Senescence and cancer — role and therapeutic opportunities Reviews Published on 2022-08-312022-10-05 Journal: Nature Reviews Clinical Oncology [Category] 변종, [키워드] anticancer benefit Cancer Cell cell cycle arrest change Clinical findings condition demonstrated Factor function involved macromolecular mechanism outcome Patients with cancer phenotype pro-inflammatory review senescence senescent cell therapeutic therapy translational tumorigenesis [DOI] 10.1038/s41571-022-00668-4 [Article Type] Reviews
Macromolecular Viral Entry Inhibitors as Broad-Spectrum First-Line Antivirals with Activity against SARS-CoV-2SARS-CoV-2에 대한 활성을 갖는 광범위한 1차 항바이러스제로서의 거대분자 바이러스 진입 억제제Article Published on 2022-07-012022-09-11 Journal: Advanced Science [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activity analyzed antiviral activity broad-spectrum antivirals Cell culture cell entry clinical isolates entry inhibitors gold Gold nanoparticle in vitro in vivo inhibitor inhibitors inhibitory activity investigated isolate macromolecular macromolecules mice pathogen Pathogens polyanions quantified respiratory syncytial virus respiratory syncytial virus (RSV). respiratory viral respiratory viruses Result RSV SARS-CoV-2 shown STYRENE sulfonate tested translational variants variants of concern viral cell virus viruses [DOI] 10.1002/advs.202201378 PMC 바로가기 [Article Type] Article
Repurposing benzbromarone as antifolate to develop novel antifungal therapy for Candida albicans벤즈브로마론을 항엽산으로 용도 변경하여 칸디다 알비칸스에 대한 새로운 항진균 요법 개발Article Published on 2022-06-182022-09-11 Journal: Journal of molecular modeling [Category] 신약개발, [키워드] Absorption Antifungal antifungal therapy approach Benzbromarone Biosynthesis Candida Candida albican Candida albicans candidiasis coenzyme complex complications Computational drug COVID-19 COVID-19 patient COVID-19 patients develop DHFR dihydrofolate drug resistance Effect enzyme folate Folic acid followed by fungal Fungal infection fungal infections Human identify Immunocompromised Infection inhibitor involved macromolecular Mild molecular molecular docking Mortality nucleotides Probability problem problems repurposing required responsible resulting Severe infection severe infections symptomatic systemic effect systemic effects tetrahydrofolate therapy toxic effects Treatment Virtual screening White-fungus. [DOI] 10.1007/s00894-022-05185-w PMC 바로가기 [Article Type] Article
Inhalable SARS-CoV-2 Mimetic Particles Induce Pleiotropic Antigen Presentation흡입 가능한 SARS-CoV-2 모방 입자는 다면 발현 항원 제시를 유도합니다Article Published on 2022-03-142022-09-11 Journal: Biomacromolecules [Category] Coronavirus, SARS, 변종, [키워드] alveolar macrophage Alveolar macrophages carrier caused cellular Community Compliance coronavirus coronavirus disease Coronavirus disease 2019 death distribution elicit epithelial cells Evidence feature glycosaminoglycan IgA level immune cells immune response immune responses Immunity immunization in vitro less lung lung epithelial cell Lung epithelial cells macromolecular Macrophage macrophages mice Mimetic mucosa mucosal mutant nucleic acid Particle Pathogenesis peptide plasmids pleiotropic presentation respiratory tract SARS-CoV-2 single dose target the SARS-CoV-2 topography Vaccine Vaccine hesitancy viral antigens virion [DOI] 10.1021/acs.biomac.1c01447 PMC 바로가기 [Article Type] Article
Comparative study of SARS-CoV-2 infection in different cell types: Biophysical-computational approach to the role of potential receptors다양한 세포 유형에서 SARS-CoV-2 감염에 대한 비교 연구: 잠재적 수용체의 역할에 대한 생물물리학적 전산적 접근Article Published on 2022-03-012022-09-12 Journal: Computers in biology and medicine [Category] MERS, SARS, 진단, [키워드] A549 ACE2 addition AGTR2 angiotensin-converting enzyme 2 approach CD147 Cell cell line cell lines Cell susceptibility cellular Comparative conditions dependent on docking early infection expected experiment expression expression level expression levels greater Heat shock HEK293 HepG2 Host host protein HSPA5 Infection Interaction kinetic less Lungs macromolecular Macromolecular crowding membrane NRP1 NTERA-2 parameter predict predicted promote protease Protein Quantitative receptor receptors Research respiratory tract SARS CoV-2 SARS-COV-2 infection serine 2 stimulate susceptibility TMPRSS2 transcriptomic data transmembrane viral dynamics viral growth viral spike Viral spike. virus [DOI] 10.1016/j.compbiomed.2022.105245 PMC 바로가기 [Article Type] Article
Complex Portal 2022: new curation frontiersAcademicSubjects/SCI00010 Published on 2022-01-072022-10-31 Journal: Nucleic Acids Research [Category] Coronavirus, [키워드] added Analysis cofactor Community collaboration complex complexes contributing to coronavirus curated database draft Escherichia coli example feature immune system include macromolecular Organisms portal produced Protein resource reuse Saccharomyces cerevisiae target Topology Transcription user Viral protein Wikidata [DOI] 10.1093/nar/gkab991 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Modeling in the Time of COVID-19: Statistical and Rule-based Mesoscale ModelsArticle Published on 2021-11-182022-10-29 Journal: IEEE transactions on visualization and computer graphics [Category] COVID-19, MERS, [키워드] 3D model applicability approach Characteristics defined determine distribution effort element Evidence geometric information Interaction knowledge macromolecular macromolecules membrane mesoscale modeling Microscopy Model modeling molecular visualization outer membrane Research resulting Spread statistical structures the SARS-CoV-2 time ultrastructure virion virus [DOI] 10.1109/TVCG.2020.3030415 PMC 바로가기 [Article Type] Article
Crocetin and related oxygen diffusion-enhancing compounds: Review of chemical synthesis, pharmacology, clinical development, and novel therapeutic applications크로세틴 및 관련 산소 확산 강화 화합물: 화학 합성, 약리학, 임상 개발 및 새로운 치료 응용 프로그램 검토Review Published on 2021-11-012022-09-11 Journal: Drug development research [Category] 임상, [키워드] among others being Blood Cancer cancers class clinical development clinical investigation clinical trial Complete Compound conditions COVID-19 Crocetin crocin diffusion disease disorders Glioblastoma glioblastoma multiforme Hemorrhagic hemorrhagic shock investigated macromolecular medical need name oxygen oxygen diffusion-enhancing compounds pandemic pharmacological phase potential therapeutic agents radiosensitizer review Shock stroke subject therapeutic therapeutic agent Therapeutic benefit these compound these compounds tissue trans-sodium crocetinate trans-sodium crocetinate. TSC unique [DOI] 10.1002/ddr.21814 PMC 바로가기 [Article Type] Review
Improving sampling of crystallographic disorder in ensemble refinementCcp4 Published on 2021-11-012022-10-27 Journal: Acta crystallographica. Section D [Category] Coronavirus, SARS, [키워드] Affect approach component conformation conformational demonstrated described disorder disorder modelling effective ensemble refinement heterogeneity improvement Improving inherent Local macromolecular macromolecule molecular molecular dynamics physically protease robust shown strained Structure structure refinement structures the SARS-CoV-2 utility [DOI] 10.1107/S2059798321010044 PMC 바로가기 [Article Type] Ccp4
Protein Data Bank Japan: Celebrating our 20th anniversary during a global pandemic as the Asian hub of three dimensional macromolecular structural dataTools for Protein Science Published on 2021-10-272022-10-28 Journal: Protein Science : A Publication of the Protein Soc [Category] COVID-19, MERS, SARS, [키워드] addition Asian BMRB Community complex COVID‐19 COVID‐19 database EMDB global pandemic improvement Japan macromolecular pandemic PDB predicted processed promote Protein Data Bank protein structures Structure unique utility [DOI] 10.1002/pro.4211 PMC 바로가기 [Article Type] Tools for Protein Science