Genome Scale-Differential Flux Analysis reveals deregulation of lung cell metabolism on SARS-CoV-2 infection게놈 규모-차이 플럭스 분석은 SARS-CoV-2 감염에 대한 폐 세포 대사의 규제 완화를 보여줍니다Research Article Published on 2021-04-092022-09-10 Journal: PLoS Computational Biology [Category] MERS, SARS, 유전자 메커니즘, [키워드] affected alteration Analysis applied arachidonic acid Author bronchial epithelial cell cholesterol conditions COVID-19 pandemic deregulation disease disturbance driving enzyme epithelial cells Fatty acid fatty acid oxidation flux gene-expression growth rate growth rates homeostasis Host host cells human cell identify imperative increasingly infected with SARS-CoV-2 Interaction lead lipid metabolism lung cell macromolecular mechanism metabolic metabolism metabolomics NHBE normal state Numerous pandemic Phosphorylation predict predicted probe protein-protein interaction proteomic reaction Reactions reconstructed reveal SARS-CoV-2 SARS-COV-2 infection therapeutic interventions transcriptomic data Viral protein Viral proteins virus while with COVID-19 [DOI] 10.1371/journal.pcbi.1008860 PMC 바로가기 [Article Type] Research Article
A review on drug repurposing applicable to COVID-19COVID-19에 적용 가능한 약물 용도 변경 검토Review Published on 2021-03-222022-08-31 Journal: Briefings in Bioinformatics [Category] SARS, 신약개발, 치료제, [키워드] AI applied approach approaches artificial intelligence chemical compound chemical compounds Clustering Compound Computational drug coronavirus disease Coronavirus disease 2019 COVID-19 drug Drug repurposing drug-target drugs evaluate identify less macromolecular molecular molecular docking moment network-based approaches new therapies. pandemic Protein target Therapies with COVID-19 [DOI] 10.1093/bib/bbaa288 PMC 바로가기 [Article Type] Review
DeepTracer for fast de novo cryo-EM protein structure modeling and special studies on CoV-related complexes530 Published on 2021-01-122022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] Accuracy Amino acid applied assist automated average cellular and molecular complex complexes Course Coverage cryo-EM de novo deep learning-based method determine disease drugs Efficiency electron explain High-resolution human cell information Interaction macromolecular macromolecule mechanism Microscopy modeling multichain Protein protein complex provide receptors residue robust SARS-CoV-2 viral sequence Significance Structure therapeutic Vaccine [DOI] 10.1073/pnas.2017525118 PMC 바로가기 [Article Type] 530
RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciencesAcademicSubjects/SCI00010 Published on 2021-01-082022-10-31 Journal: Nucleic Acids Research [Category] COVID-19, MERS, [키워드] 3D structure America applied Complete COVID-19 described example feature global pandemic host cell include macromolecular macromolecule Magnetic resonance spectroscopy Microscopy New nuclear Oceania operator PDB Protein Protein Data Bank released Research researchers resource resources SARS-CoV-2 protein Structure [DOI] 10.1093/nar/gkaa1038 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Functional Complexes of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Receptors: Expression in Adult but Not Fetal Lung Tissue안지오텐신 전환 효소 2 및 레닌-안지오텐신 시스템 수용체의 기능적 복합체: 태아 폐 조직이 아닌 성인에서의 발현Article Published on 2020-12-162022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단, [키워드] ACE2 activate acute respiratory syndrome alteration analogy angiotensin Angiotensin II angiotensin receptor Angiotensin-converting enzyme angiotensin-converting enzyme 2 assays binding CAMP CD26 Cell cell entry chemokine Chemokine receptor cleave complexes component Coronaviruses COVID-19 CXCL12 CXCR4 dipeptidyl peptidase Dipeptidyl peptidase-4 downregulation energy transfer enzyme expression fetal G-protein highlight Human human ACE2 Human immunodeficiency virus immunodeficiency virus infect interact Interaction Ligand lung lung tissue Lungs macromolecular Mas receptor MAS1 mechanism membrane mitogen-activated protein kinase organs performed potential therapeutic targets Protein protein kinase RAS receptor receptors Renin renin-angiotensin system respiratory SARS-COV-2 infection SARS-CoV-2 receptor SDF-1 Severe acute respiratory syndrome Signal transduction Signaling System target cell target cells upregulation while [DOI] 10.3390/ijms21249602 PMC 바로가기 [Article Type] Article
The 3.1-Angstrom Cryo-electron Microscopy Structure of the Porcine Epidemic Diarrhea Virus Spike Protein in the Prefusion ConformationStructure and Assembly Published on 2019-09-182022-10-30 Journal: Journal of Virology [Category] Coronavirus, MERS, [키워드] alphacoronavirus spike antigens betacoronaviruses biological processe cause concerning conformation conformational Cryo-electron microscopy cryo-EM described domain effort epidemic diarrhea facilitate glycoprotein glycosylated heterogeneity high mortality rate High-resolution host cells host immune responses IMPROVE in viral Infection information Like macromolecular membrane fusion molecular mechanism N terminus Neonatal NL63 observation other coronaviruses pathogenic PEDV prefusion conformation Receptor binding receptor engagement Receptor-binding domain reveal S protein S1 subunit S1-CTD spike Spike protein Spike proteins Stage Structure subunit the S1 subunit the spike protein These data triggering trimer trimeric spike Vaccine Vaccines virus [DOI] 10.1128/JVI.00923-19 PMC 바로가기 [Article Type] Structure and Assembly
Detection and full genome characterization of two beta CoV viruses related to Middle East respiratory syndrome from bats in ItalyResearch Published on 2017-12-192022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] aa deletion absence Analysis bat bats binding affinity cause cell lines China clade coronavirus CoV detection domain full genome sequencing Genome genome organization Host Human human DPP4 humans infect Ion Isolation Italian Italy macromolecular MERS MERS-CoV MERS-like Beta-CoV viruses Middle East Multiple PDB performed Phylogenetic Phylogenetic and molecular analyses Phylogenetic tree Pipistrellus platform pool positive predicted Protein RBD RBDs receptor Receptor binding domain recorded reported respiratory syndrome coronavirus Result RT-PCR sequence severe disease specificity Surveillance syndrome tested the RBD the S protein Transmission virus was performed [DOI] 10.1186/s12985-017-0907-1 PMC 바로가기 [Article Type] Research
Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and PathogenesisResearch Article Published on 2014-05-012022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] absence accompanied Activation activity acute respiratory distress Affect airway Amino acid ARDS assays ATPase attenuate Cell channel compensatory mutation complexes Concentration correlated Critical cytokine cytosolic death Deletion demonstrated died disease Diseases displaying E gene E protein edema ENCODE envelope eventually death experiment fitness highly pathogenic IL-1β IL-6 in viral induce inducer Infection infections Inflammasome inflammasome activation Inflammatory cytokine Inflammatory response innate immune system Interaction involved Ion ion homeostasis less Level lost weight lung lung damage lung epithelia macromolecular maturation mechanism mice multifunctional protein mutant mutant viruses Mutation outcome Pathogenesis pathology produced progression promote Protein pulmonary damage reduced reducing required respiratory restored SARS-CoV SARS-CoV E SARS-CoV infection sequence severe hypoxemia significantly suppressed survived syndrome therapy this system TNF translated transmembrane protein Transport viral infection virulence virus virus growth virus pathogenesis virus production wild-type [DOI] 10.1371/journal.ppat.1004077 PMC 바로가기 [Article Type] Research Article
The Structure of a Rigorously Conserved RNA Element within the SARS Virus GenomeResearch Article Published on 2005-01-282022-10-28 Journal: PLoS Biology [Category] Coronavirus, [키워드] 3′ end absence Anti-viral approach bind Comparisons component conserved coronavirus element explained extreme feature function Genome homology Host host cell host protein Human genome in viral include Interaction interactions interior ions macromolecular mechanism motif mutable occur pathogen pathogenic Protein protein synthesis reactive related required ribosomal RNA RNA RNA genome RNA genomes SARS virus Sequence conservation Structure target therapeutic agents unique Viral RNA virus [DOI] 10.1371/journal.pbio.0030005 PMC 바로가기 [Article Type] Research Article