Gasdermin-D activation by SARS-CoV-2 triggers NET and mediate COVID-19 immunopathologySARS-CoV-2에 의한 Gasdermin-D 활성화는 NET을 유발하고 COVID-19 면역병리를 매개합니다Article Published on 2022-07-072022-09-11 Journal: Critical Care [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] activate Activation Analysis analyzed Blood Bronchoalveolar lavage Coagulopathy COVID-19 COVID-19 patients Critical demonstrated disulfiram enrolled expression GSDMD hospitalized patient immunopathology infect Inflammasome Inflammation inhibited Innate Innate immunity live SARS-CoV-2 lung tissue lung tissue sample moderate molecular mechanism molecular mechanisms mouse model NET NETosis NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils organ damage pathway Pathways performed Protein reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus Severe case severe cases severe COVID-19 signaling pathway single-cell Structure the SARS-CoV-2 virus therapeutic strategy Transcriptome Treatment Trigger triggers [DOI] 10.1186/s13054-022-04062-5 PMC 바로가기 [Article Type] Article
Role of Acute Thrombosis in Coronavirus Disease 2019Review Published on 2022-07-012023-07-09 Journal: Critical Care Clinics [Category] COVID19(2023년), [키워드] anticoagulation coronary thrombus COVID D-dimer NETs thrombosis [DOI] 10.1016/j.ccc.2022.03.003 PMC 바로가기 [Article Type] Review
Artemisinin inhibits neutrophil and macrophage chemotaxis, cytokine production and NET release Research Published on 2022-06-302022-10-05 Journal: Scientific Reports [Category] 진단, [키워드] Activation antimalarial Artemisinin ATPase block calcium cause Cell chemokine chemotactic chemotaxis condition Critical cysteine residue cytokine production Cytokines death Excessive activation identify Immune cell in vivo Infection inhibit inhibited inhibition inhibitor innate immune system Invasion isoform life-threatening lung Macrophage mechanism murine NET NETs neutrophil Neutrophil extracellular trap pathogen invasion promote released Reticulum selective Sepsis SERCA suppressed therapy thought tissue tissue injury [DOI] 10.1038/s41598-022-15214-6 [Article Type] Research
In-vitro NET-osis induced by COVID-19 sera is associated to severe clinical course in not vaccinated patients and immune-dysregulation in breakthrough infectionCOVID-19 혈청에 의해 유도된 체외 NET-osis는 백신 접종을 하지 않은 환자의 심각한 임상 경과 및 돌발성 감염의 면역 조절 장애와 관련이 있습니다.Article Published on 2022-05-042022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] ACE Activation affected age approach Breakthrough infection breakthrough infections CD14 CD16 CD3 CD4 CD4+ CD45 CD45RA CD45RO CD64 CD8 CD8+ Cell cells characterized circulating cytokine circulating cytokines classical Clinical course Clinical features complex Concentration controls COVID-19 COVID-19 infections COVID-19 patient COVID-19 patients COVID-19 sera COVID-19 treatment cytokine Cytokines Cytometry disease disease severity dysregulation effector cells expansion healthy healthy donors healthy subject healthy subjects highlight Hospital admission IFN-γ IL-17A IL-1β IL-6 immune Immune cell immune cells immune dysregulation immune response In-vitro inhibitor Inpatients Major marker memory B-cell Mild Mild disease moderate Monocytes myeloid naïve NET NETosis NETs neutrophil Neutrophil extracellular trap overexpressing Patient patients percentage Peripheral blood pilot study ramipril reduced reduction risk sera severe COVID-19 patient Sex T cell T cells T-cell T-cells Treatment viral clearance [DOI] 10.1038/s41598-022-11157-0 PMC 바로가기 [Article Type] Article
Mechanisms of immunothrombosis and vasculopathy in antiphospholipid syndrome항인지질 증후군에서 면역혈전증과 혈관병증의 기전Review Published on 2022-05-012022-09-12 Journal: Seminars in immunopathology [Category] MERS, 진단, [키워드] activated antibody antiphospholipid antibody Antiphospholipid syndrome Autoimmune cell proliferation cells characterized circulating Coagulation Coagulopathy complement complications COVID-19 develop disease driver endothelial cells event expand Extracellular Factor fibrinolytic highlight immunothrombosis infiltration marker NETs Neutrophil extracellular trap Neutrophil extracellular traps occlusive organ damage pathogenic pathophysiology Patient phospholipid Platelets Protein recognize similarity syndrome thrombosis vascular thrombosis Vasculopathy [DOI] 10.1007/s00281-022-00916-w PMC 바로가기 [Article Type] Review
Role of Cellular Metabolism in the Formation of Neutrophil Extracellular Traps in Airway DiseasesReview Published on 2022-04-122023-07-09 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] Airway inflammation cellular metabolism Innate immunity NETs Neutrophils [DOI] 10.3389/fimmu.2022.850416 PMC 바로가기 [Article Type] Review
A targetable ‘rogue’ neutrophil-subset, [CD11b+DEspR+] immunotype, is associated with severity and mortality in acute respiratory distress syndrome (ARDS) and COVID-19-ARDS표적화 가능한 '불량' 호중구 하위 집합인 [CD11b+DEspR+] 면역형은 급성 호흡 곤란 증후군(ARDS) 및 COVID-19-ARDS의 중증도 및 사망률과 관련이 있습니다Article Published on 2022-04-042022-09-11 Journal: Scientific Reports [Category] 바이오마커, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome antibody Apoptosis ARDS arise assays association blocked Critical death detect dual dysregulated Endothelin Ex vivo expressing humanized identify IgG4 immunotype induce induction of apoptosis inhibitor inhibitors insufficiency internalization kill Ligand lung tissue MOF monocyte Monocytes Mortality NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps neutrophil function Neutrophils pathogenic Pathogens Patient peptide pleiotropic progression receptor respiratory distress Respiratory distress syndrome rhesus scRNA-seq severity syndrome Therapeutic approach tissue injury [DOI] 10.1038/s41598-022-09343-1 PMC 바로가기 [Article Type] Article
Role of the renin-angiotensin system in NETosis in the coronavirus disease 2019 (COVID-19)코로나바이러스 질병 2019(COVID-19)의 NETosis에서 레닌-안지오텐신 시스템의 역할Review Published on 2022-04-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACEi angiotensin Angiotensin II angiotensin II type 1 receptor blockers Angiotensin system angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors antagonist ARBs blocker Blood blood pressure Brain cause Complication contribute coronavirus disease COVID-19 death endocytosis Evidence explain Extracellular help hypertension induce Infarction involved kidney Low-density granulocytes lung mechanism Myocardial infarction NET NETosis NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophil extracellular traps neutrophil recruitment Numerous organ Patient patients with COVID-19 procoagulant promote recent recent findings receptor reduce regulate Renin renin-angiotensin system risk role severe COVID-19 stroke thrombosis Treatment Trigger virus [DOI] 10.1016/j.biopha.2022.112718 PMC 바로가기 [Article Type] Review
Platelet-leukocyte crosstalk in COVID-19: How might the reciprocal links between thrombotic events and inflammatory state affect treatment strategies and disease prognosis?Review Published on 2022-03-312023-06-16 Journal: Thrombosis research [Category] MERS, [키워드] anti-inflammatory agents Antiplatelet drugs COVID-19 Cytokine storms Damage-associated molecular pattern molecules Leukocyte Migration NETs Platelets thrombosis [DOI] 10.1016/j.thromres.2022.03.022 PMC 바로가기 [Article Type] Review
Neutrophil Extracellular Traps in Severe SARS-CoV-2 Infection: A Possible Impact of LPS and (1→3)-β-D-glucan in Blood from Gut TranslocationArticle Published on 2022-03-242023-06-15 Journal: Cells [Category] MERS, SARS, [키워드] blood bacteriome COVID-19 Endotoxemia glucanemia gut barrier defect NETs [DOI] 10.3390/cells11071103 PMC 바로가기 [Article Type] Article