Microvascular thrombosis – Page 3 – Communicable Diseases Research

Disseminated intravascular coagulation and its immune mechanisms

Research article

Published on 2021-08-242022-10-05
Journal: Blood [Category] 비임상,

Thromboplasminflammation in COVID-19 Coagulopathy: Three Viewpoints for Diagnostic and Therapeutic Strategies

Immunology

Published on 2021-06-112022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] activate activated acute respiratory syndrome Ang II angiotensin-converting enzyme 2 anticoagulation bleeding candidate cause circulation Coagulation Coagulopathy complement pathways condition coronavirus coronavirus disease COVID-19 critically ill patients death disseminate Disseminated intravascular coagulation DNA downregulate drug endothelial injury Endothelium exacerbate expression immunothrombosis include increase in induce Infection Inflammation Inflammatory cytokines Lungs Microvascular thrombosis molecular mechanism multiple organ dysfunction NET Neutrophil extracellular trap pathology plasmin platelet activation Prognosis receptor required resulting robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA serine protease Strategy systemic inflammation target thrombin thrombosis Treatment
[DOI] 10.3389/fimmu.2021.649122 PMC 바로가기 [Article Type] Immunology

Comparison of renal histopathology and gene expression profiles between severe COVID-19 and bacterial sepsis in critically ill patients

중증 코로나19와 중증 환자의 세균성 패혈증 사이의 신장 조직병리 및 유전자 발현 프로파일 비교

Research

Published on 2021-06-102022-09-11
Journal: Critical Care [Category] MERS, 유전자 메커니즘, 치료제,

[키워드] ACE2 mRNA Activation Acute kidney injury acute tubular necrosis AKI AKI patient Analysis angiopoietin Bacterial Bacterial sepsis biopsy cadherin CD31 Cohort collected Control tissue controls COVID-19 COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients Critically ill patient death detect determine disease onset downregulated driving endothelial endothelial integrity Extensive feature Fold change gene expression profile histopathological Histopathology ICU ICU admission individual Inflammation Injury involved kidney lack lung tissue marker mechanism Microvascular thrombosis mRNA mRNA expression mRNA level mRNA levels normal not differ observation pathophysiological Patient patients patients with COVID-19 PCR positive peritubular renal renal tissue required Result SARS-CoV-2 RNA Sepsis severe COVID-19 supplementary material the timing thrombi thrombosis tissue total nephrectomy Tubular Necrosis VE-cadherin was obtained
[DOI] 10.1186/s13054-021-03631-4 PMC 바로가기 [Article Type] Research

Immunothrombosis in Acute Respiratory Dysfunction of COVID-19

Immunology

Published on 2021-06-022022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

A potential association between immunosenescence and high COVID-19 related mortality among elderly patients with cardiovascular diseases

Review

Published on 2021-06-012022-10-30
Journal: Immunity & Ageing : I & A [Category] COVID-19,

[키워드] acute respiratory distress Adaptive immune response aggravate association cardiovascular disease cardiovascular diseases cascade cause characterized chronic inflammation Corona virus COVID-19 COVID-19 infection COVID-19 patients COVID-19 related mortality death deaths elderly Elderly patient elderly patients high mortality Host immune immunosenescence inflammatory process lung lymphocyte Microvascular thrombosis MODS Mortality multiple organ dysfunction New coronavirus pathophysiological mechanism Patient patients proportion subject syndrome systemic inflammatory response systemic inflammatory responses target triggering
[DOI] 10.1186/s12979-021-00234-z PMC 바로가기 [Article Type] Review

Extensive Coronary Thrombosis as a Sequelae of COVID-19 Presenting as a STEMI

Cardiology

Published on 2021-05-262022-10-31
Journal: Cureus [Category] COVID-19,

Differences in coagulopathy indices in patients with severe versus non-severe COVID-19: a meta-analysis of 35 studies and 6427 patients

Article

Published on 2021-05-172022-10-04
Journal: Scientific Reports [Category] 바이오마커,

[키워드] activated Activation Analysis analyzed Cardiology China Coagulation Coagulation factors coagulation parameter Coagulopathy complications conducted contagious Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patient criteria D-dimer value D-dimer values database develop difference disease Disseminated intravascular coagulation Disseminated intravascular coagulopathy Google Scholar group Infectious diseases Meta-analysis Microvascular thrombosis pathogenesis of COVID-19 Patient patients Platelet primary analysis primary endpoint Prothrombin time resulting Severe COVID-19 Infection significantly lower SMD Spread was performed widespread
[DOI] 10.1038/s41598-021-89967-x PMC 바로가기 [Article Type] Article

High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages

초기 인간 항-SARS-CoV-2 IgG의 높은 역가 및 낮은 푸코실화는 폐포 대식세포에 의한 염증을 촉진합니다

Research Article

Published on 2021-05-112022-09-12
Journal: Science Translational Medicine [Category] MERS, SARS, 임상, 진단,

[키워드] Activation acute respiratory distress acute respiratory distress syndrome Adaptive immune response addition alveolar alveolar macrophage Alveolar macrophages anti-SARS-CoV-2 IgG Anti-spike anti-Spike IgG anti-spike protein IgG antibody coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients cytokine Cytokines dependent on diagnosed disease driven by early phase Evidence excessive inflammatory response Fcγ receptor FcγR FDA feature fostamatinib glycosylation hallmark human macrophage IgG IIa in vitro induce infection with SARS-CoV-2 Inflammation Inflammatory response inhibitor initial interleukin interleukin-6 intrinsically Macrophage macrophage activation macrophages Microvascular thrombosis Necrosis occur Patient pro-inflammatory promote promote inflammation pulmonary endothelial receptor respiratory distress Respiratory distress syndrome responsible SARS-CoV-2 second Seroconversion serum severe COVID-19 severe disease small molecule Spike protein syndrome therapeutic thrombosis Tumor tumor necrosis tumor necrosis factor was normalized worsening
[DOI] 10.1126/scitranslmed.abf8654 PMC 바로가기 [Article Type] Research Article

Placenta histopathology in SARS-CoV-2 infection: analysis of a consecutive series and comparison with control cohorts

Original Article

Published on 2021-05-012022-10-29
Journal: Virchows Archiv [Category] COVID-19, MERS, SARS,

D-dimer at hospital admission for COVID-19 are associated with in-hospital mortality, independent of venous thromboembolism: Insights from a French multicenter cohort study

Observational Study

Published on 2021-05-012022-10-05
Journal: Archives of cardiovascular diseases [Category] 임상,

[키워드] 95% CI 95% confidence interval adjusted hazard ratio Admission analysed Analysis association AUC Coagulation coagulation disorders Concentration Coronavirus disease 2019 COVID-19 Cox proportional hazard cut-off value D-dimer D-dimères death deep Deep venous thrombosis dosage Embolie pulmonaire English enrolled French Frequency Hospital admission hospitalisation hospitalised hospitals in-hospital mortality independent insight logistic regression models Microthrombose Microvascular thrombosis multicenter multicenter cohort study not differ nous occurred Occurrence Odds ratio outcome Patient Predictive pulmonary Pulmonary embolism receiver operating characteristic ROC sensitivity specificity subgroup of patient symptomatic Thrombose veineuse profonde. venous Venous Thromboembolism worse prognosis
[DOI] 10.1016/j.acvd.2021.02.003 PMC 바로가기 [Article Type] Observational Study