphocyte count male Mortality mortality rate multicenter Multivariate analysis outcome pandemic Patient patients with COVID-19 performed postoperative preoperative primary end point procedure Prognostic factor prospective observational cohort qSOFA Respiratory failure risk factor Sepsis Serum ferritin Society Spain surgery survival syndrome Thorax Vascular with COVID-19 [DOI] 10.1016/j.avsg.2021.01.054 PMC 바로가기 [Article Type] Observational Study