Template-Based Assembly of Proteomic Short Reads For De Novo Antibody Sequencing and Repertoire ProfilingDe Novo 항체 시퀀싱 및 레퍼토리 프로파일링을 위한 Proteomic Short Read의 템플릿 기반 어셈블리Review Published on 2022-07-262022-09-11 Journal: Analytical Chemistry [Category] MERS, 유전자 메커니즘, 진단, [키워드] Accuracy antibody antibody repertoire antibody sequence antibody sequences antigens assembly B-cells cDNA sequencing complementary dataset de novo disease Fab feature fluids foundation functional Health homologous homologous antibody hypermutation IgG information light chains Liquid chromatography mass mass spectrometry molecular monoclonal antibody offer Patient patients hospitalized polyclonal polyclonal antibodies polyclonal antibody Profiling proteomic provide Read Recombination repertoire secreted sequence Sequencing sera serological assays serum step Stitch Urine with COVID-19 [DOI] 10.1021/acs.analchem.2c01300 PMC 바로가기 [Article Type] Review
Immunomodulation of Mesenchymal Stem Cells in Acute Lung Injury: From Preclinical Animal Models to Treatment of Severe COVID-19급성 폐 손상에서 중간엽 줄기 세포의 면역 조절: 전임상 동물 모델에서 중증 COVID-19 치료까지Review Published on 2022-07-252022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animal animal model antiviral properties antiviral property caused Cell Cell therapy clinical trial clinical trials coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cytokine storm highlight immunomodulation immunomodulatory Infection lung Lung injury mass Mesenchymal stem cells Model Mortality MSC MSC therapy MSCs outcome pandemic Pathogenesis patients with COVID-19 potential mechanism potential mechanisms Preclinical public health Reinfection respiratory distress Respiratory distress syndrome risk SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus STEM stem cells syndrome the SARS-CoV-2 tissue repair treat vaccination vaccine breakthrough infection vaccine breakthrough infections Viral variants [DOI] 10.3390/ijms23158196 PMC 바로가기 [Article Type] Review
COVID-19 increases the risk for the onset of atrial fibrillation in hospitalized patientsCOVID-19는 입원 환자의 심방세동 발병 위험을 높입니다Article Published on 2022-07-142022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, 치료법, [키워드] 95% CI Adequate Affect Analysis association Atrial fibrillation atrial flutter Cohort Comorbidities Comorbidity COVID-19 COVID-19 negative COVID-19 positive patient COVID-19 positive patients demographics demonstrated described detect disease electronic medical record electronic medical records eligible for inclusion hospital Hospitalized hospitalized patient hospitalized patients increase increase in increased risk Infection mass morbidity morbidity and mortality multivariable logistic regression myocardial involvement Patient patients patients with COVID-19 PCR test reduce Retrospective study risk risk factor SARS-CoV-2 screened Symptoms Treatment treatment regimen treatment regimens while [DOI] 10.1038/s41598-022-16113-6 PMC 바로가기 [Article Type] Article
Simulation of group testing scenarios can boost COVID-19 screening power그룹 테스트 시나리오의 시뮬레이션은 COVID-19 스크리닝 능력을 높일 수 있습니다Article Published on 2022-07-132022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] affected approach boost COVID-19 COVID-19 dissemination dependent on detect disease Disease prevalence dissemination group health system health systems individual mass mitigate positive individuals power Prevalence quarantine reagents shortage of reagent Simulation solution stages the disease Viral load [DOI] 10.1038/s41598-022-14626-8 PMC 바로가기 [Article Type] Article
Making waves: Wastewater surveillance of SARS-CoV-2 in an endemic future파도 만들기: 풍토병의 미래에 SARS-CoV-2의 폐수 감시Article Published on 2022-07-012022-09-11 Journal: Water research [Category] COVID19(2023년), SARS, 변종, [키워드] attribute attributes changes in circulating Cost-effective COVID-19 COVID-19 pandemic disease disease incidence Endemic epidemiological Epidemiology General population Genome Genome sequencing IMPROVE include Infection Making mass mass surveillance MONITOR Non-invasive pandemic Population population surveillance preparation public health Quantitative reduce SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 variants Spread Surveillance target targets upstream utility vaccination Vaccine variant Viral load viral loads wastewater wastewater surveillance [DOI] 10.1016/j.watres.2022.118535 PMC 바로가기 [Article Type] Article
Genetic Analysis of HPIV3 That Emerged during the SARS-CoV-2 Pandemic in Gwangju, South Korea한국 광주에서 SARS-CoV-2 전염병 동안 출현한 HPIV3의 유전자 분석Article Published on 2022-06-302022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis antigenic Biotechnology caused center Characteristics coding region Collapsing Community continuous monitoring COVID-19 COVID-19 pandemic decrease exhibiting gene sequence Genetic genetic diversity hemagglutinin homology human parainfluenza virus human parainfluenza virus type 3 Immunity India inflow Japan Lineage mass measure neuraminidase Occurrence outbreak pandemic pathogen Pathogens peaked performed Prevalence prevalent reduced Region reported respiratory viral respiratory viruses restriction sequence South Korea Spread strain Strains Surveillance the SARS-CoV-2 virus [DOI] 10.3390/v14071446 PMC 바로가기 [Article Type] Article
Analysis of 4 cases of children with false-positive results of novel coronavirus-specific antibody신종 코로나바이러스 특이항체 위양성 아동 4건 분석Article Published on 2022-06-282022-09-11 Journal: BMC Pediatrics [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] 2019 2019-nCoV 2019-nCoV infection adopted antibodies antibody Antibody detection Capital children Children's Hospital clinical experience clinical manifestations clinical records collected colloidal gold Colloidal gold antibody detection method Coronavirus infection COVID-19 COVID-19 diagnosis detect Diagnosis epidemiological history examination process examined Factor false False-positive false-positive result gold IgG IgG antibodies IgG antibody IgM IgM/IgG interfere mass mass spectrometry nCoV novel Novel coronavirus Novel coronavirus infection nucleic acid nucleic acid test nucleic acid tests outpatient clinic Patient pediatrics plasma Protein serum Serum protein single antibody specific IgM test results tested virus nucleic acid was used Whole blood [DOI] 10.1186/s12887-022-03425-9 PMC 바로가기 [Article Type] Article
Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccineBNT162b2 SARS-CoV-2 RNA 백신에 대한 항원 특이적 반응의 단일 세포 프로파일링Article Published on 2022-06-162022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 진단, [키워드] Antibody Response Antibody responses Antigen B cell BNT162b2 Breakthrough infection CD4 CD8 Cell cell population cells cellular cellular mechanisms Characteristics Cohort Coronaviruses COVID-19 disease COVID-19 disease severity Critical cross-reactivity Cytometry depth analysis disease severity driving Endemic follicular genomic healthy helper cells identify IgA IgG IgM Immunity longitudinal samples lymphocyte mass mechanism memory memory B cell memory B cells participant Participants plasmablasts platform Population progression proteomic receptor Responding response RNA RNA vaccine SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 RNA SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody Sequencing single-cell specific antibodies Spread T cell T cells Vaccine Vaccines [DOI] 10.1038/s41467-022-31142-5 PMC 바로가기 [Article Type] Article
Suspect screening of wastewaters to trace anti-COVID-19 drugs: Potential adverse effects on aquatic environment항-COVID-19 약물 추적을 위한 폐수 의심 스크리닝: 수생 환경에 대한 잠재적인 역효과Article Published on 2022-06-102022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] adverse effect antibiotic Antibiotic resistance Antibiotics antiviral drugs approach Aquatic ecosystems aquatic environment average Azithromycin Care ciprofloxacin Cluster Compound conducted COVID-19 COVID-19 case COVID-19 cases COVID-19 pandemic COVID-19 patients COVID-19 treatment deaths drug drugs Drugs consumption ecological eight Epidemiology European Evidence evidenced Health highest hospital Hydroxychloroquine lack liquid Liquid chromatography list lombardy management mass mass spectrometry metabolite pandemic plants positively correlated Potential protocol receiving Resolution risk SARS-CoV-2 SARS-CoV-2 pandemic Spectrometry starting Suspect screening the SARS-CoV-2 Therapeutic treatment Toxicity Treatment treatment of COVID-19 patients Viral resistance Wastewater-based epidemiology water water bodies water body were measured [DOI] 10.1016/j.scitotenv.2022.153756 PMC 바로가기 [Article Type] Article
Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patientsResearch article Published on 2022-06-072022-10-05 Journal: Immunity [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] accompanied Admission analyzed baseline basophils blood sample cell type changes changes in conserved courses COVID-19 COVID-19 patient Cytometry discharge disease disease resolution element elevated Frequency healthy individual heterogeneous hospital discharge hospitalized COVID-19 patient immune Immune cell immune cell signaling immune response immunological immunological change increases in Infection longitudinal analysis mass outcome pathophysiological Patient patients hospitalized phosphorylated Pneumonia recovery reduced reduction in Regulatory T cell Respiratory failure reveal Sepsis severe SARS-CoV-2 Signaling single-cell T cell trajectory while with COVID-19 [DOI] 10.1016/j.immuni.2022.06.004 [Article Type] Research article