Identifying the molecular targets and mechanisms of xuebijing injection for the treatment of COVID-19 via network pharmacology and molecular dockingResearch Article Published on 2021-06-022022-10-27 Journal: Bioengineered [Category] COVID-19, [키워드] acting affecting AKT1 alleviate baicalein clinical symptom connection COVID-19 Cytoscape disease severity enrichment analysis identify identifying IMPROVE indicated Inflammatory response ingredient inhibit injection Luteolin mechanism modulate molecular docking molecular docking analysis molecular target network pharmacology NOS pathogenic pathway potential molecular predict quercetin R language regulate screened target TCMSP therapeutic target TNF treating COVID-19 Treatment UniProt was performed was used xuebijing injection [DOI] 10.1080/21655979.2021.1933301 PMC 바로가기 [Article Type] Research Article
Identifying the molecular targets and mechanisms of xuebijing injection for the treatment of COVID-19 via network pharmacology and molecular dockingResearch Article Published on 2021-06-022022-10-27 Journal: Bioengineered [Category] Coronavirus, COVID-19, Fulltext, SARS, [키워드] acting affecting AKT1 alleviate baicalein clinical symptom connection COVID-19 Cytoscape disease severity enrichment analysis identify identifying IMPROVE indicated Inflammatory response ingredient inhibit injection Luteolin mechanism modulate molecular docking molecular docking analysis molecular target network pharmacology NOS pathogenic pathway potential molecular predict quercetin R language regulate screened target TCMSP therapeutic target TNF treating COVID-19 Treatment UniProt was performed was used xuebijing injection [DOI] 10.1080/21655979.2021.1933301 PMC 바로가기 [Article Type] Research Article
Identifying the molecular targets and mechanisms of xuebijing injection for the treatment of COVID-19 via network pharmacology and molecular docking네트워크 약리학 및 분자 도킹을 통한 COVID-19의 처리를위한 Xuebijing 주입의 분자 표적 및 메커니즘 식별Research Article Published on 2021-06-022022-08-31 Journal: Bioengineered [Category] 치료제, [키워드] acting affecting AKT1 alleviate baicalein clinical symptom Clinical symptoms connection COVID-19 Cytoscape disease severity enrichment analysis identify identifying IMPROVE indicated Inflammatory response ingredient inhibit injection lipopolysaccharide Luteolin mechanism modulate molecular docking molecular docking analysis molecular target network pharmacology NOS pathogenic pathway potential molecular predict quercetin R language regulate screened STRING target TCMSP therapeutic target therapeutic targets TNF treating COVID-19 Treatment UniProt was performed was used xuebijing injection [DOI] 10.1080/21655979.2021.1933301 PMC 바로가기 [Article Type] Research Article
The important herbal pair for the treatment of COVID-19 and its possible mechanismsResearch Published on 2021-03-032022-11-01 Journal: Chinese Medicine [Category] COVID-19, [키워드] Amygdalus Communis Vas Ephedra sinica Stapf 3CLpro ACE2 activated acute respiratory syndrome ACV affecting Analysis analyzed Apoptosis approach association Association rules B cell can be used Cell Chinese Cluster Combination component components Compound coronavirus COVID-19 curative demonstrated Diseases distribution domain EAS effective Effects enzyme II Ephedra sinica ESS help Herbal Herbal pair HIF-1 highest hypoxia identify IL-1β IL-6 immune responses Inflammatory ingredient interleukin 6 investigated involved kaempferol kinase Luteolin MAPK8 mechanism molecular docking Necrosis network pharmacology NF-kB NLRs novel coronavirus pneumonia oligomerization p65 pathway Pathways potential mechanism potential mechanisms PPI PPI network protein-protein interaction quercetin receptor RELA Result selected shown Stage subunit Support target targets TCM the disease therapeutic effect TLR TNF treating COVID-19 Treatment treatment for COVID-19 [DOI] 10.1186/s13020-021-00427-0 PMC 바로가기 [Article Type] Research
Neuroprotective effects of flavone luteolin in neuroinflammation and neurotraumaReview Published on 2021-03-012023-07-06 Journal: BioFactors (Oxford, England) [Category] SARS, [키워드] blood-brain barrier Luteolin Mast cells Neurodegenerative diseases Neuroinflammation Neurotrauma Tight junction proteins Traumatic brain injury [DOI] 10.1002/biof.1687 [Article Type] Review
Propolis, Bee Honey, and Their Components Protect against Coronavirus Disease 2019 (COVID-19): A Review of In Silico, In Vitro, and Clinical Studies프로폴리스, 꿀벌 꿀 및 그 구성 요소는 코로나바이러스 질병 2019(COVID-19)로부터 보호합니다: In Silico, In Vitro 및 임상 연구에 대한 검토Review Published on 2021-02-252022-09-10 Journal: Molecules [Category] MERS, 임상, 치료제, [키워드] ACE-II activities Anti-inflammatory antioxidant Antiviral antiviral drug Antiviral effect Antiviral treatment bee bee honey bee products caffeic acid clinical Combination component Compound coronavirus disease Coronavirus disease 2019 Coronaviruses COVID -19 COVID-19 cytokine Cytokine storm discharge Effect Effects examined exhibited Express fatality flavonoids green Honey hospital hospitalized COVID-19 patient hospitalized COVID-19 patients host cells immune immunomodulatory in silico in vitro inhibit inhibited less Liposome Luteolin main protease molecular docking/biochemical modeling molecular simulations Mortality naringin natural Nigella Sativa non-structural protein non-structural proteins Prophylactic Propolis randomized clinical trials receiving Remdesivir respiratory review rutin SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome spike glycoprotein standard care Symptom the cytokine storm these compound these compounds Treatment treatment for COVID-19 Treatment outcome Trigger Vero E6 VERO E6 cells Viral viral clearance viral replication viral spike viral-host interaction virulence [DOI] 10.3390/molecules26051232 PMC 바로가기 [Article Type] Review
A network pharmacology based approach for predicting active ingredients and potential mechanism of Lianhuaqingwen capsule in treating COVID-19COVID-19 치료에서 Lianhuaqingwen 캡슐의 활성 성분 및 잠재적 기전을 예측하기 위한 네트워크 약리학 기반 접근 방식Observational Study Published on 2021-02-242022-08-31 Journal: International Journal of Medical Sciences [Category] 임상, 치료제, [키워드] (quercetin 3CL pro Analysis Anti-inflammatory approach binding affinity biological processes caused cell differentiation Chinese chymotrypsin Chymotrypsin-like protease component conducted coronavirus disease Coronavirus disease 2019 COVID-19 docking enrichment analysis GO enrichment analysis Health Host IL-17 immune indicate indicated Infection Inflammatory response ingredient kaempferol KEGG KEGG pathway LianhuaQingwen Lianhuaqingwen capsule Luteolin mechanism modulate network analysis network pharmacology outbreak oxidative stress pathway Pathways pharmacokinetic potential mechanism predicted protease quercetin raised respiratory Respiratory disease respiratory diseases SARS-CoV-2 severe respiratory disease severely ill patient severely ill patients signaling pathway stress reaction target targets TCM Th17 the SARS-CoV-2 therapeutic therapeutic efficacy TNF signaling Traditional Chinese medicine treating COVID-19 with COVID-19 wogonin [DOI] 10.7150/ijms.53685 PMC 바로가기 [Article Type] Observational Study
In Silico Screening of Natural Products Isolated from Mexican Herbal Medicines against COVID-19COVID-19에 대한 멕시코 약초에서 분리된 천연 제품의 실리코 스크리닝Communication Published on 2021-02-042022-08-31 Journal: Biomolecules [Category] MERS, 신약개발, [키워드] (quercetin ADME aesculin Analysis Antiviral compounds appear aucubin chemoinformatics cichoriin Compound coumarin COVID-19 COVID-19 pandemic criteria develop distribution docking docking analysis Drug development emodin Herbal identify in silico Isolated kaempferol life lung Luteolin matricin Medicine metabolism natural natural products novel molecule novel molecules pharmacokinetic pharmacological treatments plants product Protein quercetin Research Safe SARS-CoV-2 SARS-CoV-2 virus Screening tartaric acid the SARS-CoV-2 virus therapeutic Treatment Vaccine [DOI] 10.3390/biom11020216 PMC 바로가기 [Article Type] Communication
Network pharmacology for the identification of phytochemicals in traditional Chinese medicine for COVID-19 that may regulate interleukin-6인터루킨-6을 조절할 수 있는 COVID-19에 대한 중국 전통 의학의 파이토케미컬 식별을 위한 네트워크 약리학Bioinformatics Published on 2021-01-292022-08-31 Journal: Bioscience Reports [Category] 유전자 메커니즘, 치료제, [키워드] analyzed anti-inflammation effect approach approaches binding affinity biological processe biological processes Capsule Chinese collected Compound compounds construction core gene core genes coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment Cytoscape Decoction decrease docking result down-regulate effective evaluate excavation Formula gene cluster gene clusters Granule identify IL-6 indicated ingredient inhibit interleukin-6 Luteolin mechanism molecular molecular docking network network pharmacology pathway Pathways pharmacological positive potential mechanism potential mechanisms Protein–protein interaction quercetin regulate rehabilitation Research rutin screened TCM the binding affinity Traditional Chinese medicine Treatment ursolic acid was used [DOI] 10.1042/BSR20202583 PMC 바로가기 [Article Type] Bioinformatics
Calming the Storm: Natural Immunosuppressants as Adjuvants to Target the Cytokine Storm in COVID-19Pharmacology Published on 2021-01-272022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] absence adjuvant alleviate Antiviral antiviral agent approach ARDS can be used caused chemokine chemokines Combination compounds Consequences COVID-19 COVID-19 pandemic CXCL8 cytokine Cytokine storm disease drug effective G-CSF GM-CSF Health HGF IL-10 IL-12 IL-13 IL-17 IL-1β IL-2 IL-4 IL-6 IL-7 IL-9 immune response Immunomodulatory agents Immunopathogenesis Immunosuppressant individual Infection inhibit inhibitory effect involved IP10 JAK/STAT Luteolin MCP1 morbidity and mortality natural NF-κB pathway Patient piperine plant-derived immunosuppressants Prevent pro-inflammatory cytokine resveratrol SARS-COV-2 infection Sepsis serious complication storm subsequent synergistic target targeting the cytokine storm the SARS-CoV-2 TNFα treat treating COVID-19 Treatment Vaccine while [DOI] 10.3389/fphar.2020.583777 PMC 바로가기 [Article Type] Pharmacology