Drug-repurposing against COVID-19 by targeting a key signaling pathway: An in silico study주요 신호 경로를 표적으로하여 COVID-19에 대한 약물 보장 : In Silico StudyArticle Published on 2021-10-012022-08-31 Journal: Medical Hypotheses [Category] MERS, SARS, 신약개발, 치료제, [키워드] accumulated AKT1 AKT1-HSP90AB1-BCL2 Akti-1/2-HSP990-S55746 alleviate anti-inflammatory effect Anti-inflammatory effects BCl2 concerning COVID-19 COVID-19 symptom COVID-19 symptoms element Estrogen Estrogen signaling pathway. Hsp90 HSP90AB1 Human in silico Infection information lung cells pathway Pathways plethora provide PubChem retrieved S55746 Signaling signaling pathway suggested target targets the strongest Transmission [DOI] 10.1016/j.mehy.2021.110656 PMC 바로가기 [Article Type] Article
Evolution of Diploid Progenitor Lung Cell Applications: From Optimized Biotechnological Substrates to Potential Active Pharmaceutical Ingredients in Respiratory Tract Regenerative MedicineReview Published on 2021-09-242022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] active pharmaceutical ingredient administration Allogeneic API approach Burn Cell cell banking Cell therapy cell type COVID-19 COVID-19 patient diploid diploid progenitor cells effective effort Evolution FIVE function GMP good manufacturing practice homologous inflammatory lung disease ingredient Local lung lung cell lung cells lung tissue management Medicine MRC-5 cells Patient platform Potential produced progenitor progenitor cell recent regenerative regenerative medicine Research respiratory respiratory tract Safe substrate substrates Symptom syndrome therapeutic therapeutic use therapy tract Vaccine vaccine production vaccine substrate [DOI] 10.3390/cells10102526 PMC 바로가기 [Article Type] Review
Systematic Network and Meta-analysis on the Antiviral Mechanisms of Probiotics: A Preventive and Treatment Strategy to Mitigate SARS-CoV-2 Infection프로바이오틱스의 항바이러스 메커니즘에 대한 체계적인 네트워크 및 메타 분석: SARS-CoV-2 감염을 완화하기 위한 예방 및 치료 전략Comment Published on 2021-08-012022-09-11 Journal: Probiotics and antimicrobial proteins [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Activation affecting Analysis association biological network Biological network analysis boosting immunity candidate gene Clinical outcome common cold Comorbidities concerning country COVID-19 deaths domain functional Glucose Gut gut microbiome gut microbiota gut-lung axis Immune cell immune system immunomodulatory Immunosuppressed implementation IMPROVE individuals with COVID-19 infect infected case infected cases lung cells Lung infection lung tissue Meta-analysis metabolic pathway Microbiome Migration modulating molecular target network NLRP3 offer pandemic Pathway enrichment analysis Pathways Pneumonia Probiotics Prognosis rationale Respiratory illness resulting SARS-CoV-2 severity shown specific treatment Strategy systemic immune response the disease therapeutic effect therapeutic effects therapeutic strategy treating COVID-19 Treatment viral infection virus virus entry with COVID-19 [DOI] 10.1007/s12602-021-09748-w PMC 바로가기 [Article Type] Comment
Improving gene network inference with graph wavelets and making insights about ageing-associated regulatory changes in lungs그래프 웨이블릿으로 유전자 네트워크 추론 개선 및 폐의 노화 관련 규제 변화에 대한 통찰력 만들기Article Published on 2021-07-202022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘, [키워드] Ageing ageing lung Analysis Applying approach Cell changes changes in Consistency Coronavirus infection COVID Effect estimate expression profile Factors gene network gene regulatory network human lung Improving lung lung cells lung; master regulator MOST Novel coronavirus Novel coronavirus infection pathway Pathways pneumocyte predicted Regulatory similarity single-cell Transcriptome transcriptome profile [DOI] 10.1093/bib/bbaa360 PMC 바로가기 [Article Type] Article
The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cellsArticle Published on 2021-07-012022-10-29 Journal: Nature Communications [Category] COVID-19, SARS, [키워드] ACE2 Activation Analysis attack Cell signalling cellular entry clinical trial co-expression COVID-19 dataset downregulate Efficacy Evidence host cell surface human lung cell increase Infection Infectious diseases lung lung cell lung cells Lung infection Mechanisms of disease organs Prostate Prostate cancer provide receptor reduce reduced regulated SARS-CoV-2 SARS-CoV-2 entry significantly Support Therapeutic approach TMPRSS2 TMPRSS2 level Transcription Treatment various tissues viral entry [DOI] 10.1038/s41467-021-24342-y PMC 바로가기 [Article Type] Article
Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung CellsAntiviral Agents Published on 2021-06-142022-10-27 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID-19, [키워드] Alanine Antiviral antiviral activity biochemical bioinformatic analysis carboxylesterase 1 CatA catalytic cathepsin A Cell culture cells cellular CES1 COVID-19 Critical data sets demonstrated Effect enzyme Enzymes GS-5734 HINT1 histidine Human human lung tissue hydrolyzed Hypothesis inhibitor involved lung lung cells metabolic metabolism monophosphate mRNA mRNA expression nucleotide analogs nucleotide-binding protein 1 pathway phosphorylated Phosphorylation polymerases prodrug activation Protein quantification RDV Remdesivir respiratory viral infection RNA-Seq SARS-CoV-2 selective sequence single-cell Support target cell tissue treat Treatment turn unique Viral RNA [DOI] 10.1128/AAC.00602-21 PMC 바로가기 [Article Type] Antiviral Agents
Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung CellsAntiviral Agents Published on 2021-06-142022-10-27 Journal: Antimicrobial Agents and Chemotherapy [Category] Coronavirus, COVID-19, SARS, [키워드] Alanine Antiviral antiviral activity biochemical bioinformatic analysis carboxylesterase 1 CatA catalytic cathepsin A Cell culture cells cellular CES1 COVID-19 Critical data sets demonstrated Effect enzyme Enzymes GS-5734 HINT1 histidine Human human lung tissue hydrolyzed Hypothesis inhibitor involved lung lung cells metabolic metabolism monophosphate mRNA mRNA expression nucleotide analogs nucleotide-binding protein 1 pathway phosphorylated Phosphorylation polymerases prodrug activation Protein quantification RDV Remdesivir respiratory viral infection RNA-Seq SARS-CoV-2 selective sequence single-cell Support target cell tissue treat Treatment turn unique Viral RNA [DOI] 10.1128/AAC.00602-21 PMC 바로가기 [Article Type] Antiviral Agents
Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells인간 폐 세포에서 Remdesivir 활성화에 관여하는 주요 대사 효소Antiviral Agents Published on 2021-06-142022-09-10 Journal: Antimicrobial Agents and Chemotherapy [Category] 치료제, [키워드] adenosine Alanine Antiviral antiviral activity biochemical bioinformatic analysis carboxylesterase carboxylesterase 1 CatA catalytic cathepsin A Cell culture cells cellular CES1 COVID-19 Critical data sets demonstrated Effect enzyme Enzymes GS-5734 HINT1 histidine Human human lung tissue hydrolyzed Hypothesis inhibitor involved lung lung cells metabolic metabolic pathway metabolism monophosphate mRNA mRNA expression nucleoside nucleoside triphosphate nucleotide nucleotide analogs nucleotide-binding protein 1 pathway phosphorylated Phosphorylation polymerases prodrug activation Protein quantification RDV Remdesivir respiratory respiratory viral infection RNA-Seq SARS-CoV-2 selective sequence single-cell Support target cell target cells tissue treat Treatment triphosphate turn unique Veklury Viral Viral RNA [DOI] 10.1128/AAC.00602-21 PMC 바로가기 [Article Type] Antiviral Agents
Elovanoids downregulate SARS-CoV-2 cell-entry, canonical mediators and enhance protective signaling in human alveolar cellsElovanoids는 SARS-COV-2 세포 진입, 표준 매개체를 하향 조절하고 인간 폐포 세포에서 보호 신호를 향상시킵니다.Article Published on 2021-06-102022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 치료제, [키워드] ACE2 activate addition alveolar cell angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 attenuate binding canonical Cell COVID-19 Culture domain downregulate ENhance enzyme expression fatty Fatty acid Lipid lipid mediator lipids lung cells lung damage mediators open Polyunsaturated precursor Protective Protein RBD reduce SARS virus SARS-CoV-2 SARS-CoV-2 infected cells SARS-CoV-2 virus signal Signaling the SARS-CoV-2 the SARS-CoV-2 virus Therapeutic approach upregulating Viral viral infection virus [DOI] 10.1038/s41598-021-91794-z PMC 바로가기 [Article Type] Article
Transcriptional Start Site Coverage Analysis in Plasma Cell-Free DNA Reveals Disease Severity and Tissue Specificity of COVID-19 PatientsGenetics Published on 2021-05-282022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] acute respiratory distress affected Analysis antiviral activity Asymptomatic biological processe Biomarker blood cell Blood cells cell-free DNA cfDNA Characteristics Clinical management control group coronavirus disease Coverage COVID-19 COVID-19 patients COVID-19 progression COVID-19 severity critical condition Cytokine storm death demonstrated disease severity DNA downregulated gene evidenced feasibility function Gene Expression high risk immune system individual Infection involved lung cell lung cells mechanism noninvasive plasma plasma DNA provided Region SARS-CoV-2 Severe case severe COVID-19 patient severe COVID-19 symptoms Severe patient severe patients severe pneumonia Site the disease tissue tissue specificity transcriptional Transcriptome TSS coverage upregulated gene utility Variation viral replication [DOI] 10.3389/fgene.2021.663098 PMC 바로가기 [Article Type] Genetics