Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity상승된 Myl9는 SARS-CoV-2 유발 폐삼출성 혈관염에서 Myl9 함유 미세혈전을 반영하고 COVID-19 중증도를 예측합니다Article Published on 2022-08-162022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] accompanied accumulated activation of platelets acute respiratory syndrome Analysis Autopsy Clinical severity coronavirus coronavirus disease correlated COVID-19 COVID-19 patient COVID-19 severity exudative vasculitis fatal disease histological immune dysregulation immunothrombosis lung marker Microscopy microthrombi monocyte mononuclear cell Mortality nonconventional monocytes Pathogenesis pathology Peripheral blood plasma plasma Myl9. predict provide reflect SARS-CoV-2 severity Single-cell RNA sequencing the disease treatment for COVID-19 Vascular Vasculitis vessels X-ray spectroscopy [DOI] 10.1073/pnas.2203437119 PMC 바로가기 [Article Type] Article
Perinatally Human Immunodeficiency Virus-Infected Adolescents and Young Adults Demonstrate Distinct BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccine Immunogenicity주산기 인간 면역결핍 바이러스에 감염된 청소년 및 젊은 성인은 뚜렷한 BNT162b2 메신저 RNA 코로나바이러스 질병 2019 백신 면역원성을 나타냅니다.Article Published on 2022-08-152022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adolescent anti-SARS-CoV-2 humoral antibody Antigen Antigen-specific T cells Antiretroviral therapy ART baseline BNT162b2 BNT162b2 mRNA BNT162b2 mRNA COVID-19 vaccine CD4+ T cell CD4+ T-cell CD40L Cellular responses characterized Cluster collected coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 demonstrated dose Efficacy eligibility evaluated expand feature Follow-up group HCs healthy control HIV HIV-infected patient HIV-infected patients Human Human immunodeficiency virus humoral immune response Immunity immunization immunodeficiency virus immunogenicity involved messenger Messenger RNA molecules mononuclear cell mononuclear cells mounted mRNA of BNT162b2 Olink perinatally HIV-infected patients. Peripheral blood Peripheral blood mononuclear cells plasma samples Population populations profile protein level protein levels proteomic proximity extension assay Regulation respiratory response responses RNA RNA coronavirus Safety Sample SARS-CoV-2 SARS-CoV-2 antibody second dose severe acute respiratory syndrome Coronavirus study groups T cell T cells vaccination Vaccine Vulnerable populations were assessed [DOI] 10.1093/cid/ciac408 PMC 바로가기 [Article Type] Article
T-cell responses to SARS-CoV-2 Omicron spike epitopes with mutations after the third booster dose of an inactivated vaccine비활성화 백신의 세 번째 추가 접종 후 돌연변이가 있는 SARS-CoV-2 오미크론 스파이크 에피토프에 대한 T 세포 반응Article Published on 2022-08-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Antibody Response Antibody responses booster dose booster vaccination conserved CoronaVac coronavirus dose elicited enhancement Epitopes escape estimate evaluated Impact Inactivated vaccine individual individuals Infection mononuclear cell mononuclear cells Mutation mutations omicron Omicron variant participant Participants PBMCs peptide peptides Peripheral blood Peripheral blood mononuclear cells Protective respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus significantly spike epitope Spike protein Spike proteins stimulate T-cell T-cell activation T-cell Response T-cell responses the SARS-CoV-2 the spike protein Vaccine Vaccines variant virus volunteers weakened were used [DOI] 10.1002/jmv.27814 PMC 바로가기 [Article Type] Article
Bioinformatics approach reveals the critical role of the NOD-like receptor signaling pathway in COVID-19-associated multiple sclerosis syndrome생물 정보학 접근법은 COVID-19 관련 다발성 경화증 증후군에서 NOD 유사 수용체 신호 전달 경로의 중요한 역할을 보여줍니다Article Published on 2022-08-012022-09-11 Journal: Journal of neural transmission (Vienna, Austria : [Category] 유전자 메커니즘, [키워드] Affect Analysis analyzed approach association Autoimmune disease bioinformatics Brain CASP1 Central nervous system CNS Complete coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical cross disease Diseases functional protein genetic information GEO database identify IFNB1 IFNg IL1B immune indicated Inflammation mechanism monocyte mononuclear cell Multiple multiple sclerosis network analysis NLR NLRP3 Occurrence P2RX7 pathway Patient patients PBMC Peripheral blood platform PPI Protein protein-protein interaction receptor receptor signaling reported reveal RNA sequencing data SARS-CoV-2 selected Signaling signaling pathway spinal cord STRING syndrome the patient TNF was collected with COVID-19 [DOI] 10.1007/s00702-022-02518-0 PMC 바로가기 [Article Type] Article
Single-cell RNA sequencing to decipher the immunogenicity of ChAdOx1 nCoV-19/AZD1222 and mRNA-1273 vaccines in patients with autoimmune rheumatic diseases자가면역 류마티스 질환 환자에서 ChAdOx1 nCoV-19/AZD1222 및 mRNA-1273 백신의 면역원성을 해독하기 위한 단일 세포 RNA 시퀀싱Article Published on 2022-08-012022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] Analysis analyzed anti-rheumatic medications anti-SARS-CoV-2 IgG antibodies Antigen presentation Arthritis Autoimmune AZD1222 CD16 CD4 ChAdOx1 COVID-19 COVID-19 vaccine database domain dose electrochemiluminescence immunoassay enriched pathway enrolled exhibited Gene Expression Omnibus GEO healthy controls HLA-DRA immunized inhibitor Interaction Janus kinase methotrexate MHC class Moderna monocyte mononuclear cell mRNA-1273 mRNA-1273 vaccine mRNA-based vaccine Necrosis Oxford-AstraZeneca participant pathway Patient patients PBMC PBMCs Peripheral blood predominant quantified receiving rheumatic disease RNA sequencing scRNA-seq serum IgG antibody Single-cell RNA sequencing the SARS-CoV-2 vaccination Vaccine [DOI] 10.3389/fimmu.2022.920865 PMC 바로가기 [Article Type] Article
Alterations in CD39/CD73 axis of T cells associated with COVID-19 severityCOVID-19 중증도와 관련된 T 세포의 CD39/CD73 축 변경Article Published on 2022-08-012022-09-11 Journal: Journal of cellular physiology [Category] MERS, 바이오마커, 진단, [키워드] Activation adenosine adenosine triphosphate alteration Annexin Apoptosis ATP Blood CD25 CD27 CD28 CD4 CD73 CD8 Cell collected controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cytokine Cytokines decrease effector cell expression Extracellular Frequency healthy controls healthy donor immune function Immunopathogenesis immunopathology in vitro Inflammation involved knowledge memory T mild COVID-19 patient mild COVID-19 patients modulate Monocytes mononuclear cell nuclear pathway patients PD-1 Peripheral blood plasma samples Purinergic purines purines. reduced Regulation Regulatory Regulatory T cell SARS-CoV-2 severe COVID-19 patient severe COVID-19 patients severity Signaling T cell T cells T lymphocytes T-cell These data triphosphate Viral viral infections with COVID-19 [DOI] 10.1002/jcp.30805 PMC 바로가기 [Article Type] Article
Unsuppressed HIV infection impairs T cell responses to SARS-CoV-2 infection and abrogates T cell cross-recognition억제되지 않은 HIV 감염은 SARS-CoV-2 감염에 대한 T 세포 반응을 손상시키고 T 세포 교차 인식을 폐지합니다Article Published on 2022-07-262022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 변종, [키워드] abrogate abrogation Beta Beta variant CD4 CD8 correlated COVID-19 disease COVID-19 epidemic Cytometry determine diminishe epitope epitope specificity explain First wave Flow flow cytometry greater highlight HIV HIV infection Human identify immunodominance immunology impair in some individual Infection Inflammation instances mechanism mononuclear cell Mutation peptide peptide pools Peripheral blood PLWH Protein Recognition SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants second wave severe COVID-19 severe COVID-19 disease significantly South Africa specificity Spike protein susceptibility T cell T cell activation T cell response T cell responses the Spike variant was used with HIV [DOI] 10.7554/eLife.78374 PMC 바로가기 [Article Type] Article
A diagnostic classifier for gene expression-based identification of early Lyme disease Research Published on 2022-07-222022-10-05 Journal: Communications Medicine [Category] 바이오마커, 진단, [키워드] Accuracy Algorithm association Bacteremia Borrelia cause Cell culture Classifier clinical investigation clinical utility controls database described Diagnosis diagnostic diagnostic test differentially expressed gene evaluated false-discovery rate Gene Expression highlight identify in vitro independent Infection Influenza lack Lyme disease mononuclear cell New Patient patients Peripheral blood positive Result RNA sequencing selected sensitivity Sensitivity and specificity serologic testing seronegative patient specificity subject subjects The United States Transcriptome Tuberculosis uninfected control [DOI] 10.1038/s43856-022-00127-2 [Article Type] Research
Specific CD4+ T Cell Responses to Ancestral SARS-CoV-2 in Children Increase With Age and Show Cross-Reactivity to Beta Variant어린이의 조상 SARS-CoV-2에 대한 특정 CD4+ T 세포 반응은 나이가 들어감에 따라 증가하고 베타 변이체에 대한 교차 반응성을 나타냅니다Article Published on 2022-07-152022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] accompanied Activation activation induced marker (AIM) activation-induced marker activation-induced markers age ancestral Antiviral average Beta Beta variant beta variants Blood CD4+ CD4+ T cell children Control convalescent coronavirus COVID-19 cross-reactivity Cytokines cytometric disease course Effective vaccines Flow global health granzyme granzyme B HCoV Health human coronavirus human coronavirus (HCoV) IFN-γ immune response increase Infection infection rate infection rates marker Mild mononuclear cell PBMC pediatric peptide peripheral Peripheral blood Peripheral blood mononuclear cells reduced reduction response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant secreted cytokine secretion seronegative show social distancing measures Specific stimulated T cell T cell responses T cells the SARS-CoV-2 vaccination variant variant of concern (VOC) viral variant VoC was reduced were used [DOI] 10.3389/fimmu.2022.867577 PMC 바로가기 [Article Type] Article
SARS-CoV-2 spike and nucleocapsid proteins fail to activate human dendritic cells or γδ T cellsSARS-CoV-2 스파이크 및 뉴클레오캡시드 단백질은 인간 수지상 세포 또는 γδ T 세포를 활성화하지 못합니다Article Published on 2022-07-142022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] activate activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 CD3+ cell co-cultured contribute coronavirus COVID-19 patient COVID-19 patients Cytokines dendritic cell dendritic cells digestion downstream flow cytometry healthy donors immune immune cells Immunity indicated induce interferon interferon-γ interleukin-12 investigated Ligand mechanism mononuclear cell mononuclear cells nucleocapsid nucleocapsid protein Nucleocapsid proteins protease Protein SARS-CoV-2 SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus stimulated stimulatory structural protein structural proteins T cell T cell activation T cells thought Viral RNA virus [DOI] 10.1371/journal.pone.0271463 PMC 바로가기 [Article Type] Article