Risk factors associated with mortality in ıntensive care COVID-19 patients: the importance of chest CT score and intubation timing as risk factors중환자실 코로나19 환자의 사망과 관련된 위험인자: 위험인자로서 흉부 CT 점수와 삽관 시기의 중요성Observational Study Published on 2021-08-302022-09-12 Journal: Turkish Journal of Medical Sciences [Category] MERS, SARS, 임상, 진단, [키워드] adjusted admitted to ICU age Analysis APACHE II APACHE II score assist base excess being blood gas blood gas analysis calculated Care Chest Chest computerized tomography Chest CT Clinical outcome clinical outcomes collected Comorbidity Computerized tomography coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical Critical illness Critically ill Critically ill patient critically ill patients CT score D-dimer Dementia disease enrolled evaluated Factor Favipiravir feasible gas analysis Health hospital hypertension ICU ICU admission ICU mortality identify information intensive care intensive care unit intubation intubation timing investigated Kaplan–Meier Laboratory log-rank test male material Mortality mortality rate mortality risk factor no difference nonsurvivor nonsurvivors Patient patients with COVID-19 Predictive predictor preexisting comorbidities progression Regression model Result Retrospective study risk factor Risk factors survival survival analysis survivor the patient thought Treatment troponin Turkey WBC [DOI] 10.3906/sag-2101-89 PMC 바로가기 [Article Type] Observational Study
Combining IL-6 and SARS-CoV-2 RNAaemia-based risk stratification for fatal outcomes of COVID-19COVID-19의 치명적인 결과에 대한 IL-6 및 SARS-CoV-2 RNA빈혈 기반 위험 계층화 결합Research Article Published on 2021-08-112022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 진단, [키워드] Accuracy acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission clinical collected copy number coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Deterioration ECMO ELISA kit extracorporeal membrane oxygenation FiO2 fraction high mortality high risk highest hyperinflammation identify IL-6 In-hospital death increase interleukin intubation Laboratory log-rank test mechanical ventilation moderate to severe objective outcome oxygen oxygen saturation pandemic Patient patients died patients with moderate plasma Predictive prognostic biomarker Prognostic biomarkers quantitative PCR required respiratory distress Respiratory distress syndrome Result risk stratification RNA SARS-CoV-2 SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus severe COVID-19 significantly higher SpO2 SpO2/FiO2 syndrome variables were assessed [DOI] 10.1371/journal.pone.0256022 PMC 바로가기 [Article Type] Research Article
Interferon-induced transmembrane protein-3 genetic variant rs12252 is associated with COVID-19 mortality인터페론으로 유도된 막횡단 단백질-3 유전자 변이체 rs12252는 COVID-19 사망률과 관련이 있습니다Article Published on 2021-07-012022-09-11 Journal: Genomics [Category] SARS, 변종, 유전자 메커니즘, [키워드] allele Clinical outcome COVID-19 COVID-19 phenotypes death examined Genetic variant genetics Genotype genotyped heterogeneous higher risk Hospital admission IFITM IFITM3 IFNγ individual interferon less log-rank test membrane protein Mortality Patient PCR-confirmed Plasma level Plasma levels Precision Probability public health risk factor SARS-CoV-2 SARS-COV-2 infection significantly lower subset survival transmembrane underlie variant Viral diseases with COVID-19 [DOI] 10.1016/j.ygeno.2021.04.002 PMC 바로가기 [Article Type] Article
Abnormal Fibrinogen Level as a Prognostic Indicator in Coronavirus Disease Patients: A Retrospective Cohort StudyMedicine Published on 2021-06-142022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 95% confidence interval abnormality Admission analyses Analysis assist association Clinical management Coagulation Cohort conducted coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical disease disease severity elevated enrolled examined fibrinogen Follow-up greater Indicator Kaplan–Meier Level log-rank test Logistic regression Mortality mortality risk pandemic Patient predict Prognosis prognostic biomarker prognostic indicators retrospective cohort study Retrospective study risk survival survival curve three group were used Wuhan, China [DOI] 10.3389/fmed.2021.687220 PMC 바로가기 [Article Type] Medicine
Hospital length of stay among COVID-19-positive patientsOriginal Article Published on 2021-06-052022-10-29 Journal: Journal of Clinical and Translational Research [Category] COVID-19, [키워드] accelerated Accuracy age approach Bivariate analyses bivariate analysis Cardiac arrhythmia Care Coagulopathy Community Comorbidities Comorbidity congestive heart failure Coronary artery disease COVID-19 COVID-19 patient demographics determine diabetes discharged disorder Factor Factors help hospital hypertension Length of stay log-rank test LOS men multivariable analysis multivariable model Neurological disorder pandemic Patient positive COVID-19 Prevent Relevance renal resource Retrospective study Sex significantly the patient time-to-event analysis understanding USA vascular disease white PMC 바로가기 [Article Type] Original Article
Cyclosporine A plus low-dose steroid treatment in COVID-19 improves clinical outcomes in patients with moderate to severe disease: A pilot studyClinical Trial Published on 2021-06-012022-10-05 Journal: Journal of internal medicine [Category] 임상, [키워드] 95%CI added age Analysis assigned benefit cause Clinical improvement Clinical outcome control group Controlled clinical trial COVID-19 COVID-19 pandemic COVID-19 patient cumulative cyclosporine A death death rate determine diabete evaluated highest Hospitalized hypertension IMPROVE improvement Infection Laboratory log-rank test low-dose lung tomography medical treatment men Methylprednisolone moderate morbidity and mortality Mortality outcome Patient patients patients with COVID-19 patients with moderate pilot study Pneumonia Prednisone Randomized receive reduce mortality SARS-CoV-2 severe disease severe patients severity steroid steroid treatment Steroids Treatment [DOI] 10.1111/joim.13223 PMC 바로가기 [Article Type] Clinical Trial
Timeliness of contact tracing among flight passengers during the COVID-19 epidemic in Vietnam베트남에서 COVID-19 전염병 동안 항공기 승객 간의 접촉 추적의 적시성Research Published on 2021-04-282022-09-01 Journal: BMC Infectious Diseases [Category] MERS, SARS, 진단, 치료기술, [키워드] approach close contact completion Contact tracing COVID-19 COVID-19 case COVID-19 cases COVID-19 epidemic early stage Factor hazard Health health facilities high-risk area high-risk areas identify index case investigated log-rank test mandatory median multivariable National occurred Poisson regression model public health reduce Result SARS-CoV-2 SARS-CoV-2 testing Spread supplementary material Timeliness Travel Vietnam [DOI] 10.1186/s12879-021-06067-x PMC 바로가기 [Article Type] Research
Efficacy and safety of nelfinavir in asymptomatic and mild COVID-19 patients: a structured summary of a study protocol for a multicenter, randomized controlled trial무증상 및 경증 COVID-19 환자에 대한 nelfinavir의 효능 및 안전성: 다기관, 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-04-282022-09-10 Journal: Trials [Category] SARS, 임상, 치료기술, [키워드] 1:1 Administered administration adverse event adverse events age all-cause mortality ALT Analysis anticipated Antigen antiviral efficacy AST Asymptomatic asymptomatic patients blinded blinded outcome assessment Blinding blood glucose body temperature both group both groups capture caused childbearing potential clearance clinical Clinical efficacy clinical examinations Clinical symptoms clinical trial clinical trials comparator Patients condition Consent contraceptive method Controlled clinical trial cough COVID-19 creatinine creatinine clearance dataset Day defervescence diabete diabetes diarrhea discretion dissemination distribution drug element enrolled enrolment evaluate event exclusion criteria exploratory Factor female patient Fever Frequency Glucose group hazard ratio Hemophiliac Hemorrhagic history HIV infection hospital hypersensitivity incidence incidence rate Inclusion inclusion and exclusion criteria inclusion criteria Infection Informed consent initial investigator investigator-initiated investigators Japan Japanese LAMP limit log-rank test male Mild mild COVID-19 patient Mild disease mixed-effects model multicenter Nasopharyngeal swab Negative conversion Negative PCR nelfinavir null hypothesis number objective Open-label outcome oxygen Oxygen administration p value parallel group parameter participant Patient patients with asymptomatic PCR PCR test Pneumonia power Pregnancy primary endpoint Primary outcome principal investigator Probability probability distribution protocol random randomization Randomized Randomized controlled trial Registered registry reported required respiratory tract rifampicin room air safety endpoint Saliva saliva samples Sample size SARS-CoV-2 SARS-CoV-2 vaccination secondary efficacy endpoint serious complication serum creatinine severity specimen Standard status study period Study protocol supplementary material survival survival function Symptom symptomatic symptomatic COVID-19 Symptomatic treatment the log-rank test Three times daily Treatment treatment for HIV treatment period Trial Trial registration two-sided Unsuitable Viral viral dynamics Viral load virus was determined website Withdrawal withdrawal of consent [DOI] 10.1186/s13063-021-05282-w PMC 바로가기 [Article Type] Letter
Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical TrialRandomized Controlled Trial Published on 2021-04-132022-10-05 Journal: JAMA [Category] SARS, 임상, [키워드] adverse event clinical clinical benefit clinically collected conducted Course COVID-19 database determine Effect enrolled follow-up period hazard ratio headache Health Hospitalized IMPROVE IQR Ivermectin ivermectin group laboratory-confirmed log-rank test median age median time Mild multiorgan failure outcome outcomes Patient per day Placebo Potential Potential treatment primary analysis population random Randomized randomized trial receive reported Resolution resolution of symptom resolution of symptoms resolved Serious Adverse Event significantly study participant study period Support Symptom symptomatic Symptoms the placebo group time Treatment Trial with mild disease women [DOI] 10.1001/jama.2021.3071 PMC 바로가기 [Article Type] Randomized Controlled Trial
Novel Chest Radiographic Biomarkers for COVID-19 Using Radiomic Features Associated with Diagnostics and Outcomes진단 및 결과와 관련된 방사성 특징을 사용하는 COVID-19에 대한 새로운 흉부 방사선학적 바이오마커Article Published on 2021-04-012022-09-11 Journal: Journal of digital imaging [Category] MERS, SARS, 바이오마커, [키워드] acute infectious disease acute infectious diseases acute respiratory diseases Analysis Biomarker calculated Characteristics characterized Chest radiography chest X-ray chest X-rays co-occurrence Cohort contagious contagious disease coronavirus correlated COVID-19 COVID-19 patients dependence diagnosed diagnostic disease etiologic agent feature Features Formula hazard ratio highest histogram identify Image analysis imaging diagnosis Infection Infectious diseases Kaplan-Meier Kaplan-Meier curve Kaplan-Meier curves log-rank test Mann-Whitney Mann-Whitney U test marker measure Medical image analysis MOST novel Patient patients Pneumonia predict Prognostic value Quantitative Radiographic Radiomics respiratory respiratory diseases Retrospective study risk of COVID-19 sensitivity severe pneumonia statistical analysis Support survival text the log-rank test undergo uniformity with COVID-19 zone [DOI] 10.1007/s10278-021-00421-w PMC 바로가기 [Article Type] Article