Integrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 InfectionArticle Published on 2020-11-062023-07-12 Journal: Journal of Proteome Research [Category] SARS, [키워드] amino acids Biomarkers COVID-19 Lipoproteins mass spectrometry metabolic phenotyping mosaic disease Multiorgan damage NMR spectroscopy SARS-CoV-2 systems model. [DOI] 10.1021/acs.jproteome.0c00519 PMC 바로가기
Lipoprotein concentrations over time in the intensive care unit COVID-19 patients: Results from the ApoCOVID study중환자실 COVID-19 환자의 시간 경과에 따른 지단백질 농도: ApoCOVID 연구 결과Research Article Published on 2020-09-242022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Admission Anti-inflammatory antioxidant association Bacterial Bacterial sepsis bacterial superinfection caused change cholesterol clearance Concentration conducted consecutive patient coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pneumonia dead patient decrease Diagnosis functions global pandemic HDL HDL-C HDLs High-density lipoprotein High-density lipoproteins Hospitalization Hospitalized ICU ICU admission ICU patient incidence increase in intensive care LDL cholesterol LDL-C lipopolysaccharides lipoprotein Lipoproteins Low-density lipoprotein low-density lipoproteins Mortality neutralize nonsurvivors outcome outcomes Particle Particles Patient pleiotropic Pneumonia profile Prospective Study reference values reported respiratory Result Sepsis Severe COVID-19 pneumonia statistically significant superinfection survival survivor Transport university hospital VAP Ventilator-associated pneumonia were assessed [DOI] 10.1371/journal.pone.0239573 PMC 바로가기 [Article Type] Research Article
Low high-density lipoprotein level is correlated with the severity of COVID-19 patients: an observational study낮은 고밀도 지단백 수치는 COVID-19 환자의 중증도와 상관관계가 있습니다: 관찰 연구Research Published on 2020-09-072022-08-13 Journal: Lipids in Health and Disease [Category] Biochemistry, COVID-19, SARS, [키워드] 95% CI Admission adopted age age and gender blood lipid blood lipid level blood lipid levels C-reactive protein C-reactive protein (CRP China cholesterol Clinical data coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 COVID-19 adult patients COVID-19 patient COVID-19 patients Cox regression analysis diagnosed elevated enrolled event events Gender HDL-C healthy high-density High-density lipoprotein High-density lipoprotein cholesterol higher risk infected with COVID-19 interquartile range Kaplan-Meier LDL-C lipoprotein cholesterol Lipoproteins Low-density lipoprotein Low-Density Lipoprotein cholesterol male Mann-Whitney test median non-severe patients participant Patient Prognosis proportion RANK Result Retrospective analysis Severe case severe cases severe COVID-19 patient severe COVID-19 patients severity of COVID-19 significantly lower Total cholesterol Triglyceride underlying diseases were used [DOI] 10.1186/s12944-020-01382-9 PMC 바로가기 [Article Type] Research
A point mutation decouples the lipid transfer activities of microsomal triglyceride transfer protein점 돌연변이는 마이크로솜 트리글리세리드 전달 단백질의 지질 전달 활동을 분리합니다Research Article Published on 2020-08-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect ApoB ApoB-containing lipoprotein ApoB-containing lipoproteins Apolipoprotein B Apolipoprotein B-containing lipoprotein Apolipoprotein B-containing lipoproteins assembly B-lp B-lps bind block blood vessels cardiovascular cardiovascular disease circulation complex conserved Critical crystal structure cytoplasmic lipid droplet cytoplasmic lipid droplets disease Disruption drug design dyslipidemia dyslipidemias Embryo endogenous lipid fat malabsorption feasible G863V G863V mttp mutant protein G863V mutant protein glycine growth growth defects growth retardation growth retardation) health condition heterodimeric highlight Human human MTP humans hydrophobic identify inhibitor insect Insects intestinal fat malabsorption L475P Lipid lipid transfer activity lipids Lipoproteins metabolism microsomal triglyceride transfer protein Missense mutation modeling morphology Mtp MTP complex MTP triglyceride transfer activity MTTP mutant mutants Mutation opacity phenotype Phospholipids plasma lipoproteins Point mutation power Prevent Protein reduce reported required residue secretion selective selective inhibition Support synthesis Therapeutic approach These data tissues transfer Transport treat Triglyceride triglycerides valine vertebrates wall yolk yolk opacity yolk syncytial layer YSL zebrafish [DOI] 10.1371/journal.pgen.1008941 PMC 바로가기 [Article Type] Research Article
COVID‐19—Associated dyslipidemia: Implications for mechanism of impaired resolution and novel therapeutic approachesArticle Published on 2020-06-262023-06-16 Journal: FASEB journal : official publication of the Federa [Category] MERS, [키워드] COVID‐19 dyslipidemia Inflammation Lipoproteins Oxidation [DOI] 10.1096/fj.202001451 PMC 바로가기
Association of Lipid Levels with Mefloquine and Carboxy-Mefloquine Concentrations in Patients with Uncomplicated Falciparum MalariaArticle Published on 2020-02-212024-08-28 Journal: Med Instrum [Category] 말라리아, [키워드] Infectious diseases lipids Lipoproteins malaria mefloquine
Antimalarial Activity of Human Group IIA Secreted Phospholipase A2 in Relation to Enzymatic Hydrolysis of Oxidized LipoproteinsArticle Published on 2019-10-182024-08-28 Journal: Infection and Immunity [Category] 말라리아, [키워드] Lipoproteins malaria Oxidation phospholipase A2. Plasmodium falciparum
Three-dimensional structures of Lipoproteins from Streptococcus pneumoniae and Staphylococcus aureusarticle Published on 2018-08-312024-09-01 Journal: International Journal of Medical Microbiology [Category] 폐렴구균 감염증, [키워드] Lipoproteins protein structure Staphylococcus aureus Streptococcus pneumoniae virulence [Article Type] article
Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway죽상경화증 퇴행 동안 플라크 대식세포의 전사체에 대한 후성유전체 분석은 Wnt 신호 전달 경로의 활성화를 보여줍니다Research Article Published on 2014-12-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated Affect Analysis annotations approach arterial plaque macrophage arteries Atherosclerosis binding site canonical Cell cell motility cell type chromatin circulating condition control group demonstrated detect differentially expressed drug treatments eight element enrichment epigenomic eQTL Evidence expression foam cell functional Gene Expression humans identify in vitro in vivo increase Inflammation inflammatory disease inflammatory state innate immune system less Lipoproteins lowering Macrophage Macrophage response macrophage responses macrophages mice Migration molecular mouse model network overlap plaque plaque macrophage plaque macrophage response plaque macrophage responses plaque macrophages plaque regression plaques plasma lipoprotein plasma lipoproteins power promoter promoters reducing regressing plaque regressing plaques Regression Regression model regression models regulatory region response reversed risk significantly SNPs statins statistically Stimulation Systems biology TCF/LEF therapeutic target transcription factor transcription factors transcriptional change Transcriptome upregulated upregulated gene upregulated genes upstream validation study while Wnt Wnt signaling Wnt signaling pathway β-catenin [DOI] 10.1371/journal.pgen.1004828 PMC 바로가기 [Article Type] Research Article
Molecular architecture of Streptococcus pneumoniae surface thioredoxin-fold lipoproteins crucial for extracellular oxidative stress resistance and maintenance of virulence스트렙토코커스 폐렴균 표면 티오레독신-폴드 리포단백질의 분자 구조는 세포외 산화 스트레스 저항과 병원성 유지에 중요합니다.Research Article Published on 2013-12-182024-08-04 Journal: EMBO Molecular Medicine [Category] 폐렴구균 감염증, [키워드] Lipoproteins Meningitis oxidative stress pneumococci Pneumonia [DOI] 10.1002/emmm.201202435 PMC 바로가기 [Article Type] Research Article