Metadichol®: A Novel Nanolipid Formulation That Inhibits SARS-CoV-2 and a Multitude of Pathological Viruses In VitroResearch Article Published on 2022-01-152022-10-27 Journal: BioMed Research International [Category] Coronavirus, COVID-19, SARS, [키워드] ACE ACE2 acute respiratory syndrome alcohols approach Bacteria Caco-2 cell Camostat mesylate Chloroquine coronavirus Critical demonstrated develop entry of SARS-CoV-2 Formulation host cell host cells human host cells Increasing Infection inhibit inhibitor Interaction mechanism membranes multitude Naturally novel outbreak pandemic pathogenic virus pathological performed plasma membrane proliferation promoted receptor ACE2 reduce Remdesivir SARS-CoV-2 SARS-CoV-2 replication saturated serine protease TMPRSS2 Spread time-consuming TMPRSS2 Vaccines viral infectivity viral S protein virus [DOI] 10.1155/2022/1558860 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterol-increased endosomal pH of alveolar macrophagesACE2 발현 미립자에 의한 SARS-CoV-2 치료 효과는 폐포 대식세포의 산화된 콜레스테롤 증가 엔도솜 pH로 설명Article Published on 2022-01-042022-09-12 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] A549 addition Administered alveolar macrophage Alveolar macrophages anatomical cell-derived microparticle cholesterol cross-talk decrease Degradation Effect Efficacy emerging respiratory virus Endosomal acidification endosomal pH Endosomes explained feasibility feature highlight immune system impairing inhibit lung lysosomal lysosome Lysosomes membranes Microparticle microparticles oxidized phenotype proinflammatory Regulation SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 treatment SARS-CoV-2-infected patient Side effects therapeutic therapy translocated treat Treatment viral infection [DOI] 10.1038/s41423-021-00813-6 PMC 바로가기 [Article Type] Article
A SARS-CoV-2 Delta Variant Case Manifesting as Extensive Placental Infection and Fetal TransmissionArticle Published on 2022-01-012022-11-15 Journal: Gynecologic and obstetric investigation [Category] SARS, 변종, 치료기술, [키워드] analyzed Apoptosis B.1.167.2 Cell COVID-19 Delta delta variant determine dominant exhibited Extensive Ferroptosis fetal fixed higher infectivity Infection membrane membranes mother Mutation Necrosis Placenta placental Placental infection placental tissue positive Pregnancy Premature Probability receptor-binding motif rupture SAR-CoV-2 SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection Spike protein tested Transmission umbilical variant Vascular endothelium vertical transmission Viral RNA with COVID-19 [DOI] 10.1159/000524905 PMC 바로가기
Lateral Flow Immunoassay of SARS-CoV-2 Antigen with SERS-Based Registration: Development and Comparison with Traditional ImmunoassaysSERS 기반 등록을 갖는 SARS-COV-2 항원의 측면 흐름 면역 분석 : 전통적인 면역 분석법과의 개발 및 비교Comparative Study Published on 2021-12-102022-09-01 Journal: Biosensors [Category] 진단, 치료기술, [키워드] Analysis antibody Antigen binding causative agent characterized COVID-19 COVID-19 pandemic Detection limit development disadvantage Effect ELISA ENhance enzyme-linked immunosorbent enzyme-linked immunosorbent assay Flow gold Gold nanoparticle immune immunoassay immunoassays immunochemical immunochromatography include Laboratory Lateral lateral flow immunoassay LFIA membrane membranes nucleic acid nucleic acid amplification pathogen detection promise Raman spectra reagents SARS-CoV-2 scattering sensitivity specific antigen spike receptor-binding domain surface antigen test strips Traditional were used [DOI] 10.3390/bios11120510 PMC 바로가기 [Article Type] Comparative Study
Detection of SARS-CoV-2 in biological samples of pregnant women infected with COVID-19: A prospective cross-sectional studyCOVID-19에 감염된 임산부의 생물학적 샘플에서 SARS-CoV-2 검출: 전향적 횡단면 연구Article Published on 2021-12-012022-09-11 Journal: International journal of gynaecology and obstetric [Category] SARS, 치료기술, [키워드] amniotic Amniotic fluid biological sample biological samples Blood breastmilk Cord blood COVID-19 cross-sectional detection membranes placental pregnant women SARS-CoV-2 SARS‐CoV‐2 Transmission vertical transmission [DOI] 10.1002/ijgo.13928 PMC 바로가기 [Article Type] Article
Interaction of Spike protein and lipid membrane of SARS-CoV-2 with Ursodeoxycholic acid, an in-silico analysisArticle Published on 2021-11-152022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 신약개발, [키워드] acid addition Alpha Analysis cholesterol Cluster Computational biology and bioinformatics decrease drug Drug development Dynamics evaluated exhibit form gallstone heptad repeat higher affinity host cell Hydrogen bond in-silico interact Interaction membrane membranes molecular docking monomer Numerous Physicochemical properties prefusion Protein protein sequences random reduce reduction in Region remained residue RMSD RMSF SARS-CoV-2 SARS-COV-2 infection severity shown spike tension the SARS-CoV-2 the Spike trajectory treat Ursodeoxycholic acid Viral hepatitis was performed [DOI] 10.1038/s41598-021-01705-5 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Infection in Pregnancy: Clinical Signs, Placental Pathology, and Neonatal Outcome—Implications for Clinical CareMedicine Published on 2021-11-082022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] analyzed Asymptomatic chronic histiocytic intervillositis clinical Clinical sign correlation COVID-19 pandemic demonstrated Effect evaluated examined fetal Frequency histopathological Injury latency lesion membranes morbidity morphology Mortality MOST Neonatal Neonate outcome outcomes pathogen performed Placenta placental placental tissue positive Pregnancy pregnant women risk risk of infection SARS-CoV-2 SARS-COV-2 infection significant difference Symptoms the SARS-CoV-2 virus tissue Transmission transplacental transmission of viruses Vascular women [DOI] 10.3389/fmed.2021.676870 PMC 바로가기 [Article Type] Medicine
Diosmectite inhibits the interaction between SARS-CoV-2 and human enterocytes by trapping viral particles, thereby preventing NF-kappaB activation and CXCL10 secretionArticle Published on 2021-11-052022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] ACE2 ACE2 receptor Activation analyzed angiotensin-converting enzyme 2 anti-inflammatory property binding Caco-2 Caco-2 cell Cell cells component COVID-19 management protocols CXCL10 diarrhea Diosmectite domain downstream Effect Effects ELISA Enterocyte Evidence gastroenterology Gastrointestinal models gastrointestinal system heat-inactivated immunofluorescence Inflammation inhibit inhibited Interaction intestine limit management membranes nuclear Pathogenesis pathogenic patients Prevent public health RBD receptor SARS-CoV-2 secretion Spike protein Symptom tested the spike protein Trapping Treatment Viral particles viral spread virus [DOI] 10.1038/s41598-021-01217-2 PMC 바로가기 [Article Type] Article
The Rare Case of a COVID-19 Pregnant Patient with Quadruplets and Postpartum Severe Pneumonia. Case Report and Review of the LiteratureCase Report Published on 2021-11-012022-10-30 Journal: Medicina [Category] COVID-19, MERS, SARS, [키워드] Admission anesthesiologists Antiviral treatment APGAR score association changes childhood clinical COVID-19 COVID19 Deterioration Diagnosis Evolution Follow-up gestation Gynecology ICU infection with COVID-19 Infectious disease intensive care Intervention knowledge literature managing material membranes moderate multiple pregnancy neonatology Newborn objective paroxysmal Patient performed Pneumonia Postpartum postpartum pneumonia Pregnancy Premature Prognosis Quadruplet report Respiratory Support resulting review Romania septal specific treatment supraventricular Tachycardia the patient Tocolysis took place transferred treatment for COVID-19 with COVID-19 [DOI] 10.3390/medicina57111186 PMC 바로가기 [Article Type] Case Report
SARS-CoV-2 S1 Protein Induces Endolysosome Dysfunction and Neuritic DystrophyCellular Neuroscience Published on 2021-10-272022-10-31 Journal: Frontiers in Cellular Neuroscience [Category] COVID-19, [키워드] Brain Cell contribute cortical COVID-19 pandemic cross Dystrophy endocytosis endolysosomal acidification endolysosome Hypothesis incidence Incubation induce Injury lysosome membranes morphology neuritic dystrophy Neurological disorder Neuron neuronal neurons Pathogenesis released reported SARS-CoV-2 SARS-CoV-2 S1 SARS-CoV-2 S1 protein specimens tested the S1 protein undetectable with COVID-19 [DOI] 10.3389/fncel.2021.777738 PMC 바로가기 [Article Type] Cellular Neuroscience