natural killer cell – Page 3 – Communicable Diseases Research

Immune-Mediated Mechanisms in Patients Testing Positive for SARS-CoV-2: Protocol for a Multianalysis Study

Protocol

Published on 2022-01-252022-10-29
Journal: JMIR Research Protocols [Category] COVID-19,

A Rare STXBP2 Mutation in Severe COVID-19 and Secondary Cytokine Storm Syndrome

Article

Published on 2022-01-202022-10-29
Journal: International Review of Cell and Molecular Biology [Category] COVID-19,

[키워드] accompanied Activation approach Blood caused CD107a CD8 T cell Cell clinical feature Coronavirus disease 2019 COVID-19 cytokine levels Cytokine storm Cytokine storm syndrome cytolysis cytotoxicity death degranulation disease dominant-negative elevated erythroleukemia etiologies Ex vivo expression feature gene mutations genetic defect genetic evaluation genetic mutations genetics hemophagocytic lymphohistiocytosis heterozygous HLH homozygous hyperinflammation hypomorphic Hypothesis immune response immune system implicated implication in vitro infancy Laboratory lentiviral macrophage activation syndrome Missense mutation monoallelic mutant Mutation natural killer natural killer cell NK cell NK cell function resulting secondary Severe case severe COVID-19 sHLH significantly stimulated storm STXBP2 syndrome system failure target cell transduced triggered viral infection were measured while wild-type
[DOI] 10.3390/life12020149 PMC 바로가기 [Article Type] Article

Latency reversal plus natural killer cells diminish HIV reservoir in vivo

Article

Published on 2022-01-102022-10-04
Journal: Nature Communications [Category] 유전자 메커니즘,

Recalcitrant Herpes Zoster Ophthalmicus in a Patient Discovered to Have Underlying Functional Natural Killer Cell Deficiency

재발성 대상포진 안구염 환자에서 발견된 기저 기능적 자연 살해 세포 결핍

Case Reports

Published on 2022-01-022023-06-01
Journal: Ocular immunology and inflammation [Category] 대상포진, 두창, 수두, 홍역,

[키워드] Herpes Zoster Ophthalmicus immunodeficiency natural killer cell Uveitis Viral keratitis
[DOI] 10.1080/09273948.2020.1795205 [Article Type] Case Reports

T cell counts and IL-6 concentration in blood of North African COVID-19 patients are two independent prognostic factors for severe disease and death

북아프리카 COVID-19 환자의 혈액 내 T 세포 수와 IL-6 농도는 심각한 질병 및 사망에 대한 두 가지 독립적인 예후 인자입니다

Article

Published on 2022-01-012022-09-11
Journal: Journal of leukocyte biology [Category] 바이오마커,

[키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition African Analysis B cells Blood CD4+ T cells CD8+ T cell CD8+ T cells characteristic clinician Concentration coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients cutoff value cytokine cytokine level cytokine levels Cytokines death death group develop disease flow cytometry healthy control healthy controls help high risk IL-10 IL-6 immune parameter immune system independent investigated lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes Mild Mortality multivariate logistic regression multivariate logistic regression analysis natural killer cell Natural killer cells North outcome parameter pathology Patient patients percentage percentages performed Peripheral blood peripheral blood lymphocyte predict Prognosis Prognostic factor receiver operating characteristic respiratory risk ROC ROC curves SARS-CoV2 severe acute respiratory syndrome Coronavirus severe cases severe disease severity severity of illness significant difference significant differences significantly higher statistical difference statistical differences subset survival T cell T cells Th17 Th2 the disease the patient threshold Total two group two groups
[DOI] 10.1002/JLB.4COVA1020-703R PMC 바로가기 [Article Type] Article

Role of Heat Shock Proteins in Immune Modulation in Malaria

Article

Published on 2021-12-312024-09-10
Journal: Adv Exp Med Biol [Category] 말라리아,

[키워드] eryptosis granzyme B Immunotherapy Infected erythrocyte natural killer cell Parasite heat shock protein.
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Perforin, COVID-19 and a possible pathogenic auto-inflammatory feedback loop

퍼포린, COVID-19 및 가능한 병원성 자가염증 피드백 루프

Review

Published on 2021-11-012022-09-11
Journal: Scandinavian journal of immunology [Category] SARS, 유전자 메커니즘,

[키워드] addition association auto‐inflammatory Cell COVID COVID-19 COVID-19 infection cytokine Cytokine storm Cytokines cytotoxic T lymphocyte cytotoxic T lymphocytes cytotoxicity downregulation dysregulation epidemiological Evidence excess expression haemophagocytic lymphohistiocytosis host cells IL-6 IL-6 expression immune response immune responses increase interleukin‐6 Killer cell mechanism microbial infection monocytosis natural killer natural killer cell NK cell NK cells overproduction pathogenic perforin promote raised reduced reduction in scar severe COVID-19 synergistic therapy Thrombus thrombus formation turn viral clearance
[DOI] 10.1111/sji.13102 PMC 바로가기 [Article Type] Review

Distinct patterns of whole blood transcriptional responses are induced in mice following immunisation with adenoviral and poxviral vector vaccines encoding the same antigen

전혈 전사 반응의 뚜렷한 패턴은 동일한 항원을 암호화하는 아데노 바이러스 및 poxviral 벡터 백신으로 예방 접종 후 마우스에서 유도된다.

Research

Published on 2021-10-302022-09-10
Journal: BMC Genomics [Category] MERS, SARS, 유전자 메커니즘,

[키워드] adaptive immune responses Adenovirus Administered Analysis Antigen antigens cell activation cellular ChAdOx1 change changes characterisation Combination combinations Comparative analysis COVID-19 vaccine Diseases effective Emerging infectious diseases Epigenetic evaluate Express expression Gene Expression gene signature Genes greater heterologous prime-boost human clinical trial human clinical trials humoral immune response immune responses Infectious diseases innate immune involved Killer cell leads magnitude mechanism MHC class I mice natural killer natural killer cell Pathogens pathway Protective protective response protective responses Rapid induction regimen Regulation response Result significant enrichment single dose supplementary material T cell These data TLR2 transcriptional transcriptional response transgene type I interferon type I interferon genes Vaccine vaccine construct vaccine platform valuable resource vector vectors Viral Viral vector vaccine was used Whole blood
[DOI] 10.1186/s12864-021-08061-8 PMC 바로가기 [Article Type] Research

Differential dynamics of peripheral immune responses to acute SARS-CoV-2 infection in older adults

Research

Published on 2021-10-282022-10-05
Journal: Nature Aging [Category] SARS, 임상,

Transcriptomic characteristics and impaired immune function of patients who retest positive for SARS-CoV-2 RNA

SARS-CoV-2 RNA에 대해 재검사를 받은 환자의 전사 특성 및 면역 기능 장애

Article

Published on 2021-10-232022-09-10
Journal: Journal of Molecular Cell Biology [Category] Coronavirus, SARS, 바이오마커, 유전자 메커니즘,

[키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis caused CD4 CD8 CD8⁺ Characteristics contribute Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated differentiation discharge enrolled expression global public health Health crisis healthy control hospital ID1 IFITM10 Immune cell immune cells immune function immunological characteristics Infection inhibitor interferon low expression marker mechanism mononuclear cells natural killer cell Natural killer cells NK cells Occurrence Pathogenesis Patient patients Peripheral blood Peripheral blood mononuclear cells positive reduced respiratory RTP patients SARS-CoV-2 SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus significantly T cell T cells these cell These cells Transcriptome transcriptome sequencing transmembrane protein with COVID-19
[DOI] 10.1093/jmcb/mjab067 PMC 바로가기 [Article Type] Article