Optical coherence tomography as retinal imaging biomarker of neuroinflammation/neurodegeneration in systemic disorders in adults and children Reviews Published on 2022-04-152022-10-05 Journal: Eye (London, England) [Category] 바이오마커, [키워드] activated addressed Amyotrophic lateral sclerosis Ataxia Biomarker Central nervous system changes in children CNS complex Diabetes Mellitus disease Diseases disorder disorders domain Encephalopathy extension ganglion cell glial cell Human immunodeficiency virus hypoxic include Inflammatory invasive layer thickness lysosomal microglial cell Modification multiple sclerosis neurodegenerative neuronal Optical coherence tomography Retina retinal imaging Schizophrenia Spectral systemic and local systemic disorder tomography [DOI] 10.1038/s41433-022-02056-9 [Article Type] Reviews
CSF Biomarkers in COVID-19 Associated Encephalopathy and Encephalitis Predict Long-Term OutcomeCOVID-19 관련 뇌병증 및 뇌염의 CSF 바이오마커는 장기적인 결과를 예측합니다Article Published on 2022-04-112022-09-11 Journal: Frontiers in Immunology [Category] Coronavirus, COVID19(2023년), SARS, 바이오마커, [키워드] activity acute COVID-19 antibodies antibody Antigen antigens Autoimmunity blood-brain barrier both groups Complication coronavirus disease Coronavirus disease 2019 correlated COVID-19 CSF cytokine cytokine profile Cytokine storm syndrome Cytokines develop diagnostic elevated Encephalitis Encephalopathy evaluate Follow-up functional group healthy control healthy controls Hospitalized IgG IL-10 IL-18 IL-1ra IL-6 IL-8 in both groups include Inflammation Inflammatory Inflammatory cytokines inflammatory process IP-10 manifestation MCP1 MIG neuro-COVID neurofilaments neurologic Neurological involvement neuronal neuronal antibodies. no difference no differences outcome Patient patients predict pro-inflammatory cytokine pro-inflammatory cytokines Prognosis prognostic Proinflammatory cytokine proinflammatory cytokines promoted Protein SARS-CoV-2 SARS-COV-2 infection serum serum biomarker serum biomarkers severity significantly viral-induced while [DOI] 10.3389/fimmu.2022.866153 PMC 바로가기 [Article Type] Article
Amyloid processing in COVID-19-associated neurological syndromesCOVID-19 관련 신경 증후군에서 아밀로이드 처리Article Published on 2022-04-012022-09-11 Journal: Journal of neurochemistry [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] Activation Acute disseminated encephalomyelitis Altered Alzheimer's disease amyloid amyloid precursor protein amyloid processing app Beta beta amyloid. Biomarker Central pain central pain syndrome cerebrospinal fluid cohort study controls correlated COVID-19 COVID-19 negative cross-sectional CSF Cytokines described Disseminated encephalomyelitis Encephalitis Encephalopathy exploratory GFAp greater Guillain-barrè syndrome healthy hypertension IL-1β IL-8 impairment Infection Injury interleukin Intracranial Hypertension mechanism Necrosis nervous system Neuroinflammation neurological neurological manifestation neuronal Pain Patient patients with COVID-19 pilot study positively correlated Proinflammatory cytokine proinflammatory cytokines raise reduced SARS-CoV-2 SARS-COV-2 infection sensitivity analysis serum biomarker serum biomarkers significantly significantly increased syndrome tissue with COVID-19 [DOI] 10.1111/jnc.15585 PMC 바로가기 [Article Type] Article
SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal deathSARS-CoV-2 스파이크 단백질은 비 세포 자율 해마 신경 세포 죽음을 통해 마우스에서인지 결핍 및 불안과 같은 행동을 유도합니다Article Published on 2022-03-312022-09-12 Journal: Scientific Reports [Category] MERS, SARS, 진단, [키워드] accompanied Activation acute respiratory syndrome administration autonomous cell death cognitive contribute coronavirus COVID-19 patient death disorder Glia glial cell in vitro in vivo induce Infection interleukin-1β mechanism neurological Neurological symptom neuronal pathogenic S1 protein S1 subunit SARS-CoV-2 SARS-CoV-2 spike protein the S1 protein [DOI] 10.1038/s41598-022-09410-7 PMC 바로가기 [Article Type] Article
Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmiaCOVID-19 유발 후각장애의 잠재적 원인으로서 핵 구조의 비-세포 자율적 파괴Article Published on 2022-03-172022-09-11 Journal: Cell [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] Alter Anosmia can not cause Cell cellular cellular and molecular cognitive components COVID-19 COVID-19 patients dissipation downregulation Effect Genes genomic hamsters Human human body imperative infect less morphology neuronal nuclear nuclear architecture. Olfaction olfactory olfactory dysfunction olfactory receptors organs patients potential mechanism receptor SARS-CoV-2 SARS-COV-2 infection sensory deficit Signaling symptoms of COVID-19 systemic effect Transcriptome variety widespread [DOI] 10.1016/j.cell.2022.01.024 PMC 바로가기 [Article Type] Article
Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms코로나바이러스 질환 2019 및 신경학적 증상이 있는 환자의 혈청 및 뇌척수액에서 중증 급성 호흡기 증후군 코로나바이러스 2에 대한 항체 반응Article Published on 2022-03-152022-09-11 Journal: The Journal of Infectious Diseases [Category] MERS, SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody Response Antibody responses Central nervous system cerebrospinal fluid clinical variables coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 CSF disease severity elevated highest IgG Immunoglobulin Immunoglobulin G independent Level marker neurological Neurological symptom Neurological symptoms neuronal Patient Predictive Predictive value respiratory response SARS-CoV-2 SARS-CoV-2 IgG serological serology serum severe acute respiratory syndrome Coronavirus Spike protein tested virus spike protein were assessed [DOI] 10.1093/infdis/jiab153 PMC 바로가기 [Article Type] Article
Plasma Biomarkers of Neuropathogenesis in Hospitalized Patients With COVID-19 and Those With Postacute Sequelae of SARS-CoV-2 Infection입원한 COVID-19 환자 및 SARS-CoV-2 감염의 급성 후유증이 있는 환자의 신경병증 발생에 대한 혈장 바이오마커Article Published on 2022-03-072022-09-11 Journal: Neurology® neuroimmunology & neuroinflammation [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, 치료법, [키워드] Acidic Activation addition Antigen antigenemia antigenic antigenic stimulation Anxiety assessments association biochemical evidence Blood calculated CNS cognitive concentrations coronavirus correlated COVID-19 COVID-19 disease detectable detection develop diagnosis of COVID-19 dysfunction Encephalopathy enrolled Evidence evidence of exhibited groups healthy control Hospitalization Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient Infection initial Injury latent infection life light chain manifestation Measures Mild neurologic neuronal Neuropathogenesis Neuropsychiatric nucleocapsid antigen occur Older PASC pathogenic mechanism pathogenic mechanisms Patient patients patients hospitalized plasma plasma biomarker PNP presenting Protein recruited required respiratory Respiratory Coronavirus SARS-CoV-2 SARS-CoV-2 N Simoa Study participants subjects Symptom Symptoms symptoms onset These data were measured with COVID-19 [DOI] 10.1212/NXI.0000000000001151 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Infects Primary Neurons from Human ACE2 Expressing Mice and Upregulates Genes Involved in the Inflammatory and Necroptotic PathwaysArticle Published on 2022-02-172022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] ACE2 activate acute respiratory syndrome addition Brain brains CCL2 Central nervous system CNS Coronavirus-2 COVID-19 Culture cultures CXCL10 cytokeratin 18 promoter Effect evaluated expressing expression of gene Human human Angiotensin-converting enzyme IFN-α IL-6 Immunological response Infection Inflammation Innate immunity involved K18-hACE2 K18-hACE2 mice mechanism mice necroptosis Neuron neuronal neurons Neuropathogenesis occur Pathogenesis pathway replication of SARS-CoV-2 SARS-CoV-2 SARS-COV-2 infection Support tissue tropism TNF-α upregulated virus replication [DOI] 10.3390/pathogens11020257 PMC 바로가기 [Article Type] Article
Impact of the COVID-19 pandemic on access to the cerliponase alfa managed access agreement in England for CLN2 treatmentResearch Published on 2022-01-192022-10-29 Journal: Orphanet Journal of Rare Diseases [Category] COVID-19, SARS, [키워드] Administered affected Anxiety Cerliponase alfa ceroid lipofuscinosis children conducted coronavirus disease Coronavirus infection COVID-19 COVID-19 pandemic COVID-19 testing Deterioration disease England enzyme family hcp Healthcare professional Impact London MAA Managed access agreement management neuronal Neuronal ceroid lipofuscinosis type 2 (CLN2) nine pandemic Precaution precautions representing Research Result risk shielding Street telephone therapy Treatment [DOI] 10.1186/s13023-021-02147-y PMC 바로가기 [Article Type] Research
miRNAs, from Evolutionary Junk to Possible Prognostic Markers and Therapeutic Targets in COVID-19miRNA, 진화 적 쓰레기에서 가능한 예후 마커 및 covid-19의 치료 표적까지Review Published on 2021-12-272022-09-10 Journal: Viruses [Category] SARS, 치료제, [키워드] addition among others Antiviral treatment cellular Complication complications COVID-19 COVID-19 pandemic COVID-19 patients cytokine Cytokine storm element Exacerbation Genes Genetic genetic regulation high risk highlight Host identify increased expression inflammatory process intensive care intensive care unit Interaction microRNA miR-122 miR-155 miR-200 miR-21 miRNA miRNAs molecular Mortality neuronal pathophysiology Patient predictor Prognosis prognostic public health Regulation renal required risk SARS-CoV-2 target the disease therapeutic therapeutic targets Viral virus [DOI] 10.3390/v14010041 PMC 바로가기 [Article Type] Review