A novel LC-MS/MS method for determination of the potential antiviral candidate favipiravir for the emergency treatment of SARS-CoV-2 virus in human plasma: Application to a bioequivalence study in Egyptian human volunteers인간 혈장에서 SARS-CoV-2 바이러스의 긴급 치료를 위한 잠재적인 항바이러스 후보 favipiravir의 결정을 위한 새로운 LC-MS/MS 방법: 이집트 인간 지원자의 생물학적 동등성 연구에 적용Article Published on 2021-05-302022-09-11 Journal: Journal of pharmaceutical and biomedical analysis [Category] SARS, 치료제, [키워드] acetic acetic acid adopted Antiviral antiviral agent application applied bioanalysis Bioequivalence Bioequivalence study composed Concentration COVID-19 Eclipse electrospray ionization Favipiravir flow rate healthy Human Human plasma isocratic LC–MS/MS Linear regression linearity m/z mass spectrometer methanol pharmacokinetic plasma sample positive protein precipitation pumped pyrazinamide quantification SARS-CoV-2 SARS-CoV-2 virus simple Treatment US-FDA Volunteer volunteers was used [DOI] 10.1016/j.jpba.2021.114057 PMC 바로가기 [Article Type] Article
Phytoconstituents, In Vitro Anti-Infective Activity of Buddleja indica Lam., and In Silico Evaluation of its SARS-CoV-2 Inhibitory PotentialPharmacology Published on 2021-04-122022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Buddleia indica 3CL pro active site active sites activity antimicrobial Antiviral antiviral activity Bacillus subtilis Buddleja caffeic acid comparable Compound consolidation COVID-19 COVID-19 pandemic dihydrofolate dose exhibited glucoside Helicobacter pylori herpes simplex highest HSV-1 Isolation kaempferol methanol molecular docking Molecular modeling notable phytochemical Phytoconstituents Potential Pro quercetin Safe SARS-CoV-2 Scrophulariaceae susceptible vesicular stomatitis viral replication virus VSV [DOI] 10.3389/fphar.2021.619373 PMC 바로가기 [Article Type] Pharmacology
Temperament and character of patients with alcohol toxicity during COVID − 19 pandemicResearch Article Published on 2021-01-202022-10-27 Journal: BMC Psychiatry [Category] Coronavirus, MERS, [키워드] Affect age alcohol conducted control group cooperativeness Corona virus correlation COVID COVID-19 COVID-19 pandemic demographic disorders Epidemic exhibited Factor females group Health Iran likelihood male mean score mental health methanol not significantly different pandemic participant Patient persistence physical problem question questionnaire Randomly reactive Result seeking selected shown temperament Temperament and character Toxicity trauma [DOI] 10.1186/s12888-021-03052-1 PMC 바로가기 [Article Type] Research Article
In vitro Dissolution Profile at Different Biological pH Conditions of Hydroxychloroquine Sulfate Tablets Is Available for the Treatment of COVID-19Molecular Biosciences Published on 2021-01-142022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] absorbance Acetate Agilent antimalarial applied Autoimmune diseases Biological buffer Concentration condition coronavirus Coronavirus disease 2019 COVID-19 DAD detection dissolution evaluate experiments globe harmonization HCl HCQ Hydroxychloroquine hydroxychloroquine sulfate ICH in vitro injection International Conference linear methanol parameter pH phosphate buffer Precision profile purified R 2 rheumatoid arthritis specificity Standard deviation sulfate sulfonic acid tablets Treatment validation Volume [DOI] 10.3389/fmolb.2020.613393 PMC 바로가기 [Article Type] Molecular Biosciences
Atypical presentation of COVID-19; an observational retrospective studyObservational Study Published on 2020-11-232022-10-04 Journal: BMC Infectious Diseases [Category] SARS, 임상, [키워드] age alcohols Atypical clinical presentation COVID-19 COVID-19 infection database diagnosis of COVID-19 died Dyspnea evaluate evaluated False negative feature Final Glasgow coma scale Health care worker healthy hospital Infection Inpatient Invasive mechanical ventilation Iran male methanol Patient PCR PCRs polymerase chain positive positive COVID-19 presenting symptoms respiratory symptoms Result Retrospective study signs Symptom Symptoms Tehran were excluded [DOI] 10.1186/s12879-020-05617-z PMC 바로가기 [Article Type] Observational Study
Diagnosis of COVID-19 by analysis of breath with gas chromatography-ion mobility spectrometry – a feasibility studyResearch article Published on 2020-10-242022-10-05 Journal: EClinicalMedicine [Category] 바이오마커, [키워드] 95% CI Accuracy acetone Aldehydes Analysis approach Asthma AUROC Bacterial breath Breath-analysis Breath-testing career Cohort Compound condition conditions Contact COPD COVID-19 COVID-19 diagnostics COVID-19 infection development diagnose Diagnosis diagnosis of COVID-19 differentiation Dortmund Edinburgh Effects Endemic ethanal feasibility finding flu funding Gas chromatography-ion mobility spectrometry GC-IMS Germany health-care healthcare hospital identity Inflammatory Influenza ketones Laboratory marker methanol Multi-variate analysis Multivariate analysis NHS Non-COVID-19 Other participant Patient patients with COVID-19 Pneumonia polymerase chain predictive power prevalence study PROTECT qPCR recruited sensitivity specificity Support supported Swab tested Transcription university VoC with COVID-19 [DOI] 10.1016/j.eclinm.2020.100609 [Article Type] Research article
Qualitative and Quantitative Analysis of Ukrainian Iris Species: A Fresh Look on Their Antioxidant Content and Biological ActivitiesArticle Published on 2020-10-082022-10-30 Journal: Molecules [Category] Coronavirus, MERS, [키워드] Iris rhizomes 229E activity Analysis analyzed anti-allergic Anti-inflammatory anti-inflammatory activity antioxidant Biological caffeic acid Cancer cells Compound compounds content coronavirus 229E cytotoxic cytotoxic effect demonstrated evaluated examined exhibited expression Fresh gallic acid group highest HPLC-ABTS HPLC-DAD human neutrophils IRIS Iris sibirica limit marker methanol Nrf2 Phenolic compounds Qualitative quantification Quantitative standard reference UPLC–MS/MS [DOI] 10.3390/molecules25194588 PMC 바로가기 [Article Type] Article
Electrocardiographic findings of methanol toxicity: a cross-sectional study of 356 cases in IranResearch Article Published on 2020-09-142022-10-27 Journal: BMC Public Health [Category] Coronavirus, SARS, [키워드] adjusted Analysis blindness Blood Clinical finding collected concerning confounding factor correlated COVID-19 pandemic creatinine cross-sectional ECG electrocardiographic Electrolytes Factor females independent Infarction Iran knowledge lab male methanol Methanol toxicity Myocardial infarction Odds ratio outbreak QTC prolongation reported Result Science severity Tachycardia Tertiary Toxicity university Variation [DOI] 10.1186/s12872-020-01691-y PMC 바로가기 [Article Type] Research Article
Methods of Inactivation of SARS-CoV-2 for Downstream Biological AssaysMajor Article Published on 2020-08-152022-10-29 Journal: The Journal of Infectious Diseases [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Biological cells coronavirus coronavirus disease COVID-19 detergents disease downstream effective strategy experiments facilitate heat inactivated inactivation Incubation infected cell infectious sample methanol pandemic paraformaldehyde protocol reagent reagents reduce Research researcher Safe SARS-CoV-2 SARS-CoV-2 research Scientific community temperature tested transfer Trizol virus [DOI] 10.1093/infdis/jiaa507 PMC 바로가기 [Article Type] Major Article
Potential methanol toxicity and the importance of using a standardised alcohol-based hand rub formulation in the era of COVID-19Short Report Published on 2020-08-082022-10-28 Journal: Antimicrobial Resistance and Infection Control [Category] Coronavirus, MERS, [키워드] Alcohol-based-hand-rubs COVID-19 explain hand highlight ingestion methanol Methanol toxicity methylated objective Potential producing SARS-CoV-2 the WHO Toxicity WHO [DOI] 10.1186/s13756-020-00788-5 PMC 바로가기 [Article Type] Short Report