Evaluating the potential for respiratory metagenomics to improve treatment of secondary infection and detection of nosocomial transmission on expanded COVID-19 intensive care units확장된 COVID-19 중환자실에서 2차 감염 치료 및 병원 전파 감지를 개선하기 위한 호흡기 메타유전체학의 잠재력 평가Research Published on 2021-11-172022-09-10 Journal: Genome Medicine [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] 95% CI absence added Antibiotic resistance Antibiotics approach Aspergillus fumigatus Bacterial carried clinical clinical assessment COVID-19 COVID-19 pandemic Critical care Culture detect evaluated Evaluating expansion Genome genomic Genomic surveillance ICU ICUs IMPROVE increased risk Infection infection control infections initial intensive care unit intubated patient Laboratory MDR modify Nanopore nanopore sequencing nosocomial Nosocomial transmission outbreak pathogen pathogen detection Pathogens Patient pneumoniae positive presence or absence provide quantitative PCR reported Research respiratory respiratory sample Respiratory samples Result SARS-CoV-2 pandemic Secondary infection Sequencing sequencing data Seven supplementary material Surveillance translated Transmission Treatment [DOI] 10.1186/s13073-021-00991-y PMC 바로가기 [Article Type] Research
385. SARS-CoV-2 Infections Among Military Personnel Deployed on the USNS COMFORT to New York City During the COVID-19 Pandemic and One-Year Follow-UpPoster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] 95% CI acute respiratory syndrome antibody Antibody testing Asymptomatic blood draw Care Cohort collected community transmission Complete conducted Coronavirus-2 COVID-19 COVID-19 vaccine cumulative Day defined determine enrolled figure Follow-up follow-up period HCW Health Health care worker hospital Hospitalized identify IgG Immunoglobulin incidence Infection majority MDR median New York City nosocomial number occurred PCR PCR positive PCR test PCR testing performed Personal protective equipment positive PPE Prevalence proportion questionnaire Re-infection reported Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike glycoprotein screening swab screening swabs serum subject symptomatic System table Transmission Vaccine [DOI] 10.1093/ofid/ofab466.586 PMC 바로가기 [Article Type] Poster Abstracts
Case Report: Interferon- γ Rescues Monocytic Human Leukocyte Antigen Receptor (mHLA-DR) Function in a COVID-19 Patient With ARDS and Superinfection With Multiple MDR 4MRGN Bacterial StrainsImmunology Published on 2021-11-012022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] Acinetobacter acute respiratory distress adaptive adaptive immune system antibiotic Antigen Antigen presentation ARDS Bacterial bacterial pathogen bloodstream boost carbapenem CD14+ monocyte Cefiderocol Cell Citrobacter complication of COVID-19 complications COVID-19 deficiency described discharge ECMO expressed expression expression level extracorporeal membrane oxygenation FACS analysis function HLA-DR hospital Human identify IFNγ immune Immune cell immune response Immune status immune system Immunity immunological synapse Immunosuppression indicated Infection interferon invasive isolate Klebsiella pneumoniae leukocyte lung MDR mHLA-DR monocyte multidrug-resistant Multiple outcomes Patient Pneumonia pneumoniae positive present antigen profile Pseudomonas aeruginosa rapid increase receptor regimen report rescue risk factor Secondary infection Sepsis septicemia severe immunosuppression severe pneumonia strain suggested superinfection Support suppressed syndrome the patient therapeutic therapy [DOI] 10.3389/fimmu.2021.753849 PMC 바로가기 [Article Type] Immunology
Characterization of a pESI-like plasmid and analysis of multidrug-resistant Salmonella enterica Infantis isolates in England and WalespESI 유사 플라스미드의 특성화 및 영국과 웨일스에서의 다제내성 Salmonella enterica Infantis 분리주 분석Article Published on 2021-10-142024-07-29 Journal: Microbial Genomics [Category] 살모넬라증, [키워드] bla CTX-M-65 S. Infantis ESBL MDR pESI and pESI-like plasmids [DOI] 10.1099/mgen.0.000658 PMC 바로가기
Bacterial and fungal ventilator associated pneumonia in critically ill COVID-19 patients during the second wave2차 유행 동안 중환자 COVID-19 환자의 박테리아 및 곰팡이 인공 호흡기 관련 폐렴Article Published on 2021-10-012022-09-11 Journal: Journal of infection and public health [Category] SARS, 치료기술, [키워드] 95% CI 95% confidence interval Acinetobacter admitted to ICU antimicrobial antimicrobial resistance antimicrobial susceptibility Aspergillus Bacteria Bacterial Bacterial infections Candida caused Chest collected coronavirus disease Corticosteroid Corticosteroids COVID-19 COVID-19 patient Critical Critically ill critically ill COVID-19 patients Culture diabetes Diabetes Mellitus diagnosed disease element followed by fungal fungi Hypothyroidism ICUs identify intensive care unit intensive care units isolate isolates Klebsiella pneumoniae MDR mechanical ventilation Mucor multi outcomes pandemic Patient PDR Pneumonia pneumoniae positive respiratory Respiratory samples risk factor Risk factors SARS-CoV2 second wave specimen specimens subsequent susceptibility Tocilizumab Treatment VAP ventilator Ventilator associated pneumonia [DOI] 10.1016/j.jiph.2021.08.003 PMC 바로가기 [Article Type] Article
Multi-Drug Resistance Bacterial Infections in Critically Ill Patients Admitted with COVID-19Review Published on 2021-08-202022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] 95% CI adjust affected affecting antimicrobial drug Antimicrobial therapy Bacterial bacterial co-infection Bacterial infection Co-infection concomitant increase contributed coronavirus disease COVID-19 COVID-19 outbreak COVID-19 patient Critically ill Critically ill patient critically ill patients Culture death higher risk hospital Hospital acquired infection Hospital stay Hospitalization hospitalized patients ICU ICU admission Ill incidence Infection infections Influenza Invasive mechanical ventilation majority MDR morbidity and mortality MOST multi-drug resistance pathogen Patient performed Prevalence profile reported resistance retrospective risk factor SARS-CoV-2 Secondary bacterial infections Secondary infection therapy Ventilated viral respiratory with COVID-19 [DOI] 10.3390/microorganisms9081773 PMC 바로가기 [Article Type] Review
Secondary bacterial infections and antimicrobial resistance in COVID-19: comparative evaluation of pre-pandemic and pandemic-era, a retrospective single center studyResearch Published on 2021-08-052022-10-28 Journal: Annals of Clinical Microbiology and Antimicrobials [Category] COVID-19, MERS, [키워드] Acinetobacter analyzed antimicrobial resistance bacterial co-infection Bacterial infection Bacterial infections bacterial pathogen Co-infections collected Comparisons control group COVID-19 COVID-19 diagnosed patient COVID-19 group COVID-19 patient COVID-19 patients Culture database Epidemiology evaluate evaluated Frequency MDR multidrug-resistant pandemic pandemic era pathogen Patient patients died patients with COVID-19 positive reported respiratory infection Result retrospective secondary secondary bacterial infection Secondary bacterial infections significant decrease significantly higher single center supplementary material university while [DOI] 10.1186/s12941-021-00454-7 PMC 바로가기 [Article Type] Research
Biodegradable Nanofibrous Membranes for Medical and Personal Protection Applications: Manufacturing, Anti-COVID-19 and Anti-Multidrug Resistant Bacteria EvaluationArticle Published on 2021-07-102022-10-30 Journal: Materials [Category] COVID-19, [키워드] activity alcohol analogues anti-COVID-19 nanofibers anti-multi-drug resistant bacterial nanofibers antimicrobial agent Antiviral antiviral action antiviral agent average Bacteria Bacterial biodegradable nanofibrous membrane changed characterized Compound Concentration condition Contact COVID-19 Effectiveness equipment evaluated fiber homogenous Hydrogen bond hydrophobic MDR membrane Microscope Morphological morphological changes multi-drug resistant protection PVA-ZnO or -CuO nanohybrids Resistant rupture SEM Strains Structure tested variety Viral proteins [DOI] 10.3390/ma14143862 PMC 바로가기 [Article Type] Article
Imaging Enterobacterales infections in patients using pathogen-specific positron emission tomographyArticle Published on 2021-05-072022-11-01 Journal: Science Translational Medicine [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Analysis antibiotic Bacteria bacterial pathogen cartridge Clinical improvement Complication conserved coronavirus death decrease demonstrated detect Efficacy enrolled facilitate hospitalized patient Human imaging in vitro Infection infections Inflammation isolates Klebsiella pneumoniae lesions MDR microbiologically multidrug-resistant murine models noninvasive occur pathogen pathogen-specific Pathogens pathology pathway Patient pet PET/CT Pneumonia Repeat responsible resulting Safe SARS-CoV-2 Sepsis specificity Strains Support temperature tomography with COVID-19 [DOI] 10.1126/scitranslmed.abe9805 PMC 바로가기 [Article Type] Article
The Building Blocks of Antimicrobial Resistance in Pseudomonas aeruginosa : Implications for Current Resistance-Breaking Therapies녹농균(Pseudomonas aeruginosa)의 항생제 내성 빌딩 블록: 현재 내성 파괴 요법에 대한 시사점Review Published on 2021-04-162022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 유전자 메커니즘, [키워드] accelerate acquired resistance adaptive addition adjuvant adjuvant therapies adjuvant therapy antibiotic Antibiotic treatment Antibiotics antimicrobial antimicrobial resistance (AMR) Antimicrobials arsenal bacterial cell Bacterial infection block blocks building causative agent contributing to COVID-19 pandemic current cystic fibrosis described drug effectors fibrosis focus genetic disease handling Hospitalized Host immune Infectious disease Infectious diseases Innovation lead lung Lungs majority MDR morbidity morbidity and mortality multidrug resistant multidrug-resistance (MDR) multidrug-resistant nosocomial P. aeruginosa pathogen Pathogens penetration predicted Prolonged Pseudomonas aeruginosa recent reduce resistance resistance mechanism resistance mechanism interplay resistance mechanisms resistance-breaking therapy SARS-CoV2 infection secondary bacterial infection selective selective pressure selective pressures Spread Strains target targets therapeutic agents therapy Threats widespread World Health Organisation [DOI] 10.3389/fcimb.2021.665759 PMC 바로가기 [Article Type] Review