SARS-CoV-2 spike protein detection using slightly tapered no-core fiber-based optical transducer약간 테이퍼진 노코어 광섬유 기반 광 변환기를 사용한 SARS-CoV-2 스파이크 단백질 검출Article Published on 2022-08-062022-09-11 Journal: Mikrochimica Acta [Category] SARS, 치료기술, [키워드] ACE2 adopted Antigen binding buffer cause changes in Concentration COVID-19 cross-reactivity demonstrated Detection sensitivity effective expected facilitate fiber lAbel medium MERS MERS-CoV modulation No-core fiber optical Optical fiber Optical fiber biosensor platform probe Protein protocol reconstructed refractive index reproducibility Saliva SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein selective Spike protein Tapered optical fiber. Transmission was selected [DOI] 10.1007/s00604-022-05413-3 PMC 바로가기 [Article Type] Article
Alveolar macrophages: Achilles’ heel of SARS-CoV-2 infection폐포 대식세포: SARS-CoV-2 감염의 아킬레스건Review Published on 2022-07-192022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 치료제, [키워드] Achille Acidic acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alveolar macrophage Alveolar macrophages alveoli Antiviral compound Antiviral compounds antiviral drug antiviral drugs can not caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytosol dampen death Degradation effort endosomal pH endosome Endosomes exploration facilitate gloom Immune cell immune cells individuals infected individuals initiate lysosomal macrophages modulation Neutralizing antibodies neutralizing antibody pandemic prophylactically Replication respiratory viruses SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus specificity Spread treat Vaccine viral escape viral mutation virus viruses [DOI] 10.1038/s41392-022-01106-8 PMC 바로가기 [Article Type] Review
Neddylation tunes peripheral blood mononuclear cells immune response in COVID-19 patients Research Published on 2022-07-132022-10-05 Journal: Cell Death Discovery [Category] 치료법, [키워드] activated Activation acute respiratory distress acute respiratory syndrome addition approach ARDS avoidance caused contagious Control cough COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients Critical cytokine production Cytokine storm death develop early response effective exacerbated Fever hospitalized patient IL-6 immune response immune system implication in viral include increase in induce Infection inhibition MCP-1 mechanism modulation mononuclear cell pathology Patient patients PBMCs Peripheral blood Pneumonia post-translational modification previous study proliferation Protein proteome reached reduce regulate SARS-CoV-2 serum severe pneumonia stability subsequent syndrome systemic inflammation therapeutic Vaccine viral infection [DOI] 10.1038/s41420-022-01115-0 [Article Type] Research
Recent Progress in the Development of Opaganib for the Treatment of Covid-19Covid-19 치료를 위한 Opaganib 개발의 최근 진행 상황Review Published on 2022-07-122022-09-11 Journal: Drug design, development and therapy [Category] COVID19(2023년), SARS, 치료제, [키워드] ABC294640 acceleration active against Administered Anti-SARS-CoV-2 Activity Antiviral antiviral activity biochemical Cancer clearance clinical trial COVID-19 pandemic decrease demonstrated development dihydroceramide desaturase disease driven by drug enzyme glucosylceramide glucosylceramide synthase Host Infection Inflammation Inflammatory diseases inhibit inhibiting mechanism metabolism Mild Mild disease moderate moderately severe COVID-19 modulation Mortality multi-organ dysfunction opaganib pandemic pathologic pathologic processes Patient patients patients hospitalized phase Progress recent regulate Replication replication of SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 virus Signaling sphingolipid sphingolipids sphingosine sphingosine kinase. Stress subpopulation suppresse the SARS-CoV-2 virus treat Treatment treatment protocols understanding viral proliferation virus virus [DOI] 10.2147/DDDT.S367612 PMC 바로가기 [Article Type] Review
Repurposing the Antiplatelet Agent Ticlopidine to Counteract the Acute Phase of ER Stress Condition: An Opportunity for Fighting Coronavirus Infections and Cancer응급실 스트레스 상태의 급성기에 대응하기 위해 항혈소판제 티클로피딘의 용도 변경: 코로나바이러스 감염 및 암 퇴치를 위한 기회Article Published on 2022-07-062022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 신약개발, [키워드] Achille agent antiplatelet Antiplatelet agent approach approved drugs attribute Cancer Cancer cells Cell Coronavirus infections Coronavirus-2 COVID-19 demonstrated Endoplasmic reticulum endoplasmic reticulum (ER) ER membranes ER stress exacerbating Fighting heel homeostasis life cycle Metastasis Modification modulation opportunity P2Y12 P2Y12 inhibitors pathological conditions Perturbation phase promote receptor representing repurposing responsible SARS Coronavirus SARS-CoV-2 sigma sigma 1 receptor (S1R) terminal UPR the disease therapeutic intervention Therapies ticlopidine ticlopidine. Tumor tumor growth unfolded protein response UPR viral glycoprotein viral glycoproteins viral infection viral infections viral life cycle [DOI] 10.3390/molecules27144327 PMC 바로가기 [Article Type] Article
Computational investigation of benzalacetophenone derivatives against SARS-CoV-2 as potential multi-target bioactive compoundsSARS-CoV-2에 대한 벤잘아세토페논 유도체의 잠재적 다중 표적 생리활성 화합물의 전산 조사Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CL pro 3CL(pro) addition Anti-SARS-CoV-2 Activity Antiviral antiviral activities Antiviral agents AutoDock Benzalacetophenones binding affinity binding energy binding free energy biological processes Candidates cellular components Compound COVID-19 derivative develop Diseases domain down-regulated enrichment analysis evaluated FIVE flavonoids free energy highest highest binding affinity identify Immune boost immune system Immunity immunostimulant Interaction lab modulated modulation molecular molecular docking molecular dynamics Molecular dynamics simulation molecular functions Molecular mechanics multiple pathway multiple pathways network network pharmacology nine non-infectious Papain Papain-like protease pathway Pathways Patient pharmacological PL(pro) precursor precursors protease Protein recorded reflected regulated retrieved SARS-CoV-2 scored screened Simulation spike Spike protein spike protein. surface area target upregulated was performed [DOI] 10.1016/j.compbiomed.2022.105668 PMC 바로가기 [Article Type] Article
Symptomatic but not Asymptomatic COVID-19 Impairs Conditioned Pain Modulation in Young AdultsResearch article Published on 2022-07-012022-10-05 Journal: The Journal of Pain [Category] 바이오마커, [키워드] Asymptomatic COVID-19 condition conditioned Conditioned pain modulation Control COVID-19 COVID-19 patients CPM dominant Effect Exercise induced hyperalgesia extension First wave groups healthy control Impaired implication individual mechanism modulation not different Pain pain threshold participant performed pressure Pressure pain thresholds reported reveal sensitivity Symptom symptomatic Symptoms Vaccine was impaired were assessed were infected [DOI] 10.1016/j.jpain.2022.06.010 [Article Type] Research article
Chinese Medicine Meets Conventional Medicine in Targeting COVID-19 Pathophysiology, Complications and Comorbidities한의학, COVID-19 병태생리학, 합병증 및 동반질환을 표적으로 하는 기존 의학과의 만남Comparative Study Published on 2022-07-012022-09-11 Journal: Chinese journal of integrative medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] activity approved China Chinese Chinese medicine clinical trial clinically Comorbidities Comorbidity Complication Conventional coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 complication COVID-19 complications diabetes drug DrugBank DrugBank database genomes headache hypertension ingredient investigated Kyoto mechanism Medicine Medicines modulate modulated modulation National Health Commission natural NHCC obesity Pain pathophysiology Pathways product searched Source Specy target targeting targets therapeutic therapeutic mechanism. Traditional Traditional Chinese medicine Treatment viral replication was obtained [DOI] 10.1007/s11655-022-3573-0 PMC 바로가기 [Article Type] Comparative Study
Diarrhoea-causing enteric protist species in intensively and extensively raised pigs (Sus scrofa domesticus) in Southern Spain. Part II: Association with Hepatitis E virus susceptibilityArticle Published on 2022-07-012023-06-10 Journal: Transboundary and emerging diseases [Category] E형 간염, [키워드] Balantioides coli Blastocystis Co-infection cryptosporidium Enterocytozoon bieneusi Giardia duodenalis hepatitis E Iberian pig Large White pig modulation Spain Transmission. [DOI] 10.1111/tbed.14408 PMC 바로가기
The Role of Vitamin D in SARS-CoV-2 Infection and Acute Kidney InjurySARS-CoV-2 감염 및 급성 신장 손상에서 비타민 D의 역할Review Published on 2022-07-012022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute kidney Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive addition AKI alveolar Anti-inflammatory Anti-inflammatory effects antioxidant benefit broad spectrum calcium Cell cell metabolism Chronic kidney disease CKD contribute Control coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) correlation COVID-19 COVID-19 severity Critically ill Critically ill patient critically ill patients cytokine release deficiency described Effects endothelial damage essential nutrient Genes homeostasis hormone in-hospital mortality Infection influence Innate immunity involved Kidney disease manifestation mechanism metabolism mitochondrial modulation molecular Mortality non-genomic nuclear outcome Pathologies Pathways phosphate proinflammatory recruitment regulate risk role SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severe coronavirus disease Side effects targets therapeutic strategy Toxicity Transcription Vitamin Vitamin D vitamin D deficiency vitamin D deficiency. vitamin D level vitamin D serum Vitamin D supplementation [DOI] 10.3390/ijms23137368 PMC 바로가기 [Article Type] Review