Linkage disequilibrium – Page 3 – Communicable Diseases Research

Shared genetic etiology between idiopathic pulmonary fibrosis and COVID-19 severity

특발성 폐섬유증과 COVID-19 중증도 사이의 유전적 병인 공유

Article

Published on 2021-03-012022-09-11
Journal: EBioMedicine [Category] SARS, 변종, 유전자 메커니즘, 진단, 치료기술,

Association of MICA and HLA-B alleles with leprosy in two endemic populations in Brazil

article

Published on 2021-02-282024-09-01
Journal: International Journal of Immunogenetics [Category] 한센병,

[키워드] Genetic polymorphism HLA-B alleles leprosy Linkage disequilibrium MICA alleles
[Article Type] article

The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types

Spike D614G 돌연변이는 여러 인간 세포 유형의 SARS-CoV-2 감염을 증가시킵니다

Research Article

Published on 2021-02-112022-09-10
Journal: eLife [Category] MERS, 변종, 유전자 메커니즘,

[키워드] A549 ACE2 ACE2 receptor binding Caco-2 Calu Calu-3 cell Cell coronavirus COVID-19 D614G D614G mutation D614G variant effective epithelial cells expressing fold functional G614 variant genetics Huh7.5 Human human cell human cell lines human cells human lung human lung epithelial cells increase Lentiviral particle lentiviral particles Linkage disequilibrium mechanism Mutation ORF1b overexpressing Point mutation Population genetics Prevalence Protein proteolytic cleavage pseudotyped ranged SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus site-directed mutagenesis spike Spike protein surpassed the SARS-CoV-2 virus the Spike transducing variant variants virus wild-type
[DOI] 10.7554/eLife.65365 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 genomic variations associated with mortality rate of COVID-19

Article

Published on 2020-07-222022-10-04
Journal: Journal of Human Genetics [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료법,

[키워드] Affect analyses association caused Cluster Clustering conducted coronavirus disease correlation country COVID-19 deaths Factor fatality Fatality rate frequencies Frequency Genetic genomic variation Genotype global pandemic Hierarchical HLA HLA alleles Host Immunogenetics independent infected cases Infection investigated Linkage disequilibrium mortality rate mutant Mutation number of infected ORF1ab outbreak positive correlation S protein SARS-CoV-2 SARS-CoV-2 genome sequence SARS-COV-2 infection SARS-CoV-2 mutation SARS-CoV-2 sequence severity of COVID-19 significantly susceptibility variant variants
[DOI] 10.1038/s10038-020-0808-9 PMC 바로가기 [Article Type] Article

Eliciting priors and relaxing the single causal variant assumption in colocalisation analyses

colocalization 분석에서 사전의 도출 및 단일 인과적 변이 가정 완화

Research Article

Published on 2020-04-202022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

Benchmarking bacterial genome-wide association study methods using simulated genomes and phenotypes

시뮬레이션된 유전체와 표현형을 사용한 박테리아 유전체 전반의 연관 연구 방법 벤치마킹

Article

Published on 2020-03-252024-07-31
Journal: Microbial Genomics [Category] 폐렴구균 감염증,

[키워드] Bacteria Benchmarking GWAS Linkage disequilibrium power Simulation
[DOI] 10.1099/mgen.0.000337 PMC 바로가기

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

정밀 의학(TOPMed)을 위한 100,000개 이상의 NHLBI Trans-Omics 컨소시엄 전체 게놈 서열의 사용은 아프리카 및 히스패닉/라틴계 혼합 인구 집단에서 전가 품질 및 희귀 변이 연관성 검출 개선

Research Article

Published on 2019-12-232022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] 1000 Genomes Project addition African allele Analysis Anemia approach association average blood cell complex complex diseases conducted demonstrated European Frequency genetic architecture Genetic studies genetic study genome coverage genome-wide association genome-wide genotyping genome-wide significant Genotype genotype data genotype imputation genotypes Haplotype Reference Consortium HBB HBB gene HCT hematocrit hematological hemoglobin highlight homozygous impair IMPROVE imputation increase in independent individual information Linkage disequilibrium low frequency MAF mapping Medicine minor allele frequency MOST NHLBI phase Population populations power Quantitative rare variant Rare variants reference panel replicated rescued sequence Sequencing sequencing data subsequent traits utility variant variants WBC White blood cell white blood cell count whole genome whole genome sequence Whole genome sequencing
[DOI] 10.1371/journal.pgen.1008500 PMC 바로가기 [Article Type] Research Article

SuperDCA for genome-wide epistasis analysis

유전체 전반의 에피스타시스 분석을 위한 SuperDCA

Article

Published on 2018-06-292024-07-31
Journal: Microbial Genomics [Category] 폐렴구균 감염증,

[키워드] epistasis Linkage disequilibrium population genomics
[DOI] 10.1099/mgen.0.000184 PMC 바로가기

Variable number of tandem repeats of 9 Plasmodium vivax genes among Southeast Asian isolates

article

Published on 2017-06-302024-09-01
Journal: Family process [Category] 말라리아,

[키워드] heterozygosity Linkage disequilibrium malaria Variable number of tandem repeats (VNTR)
[Article Type] article

Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis

게놈 전반에 걸친 상위성 분석으로 식별된 저항성, 독성 및 핵심 기계 유전자의 상호 작용 네트워크

Research Article

Published on 2017-02-162022-09-06
Journal: PLoS Genetics [Category] Communicable Disease, 폐렴구균 감염증,

[키워드] activity Algorithm Analysis Antibiotic resistance applied approach arising Bacteria Bacterial bases Beta-lactam beta-lactam antibiotics candidate cellular change chromosome coding sequence complement contribute Critical data set data sets dataset dihydrofolate Diversity DNA driver ENhance epistasis epistatic interaction epistatic interactions Evolution experimental work functions Genes Genetic variation Genome Genome-wide association studies Genome-wide association study genomic Genomic analysis genomic data highlight human pathogen hypothese hypotheses identify Interaction interactions lack Linkage disequilibrium loci locus non-susceptibility Organisms over parameter Pathogens pbp1a phenotype pneumococcus polymorphism Polymorphisms Protein pseudouridine recent representing reveal RNA sequence sequences significantly statistical statistical model statistically Streptococcus Streptococcus pneumoniae Streptococcus pyogene Streptococcus pyogenes structural biology synthases Systems biology target targets the strongest trimethoprim underlie virulence
[DOI] 10.1371/journal.pgen.1006508 PMC 바로가기 [Article Type] Research Article