Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16 †Chemistry Published on 2021-10-062022-10-29 Journal: RSC Chemical Biology [Category] COVID-19, [키워드] activities affinity analogue applied binding complex conserved Coronavirus infections develop drug drug design enzyme exhibiting experiment Health identification identify increasingly inhibit Interaction Intervention less Ligand methyltransferase nsp14 Proofreading Protein Replication reveal RNA SARS-CoV-2 Small molecules starting point Vaccine viral replication were used X-ray crystallography [DOI] 10.1039/d1cb00135c PMC 바로가기 [Article Type] Chemistry
Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate InhibitorsSAM 경쟁 억제제를 사용한 시험관 내 SARS-CoV-2 Nsp14의 SAM 결합 부위 조사 선택적 이중 기질 억제제 개발 가이드Article Published on 2021-10-012022-09-11 Journal: SLAS discovery : advancing life sciences R & D [Category] SARS, 유전자 메커니즘, 치료제, [키워드] adenosylmethionine Antiviral binding cause competitive inhibitor Consequences coronavirus COVID-19 COVID-19 pandemic Developing DNA evade Guanosine guide Healthcare system Healthcare systems house Human immune system inhibited inhibitor library lysine mechanism of action Methylation methyltransferase NSP nsp14 Nsps optimization other coronaviruses path Probing Protein provided RNA SAM SARS-CoV-2 SARS-CoV-2 virus selective significant difference significant differences Site the disease these compound these compounds Viral RNA [DOI] 10.1177/24725552211026261 PMC 바로가기 [Article Type] Article
A Convenient and Biosafe Replicon with Accessory Genes of SARS-CoV-2 and Its Potential Application in Antiviral Drug DiscoverySARS-CoV-2의 보조 유전자와 항바이러스 약물 발견에 대한 잠재적 응용을 포함하는 편리하고 생물학적으로 안전한 복제품Article Published on 2021-10-012022-09-11 Journal: Virologica Sinica [Category] SARS, 치료제, [키워드] absence Accessory Analysis anti-SARS-CoV-2 antiviral drug Antiviral drug screening antiviral drugs application BAC Bacterial bacterial artificial chromosome benefit biosafety level Biosafety Level 3 BSL3 can be used cause cDNA Cell chromosome Containment costly Deletion disease drug effective drug effective drugs exonuclease expression genetics Genome genome replication Infection infectious inhibition assay Inhibition assays inhibitors Laboratory level 3 Live virus luciferase reporter gene methyltransferase Nsp12 nsp14 pandemic of COVID-19 pathogenicity Potential profile Replication replicon reporter gene Research research and development reverse genetics RNA RNA polymerase S protein SARS-CoV-2 sgRNA subgenomic RNA subgenomic RNAs this system transfection viral cDNA virion assembly virus wild-type virus [DOI] 10.1007/s12250-021-00385-9 PMC 바로가기 [Article Type] Article
A Methyltransferase-Defective Vesicular Stomatitis Virus-Based SARS-CoV-2 Vaccine Candidate Provides Complete Protection against SARS-CoV-2 Infection in Hamsters메틸트랜스퍼라제-결함 수포성 구내염 바이러스 기반 SARS-CoV-2 백신 후보는 햄스터의 SARS-CoV-2 감염에 대한 완전한 보호를 제공합니다Article Published on 2021-09-272022-09-11 Journal: Journal of Virology [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition approved candidate Candidates caused Cell culture convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-protection cytokine Cytokine storm domain effective exploration expressed expressing full-length full-length S golden hamsters hamster hamsters Health immune responses immunized Immunocompromised induce innate immune lung Lung pathology mammalian cell mammalian cells methyltransferase mice mRNA mRNA cap methyltransferase mRNA stability NAb NAbs nasal nasal turbinate Neutralizing antibodies pandemic protection Protein protein translation RBD Receptor-binding domain Recovered COVID-19 patients respiratory S protein Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 S protein SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2-specific neutralizing antibodies SARS-CoV-2-specific neutralizing antibody Serum level serum levels severe acute respiratory syndrome Coronavirus specific neutralizing antibodies storage Strains Syrian golden hamster Syrian Golden hamsters T-cell immune response Th1-biased immune response Th1-biased immune responses the RBD tissues triggered Vaccine vaccine candidate vaccine candidates Vaccines variant vectored vaccine vesicular vesicular stomatitis vesicular stomatitis virus Viral virus viruses VSV [DOI] 10.1128/JVI.00592-21 PMC 바로가기 [Article Type] Article
Methylation of PhoP by CheR Regulates Salmonella VirulenceCheR에 의한 PhoP의 메틸화가 살모넬라 병원성을 조절한다.Research Article Published on 2021-09-212024-07-29 Journal: mBio [Category] 살모넬라증, [키워드] CheR Methylation methyltransferase PhoP virulence [DOI] 10.1128/mBio.02099-21 PMC 바로가기 [Article Type] Research Article
Coronavirus induces diabetic macrophage-mediated inflammation via SETDB2420 Published on 2021-09-212022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] “cytokine storm” acute respiratory syndrome administration affected binding site blockade contribute coronavirus Coronavirus infection COVID-19 COVID-19 pandemic Cytokine storm decrease develop diabetes Diabetic diabetic patient enzyme epigenetics expression Hepatitis Hyperinflammatory IFNβ increase in induce Infection Inflammation Inflammatory inflammatory cytokine production Inflammatory cytokines Inflammatory response innate immune cell interferon beta lysine mechanism methyltransferase MHV-A59 mice monocyte monocyte/macrophage morbidity and mortality murine murine model NFkB obesity pathologic pathway Patient patients with comorbidities potential mechanism promote promoters regulate regulated responsible reverse inflammation reversed robust SARS-CoV-2 sera SETDB2 severe COVID-19 shown Signaling Significance T2D the cytokine storm therapeutic targeting Transcription type 2 diabete type 2 diabetes with COVID-19 [DOI] 10.1073/pnas.2101071118 PMC 바로가기 [Article Type] 420
COVID-19 disease and malignant cancers: The impact for the furin gene expression in susceptibility to SARS-CoV-2Research Paper Published on 2021-09-212022-10-29 Journal: International Journal of Biological Sciences [Category] COVID-19, [키워드] ACE2 ACE2 expression activate addition analyzed anti-SARS-CoV-2 biosynthetic Cancer cancer patient Cancer patients cancer tissue cancer treatment cancer type cancers Cell cell entry cleavage site cordycepin Cordycepin (CD) correlated COVID-19 COVID-19 disease COVID-19 pandemic Critical demonstrated develop disease domain dosage expression expression profile facilitate Frequency function functional functional enrichment furin FURIN expression Gene Expression highest highlight HSPA5 IHC increased expression inhibited inhibiting isoform isoforms KEGG LINE Lungs Malignant cancers metabolism Methylation methyltransferase Mutation outcome Pathogenesis Prognostic marker promoter Proteins reduce Regulatory SARS-CoV-2 SARS-CoV-2 spike protein severity of COVID-19 significantly significantly increased survival survival rate susceptibility Symptom the disease therapy tissues TMPRSS2 TMPRSS2 expression tRNA Tumor tumorigenesis viral entry [DOI] 10.7150/ijbs.63072 PMC 바로가기 [Article Type] Research Paper
Substrate Specificity of SARS-CoV-2 Nsp10-Nsp16 MethyltransferaseArticle Published on 2021-08-302022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] approach classical complex COVID-19 pandemic ENCODE Enzymes inhibitor innate immune Methylation methyltransferase non-canonical RNA nucleotide positive RNA RNA genome SARS Coronavirus SARS-CoV-2 substrate tested viral infections virus [DOI] 10.3390/v13091722 PMC 바로가기 [Article Type] Article
Predicted antiviral drugs Darunavir, Amprenavir, Rimantadine and Saquinavir can potentially bind to neutralize SARS-CoV-2 conserved proteinsResearch Published on 2021-08-042022-10-30 Journal: Journal of Biological Research [Category] COVID-19, [키워드] Abstract active site Amprenavir analyzed anti-viral drug antiviral drug antiviral drugs binding conserved Coronavirus disease 2019 COVID-19 COVID-19 patient darunavir drug drug target drugs enzyme Enzymes Helicase Host humans include life cycle methyltransferase Mortality motif neutralize non-structural proteins novel Papain-like protease pathogenicity predicted Prevent protease Protein Proteins replicase repurposing Result Rimantadine RNA-dependent RNA polymerase saquinavir SARS-CoV-2 supplementary material target the SARS-CoV-2 treat Trial [DOI] 10.1186/s40709-021-00149-2 PMC 바로가기 [Article Type] Research
Targeting SARS-COV-2 non-structural protein 16: a virtual drug repurposing studySARS-COV-2 비 구조 단백질 16 : 가상 약물 재생 연구Article Published on 2021-08-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] MERS, SARS, 신약개발, 치료제, [키워드] active site addition Anti-inflammatory Anti-viral approach approved drugs best binding energy candidate carried clinical trial Compound compounds coronavirus COVID-19 drug drug candidate Drug discovery Drug repurposing effective Effectiveness enzyme Favipiravir FDA approved Drugs Final inhibit inhibiting inhibitor Interaction Maraviroc MD simulation methyltransferase molecular docking molecular dynamics Molecular dynamics simulation non-structural protein nucleoside nucleoside analog other compound other compounds performed Prednisolone Protein raltegravir SARS-CoV-2 selected similarity suggested target targeting Treatment Viral Viral RNA was done [DOI] 10.1080/07391102.2020.1779133 PMC 바로가기 [Article Type] Article