multiplicity of infection

[키워드] ACE2angiotensin-converting enzyme 2 acute respiratory distress syndrome acute respiratory syndrome angiotensin-converting enzyme 2 animal models annexinA5 Anti-inflammatory anti-malarial drug Anti-phospholipid anti-phospholipid syndrome anti-thrombotic properties Anti-viral anti-viral effect antigen-presenting cell AnxA5annexinA5 APCantigen-presenting cell aPLanti-phospholipid APSanti-phospholipid syndrome ARDSacute respiratory distress syndrome Autoimmune disease BMP/SMADbone morphogenetic/small mother against decapentaplegic bone morphogenetic/small mother against decapentaplegic caused Cell culture Chloroquine chloroquine/hydroxychloroquine chronic obstructive pulmonary disease Clathrin-mediated endocytosis Clinical course Clinical efficacy Clinical improvement CMEclathrin-mediated endocytosis COPDchronic obstructive pulmonary disease coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients COVID-19Sars-Cov-2 infection CQChloroquine DCdendritic cell dendritic cell disease divalent metal-ion transporter 1 DMT1divalent metal-ion transporter 1 drug early endosome EEearly endosome Effects Efficacy Endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment endosomal NADPH oxidase endothelial nitric oxide synthetase eNOSendothelial nitric oxide synthetase eNOXendosomal NADPH oxidase EPOerythropoietin ERendoplasmic reticulum ERFEerythroferrone ERGICendoplasmic reticulum-Golgi intermediate compartment erythroferrone erythropoietin experimental evidence ferritin ferroportin 1 FPN1ferroportin 1 FTferritin HAEChuman aortic endotelial cell HAMPhepcidin haptoglobin HCMVHuman Cytomegalovirus HCQ HCQhydroxychloroquine HCVHepatitis C virus hemochromatosis hemochromatosis gene hemopexin hepatitis C virus hepcidin HFEhemochromatosis gene HHhemochromatosis HIV-1Human Deficiency Virus 1 HPhaptoglobin HPXhemopexin human aortic endotelial cell Human Cytomegalovirus Human Deficiency Virus 1 human umbilical vein endothelial cell HUVEChuman umbilical vein endothelial cell Hydroxychloroquine ICUIntensive Care Unit IDAiron deficiency anemia IDiron deficiency IDUinfectious disease unit IFN-γinterferon-γ IFN1type interferon IgGimmunoglobulin G IL-12interleukin-12 IL-13interleukin-13 IL-17interleukin-17 IL-1βinterleukin-1β IL-4interleukin-4 IL-6interleukin-6 Immunoglobulin G immunomodulatory Infection infectious disease unit intensive care unit interferon-γ interleukin-12 interleukin-13 interleukin-17 interleukin-1β Interleukin-4 interleukin-6 iron deficiency iron deficiency anemia iron homeostasis JAK/STAT3Janus kinase/signal transducers and activators of transcription 3 Janus kinase/signal transducers and activators of transcription 3 knowledge lactoferrin late endosome-lysosome LELlate endosome-lysosome less LFlactoferrin lipopolysaccharide LPSlipopolysaccharide mAbMonoclonal antibody major histocompatibility complex MAPKmitogen-activated protein kinase matrix metalloproteinase mechanism metalloreductase six-transmembrane epithelial antigen of the prostate 3 MHCMajor Histocompatibility Complex MHV-3mouse hepatitis virus type 3 mitogen-activated protein kinase MMPmatrix metalloproteinase MOImultiplicity of infection monoclonal antibody mouse hepatitis virus type 3 mucolipin 1 multiplicity of infection Mviral envelope membrane protein NADPH oxidase 2 natural killer NETneutrophil extracellular trap Neutrophil extracellular trap NKnatural killer NOX2NADPH oxidase 2 NPvirus nucleoprotein pandemic Patient pharmacological phosphatidylinositol binding clathrin assembly protein PICALMphosphatidylinositol binding clathrin assembly protein potential mechanism Randomized controlled studies RArheumatoid arthritis RBCred blood cell red blood cell regimen rheumatoid arthritis SARS-COV-2 infection severity SLEsystemic lupus erythematosus (SLE) STEAP3metalloreductase six-transmembrane epithelial antigen of the prostate 3 Sviral spike protein systemic lupus erythematosus (SLE) T helper TFR1transferrin receptor 1 TFtissue factor TGNtrans-Golgi network TGTthrombin generating time therapeutic thrombin generating time ThT helper Tissue Factor TLRToll-like receptor TMPRSS2transmembrane serine protease 2 TNF-αtumor necrosis factor-α Toll-like receptor trans-Golgi network transferrin receptor 1 transmembrane serine protease 2 treat Treatment TRPML1/MCOLN1mucolipin 1 tumor necrosis factor-α type interferon vascular cellular adhesion molecule 1 VCAM-1vascular cellular adhesion molecule 1 viral envelope membrane protein viral infections viral spike protein virus nucleoprotein β2-glicoprotein I β2GPIβ2-glicoprotein I
[DOI] 10.1016/j.phrs.2020.104904 [Article Type] Review article