Immunological investigation of a multiepitope peptide vaccine candidate based on main proteins of SARS-CoV-2 pathogenSARS-CoV-2 병원체의 주요 단백질에 기반한 다중 에피토프 펩타이드 백신 후보의 면역학적 조사Article Published on 2022-06-092022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] antigenic Cell complex cytotoxic T lymphocyte develop DNA E. coli Epitopes eukaryotic evaluated expression expression vectors granzyme granzyme B groups helper T lymphocyte Heterologous homologous IFN-γ IgG IgG2a IL-15 IL-21 IL-6 immune response immune responses Immunity immunized in silico in vitro in vivo indicated induce linear B linear B lymphocyte lymphocyte mammalian cell membrane protein mice multiepitope peptide vaccine multiepitope vaccine Multiepitope vaccines nucleocapsid Nucleocapsid phosphoprotein pathogen Pathogens pcDNA3.1 Penetrating peptide produced Protein regimen regimens SARS-CoV-2 SARS-COV-2 infection secretion significantly spike glycoprotein stimulated subcloned T lymphocyte target targets TNF-α Vaccine vaccine candidate variants were used [DOI] 10.1371/journal.pone.0268251 PMC 바로가기 [Article Type] Article
Computational study and design of effective siRNAs to silence structural proteins associated genes of Indian SARS-CoV-2 strains인도 SARS-CoV-2 균주의 구조 단백질 관련 유전자를 침묵시키는 효과적인 siRNA의 계산 연구 및 설계Article Published on 2022-06-012022-09-11 Journal: Computational biology and chemistry [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] absence acute respiratory disease Ago2 Algorithm animal models antiviral drug antiviral drugs Antiviral treatment binding candidate collected complementary Consensus COVID-19 deaths docking Effect effective envelope protein feature free energy GC content gene silencing Genes Genome Health Organization heat capacity Human Human genome in vitro in vivo India melting temperature membrane protein molecular docking analysis nucleic acid nucleocapsid nucleotide nucleotides outbreak pandemic parameter pathogenic coronavirus pathway Post-transcriptional gene silencing Protein public health Region reported Respiratory disease RNA RNA interference RNAi SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains selected sequence sequenced siRNA siRNA molecule siRNA molecules siRNAs structural protein structural proteins Surface glycoprotein target target gene target mRNA temperature Therapeutic treatment triggered viral pathogenesis WHO World Health Organization [DOI] 10.1016/j.compbiolchem.2022.107687 PMC 바로가기 [Article Type] Article
High-resolution analysis of long-term serum antibodies in humans following convalescence of SARS-CoV-2 infectionSARS-CoV-2 감염 회복 후 인간의 장기 혈청 항체에 대한 고해상도 분석Article Published on 2022-05-312022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 진단, 치료법, [키워드] Accuracy aligned Analysis antibody Antibody Response antibody tests Antibody titer Antibody titers binding site Biomarker Blood Complete contribute convalescent serum COVID-19 diagnostic Diagnostic accuracy domain dominant epitope epitope Epitopes evaluated full-length full-length spike protein high-density Human identify Immunity Infection maintenance membrane protein neutralize nucleoprotein peptide peptide microarray polyclonal antibodies polyclonal antibody Previous studies previous study proteome provide reactivity Region representing resolved response SARS-CoV-2 SARS-COV-2 infection serological serum antibodies serum antibody spike epitope spike epitopes Spike protein Viral [DOI] 10.1038/s41598-022-12032-8 PMC 바로가기 [Article Type] Article
Characterization of the Interaction Between SARS-CoV-2 Membrane Protein (M) and Proliferating Cell Nuclear Antigen (PCNA) as a Potential Therapeutic Target잠재적 치료 표적으로서 SARS-COV-2 막 단백질 (M)과 증식 세포 핵 항원 (PCNA) 사이의 상호 작용의 특성화Article Published on 2022-05-232022-08-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] addition association Cell characterization Coronaviridae family COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 therapy cytoplasm DNA DNA damage DNA replication expression function immunofluorescence immunohistochemistry immunoprecipitation in vitro increase in infected with SARS-CoV-2 Interaction ligation Localization lung M protein marker membrane protein nucleus PCNA Potential reduction repair reported responsible SARS-CoV-2 target the Coronaviridae therapy transfected with translocation Transport Verdinexor viral-host interaction virion virus [DOI] 10.3389/fcimb.2022.849017 PMC 바로가기 [Article Type] Article
Bacteria-enabled oral delivery of a replicon-based mRNA vaccine candidate protects against ancestral and delta variant SARS-CoV-2레플리콘 기반 mRNA 백신 후보의 박테리아 지원 경구 전달은 조상 및 델타 변이형 SARS-CoV-2로부터 보호Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alphaviruses antibody antigenic diversity B.1.617.2 Bacteria Cellular immune response cellular immune responses clade contributed contributing to Coronavirus-2 COVID-19 cross-protective domain Efficacy epitope Epitopes Evolution feasible forest gene delivery hamster hamsters heptad repeat immune responses immunization immunized immunized mice Immunoglobulin lung Lungs mass vaccination membrane protein mRNA mRNA vaccine mucosal mucosal vaccine NAbs nasal Nasal cavity Neutralizing antibodies neutralizing antibody non-structural protein nsp13 offer oral Oral Immunization oral route Pneumonia principle PROTECT provide RBD Receptor binding domain recorded replicon-based respiratory Salmonella Salmonella-mediated SARS-CoV-2 secretory IgA SIgA the vaccine vaccination Vaccine vaccine efficacy variant variants Viral viral replication virus [DOI] 10.1016/j.ymthe.2022.01.042 PMC 바로가기 [Article Type] Article
Structure and dynamics of the SARS-CoV-2 envelope protein monomerArticle Published on 2022-05-012023-07-08 Journal: Proteins [Category] COVID19(2023년), [키워드] envelope protein glycosylation membrane curvature membrane protein molecular dynamics palmitoylation SARS-CoV-2 [DOI] 10.1002/prot.26317
Angiotensin-converting enzyme 2 (ACE2): Two decades of revelations and re-evaluation안지오텐신 전환 효소 2(ACE2): 20년 간의 폭로와 재평가Review Published on 2022-05-012022-09-11 Journal: Peptides [Category] Coronavirus, COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE ACE2 acting Amino acid amyloid angiotensin Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme-2 binding cardiovascular caused cell membrane cell type conversion coronavirus counterbalance COVID COVID-19 pandemic driving ectoenzyme enzyme event expressed Factor homology implicated Inflammatory mechanisms membrane protein neprilysin pathological conditions Pathologies pathology Pathways peptide peptides physiological producing Protective provide provided receptor regulate Renin renin-angiotensin system sACE2 SARS SARS virus SARS-CoV2 specificity susceptibility therapeutic target Transport Treatment Vascular Vasoactive Vasopeptidase. virus Zinc [DOI] 10.1016/j.peptides.2022.170766 PMC 바로가기 [Article Type] Review
Mitoxantrone modulates a heparan sulfate-spike complex to inhibit SARS-CoV-2 infection Research Published on 2022-04-192022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] activity addition Breakthrough infection Cell complex COVID-19 DNA topoisomerase downstream entry of SARS-CoV-2 expression profiling facilitate human airway epithelial human lung in viral Infection inhibit inhibit SARS-CoV-2 inhibitor interact Interaction membrane protein modulate offer overcome plasma membrane Post-vaccine promote Protein receptor receptors reduced SARS-CoV-2 strain Support target the SARS-CoV-2 therapeutic target therapy tissues viral entry [DOI] 10.1038/s41598-022-10293-x [Article Type] Research
Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry게놈 전체에 걸친 CRISPR 활성화 스크린은 SARS-CoV-2 진입에 대한 후보 수용체를 식별합니다Article Published on 2022-04-012022-09-11 Journal: Science China. Life sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 Activation caused CLEC4G components coronavirus disease Coronavirus disease 2019 COVID-19 CRISPR CRISPRa screen Entry mechanism entry mechanisms Factor functional receptor functional receptors Health Health crisis Host host proteins identify infect Infection LDLRAD3 liver cells membrane protein Membrane proteins Multiorgan N-terminal domain novel receptors. NRP1 NTD outbreak Pathways performed physiological receptor receptor ACE2 receptors SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection tissue tissues TMEM30A TMPRSS2 tropism of SARS-CoV-2 variety viral entry [DOI] 10.1007/s11427-021-1990-5 PMC 바로가기 [Article Type] Article
Antiviral activity of traditional medicinal plants from Ayurveda against SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 아유르베다 전통 약용 식물의 항바이러스 활성Article Published on 2022-03-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] ACE2 ACE2 receptor amarogentin Analysis angiotensin Antiviral antiviral activity antiviral role apoptotic pathway approach attachment inhibitor Ayurveda belladonnine COVID-19 criteria demonstrated disease drug design drug-likeness drug-target interaction Drug-target interactions Efficacy etiological agent G-protein gene network gene network analysis highest affinity Host membrane protein MOST Necrosis network analysis nuclear parameter pathway Pathways pharmacokinetic pharmacokinetics Phosphorylation plant positive potential therapy predicted Protein protein kinase Protein kinase B receptor Regulation responsible SARS-CoV-2 SARS-COV-2 infection secretion Serine Signaling spike glycoprotein Structure-based drug design suggested target target prediction. Toxicity Transport Tumor tumor necrosis tumor necrosis factor Vaccine was performed [DOI] 10.1080/07391102.2020.1832577 PMC 바로가기 [Article Type] Article