Anti-inflammatory therapy with nebulized dornase alfa for severe COVID-19 pneumonia: a randomized unblinded trialMedicine Published on 2024-07-162024-09-05 Journal: eLife [Category] update2024, [키워드] COVID-19 DNA DNase Dornase alfa histone Incomplete Inflammation NETs Valuable viruses [DOI] 10.7554/eLife.87030 PMC 바로가기 [Article Type] Medicine
Spontaneous Lethal Outbreak of Influenza A Virus Infection in Vaccinated Sows on Two Farms Suggesting the Occurrence of Vaccine-Associated Enhanced Respiratory Disease with Eosinophilic Lung PathologyArticle Published on 2024-06-132024-09-05 Journal: Viruses [Category] update2024, [키워드] eosinophilic lung pathology eosinophils NETs PIGS swine influenza virus VAERD [DOI] 10.3390/v16060955 PMC 바로가기 [Article Type] Article
Role and intervention of PAD4 in NETs in acute respiratory distress syndromeReview Published on 2024-01-302024-09-05 Journal: Respiratory Research [Category] update2024, [키워드] ARDS NETs PAD4 Sepsis [DOI] 10.1186/s12931-024-02676-7 PMC 바로가기 [Article Type] Review
Low-Density Neutrophils Contribute to Subclinical Inflammation in Patients with Type 2 DiabetesArticle Published on 2024-01-302024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] Cytokines NETs neutrophil type 2 diabetes [DOI] 10.3390/ijms25031674 PMC 바로가기 [Article Type] Article
Characterization of young and aged ferrets as animal models for SARS-CoV-2 infection with focus on neutrophil extracellular trapsImmunology Original Research Published on 2023-12-152024-09-05 Journal: Frontiers in immunology [Category] update2024, [키워드] age animal model COVID-19 ferret NETs SARS-CoV-2 virus [DOI] 10.3389/fimmu.2023.1283595 PMC 바로가기 [Article Type] Immunology Original Research
Circulating neutrophil anti-pathogen dysfunction in cirrhosisarticle Published on 2023-08-012024-09-05 Journal: JHEP Reports [Category] update2024, [키워드] chemotaxis cirrhosis NETs Neutrophils phagocytosis ROS [DOI] 10.1016/j.jhepr.2023.100871 PMC 바로가기 [Article Type] article
The role of extracellular histones in COVID-19Review Published on 2023-03-012023-07-10 Journal: Journal of internal medicine [Category] COVID19(2023년), [키워드] COVID-19 DAMPs Extracellular histones histones. NETosis NETs [DOI] 10.1111/joim.13585 PMC 바로가기 [Article Type] Review
Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumoniaArticle Published on 2022-12-132023-06-20 Journal: Immunity [Category] Fulltext, MERS, [키워드] Actin COVID-19 Degradation DNA DNase I histone Inflammation NETs proteomics Sepsis [DOI] 10.1016/j.immuni.2022.11.007 PMC 바로가기
COVID-19: imbalanced cell-mediated immune response drives to immunopathologyArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome alveolar damage Antiviral caused cell-mediated immune cell-mediated immune response changes in consequence coronavirus coronavirus disease COVID-19 Critical cytokine Cytokine storm effective Endotheliitis exacerbated excessive inflammation fluid overload homeostasis Host host cells immune immune responses immune system Immunological response immunopathology Inflammatory response Invasion involved lung damage Lung injury manifested mechanism NETs neutrophil activation organs pandemic Pathogenesis pathophysiological progression SARS-CoV-2 SARS-CoV-2-specific immune responses severe disease syndrome therapeutic agent Therapeutic strategies tissue Trigger viral infection [DOI] 10.1080/22221751.2022.2122579 PMC 바로가기
Neutrophil Extracellular Traps, Local IL-8 Expression, and Cytotoxic T-Lymphocyte Response in the Lungs of Patients With Fatal COVID-19Article Published on 2022-11-012022-11-16 Journal: Chest [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis analyzed association Bacteria bronchiolar CD8+ T-cell chemokine correlated COVID-19 CXCL8 Cytokines cytotoxic death Defense Diseases eight exploratory expression Extracellular fatal COVID-19 function heterogeneity IL-8 immune response immunohistochemistry infiltration Inflammation Inflammatory inherent leukocyte liver tissues Local lung Lungs mechanism Messenger RNA mRNA mRNA levels multiplexed immunofluorescence NET NETosis NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils no correlation pathogenic Patient polymerase chain pulmonary thrombi quantified Respiratory failure response SARS-CoV-2 severe COVID-19 shown T-lymphocyte the SARS-CoV-2 tissue tissue damage tissue viral load validation cohorts viral loads [DOI] 10.1016/j.chest.2022.06.007 PMC 바로가기