Lung fibrosis – Page 3 – Communicable Diseases Research

Acute worsening of native lung fibrosis after single lung transplantation for pulmonary fibrosis: two case reports

Case Report

Published on 2022-01-032022-10-30
Journal: Journal of Medical Case Reports [Category] Coronavirus, SARS,

Identifying potential novel insights for COVID-19 pathogenesis and therapeutics using an integrated bioinformatics analysis of host transcriptome

숙주 전사체의 통합 생물정보학 분석을 사용하여 COVID-19 병인 및 치료법에 대한 잠재적인 새로운 통찰력 식별

Article

Published on 2022-01-012022-09-11
Journal: International journal of biological macromolecules [Category] SARS, 신약개발, 유전자 메커니즘, 치료제,

[키워드] Analysis analyzed axon guidance Bioinformatics analysis clinical trials combating COVID-19 COVID-19 pathogenesis database DEGs differentially expressed gene Differentially expressed genes DNA drug drug candidate drug candidates Drug repurposing drug target dysfunction enrichment enrichment analysis entrectinib exacerbate Exemestane expressed fibrosis Functional module analysis gene expression profile help hidden host transcriptome Host transcriptome and drug repurposing hub genes hypercytokinemia identify identifying IMPROVE induce Interaction kinase kinases Lung fibrosis mechanism molecular mechanism molecular mechanisms omeprazole overexpression overlapping Pathogenesis pathogenesis of COVID-19 pathogenic pathway Pathway analysis Pathways performed PPI predicted protein-protein interaction Protein-protein interaction network selected Sema7A System Systems biology target targets TINF2 transcription factor transcription factors transcriptional profile transcriptional profiles Transcriptome Treatment was performed was used
[DOI] 10.1016/j.ijbiomac.2021.11.124 PMC 바로가기 [Article Type] Article

GP consultation rates for sequelae after acute covid-19 in patients managed in the community or hospital in the UK: population based study

Research

Published on 2021-12-292022-10-28
Journal: The BMJ [Category] COVID-19, Fulltext, SARS,

[키워드] 95% confidence interval abdominal pain adjusted hazard ratio Analysis Anxiety Asthma Aurum breathlessness Chest clinical Cognitive impairment cohorts Community contributing to Cox regression database Depression described determine Diagnosis diarrhoea disease Diseases dose England first vaccination Follow-up healthcare hospital individual Infection Influenza Ischaemic heart disease joint Loss of Smell Lung fibrosis median age nausea negative control neuropathic non-steroidal anti-inflammatory drug objective outcome outcome measure Pain pandemic Paracetamol participant Patient patients with influenza Population Practice proportions Rate reduced relative renal repeated Result setting significantly higher symptomatic Symptoms vaccination Venous Thromboembolism
[DOI] 10.1136/bmj-2021-065834 PMC 바로가기 [Article Type] Research

Efficacy and safety of the combination of modern medicine and traditional Chinese medicine in pulmonary fibrosis caused by novel coronavirus disease A protocol for Bayesian network meta-analysis

새로운 코로나 바이러스 질병으로 인한 폐 섬유증에서 현대 의학과 한약의 조합의 효능 및 안전성 베이지안 네트워크 메타 분석을위한 프로토콜

6700

Published on 2021-12-232022-08-31
Journal: Medicine [Category] meta-analysis, 임상, 치료제,

[키워드] Analysis Bayesian caused Chinese choice clinical Clinical significance Clinical studies Clinical treatment collaboration Combination coronavirus coronavirus disease COVID-19 Data processing database deficiency develop discharge drug Effectiveness Efficacy and safety eligibility criteria English evaluate Evidence fibrosis Health hierarchy hospital Inflammation Inflammatory Lung fibrosis medication Meta-analysis modern medicine Network meta-analysis New New coronavirus NMA novel Novel coronavirus novel coronavirus disease Patient positive protocol pulmonary fibrosis pulmonary inflammation Randomized controlled trial ranking recommendation registration number Research screened Stata Support TCM Traditional Chinese medicine Treatment treatment methods various treatment various treatments was used
[DOI] 10.1097/MD.0000000000028282 PMC 바로가기 [Article Type] 6700

Differential Effect of SARS-CoV-2 Spike Glycoprotein 1 on Human Bronchial and Alveolar Lung Mucosa Models: Implications for Pathogenicity

Article

Published on 2021-12-172022-10-28
Journal: Viruses [Category] COVID-19, SARS,

[키워드] ACE2 air–liquid interface Alpha Altered alveolar Analysis anti-viral response bronchial bronchial epithelial cell canonical cell membrane coronavirus COVID-19 COVID-19 vaccines cytokine differentially regulated gene Effect enzyme exposure to expression fibrosis host cell receptor Human IFN IFNγ IL10 IL12 IL13 IL2 IL4 IL6 IL8 Infection Influenza integrin interferon Ligand lung Lung fibrosis MERS (middle east respiratory syndrome) mRNA-based mucosa Mutation Necrosis neutralizing antibody p53 pathogenicity pathway platform pro-fibrotic pro-inflammatory cytokine pulmonary receptor Receptor binding domain Recombinant S1 protein regions robust S1 protein S1 subunit SARS (severe acute respiratory syndrome) SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant secreted Signaling significantly spike spike glycoprotein Spike protein the S1 subunit TLR TLR4 Type II pneumocyte virus
[DOI] 10.3390/v13122537 PMC 바로가기 [Article Type] Article

Post-COVID-19 Patients Who Develop Lung Fibrotic-like Changes Have Lower Circulating Levels of IFN-β but Higher Levels of IL-1α and TGF-β

Article

Published on 2021-12-172022-10-28
Journal: Biomedicines [Category] COVID-19,

Observational study of clinico-radiological follow-up of COVID-19 pneumonia: a district general hospital experience in the UK

Observational Study

Published on 2021-12-082022-10-04
Journal: BMC Infectious Diseases [Category] SARS, 임상,

[키워드] asymptomatic patient British Thoracic Society can be used change checked chest X-ray Cohort Compliance COVID-19 COVID-19 pneumonia COVID-19 positive patient CXR database died evaluate Evidence Follow-up Guidance had no hospital Hospital admission ILD IMPROVE incidence initial Interstitial lung disease limitation Local Lung fibrosis moderate Most patient observational study outcomes over Patient patients with COVID-19 Pneumonia pulmonary complication Pulmonary vascular disease radiological recovering from COVID-19 Respiratory complications Result retrospective risk-stratify patient Severe COVID-19 pneumonia severity Society supplementary material surviving patient symptomatic the disease the patient with COVID-19
[DOI] 10.1186/s12879-021-06941-8 PMC 바로가기 [Article Type] Observational Study

Long Term Impact on Lung Function of Patients With Moderate and Severe COVID-19. A Prospective Cohort Study

Public Health

Published on 2021-12-072022-10-31
Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS,

[키워드] abnormality affecting Analysis approved autoimmune condition cancers chest X-ray clinically cohort study Committee conducted connective tissue COVID 19 COVID-19 declined determine Diagnosis diffusion discharge disease disorders DLCO Effect ERC Evidence excluded function help hospital Impact indicated initial Interstitial lung disease Karachi limitation Long long-term impact lung lung capacity Lung fibrosis Lung function Lungs moderate nasopharyngeal Obstructive Oropharyngeal overcome Patient per day performed positive Prospective prospective cohort study pulmonary pulmonary hypertension reference number repeated review RT-PCR severe COVID-19 severe COVID-19 disease severe disease single-center spirometry statistical strength survived survivor Survivors Syncope term the disease university
[DOI] 10.3389/fpubh.2021.663076 PMC 바로가기 [Article Type] Public Health

Pleural Mesothelial Cells Modulate the Inflammatory/Profibrotic Response During SARS-CoV-2 Infection

Molecular Biosciences

Published on 2021-11-262022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,

[키워드] ACE2 ACE2 expression ADAM17 analysed Analysis analyzed assays Cell confocal microscopy COVID-19 COVID-19 disease COVID-19 patients cytokeratin cytokine direct infection ELLA epithelial Evidence expressed expression fibrosis highlight immune response implicated in vivo Infection Inflammatory cytokine Inflammatory cytokines interferons Lung fibrosis marker MCs mesothelial cells mesothelial to mesenchymal transition morphology NRP1 Pathogenesis Patient plasma membrane pleura produced promoter pulmonary fibrosis receptor reported response RT-PCR SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 replication shown supernatant sustained TMPRSS2 western blot WT1
[DOI] 10.3389/fmolb.2021.752616 PMC 바로가기 [Article Type] Molecular Biosciences

Exercise-based pulmonary rehabilitation for a post-COVID-19 pulmonary fibrosis patient A case report

6700

Published on 2021-11-242022-10-30
Journal: Medicine [Category] COVID-19, MERS, SARS,